ATE405572T1 - Herstellung von p-chirogenen phospholanen und deren verwendung in der asymmetrischen synthese - Google Patents
Herstellung von p-chirogenen phospholanen und deren verwendung in der asymmetrischen syntheseInfo
- Publication number
- ATE405572T1 ATE405572T1 AT05718265T AT05718265T ATE405572T1 AT E405572 T1 ATE405572 T1 AT E405572T1 AT 05718265 T AT05718265 T AT 05718265T AT 05718265 T AT05718265 T AT 05718265T AT E405572 T1 ATE405572 T1 AT E405572T1
- Authority
- AT
- Austria
- Prior art keywords
- chirogenic
- phospholanes
- asymmetric synthesis
- production
- disclosed
- Prior art date
Links
- 150000004850 phospholanes Chemical class 0.000 title abstract 3
- 238000011914 asymmetric synthesis Methods 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
- GWLJTAJEHRYMCA-UHFFFAOYSA-N phospholane Chemical class C1CCPC1 GWLJTAJEHRYMCA-UHFFFAOYSA-N 0.000 abstract 2
- 239000003054 catalyst Substances 0.000 abstract 1
- 150000005829 chemical entities Chemical class 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- AYXYPKUFHZROOJ-ZETCQYMHSA-N pregabalin Chemical compound CC(C)C[C@H](CN)CC(O)=O AYXYPKUFHZROOJ-ZETCQYMHSA-N 0.000 abstract 1
- 229960001233 pregabalin Drugs 0.000 abstract 1
- 229910052703 rhodium Inorganic materials 0.000 abstract 1
- 239000010948 rhodium Substances 0.000 abstract 1
- MHOVAHRLVXNVSD-UHFFFAOYSA-N rhodium atom Chemical compound [Rh] MHOVAHRLVXNVSD-UHFFFAOYSA-N 0.000 abstract 1
- 238000007363 ring formation reaction Methods 0.000 abstract 1
- 230000000707 stereoselective effect Effects 0.000 abstract 1
- 229910052723 transition metal Inorganic materials 0.000 abstract 1
- 150000003624 transition metals Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6568—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus atoms as the only ring hetero atoms
- C07F9/65685—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus atoms as the only ring hetero atoms the ring phosphorus atom being part of a phosphine oxide or thioxide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
- C07D327/10—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms two oxygen atoms and one sulfur atom, e.g. cyclic sulfates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/0046—Ruthenium compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6568—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus atoms as the only ring hetero atoms
- C07F9/65683—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus atoms as the only ring hetero atoms the ring phosphorus atom being part of a phosphine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55904304P | 2004-04-01 | 2004-04-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE405572T1 true ATE405572T1 (de) | 2008-09-15 |
Family
ID=34962295
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05718265T ATE405572T1 (de) | 2004-04-01 | 2005-03-23 | Herstellung von p-chirogenen phospholanen und deren verwendung in der asymmetrischen synthese |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7390931B2 (de) |
| EP (1) | EP1735324B1 (de) |
| JP (1) | JP2007530657A (de) |
| AT (1) | ATE405572T1 (de) |
| BR (1) | BRPI0508998A (de) |
| CA (1) | CA2561755A1 (de) |
| DE (1) | DE602005009161D1 (de) |
| ES (1) | ES2309731T3 (de) |
| WO (1) | WO2005095424A1 (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998003167A1 (en) | 1996-07-24 | 1998-01-29 | Warner-Lambert Company | Isobutylgaba and its derivatives for the treatment of pain |
| CN101160281A (zh) * | 2005-04-06 | 2008-04-09 | 特瓦制药工业有限公司 | 结晶形态的普瑞巴林 |
| MX2007012606A (es) * | 2005-04-11 | 2008-01-11 | Teva Pharma | Proceso para elaborar (s)-pregabalina. |
| US7488846B2 (en) * | 2005-04-11 | 2009-02-10 | Teva Pharmaceuical Industries Ltd. | Pregabalin free of lactam and a process for preparation thereof |
| JP2008505980A (ja) | 2005-05-10 | 2008-02-28 | テバ ファーマシューティカル インダストリーズ リミティド | イソブチルグルタル酸を有さないプレガバリン及びその調製方法 |
| CA2604624A1 (en) * | 2005-05-10 | 2006-11-16 | Teva Pharmaceutical Industries Ltd. | Optical resolution of 3-carbamoylmethyl-5-methyl hexanoic acid |
| EP1879851B1 (de) * | 2005-05-10 | 2010-11-03 | Teva Pharmaceutical Industries Ltd | Verfahren zur herstellung von pregabalin und salzen daraus |
| CA2619472A1 (en) * | 2005-09-19 | 2007-03-29 | Teva Pharmaceutical Industries Ltd. | Chiral 3-carbamoylmethyl-5-methyl hexanoic acids, key intermediates for the new synthesis of (s)-pregabalin |
| BRPI0702865A2 (pt) * | 2006-04-24 | 2012-08-07 | Teva Pharma | processos para preparaÇço do Ácido 3-isobutilglutÁrico e de (s)- pregabalin, a partir de combinaÇÕes de composiÇÕes com fàrmulas especÍficas para uso na dita preparaÇço |
| TW200815323A (en) * | 2006-05-24 | 2008-04-01 | Teva Pharma | Processes for the preparation of R-(+)-3-(carbamoylmethyl)-5-methylhexanoic acid and salts thereof |
| EP2071032A3 (de) * | 2006-05-31 | 2009-07-08 | Teva Pharmaceutical Industries Ltd | Enzymatische Auflösung für die Herstellung von Pregablin-Zwischenprodukten |
| US20080015385A1 (en) * | 2006-05-31 | 2008-01-17 | Lilach Hedvati | Preparation of (S)-pregabalin-nitrile |
| BRPI0803092A2 (pt) * | 2007-03-22 | 2011-08-30 | Teva Pharma | sìntese de (s)-(+)-3-(aminometil)-5-metil ácido hexanóico, (s)-pregabalina |
| US20090137842A1 (en) * | 2007-10-03 | 2009-05-28 | Vollerner Yuri | Pregabalin -4-eliminate, pregabalin 5-eliminate, their use as reference marker and standard, and method to produce pregabalin containing low levels thereof |
| JP2010043063A (ja) * | 2008-05-09 | 2010-02-25 | Agency For Science Technology & Research | 川崎病の診断及び治療 |
| KR20100107500A (ko) * | 2008-06-23 | 2010-10-05 | 테바 파마슈티컬 인더스트리즈 리미티드 | (ｓ) 또는 (ｒ)-이소-부틸-글루타릭 에스테르의 입체선택적 효소 합성방법 |
| CN103788133A (zh) * | 2014-01-22 | 2014-05-14 | 常州大学 | 一种含磷五元杂环类化合物及其合成方法 |
| CN109776486A (zh) * | 2019-02-26 | 2019-05-21 | 武汉松石科技股份有限公司 | 一种硫酸亚丙酯的制备方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6197819B1 (en) | 1990-11-27 | 2001-03-06 | Northwestern University | Gamma amino butyric acid analogs and optical isomers |
| WO1998003167A1 (en) | 1996-07-24 | 1998-01-29 | Warner-Lambert Company | Isobutylgaba and its derivatives for the treatment of pain |
| US6329429B1 (en) | 1997-06-25 | 2001-12-11 | Warner-Lambert Company | Use of GABA analogs such as Gabapentin in the manufacture of a medicament for treating inflammatory diseases |
| AU9019198A (en) | 1997-08-19 | 1999-03-08 | Warner-Lambert Company | Methods for treating physiological conditions associated with the use, or sequelae of use, of ***e or other psychomotor stimulants |
| US6127418A (en) | 1997-08-20 | 2000-10-03 | Warner-Lambert Company | GABA analogs to prevent and treat gastrointestinal damage |
| AU8668598A (en) | 1997-08-20 | 1999-03-08 | University Of Oklahoma, The | Gaba analogs to prevent and treat gastrointestinal damage |
| NZ508490A (en) | 1998-07-09 | 2003-08-29 | Warner Lambert Co | Use of a combination of a GABA analog and caffeine as an analgesic |
| JP2002520277A (ja) | 1998-07-09 | 2002-07-09 | ワーナー−ランバート・カンパニー | 不眠症を治療する方法 |
| DE69934813T2 (de) | 1998-10-16 | 2007-10-11 | Warner-Lambert Company Llc | Verwendung von gaba analogen zur herstellung eines arzneimittels zur behandlung von manie und bipolaren erkrankungen |
| EP1341799B1 (de) * | 2000-12-13 | 2005-03-16 | Warner-Lambert Company LLC | P-chirale bisphospholane ligande, deren übergangsmetall-komplexe |
-
2005
- 2005-03-23 JP JP2007505651A patent/JP2007530657A/ja not_active Withdrawn
- 2005-03-23 EP EP05718265A patent/EP1735324B1/de not_active Not-in-force
- 2005-03-23 BR BRPI0508998-0A patent/BRPI0508998A/pt not_active IP Right Cessation
- 2005-03-23 DE DE602005009161T patent/DE602005009161D1/de not_active Expired - Fee Related
- 2005-03-23 AT AT05718265T patent/ATE405572T1/de not_active IP Right Cessation
- 2005-03-23 WO PCT/IB2005/000768 patent/WO2005095424A1/en active IP Right Grant
- 2005-03-23 CA CA002561755A patent/CA2561755A1/en not_active Abandoned
- 2005-03-23 ES ES05718265T patent/ES2309731T3/es active Active
- 2005-03-31 US US11/095,044 patent/US7390931B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO2005095424A8 (en) | 2005-12-15 |
| DE602005009161D1 (de) | 2008-10-02 |
| EP1735324A1 (de) | 2006-12-27 |
| WO2005095424A1 (en) | 2005-10-13 |
| CA2561755A1 (en) | 2005-10-13 |
| JP2007530657A (ja) | 2007-11-01 |
| US20050222464A1 (en) | 2005-10-06 |
| US7390931B2 (en) | 2008-06-24 |
| BRPI0508998A (pt) | 2007-09-04 |
| EP1735324B1 (de) | 2008-08-20 |
| ES2309731T3 (es) | 2008-12-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |