ATE390436T1 - Verbesserter zerfall und rückfaltung von proteinen mittels hohen drucks - Google Patents
Verbesserter zerfall und rückfaltung von proteinen mittels hohen drucksInfo
- Publication number
- ATE390436T1 ATE390436T1 AT01270119T AT01270119T ATE390436T1 AT E390436 T1 ATE390436 T1 AT E390436T1 AT 01270119 T AT01270119 T AT 01270119T AT 01270119 T AT01270119 T AT 01270119T AT E390436 T1 ATE390436 T1 AT E390436T1
- Authority
- AT
- Austria
- Prior art keywords
- refolding
- high pressure
- proteins
- improved decay
- present
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 3
- 108090000623 proteins and genes Proteins 0.000 title abstract 3
- 238000013019 agitation Methods 0.000 abstract 1
- 238000000502 dialysis Methods 0.000 abstract 1
- 238000010790 dilution Methods 0.000 abstract 1
- 239000012895 dilution Substances 0.000 abstract 1
- 238000004090 dissolution Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000030788 protein refolding Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/57—IFN-gamma
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2462—Lysozyme (3.2.1.17)
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Wood Science & Technology (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Disintegrating Or Milling (AREA)
- Processing Of Solid Wastes (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- External Artificial Organs (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24480800P | 2000-10-31 | 2000-10-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE390436T1 true ATE390436T1 (de) | 2008-04-15 |
Family
ID=22924182
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01270119T ATE390436T1 (de) | 2000-10-31 | 2001-10-31 | Verbesserter zerfall und rückfaltung von proteinen mittels hohen drucks |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US7538198B2 (de) |
| EP (1) | EP1434789B1 (de) |
| JP (3) | JP2004530651A (de) |
| AT (1) | ATE390436T1 (de) |
| CA (1) | CA2434045A1 (de) |
| DE (1) | DE60133426T2 (de) |
| DK (1) | DK1434789T3 (de) |
| MX (1) | MXPA03003867A (de) |
| WO (1) | WO2002062827A2 (de) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE349460T1 (de) | 1998-07-09 | 2007-01-15 | Barofold Inc | Rückfaltung von protein-aggregaten und einschlussteilchen durch hohen druck |
| US7615617B2 (en) | 1999-10-25 | 2009-11-10 | University Of Delaware | Use of hydrostatic pressure to inhibit and reverse protein aggregation and facilitate protein refolding |
| MXPA03003867A (es) | 2000-10-31 | 2004-10-15 | Univ Colorado Regents | Desagregacion mejorada de proteina y replegamiento utilizando alta presion. |
| US7045297B2 (en) * | 2001-11-14 | 2006-05-16 | Prion Developmental Laboratories, Inc. | Rapid prion-detection assay |
| US7614958B2 (en) * | 2001-11-16 | 2009-11-10 | Creative Kingdoms, Llc | Interactive quest game |
| WO2006053251A2 (en) * | 2004-11-12 | 2006-05-18 | Pfizer, Inc. | Method of measuring amyloid-beta peptides |
| EP1910415A4 (de) * | 2005-07-25 | 2010-08-11 | Trubion Pharmaceuticals Inc | Zusammensetzungen und verfahren zur proteindeaggregation |
| CA2915270C (en) * | 2005-08-05 | 2017-07-11 | Amgen Inc. | Stable aqueous protein or antibody pharmaceutical formulations and their preparation |
| KR20080080129A (ko) * | 2005-11-21 | 2008-09-02 | 바로폴드, 인코포레이티드 | 단백질의 고압 리폴딩을 위한 장치 및 방법 |
| EP2059523A2 (de) * | 2006-09-15 | 2009-05-20 | Barofold, Inc. | Hochdruckbehandlung von proteinen für reduzierte immunogenizität |
| WO2008124139A1 (en) * | 2007-04-05 | 2008-10-16 | Barofold, Inc. | High pressure inclusion body solubilization in the presence of a protease |
| JPWO2008133141A1 (ja) * | 2007-04-24 | 2010-07-22 | 東洋紡績株式会社 | オスモチン組換えタンパク質およびその製造方法、並びにその利用 |
| CN101820966B (zh) * | 2007-06-04 | 2017-10-27 | 高压生物科学公司 | 分子的压力提高的提取和分配 |
| WO2009035617A1 (en) | 2007-09-10 | 2009-03-19 | Barofold, Inc. | High-pressure refolding of monoclonal antibody aggregates |
| WO2009045553A1 (en) * | 2007-10-05 | 2009-04-09 | Barofold, Inc. | High pressure treatment of aggregated interferons |
| EP2232235A2 (de) * | 2007-12-10 | 2010-09-29 | Novartis AG | Analyse von proteine enthaltenden gemischen |
| WO2009137695A2 (en) * | 2008-05-07 | 2009-11-12 | Pressure Biosciences Inc. | Extraction of biomolecular complexes assisted by alternating hydrostatic pressure |
| US8288122B2 (en) * | 2008-12-03 | 2012-10-16 | The United States Of America As Represented By The Department Of Veterans Affairs | Pressure-assisted molecular recovery (PAMR) of biomolecules, pressure-assisted antigen retrieval (PAAR), and pressure-assisted tissue histology (PATH) |
| US8697848B2 (en) | 2010-07-19 | 2014-04-15 | The Regents Of The University Of Colorado | Method for reducing immunogenicity of therapeutic protein compositions |
| US9797871B2 (en) | 2010-08-05 | 2017-10-24 | Ge Healthcare Bio-Sciences Ab | Method for storage and stabilization of a target substance |
| US9995661B2 (en) | 2010-08-18 | 2018-06-12 | Pressure Biosciences, Inc. | Flow-through high hydrostatic pressure microfluidic sample preparation device and related methods therefor |
| EP2632594A1 (de) | 2010-10-28 | 2013-09-04 | Edmund Y. Ting | System und verfahren zur unterdrucksetzung von mikroplatten |
| EP2785196B1 (de) * | 2011-12-01 | 2020-08-05 | Pressure BioSciences, Inc. | Verfahren und systeme zur proteinrückfaltung |
| CA2883296A1 (en) * | 2012-08-30 | 2014-03-06 | Merial, Inc. | Hyperbaric device and methods for producing inactivated vaccines and for refolding/solubilizing recombinant proteins |
| ZA201501696B (en) | 2012-08-30 | 2016-01-27 | Merial Ltd | Hyperbaric device and methods for producing inactivated vaccines and for refolding/solubilizing recombinant proteins |
| JP2014113108A (ja) * | 2012-12-11 | 2014-06-26 | Tokyo Medical Univ | タンパク質の可溶化活性を有する多量体タンパク質およびその用途 |
| EP2978770B1 (de) | 2013-03-29 | 2019-11-06 | Dr. Reddy's Laboratories Limited | Rückfaltung von proteinen |
| WO2015034915A1 (en) * | 2013-09-04 | 2015-03-12 | The Regents Of The University Of California | Method for improving protein functionality using vortexing fluid shear forces |
| EP2975120A1 (de) * | 2014-07-17 | 2016-01-20 | Institut Pasteur | Monomeres und funktionelles Adenylatcyclase-CyaA-Toxin |
| AU2015294389B2 (en) | 2014-07-24 | 2021-04-29 | Genentech, Inc. | Methods of conjugating an agent to a thiol moiety in a protein that contains at least one trisulfide bond |
| JPWO2017094722A1 (ja) * | 2015-12-01 | 2018-10-11 | Ｓｐｉｂｅｒ株式会社 | タンパク質溶液を製造する方法 |
| JP2020152644A (ja) * | 2019-03-18 | 2020-09-24 | 国立大学法人愛媛大学 | Ｖｎａｒのリフォールディング方法およびｖｎａｒの製造方法 |
| KR20220079572A (ko) * | 2019-09-20 | 2022-06-13 | 플라즈마 테크놀로지스, 엘엘씨 | 치료 단백질 조성물 및 방법(therapeutic protein compositions and methods) |
| CN114015758B (zh) * | 2021-10-15 | 2022-06-24 | 无锡百泰克生物技术有限公司 | 一种冻干保护剂、荧光pcr检测试剂盒及冻干工艺 |
| WO2024030679A1 (en) * | 2022-08-05 | 2024-02-08 | University Of Delaware | System and apparatus for measuring scattered light signals from pressurized solutions and method of assembly |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4064192A (en) * | 1971-02-24 | 1977-12-20 | Rhone-Poulenc S.A. | Heat-stable polyimide resins |
| US4234620A (en) * | 1978-12-26 | 1980-11-18 | A. E. Staley Manufacturing Company | Water-soluble vegetable protein aggregates |
| US4652630A (en) | 1985-02-22 | 1987-03-24 | Monsanto Company | Method of somatotropin naturation |
| US4659568A (en) | 1985-02-27 | 1987-04-21 | American Cyanamid Company | Process for solubilization, purification and characterization of protein from insoluble protein aggregates or complexes and compositions of matter therefrom |
| US4766224A (en) | 1985-08-19 | 1988-08-23 | International Minerals & Chemical Corp. | Purification and activation of proteins from insoluble inclusion bodies |
| US4677196A (en) | 1985-09-06 | 1987-06-30 | International Minerals & Chemical Corp. | Purification and activation of proteins from insoluble inclusion bodies |
| US5453363A (en) | 1985-10-23 | 1995-09-26 | Boehringer Mannheim Gmbh | Process for the activation of t-PA or Ing after genetic expression in prokaryotes |
| US4929700A (en) | 1987-04-16 | 1990-05-29 | Cetus Corporation | Production of purified, biologically active, bacterially produced recombinant human CSF-1 |
| US5162507A (en) | 1987-05-11 | 1992-11-10 | Cetus Corporation | Process for recovering purified, oxidized, renatured recombinant interleukin-2 from microorganisms |
| US4985544A (en) | 1987-08-04 | 1991-01-15 | Kyowa Hakko Kogyo Co., Ltd. | Process for renaturing fish growth hormone |
| US4923967A (en) | 1988-09-26 | 1990-05-08 | Eli Lilly And Company | Purification and refolding of recombinant proteins |
| DE3835350A1 (de) | 1988-10-17 | 1990-04-19 | Boehringer Mannheim Gmbh | Aktivierung von gentechnologisch hergestellten, in prokaryonten exprimierten antikoerpern |
| US5064943A (en) | 1988-12-16 | 1991-11-12 | American Cyanamid Company | Method for solubilization and naturation of somatotropin |
| GB8927008D0 (en) | 1989-11-29 | 1990-01-17 | Ciba Geigy | Novel process for the production of unfused protein in e.coli |
| US5109117A (en) | 1990-06-26 | 1992-04-28 | Monsanto Company | Method of somatotropin naturation using urea and a soluble organic alcohol |
| US5023323A (en) | 1990-09-12 | 1991-06-11 | Monsanto Company | Method of somatotropin naturation |
| US5288931A (en) | 1991-12-06 | 1994-02-22 | Genentech, Inc. | Method for refolding insoluble, misfolded insulin-like growth factor-I into an active conformation |
| US5288462A (en) | 1992-05-18 | 1994-02-22 | Stephen D. Carter | Sterilization apparatus and method |
| US5605691A (en) | 1992-09-17 | 1997-02-25 | Ophidian Pharmaceuticals, Inc. | Immunologically active proteins from inclusion bodies |
| US5714371A (en) | 1995-05-12 | 1998-02-03 | Schering Corporation | Method for refolding insoluble aggregates of hepatitis C virus protease |
| US5728804A (en) | 1995-06-02 | 1998-03-17 | Research Corporation Technologies, Inc. | Use of cyclodextrins for protein renaturation |
| EP0924991B1 (de) * | 1996-07-02 | 2001-10-04 | BBI Bioseq, Inc. | Druck-ermittelte bindung von biomolekularen komplexen |
| ATE349460T1 (de) * | 1998-07-09 | 2007-01-15 | Barofold Inc | Rückfaltung von protein-aggregaten und einschlussteilchen durch hohen druck |
| US7615617B2 (en) | 1999-10-25 | 2009-11-10 | University Of Delaware | Use of hydrostatic pressure to inhibit and reverse protein aggregation and facilitate protein refolding |
| MXPA03003867A (es) | 2000-10-31 | 2004-10-15 | Univ Colorado Regents | Desagregacion mejorada de proteina y replegamiento utilizando alta presion. |
| KR20080080129A (ko) | 2005-11-21 | 2008-09-02 | 바로폴드, 인코포레이티드 | 단백질의 고압 리폴딩을 위한 장치 및 방법 |
| WO2008033555A2 (en) | 2006-09-15 | 2008-03-20 | Barofold, Inc. | High-pressure refolding of difficult-to-fold proteins |
| EP2059523A2 (de) | 2006-09-15 | 2009-05-20 | Barofold, Inc. | Hochdruckbehandlung von proteinen für reduzierte immunogenizität |
| WO2008124139A1 (en) * | 2007-04-05 | 2008-10-16 | Barofold, Inc. | High pressure inclusion body solubilization in the presence of a protease |
-
2001
- 2001-10-31 MX MXPA03003867A patent/MXPA03003867A/es active IP Right Grant
- 2001-10-31 DK DK01270119T patent/DK1434789T3/da active
- 2001-10-31 CA CA002434045A patent/CA2434045A1/en not_active Abandoned
- 2001-10-31 EP EP01270119A patent/EP1434789B1/de not_active Expired - Lifetime
- 2001-10-31 JP JP2002563179A patent/JP2004530651A/ja active Pending
- 2001-10-31 AT AT01270119T patent/ATE390436T1/de not_active IP Right Cessation
- 2001-10-31 WO PCT/US2001/045728 patent/WO2002062827A2/en active IP Right Grant
- 2001-10-31 DE DE60133426T patent/DE60133426T2/de not_active Expired - Lifetime
-
2003
- 2003-04-26 US US10/425,371 patent/US7538198B2/en not_active Expired - Lifetime
-
2007
- 2007-10-17 JP JP2007270735A patent/JP2008031182A/ja active Pending
-
2008
- 2008-12-12 JP JP2008317740A patent/JP2009102352A/ja active Pending
-
2009
- 2009-04-17 US US12/425,729 patent/US8329878B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA03003867A (es) | 2004-10-15 |
| CA2434045A1 (en) | 2002-08-15 |
| EP1434789A2 (de) | 2004-07-07 |
| US20100075399A1 (en) | 2010-03-25 |
| WO2002062827A3 (en) | 2004-05-06 |
| DE60133426T2 (de) | 2008-11-13 |
| US8329878B2 (en) | 2012-12-11 |
| US7538198B2 (en) | 2009-05-26 |
| EP1434789B1 (de) | 2008-03-26 |
| US20040038333A1 (en) | 2004-02-26 |
| JP2008031182A (ja) | 2008-02-14 |
| JP2009102352A (ja) | 2009-05-14 |
| JP2004530651A (ja) | 2004-10-07 |
| DE60133426D1 (de) | 2008-05-08 |
| WO2002062827A2 (en) | 2002-08-15 |
| DK1434789T3 (da) | 2008-07-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1434789 Country of ref document: EP |
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| REN | Ceased due to non-payment of the annual fee |