ATE373659T1 - Pyrrolylsubstituierte pyrido(2,3-d)pyrimidin-7- one und derivate davon als therapeutische mittel - Google Patents

Pyrrolylsubstituierte pyrido(2,3-d)pyrimidin-7- one und derivate davon als therapeutische mittel

Info

Publication number: ATE373659T1
Authority: AT; Austria
Prior art keywords: sup; pyrimidine; derivatives; therapeutic agents; substituted pyrido
Prior art date: 2004-05-04

Application number

AT05733676T

Other languages

English (en)

Inventor

Michelle M Bruendl

Rocco D Gogliotti

A P Goodman

Gregory Reichard

Original Assignee

Warner Lambert Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-05-04

Filing date

2005-04-22

Publication date

2007-10-15

2005-04-22 Application filed by Warner Lambert Co filed Critical Warner Lambert Co

2007-10-15 Application granted granted Critical

2007-10-15 Publication of ATE373659T1 publication Critical patent/ATE373659T1/de

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

AT05733676T 2004-05-04 2005-04-22 Pyrrolylsubstituierte pyrido(2,3-d)pyrimidin-7- one und derivate davon als therapeutische mittel ATE373659T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US56790204P	2004-05-04	2004-05-04

Publications (1)

Publication Number	Publication Date
ATE373659T1 true ATE373659T1 (de)	2007-10-15

Family

ID=34966564

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT05733676T ATE373659T1 (de)	2004-05-04	2005-04-22	Pyrrolylsubstituierte pyrido(2,3-d)pyrimidin-7- one und derivate davon als therapeutische mittel

Country Status (10)

Country	Link
US (1)	US20080255162A1 (de)
EP (1)	EP1749004B1 (de)
JP (1)	JP2007536370A (de)
AT (1)	ATE373659T1 (de)
BR (1)	BRPI0510560A (de)
CA (1)	CA2563669A1 (de)
DE (1)	DE602005002562T2 (de)
ES (1)	ES2292130T3 (de)
MX (1)	MXPA06012829A (de)
WO (1)	WO2005105801A1 (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BRPI0617159B8 (pt) *	2005-10-07	2021-05-25	Exelixis Inc	compostos de piridopirimidinone inibidores de pi3ka, composições que os contem e processo para preparo
CA2624965A1 (en) *	2005-10-07	2007-04-19	Exelixis, Inc.	Pyridopyrimidinone inhibitors of pi3k.alpha.
AU2007284562B2 (en) *	2006-08-16	2013-05-02	Exelixis, Inc.	Using PI3K and MEK modulators in treatments of cancer
WO2008032162A1 (en) *	2006-09-15	2008-03-20	Pfizer Products Inc.	Pyrido (2, 3-d) pyrimidin0ne compounds and their use as pi3 inhibitors
UA100979C2 (ru) *	2007-04-10	2013-02-25	Экселиксис, Инк.	Применение пиридопиримидиноновых ингибиторов pi3k альфа для лечения рака
EP2142543B8 (de) *	2007-04-11	2013-07-03	Exelixis, Inc.	Pyrido [2,3-d]pyrimidin-7-onverbindungen als inhibitoren von pi3k-alpha zur behandlung von krebs
AU2008239596B2 (en) *	2007-04-11	2013-08-15	Exelixis, Inc.	Pyrido [2,3-D] pyrimidin-7-one compounds as inhibitors of PI3K-alpha for the treatment of cancer
JP5599783B2 (ja)	2008-05-30	2014-10-01	アムジエン・インコーポレーテツド	Ｐｉ３キナーゼの阻害薬
PA8843901A1 (es)	2008-09-30	2010-05-26		INHIBIDORES DE PIRIMIDINONA DE PI3K( ALFA) Y m TOR
GB0913345D0 (en)	2009-07-31	2009-09-16	Astrazeneca Ab	New combination 802
JPWO2011048936A1 (ja)	2009-10-19	2013-03-07	大正製薬株式会社	アミノチアゾール誘導体
WO2011061527A1 (en)	2009-11-17	2011-05-26	Astrazeneca Ab	Combinations comprising a glucocorticoid receptor modulator for the treatment of respiratory diseases
FR2955109B1 (fr)	2010-01-08	2012-09-07	Sanofi Aventis	Derives de 5-oxo-5,8-dihydro-pyrido[2, 3-d]pyrimidine, leur preparation et leur application en therapeutique
TW201139436A (en)	2010-02-09	2011-11-16	Exelixis Inc	Methods of treating cancer using pyridopyrimidinone inhibitors of PI3K and mTOR in combination with autophagy inhibitors
GB201021979D0 (en)	2010-12-23	2011-02-02	Astrazeneca Ab	New compound
GB201021992D0 (en)	2010-12-23	2011-02-02	Astrazeneca Ab	Compound
MX354074B (es)	2012-02-10	2018-02-12	Ptc Therapeutics Inc	Compuestos para tratar la atrofia muscular espinal.
EP2817308B1 (de)	2012-02-23	2016-09-07	AbbVie Inc.	Pyridopyrimidinon-derivate verwendbar als kinase inhibitoren
BR112014021531B1 (pt)	2012-03-01	2022-10-04	Ptc Therapeutics, Inc.	Composto, composição farmacêutica e usos dos mesmos
US9914722B2 (en)	2012-03-23	2018-03-13	Ptc Therapeutics, Inc.	Compounds for treating spinal muscular atrophy
EP3082820B1 (de)	2013-12-19	2022-07-20	PTC Therapeutics, Inc.	Verfahren zur modulation der menge von rna-transkripten
JP6631616B2 (ja)	2014-07-26	2020-01-15	ノース・アンド・サウス・ブラザー・ファーマシー・インベストメント・カンパニー・リミテッド	ＣＤＫ阻害剤としての２−アミノ−ピリド［２，３−ｄ］ピリミジン−７（８Ｈ）−オン誘導体及びその使用
WO2016196386A1 (en)	2015-05-30	2016-12-08	Ptc Therapeutics, Inc.	Methods for modulating rna splicing
ES2879995T3 (es)	2015-12-10	2021-11-23	Ptc Therapeutics Inc	Métodos para el tratamiento de la enfermedad de Huntington
US11702646B2 (en)	2016-11-28	2023-07-18	Ptc Therapeutics, Inc.	Methods for modulating RNA splicing
EA201992878A1 (ru)	2017-06-05	2020-05-08	ПиТиСи ТЕРАПЬЮТИКС, ИНК.	Соединения для лечения болезни хантингтона
CN111372611A (zh)	2017-06-14	2020-07-03	Ptc医疗公司	修饰rna剪接的方法
MX2019015580A (es)	2017-06-28	2020-07-28	Ptc Therapeutics Inc	Metodos para tratar la enfermedad de huntington.
BR112019027717A2 (pt)	2017-06-28	2020-07-28	Ptc Therapeutics, Inc.	métodos para tratar a doença de huntington
CN112135815A (zh)	2018-03-27	2020-12-25	Ptc医疗公司	用于治疗亨廷顿氏病的化合物
EP3814360A1 (de)	2018-06-27	2021-05-05	PTC Therapeutics, Inc.	Heteroarylverbindungen zur behandlung von morbus huntington
AU2019294478B2 (en)	2018-06-27	2023-03-23	Ptc Therapeutics, Inc.	Heterocyclic and heteroaryl compounds for treating Huntington's disease
EP4065578A1 (de)	2019-11-26	2022-10-05	Theravance Biopharma R&D IP, LLC	Kondensierte pyrimidin-pyridinon-verbindungen als jak-inhibitoren

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2001083456A1 (fr) *	2000-04-27	2001-11-08	Yamanouchi Pharmaceutical Co., Ltd.	Derives d'heteroaryle condenses
US7019002B2 (en) *	2001-12-11	2006-03-28	Pharmacia & Upjohn, S.P.A.	Pyridopyrimidinones derivatives as telomerase inhibitors
US7098332B2 (en) *	2002-12-20	2006-08-29	Hoffmann-La Roche Inc.	5,8-Dihydro-6H-pyrido[2,3-d]pyrimidin-7-ones

2005
- 2005-04-22 US US11/568,611 patent/US20080255162A1/en not_active Abandoned
- 2005-04-22 CA CA002563669A patent/CA2563669A1/en not_active Abandoned
- 2005-04-22 EP EP05733676A patent/EP1749004B1/de active Active
- 2005-04-22 MX MXPA06012829A patent/MXPA06012829A/es unknown
- 2005-04-22 AT AT05733676T patent/ATE373659T1/de not_active IP Right Cessation
- 2005-04-22 BR BRPI0510560-9A patent/BRPI0510560A/pt not_active Application Discontinuation
- 2005-04-22 JP JP2007512546A patent/JP2007536370A/ja not_active Withdrawn
- 2005-04-22 ES ES05733676T patent/ES2292130T3/es active Active
- 2005-04-22 WO PCT/IB2005/001141 patent/WO2005105801A1/en active Application Filing
- 2005-04-22 DE DE602005002562T patent/DE602005002562T2/de not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DE602005002562D1 (de)	2007-10-31
ES2292130T3 (es)	2008-03-01
WO2005105801A1 (en)	2005-11-10
US20080255162A1 (en)	2008-10-16
EP1749004B1 (de)	2007-09-19
DE602005002562T2 (de)	2008-01-31
EP1749004A1 (de)	2007-02-07
MXPA06012829A (es)	2007-01-26
JP2007536370A (ja)	2007-12-13
BRPI0510560A (pt)	2007-11-20
CA2563669A1 (en)	2005-11-10

Legal Events

Date	Code	Title	Description
2008-03-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE373659T1 (de)	2007-10-15	Pyrrolylsubstituierte pyrido(2,3-d)pyrimidin-7- one und derivate davon als therapeutische mittel
EA200700902A1 (ru)	2007-10-26	3-ариламинопиридиновые производные
IL183340A0 (en)	2007-09-20	[1,2,4] triazolo[4,3-a] pyridine derivatives and pharmaceutical compositions containing them
EP1689387A4 (de)	2007-08-29	Bicyclische inhibitoren von mek und verfahren zu deren anwendung
CR20120389A (es)	2012-08-16	COMPUESTOS SUSTITUIDOS DE N-(1H-INDAZOL-4-IL)IMIDAZO[1,2-a] PIRIDIN-3-CARBOXAMIDA COMO INHIBIDORES DE cFMS
SE0401971D0 (sv)	2004-08-02	Piperidne derivatives
RS105204A (en)	2006-12-15	Substituted 3-amino-thieno/2,3-b/pyridine- 2-carboxylic acid amide compounds and processes for preparing and their uses
ATE370139T1 (de)	2007-09-15	Pyrazolopyridin derivate als tgf beta hemmstoffe zur behandlung von krebs
MXPA05012894A (es)	2006-02-22	Benzofuranos 3-sustituidos como agentes terapeuticos.
WO2004108715A8 (en)	2005-12-01	3-aryloxy and 3-heteroaryloxy substituted benzo(b) thiophenes as therapeutic agents with pi3k activity
MY135902A (en)	2008-07-31	SUBSTITUTED HEXAHYDROPYRAZINO [1, 2-a] PYRIMIDINE-4, 7-DIONE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS
EA200701930A1 (ru)	2008-02-28	Производные пиримидина для лечения гиперпролиферативных нарушений
DE602006020295D1 (de)	2011-04-07	Azabenzimidalzolderivate, ihre herstellung und ihre verwendung als antikrebsmittel
NO20070837L (no)	2007-04-16	Pyrido-pyrido pyrimidinderivater, fremstilling derav samt terapeutisk anvendelse for behandling av cancer.
ATE365735T1 (de)	2007-07-15	Cycloalkylsulfanyl-substituierte benzo böthiophene als therapeutische mittel
MXPA05012953A (es)	2006-02-13	Benzo[b]tiofenos 3-arilsulfanil y 3-heteroarilsulfanil sustituidos como agentes terapeuticos.
EA200800223A1 (ru)	2008-06-30	ПРОИЗВОДНЫЕ ПИРИДО[2,3-d]ПИРИМИДИНА, ИХ ПОЛУЧЕНИЕ, ИХ ПРИМЕНЕНИЕ В ТЕРАПИИ
ATE399170T1 (de)	2008-07-15	Neue tricyclische derivate als ltd4 antagonisten
BRPI0507811A (pt)	2007-07-10	derivados de 7h-pirrolopirimidina
ATE365732T1 (de)	2007-07-15	Pyrimidine als inhibitoren von phosphoinositid-3- kinasen (pi3k)
DE10310106A8 (de)	2004-12-30	Substituierte Pyrido[1,2-a]pyrimidin-Verbindungen