ATE375987T1 - Arylmethyl-carbonylamino-thiazolderivate und ihre verwendung als antitumormittel - Google Patents
Arylmethyl-carbonylamino-thiazolderivate und ihre verwendung als antitumormittelInfo
- Publication number
- ATE375987T1 ATE375987T1 AT00962760T AT00962760T ATE375987T1 AT E375987 T1 ATE375987 T1 AT E375987T1 AT 00962760 T AT00962760 T AT 00962760T AT 00962760 T AT00962760 T AT 00962760T AT E375987 T1 ATE375987 T1 AT E375987T1
- Authority
- AT
- Austria
- Prior art keywords
- arylmethyl
- carbonylamino
- tumor agents
- thiazole derivatives
- thiazole
- Prior art date
Links
- 239000002246 antineoplastic agent Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/08—Antiseborrheics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Psychiatry (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/372,832 US6114365A (en) | 1999-08-12 | 1999-08-12 | Arylmethyl-carbonylamino-thiazole derivatives, process for their preparation, and their use as antitumor agents |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE375987T1 true ATE375987T1 (de) | 2007-11-15 |
Family
ID=23469806
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT00962760T ATE375987T1 (de) | 1999-08-12 | 2000-08-11 | Arylmethyl-carbonylamino-thiazolderivate und ihre verwendung als antitumormittel |
Country Status (36)
Country | Link |
---|---|
US (3) | US6114365A (de) |
EP (1) | EP1204649B1 (de) |
JP (1) | JP4864260B2 (de) |
KR (2) | KR100773709B1 (de) |
CN (1) | CN100410245C (de) |
AP (1) | AP1853A (de) |
AT (1) | ATE375987T1 (de) |
AU (1) | AU782882B2 (de) |
BG (1) | BG65484B1 (de) |
BR (1) | BR0013281A (de) |
CA (1) | CA2381097C (de) |
CY (1) | CY1107108T1 (de) |
CZ (1) | CZ303138B6 (de) |
DE (1) | DE60036803T2 (de) |
DK (1) | DK1204649T3 (de) |
EA (1) | EA005375B1 (de) |
EE (1) | EE04939B1 (de) |
ES (1) | ES2295056T3 (de) |
GE (1) | GEP20053475B (de) |
HK (1) | HK1054233B (de) |
HR (1) | HRP20020127B1 (de) |
HU (1) | HUP0202492A3 (de) |
IL (2) | IL147924A0 (de) |
IS (1) | IS2594B (de) |
MA (1) | MA25433A1 (de) |
MX (1) | MXPA02001508A (de) |
NO (1) | NO323576B1 (de) |
NZ (1) | NZ517236A (de) |
OA (1) | OA12047A (de) |
PT (1) | PT1204649E (de) |
RS (1) | RS50300B (de) |
SI (1) | SI1204649T1 (de) |
SK (1) | SK287373B6 (de) |
UA (1) | UA72538C2 (de) |
WO (1) | WO2001014353A1 (de) |
ZA (1) | ZA200201117B (de) |
Families Citing this family (66)
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US20020150921A1 (en) * | 1996-02-09 | 2002-10-17 | Francis Barany | Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays |
US6407103B2 (en) | 1998-04-21 | 2002-06-18 | Bristol-Myers Squibb Pharma Company | Indeno [1,2-c] pyrazol-4-ones and their uses |
US6610846B1 (en) * | 1999-03-29 | 2003-08-26 | Hoffman-La Roche Inc. | Heteroaromatic glucokinase activators |
US6320050B1 (en) * | 1999-03-29 | 2001-11-20 | Hoffmann-La Roche Inc. | Heteroaromatic glucokinase activators |
US7125875B2 (en) * | 1999-04-15 | 2006-10-24 | Bristol-Myers Squibb Company | Cyclic protein tyrosine kinase inhibitors |
CN1348370A (zh) | 1999-04-15 | 2002-05-08 | 布里斯托尔-迈尔斯斯奎布公司 | 环状蛋白酪氨酸激酶抑制剂 |
US6114365A (en) * | 1999-08-12 | 2000-09-05 | Pharmacia & Upjohn S.P.A. | Arylmethyl-carbonylamino-thiazole derivatives, process for their preparation, and their use as antitumor agents |
EP1229934B1 (de) | 1999-10-01 | 2014-03-05 | Immunogen, Inc. | Zusammensetzungen und verfahren zur behandlung von krebs mittels immunkonjugaten und chemotherapeutischen agenzien |
US20040048844A1 (en) * | 1999-10-20 | 2004-03-11 | Bristol-Myers Squibb Pharma Company | Acylsemicarbazides as cyclin dependent kinase inhibitors useful as anti-cancer and anti-proliferative agents |
US6291504B1 (en) | 1999-10-20 | 2001-09-18 | Dupont Pharmaceuticals Company | Acylsemicarbazides and their uses |
EP1345909A1 (de) * | 2000-11-27 | 2003-09-24 | Pharmacia Italia S.p.A. | Phenylacetamido-pyrazole derivate und ihre verwendung als antitumorverbindungen |
AU2002228692A1 (en) * | 2000-12-01 | 2002-06-11 | Bristol-Myers Squibb Pharma Company | 3-(2,4-dimethylthiazol-5-yl) indeno(1,2-c)pyrazol-4-one derivatives as cdk inhibitors |
WO2002046182A1 (en) | 2000-12-08 | 2002-06-13 | Bristol-Myers Squibb Pharma Company | Semicarbazides and their uses as cyclin dependent kinase inhibitors |
EP1347971B1 (de) * | 2000-12-21 | 2006-03-01 | Bristol-Myers Squibb Company | Thiazolyl-inhibitoren von tyrosinkinasen der tec-familie |
ATE315555T1 (de) | 2001-05-11 | 2006-02-15 | Pfizer Prod Inc | Thiazolderivate und ihre verwendung als cdk- inhibitoren |
EP1724270A3 (de) | 2001-07-19 | 2007-01-03 | Pfizer Italia S.r.l. | Phenylacetamido-thiazole Verbindungen, Verfahren zu ihren Herstellung und ihre Anwendung als antitumor Mittel |
IL159570A0 (en) * | 2001-07-19 | 2004-06-01 | Pharmacia Italia Spa | Phenylacetamido-thiazole derivatives, process for their preparation and their use as antitumor agents |
EP1436286B1 (de) * | 2001-09-27 | 2009-08-19 | Equispharm Co., Ltd. | Fumagillolderivate und verfahren zu deren herstellung |
PL370989A1 (en) * | 2001-12-21 | 2005-06-13 | Novo Nordisk A/S | Amide derivatives as gk activators |
KR101116627B1 (ko) * | 2002-06-27 | 2012-10-09 | 노보 노르디스크 에이/에스 | 치료제로서 아릴 카르보닐 유도체 |
BRPI0407456A (pt) * | 2003-02-12 | 2006-01-31 | Pfizer | Derivados antiproliferativos de 2-(sulfo-fenil)-aminotiazole e composições farmacêuticas, e métodos para o seu uso |
EP1597256A1 (de) * | 2003-02-21 | 2005-11-23 | Pfizer Inc. | N-heterocyclylsubstituierte aminothiazolderivate als proteinkinaseinhibitoren |
KR20120045062A (ko) * | 2003-03-31 | 2012-05-08 | 가부시키가이샤 아루떼꾸 우에노 | 혈관 과투과 질환의 치료방법 |
WO2005014591A1 (en) * | 2003-07-15 | 2005-02-17 | L'oreal | 2-acylamino or 2-sulfonylamino-1, 3-thiazoles as couplers for the oxidation dyeing of keratin fibres |
FR2857664B1 (fr) * | 2003-07-15 | 2007-12-14 | Oreal | Nouveaux derives thiazoles et utilisation de ces derives pour la teinture des fibres keratiniques |
US7351727B2 (en) * | 2003-09-02 | 2008-04-01 | Bristol-Myers Squibb Company | Inhibitors of 15-lipoxygenase |
US20050074424A1 (en) * | 2003-10-03 | 2005-04-07 | Lev Salnikov | Using polyion polymers with glucose infusion for a cancer selective chemotherapy compound and method |
US20070196395A1 (en) * | 2003-12-12 | 2007-08-23 | Mackerell Alexander | Immunomodulatory compounds that target and inhibit the py'binding site of tyrosene kinase p56 lck sh2 domain |
MXPA06007667A (es) * | 2004-01-06 | 2006-09-01 | Novo Nordisk As | Heteroaril-ureas y su uso como activadores de glucocinasa. |
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EP1621536A1 (de) * | 2004-07-27 | 2006-02-01 | Aventis Pharma S.A. | Amino zyklische Urea-Derivaten, ihre Herstellung und deren pharmazeutische Verwendungen als Kinase Inhibitoren |
EP1621539A1 (de) * | 2004-07-27 | 2006-02-01 | Aventis Pharma S.A. | Heterocyclische-substituirte cyclische Harnstoffderivate, Verfaren zu ihrer Herstellung, und ihre pharmaceutische Verwendung als Kinase Inhibitoren |
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EP1914234A1 (de) * | 2006-10-16 | 2008-04-23 | GPC Biotech Inc. | Pyrido[2,3-d]pyrimidinen und ihre Verwendung als kinase Inhibitoren |
WO2008084043A1 (en) * | 2007-01-09 | 2008-07-17 | Novo Nordisk A/S | Urea glucokinase activators |
WO2008084044A1 (en) | 2007-01-11 | 2008-07-17 | Novo Nordisk A/S | Urea glucokinase activators |
US8153792B2 (en) * | 2007-02-13 | 2012-04-10 | Ab Science | Process for the synthesis of 2-aminothiazole compounds as kinase inhibitors |
US8450348B2 (en) * | 2007-02-21 | 2013-05-28 | Forma Tm, Llc | Derivatives of squaric acid with anti-proliferative activity |
TWI437986B (zh) * | 2008-01-31 | 2014-05-21 | R Tech Ueno Ltd | 噻唑衍生物及使用該衍生物作為vap-1抑制劑之用途 |
WO2009151683A2 (en) | 2008-03-12 | 2009-12-17 | Link Medicine Corporation | Quinolinone farnesyl transferase inhibitors for the treatment of synucleinopathies and other indications |
EP2112152A1 (de) | 2008-04-22 | 2009-10-28 | GPC Biotech AG | Dihydropteridinones als Plk-Inhibitoren |
EP2112150B1 (de) | 2008-04-22 | 2013-10-16 | Forma Therapeutics, Inc. | Verbesserte Raf-Inhibitoren |
CN102369202A (zh) | 2008-11-13 | 2012-03-07 | 链接医药公司 | 氮杂喹啉酮衍生物及其应用 |
UA103918C2 (en) * | 2009-03-02 | 2013-12-10 | Айерем Элелси | N-(hetero)aryl, 2-(hetero)aryl-substituted acetamides for use as wnt signaling modulators |
TWI504598B (zh) * | 2009-03-20 | 2015-10-21 | Onyx Therapeutics Inc | 結晶性三肽環氧酮蛋白酶抑制劑 |
EP2440556A1 (de) * | 2009-06-10 | 2012-04-18 | Vertex Pharmaceuticals Incorporated | Phosphatidylinositol 3-kinasehemmer |
DE102009043260A1 (de) * | 2009-09-28 | 2011-04-28 | Merck Patent Gmbh | Pyridinyl-imidazolonderivate |
EP2325185A1 (de) | 2009-10-28 | 2011-05-25 | GPC Biotech AG | Plk-Inhibitor |
HU0900798D0 (en) | 2009-12-21 | 2010-03-01 | Vichem Chemie Kutato Kft | 4-phenylamino-pyrimidine derivatives having protein kinase inhibitor activity |
TWI450891B (zh) * | 2010-12-29 | 2014-09-01 | Dev Center Biotechnology | 新穎微管蛋白抑制劑 |
RU2011122942A (ru) | 2011-06-08 | 2012-12-20 | Общество С Ограниченной Ответственностью "Асинэкс Медхим" | Новые ингибиторы киназ |
CN103387551B (zh) | 2012-05-11 | 2015-05-20 | 中国人民解放军军事医学科学院毒物药物研究所 | 噻唑类化合物及其用途 |
DK2887943T3 (en) | 2012-08-23 | 2018-03-12 | Virostatics Srl | HIS UNKNOWN 4,6-DISUBSTITUTED AMINOPYRIMIDINE DERIVATIVES |
DK3442580T3 (da) | 2016-04-11 | 2020-12-21 | Genfit | Fremgangsmåder til behandling af kolestatiske og fibrotiske sygdomme |
JP7319977B2 (ja) | 2017-12-06 | 2023-08-02 | リン バイオサイエンス,インコーポレイテッド | チューブリン阻害剤 |
AU2019215799B2 (en) * | 2018-02-01 | 2022-04-14 | The University Of Sydney | Anti-cancer compounds |
AU2019287437A1 (en) | 2018-06-12 | 2020-09-10 | Vtv Therapeutics Llc | Therapeutic uses of glucokinase activators in combination with insulin or insulin analogs |
EP3712127A1 (de) | 2019-03-22 | 2020-09-23 | Deutsches Krebsforschungszentrum | Neuartige inhibitoren der histon-deacetylase 10 |
US20220151962A1 (en) | 2019-03-22 | 2022-05-19 | Deutsches Krebsforschungszentrum | Novel inhibitors of histone deacetylase 10 |
WO2021162054A1 (ja) * | 2020-02-10 | 2021-08-19 | 学校法人順天堂 | 2型リアノジン受容体活性抑制剤 |
CN115322208B (zh) * | 2021-05-10 | 2023-04-11 | 中国药科大学 | 2-氨基噻唑类衍生物及其制备方法和医药用途 |
WO2023182780A1 (ko) * | 2022-03-22 | 2023-09-28 | 오토텔릭바이오 주식회사 | 티아졸 유도체 화합물 및 이의 용도 |
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NL125062C (de) * | 1960-04-20 | |||
TW513418B (en) * | 1996-07-31 | 2002-12-11 | Otsuka Pharma Co Ltd | Thiazole derivatives, their production and use |
JPH1095777A (ja) * | 1996-07-31 | 1998-04-14 | Otsuka Pharmaceut Co Ltd | チアゾール誘導体 |
US6794392B1 (en) * | 1996-09-30 | 2004-09-21 | Schering Aktiengesellschaft | Cell differentiation inducer |
AP1445A (en) | 1997-10-27 | 2005-07-10 | Agouron Pharma | Substituted 4-amino-thiazol-2-yl compounds as CDKs inhibitors. |
US6040321A (en) * | 1997-11-12 | 2000-03-21 | Bristol-Myers Squibb Company | Aminothiazole inhibitors of cyclin dependent kinases |
ES2237919T4 (es) * | 1998-06-18 | 2007-05-01 | Bristol-Myers Squibb Company | Inhibidores aminotiazol sustituidos con carbono de quinasas dependientes de ciclina. |
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CN1348370A (zh) * | 1999-04-15 | 2002-05-08 | 布里斯托尔-迈尔斯斯奎布公司 | 环状蛋白酪氨酸激酶抑制剂 |
US6114365A (en) | 1999-08-12 | 2000-09-05 | Pharmacia & Upjohn S.P.A. | Arylmethyl-carbonylamino-thiazole derivatives, process for their preparation, and their use as antitumor agents |
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AR042941A1 (es) * | 2003-01-27 | 2005-07-06 | Fujisawa Pharmaceutical Co | Derivados de tiazol, su preparacion, composiciones farmaceuticas que los contienen y su uso en la fabricacion de medicamentos inhibidores de la proteina-1 de adhesion vascular (vap-1) |
-
1999
- 1999-08-12 US US09/372,832 patent/US6114365A/en not_active Expired - Lifetime
-
2000
- 2000-08-11 AU AU74400/00A patent/AU782882B2/en not_active Ceased
- 2000-08-11 DE DE60036803T patent/DE60036803T2/de not_active Expired - Lifetime
- 2000-08-11 MX MXPA02001508A patent/MXPA02001508A/es active IP Right Grant
- 2000-08-11 CA CA002381097A patent/CA2381097C/en not_active Expired - Fee Related
- 2000-08-11 RS YUP-97/02A patent/RS50300B/sr unknown
- 2000-08-11 EP EP00962760A patent/EP1204649B1/de not_active Expired - Lifetime
- 2000-08-11 OA OA1200200052A patent/OA12047A/en unknown
- 2000-08-11 CN CNB008127336A patent/CN100410245C/zh not_active Expired - Fee Related
- 2000-08-11 HU HU0202492A patent/HUP0202492A3/hu unknown
- 2000-08-11 DK DK00962760T patent/DK1204649T3/da active
- 2000-08-11 US US10/048,474 patent/US6784198B1/en not_active Expired - Fee Related
- 2000-08-11 JP JP2001518441A patent/JP4864260B2/ja not_active Expired - Fee Related
- 2000-08-11 KR KR1020027001844A patent/KR100773709B1/ko not_active IP Right Cessation
- 2000-08-11 EE EEP200200064A patent/EE04939B1/xx not_active IP Right Cessation
- 2000-08-11 ES ES00962760T patent/ES2295056T3/es not_active Expired - Lifetime
- 2000-08-11 AP APAP/P/2002/002441A patent/AP1853A/en active
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