ATE404176T1 - Stabilisierte lyophilisierte zubereitungen mit gewebefaktor-inhibitor (tfpi) oder varianten des gewebefaktor-inhibitors - Google Patents
Stabilisierte lyophilisierte zubereitungen mit gewebefaktor-inhibitor (tfpi) oder varianten des gewebefaktor-inhibitorsInfo
- Publication number
- ATE404176T1 ATE404176T1 AT04700827T AT04700827T ATE404176T1 AT E404176 T1 ATE404176 T1 AT E404176T1 AT 04700827 T AT04700827 T AT 04700827T AT 04700827 T AT04700827 T AT 04700827T AT E404176 T1 ATE404176 T1 AT E404176T1
- Authority
- AT
- Austria
- Prior art keywords
- tissue factor
- factor inhibitor
- tfpi
- variants
- lyophilized preparations
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/57—Protease inhibitors from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US43852403P | 2003-01-08 | 2003-01-08 | |
US49454703P | 2003-08-13 | 2003-08-13 | |
US50927603P | 2003-10-08 | 2003-10-08 | |
US51209203P | 2003-10-20 | 2003-10-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE404176T1 true ATE404176T1 (de) | 2008-08-15 |
Family
ID=32719507
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT04700827T ATE404176T1 (de) | 2003-01-08 | 2004-01-08 | Stabilisierte lyophilisierte zubereitungen mit gewebefaktor-inhibitor (tfpi) oder varianten des gewebefaktor-inhibitors |
Country Status (9)
Country | Link |
---|---|
US (2) | US20040180827A1 (de) |
EP (1) | EP1589949B1 (de) |
JP (1) | JP2008500942A (de) |
AT (1) | ATE404176T1 (de) |
CA (1) | CA2512680A1 (de) |
DE (1) | DE602004015725D1 (de) |
ES (1) | ES2311789T3 (de) |
PT (1) | PT1589949E (de) |
WO (1) | WO2004062646A1 (de) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6057287A (en) | 1994-01-11 | 2000-05-02 | Dyax Corp. | Kallikrein-binding "Kunitz domain" proteins and analogues thereof |
US7153829B2 (en) | 2002-06-07 | 2006-12-26 | Dyax Corp. | Kallikrein-inhibitor therapies |
CA2488558C (en) | 2002-06-07 | 2013-08-20 | Dyax Corp. | Prevention and reduction of blood loss |
DK2386310T3 (en) | 2002-08-28 | 2019-02-25 | Dyax Corp | Methods of preserving organs and tissues |
US20050032153A1 (en) * | 2003-04-30 | 2005-02-10 | Ropp Philip A. | Control of cyanate in aqueous urea solutions by non-1,2-ethylene diamine like compounds for the protection of protein/peptide carbamylation |
EP2311871A3 (de) * | 2004-08-17 | 2012-08-08 | Regeneron Pharmaceuticals, Inc. | IL-1 Antagonisten enthaltende flüssige stabile Zusammensetzung |
US7235530B2 (en) | 2004-09-27 | 2007-06-26 | Dyax Corporation | Kallikrein inhibitors and anti-thrombolytic agents and uses thereof |
WO2006081320A2 (en) * | 2005-01-27 | 2006-08-03 | Human Genome Sciences, Inc. | Pharmaceutical formulation |
GB0517688D0 (en) * | 2005-08-31 | 2005-10-05 | Cambridge Biostability Ltd | Improvements in the stabilisation of biological materials |
GB2430880A (en) * | 2005-10-04 | 2007-04-11 | Cambridge Biostability Ltd | Pharmaceutical compositions stabilized in glassy particles |
GB0523638D0 (en) * | 2005-11-21 | 2005-12-28 | Cambridge Biostability Ltd | Pharmaceutical device for the administration of substances to patients |
WO2007103425A2 (en) * | 2006-03-06 | 2007-09-13 | Novartis Ag | Kits and methods for preparing pharmaceutical compositions comprising tissue factor pathway inhibitor (tfpi) |
WO2007106746A2 (en) * | 2006-03-10 | 2007-09-20 | Dyax Corp. | Formulations for ecallantide |
WO2010080833A1 (en) | 2009-01-06 | 2010-07-15 | Dyax Corp. | Treatment of mucositis with kallikrein inhibitors |
SI2521568T1 (sl) | 2010-01-06 | 2019-01-31 | Dyax Corp. | Proteini, ki vežejo plazemski kalikrein |
IL269565B2 (en) | 2011-01-06 | 2024-06-01 | Dyax Corp | KALLIKREIN PLASMA BINDING PROTEINS |
CN102942597A (zh) * | 2012-10-24 | 2013-02-27 | 江苏大学 | 含氯或氟的五配位咔咯钴配合物及其合成方法 |
BR112016022318A2 (pt) | 2014-03-27 | 2017-10-31 | Dyax Corp | método, composição farmacêutica para uso no tratamento de doenças de retina e uso de um anticorpo |
EA036091B1 (ru) * | 2014-08-20 | 2020-09-25 | Портола Фармасьютикалз, Инк. | ВОДНЫЕ СОСТАВЫ АНТИДОТОВ ФАКТОРА Xa (fXa) ДЛЯ ПРЕДУПРЕЖДЕНИЯ ИЛИ УМЕНЬШЕНИЯ КРОВОТЕЧЕНИЯ И ИХ ПРИМЕНЕНИЕ |
JP7003354B2 (ja) | 2015-12-11 | 2022-03-04 | 武田薬品工業株式会社 | 遺伝性血管性浮腫の発作を治療するための血漿カリクレイン阻害薬およびその用途 |
WO2017147522A1 (en) | 2016-02-24 | 2017-08-31 | Portola Pharmaceuticals, Inc. | Lyophilized formulations for factor xa antidote |
MX2020004936A (es) * | 2017-11-16 | 2020-08-27 | Amgen Inc | Composiciones estables de compuestos de carfilzomib pegilado. |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5106833A (en) * | 1987-07-23 | 1992-04-21 | Washington University | Coagulation inhibitors |
US4966852A (en) * | 1987-07-23 | 1990-10-30 | Monsanto Company | DNA clone of human tissue factor inhibitor |
US5219994A (en) * | 1988-11-08 | 1993-06-15 | W. Alton Jones Cell Science Center, Inc. | Inhibitor of tissue factor activity |
DK408089D0 (da) * | 1989-08-18 | 1989-08-18 | Novo Nordisk As | Proteiner |
US5583107A (en) * | 1990-09-04 | 1996-12-10 | Cor Therapeutics, Inc. | Agents affecting thrombosis and hemostasis |
US5849704A (en) * | 1991-12-20 | 1998-12-15 | Novo Nordisk A/S | Pharmaceutical formulation |
US5276015A (en) * | 1992-03-18 | 1994-01-04 | Washington University | Method of inhibiting microvascular thrombosis |
US5358708A (en) * | 1993-01-29 | 1994-10-25 | Schering Corporation | Stabilization of protein formulations |
FR2719479B1 (fr) * | 1994-05-04 | 1996-07-26 | Sanofi Elf | Formulation stable lyophilisée comprenant une protéine: kit de dosage. |
US5580856A (en) * | 1994-07-15 | 1996-12-03 | Prestrelski; Steven J. | Formulation of a reconstituted protein, and method and kit for the production thereof |
JP3435946B2 (ja) * | 1994-12-21 | 2003-08-11 | 王子製紙株式会社 | 耐熱性キシラナーゼ |
ATE251141T1 (de) * | 1995-03-10 | 2003-10-15 | Berlex Lab | Benzamidin-derivate, deren herstellung und deren verwendung als anti-koagulantien |
PT1602667E (pt) * | 1995-06-07 | 2007-07-13 | Searle Llc | Formulação aquosa que compreende tfpi e agentes de solubilização |
ATE239501T1 (de) * | 1995-06-07 | 2003-05-15 | Chiron Corp | Regulierung der neutrophil elastase synthese und freisetzung |
US5919765A (en) * | 1995-06-07 | 1999-07-06 | Cor Therapeutics, Inc. | Inhibitors of factor XA |
US5888968A (en) * | 1995-06-07 | 1999-03-30 | Chiron Corporation | TFPI formulation |
US5721214A (en) * | 1995-06-07 | 1998-02-24 | Cor Therapeutics, Inc. | Inhibitors of factor Xa |
US6267958B1 (en) * | 1995-07-27 | 2001-07-31 | Genentech, Inc. | Protein formulation |
US5580107A (en) * | 1995-09-25 | 1996-12-03 | Dell U.S.A., L.P. | Hidden latch hook for portable personal computer and the like |
US5736364A (en) * | 1995-12-04 | 1998-04-07 | Genentech, Inc. | Factor viia inhibitors |
US5824660A (en) * | 1996-06-10 | 1998-10-20 | G. D. Searle & Co. | Method of inhibiting glomerulonephritis |
US6262233B1 (en) * | 1997-01-31 | 2001-07-17 | Human Genome Sciences, Inc. | Tissue factor pathway inhibitor-3 |
WO2001024814A1 (en) * | 1999-10-04 | 2001-04-12 | Chiron Corporation | Stabilized liquid polypeptide-containing pharmaceutical compositions |
PL356641A1 (en) * | 1999-12-30 | 2004-06-28 | Chiron Corporation | Methods for pulmonary delivery of interleukin-2 |
DE10022092A1 (de) * | 2000-05-08 | 2001-11-15 | Aventis Behring Gmbh | Stabilisiertes Protein-Präparat und Verfahren zu seiner Herstellung |
KR20040040489A (ko) * | 2001-10-15 | 2004-05-12 | 카이론 코포레이션 | 조직 인자 경로 억제제(tfpi)의 저용량 투여에 의한패혈증의 치료 |
-
2004
- 2004-01-08 JP JP2006500806A patent/JP2008500942A/ja active Pending
- 2004-01-08 AT AT04700827T patent/ATE404176T1/de not_active IP Right Cessation
- 2004-01-08 EP EP04700827A patent/EP1589949B1/de not_active Expired - Lifetime
- 2004-01-08 DE DE602004015725T patent/DE602004015725D1/de not_active Expired - Lifetime
- 2004-01-08 CA CA002512680A patent/CA2512680A1/en not_active Abandoned
- 2004-01-08 ES ES04700827T patent/ES2311789T3/es not_active Expired - Lifetime
- 2004-01-08 WO PCT/US2004/000235 patent/WO2004062646A1/en active Application Filing
- 2004-01-08 PT PT04700827T patent/PT1589949E/pt unknown
- 2004-01-08 US US10/753,079 patent/US20040180827A1/en not_active Abandoned
-
2006
- 2006-03-22 US US11/385,873 patent/US20060159679A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CA2512680A1 (en) | 2004-07-29 |
DE602004015725D1 (de) | 2008-09-25 |
PT1589949E (pt) | 2008-11-06 |
WO2004062646A1 (en) | 2004-07-29 |
US20060159679A1 (en) | 2006-07-20 |
ES2311789T3 (es) | 2009-02-16 |
US20040180827A1 (en) | 2004-09-16 |
EP1589949A1 (de) | 2005-11-02 |
JP2008500942A (ja) | 2008-01-17 |
EP1589949B1 (de) | 2008-08-13 |
WO2004062646A9 (en) | 2010-11-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification |
Ref document number: 1589949 Country of ref document: EP |
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REN | Ceased due to non-payment of the annual fee |