ATE366816T1 - Typ ii tgf-beta receptor/immunoglobulin konstante domäne fusionsproteine - Google Patents
Typ ii tgf-beta receptor/immunoglobulin konstante domäne fusionsproteineInfo
- Publication number
- ATE366816T1 ATE366816T1 AT98918247T AT98918247T ATE366816T1 AT E366816 T1 ATE366816 T1 AT E366816T1 AT 98918247 T AT98918247 T AT 98918247T AT 98918247 T AT98918247 T AT 98918247T AT E366816 T1 ATE366816 T1 AT E366816T1
- Authority
- AT
- Austria
- Prior art keywords
- fusion proteins
- tgf
- immunoglobulin constant
- type
- constant domain
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Toxicology (AREA)
- Plant Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurology (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Neurosurgery (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4464197P | 1997-04-18 | 1997-04-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE366816T1 true ATE366816T1 (de) | 2007-08-15 |
Family
ID=21933495
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT98918247T ATE366816T1 (de) | 1997-04-18 | 1998-04-16 | Typ ii tgf-beta receptor/immunoglobulin konstante domäne fusionsproteine |
Country Status (22)
Country | Link |
---|---|
US (1) | US20050203022A1 (de) |
EP (1) | EP0975771B1 (de) |
JP (2) | JP2001515360A (de) |
KR (1) | KR20010006534A (de) |
CN (1) | CN1257545A (de) |
AT (1) | ATE366816T1 (de) |
AU (1) | AU737106B2 (de) |
BR (1) | BR9808934A (de) |
CA (1) | CA2286933A1 (de) |
DE (1) | DE69838061T2 (de) |
DK (1) | DK0975771T3 (de) |
EA (1) | EA199900947A1 (de) |
EE (1) | EE9900492A (de) |
ES (1) | ES2289778T3 (de) |
IL (1) | IL132249A0 (de) |
IS (1) | IS5217A (de) |
NO (1) | NO994998L (de) |
NZ (1) | NZ500284A (de) |
PL (1) | PL336306A1 (de) |
PT (1) | PT975771E (de) |
TR (1) | TR199902878T2 (de) |
WO (1) | WO1998048024A1 (de) |
Families Citing this family (65)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7018793B1 (en) | 1995-12-07 | 2006-03-28 | Diversa Corporation | Combinatorial screening of mixed populations of organisms |
US5830696A (en) | 1996-12-05 | 1998-11-03 | Diversa Corporation | Directed evolution of thermophilic enzymes |
US6939689B2 (en) | 1995-12-07 | 2005-09-06 | Diversa Corporation | Exonuclease-mediated nucleic acid reassembly in directed evolution |
US6171820B1 (en) | 1995-12-07 | 2001-01-09 | Diversa Corporation | Saturation mutagenesis in directed evolution |
US6358709B1 (en) | 1995-12-07 | 2002-03-19 | Diversa Corporation | End selection in directed evolution |
US6361974B1 (en) | 1995-12-07 | 2002-03-26 | Diversa Corporation | Exonuclease-mediated nucleic acid reassembly in directed evolution |
US6537776B1 (en) | 1999-06-14 | 2003-03-25 | Diversa Corporation | Synthetic ligation reassembly in directed evolution |
US6238884B1 (en) | 1995-12-07 | 2001-05-29 | Diversa Corporation | End selection in directed evolution |
US6562594B1 (en) | 1999-09-29 | 2003-05-13 | Diversa Corporation | Saturation mutagenesis in directed evolution |
US6352842B1 (en) | 1995-12-07 | 2002-03-05 | Diversa Corporation | Exonucease-mediated gene assembly in directed evolution |
US6713279B1 (en) | 1995-12-07 | 2004-03-30 | Diversa Corporation | Non-stochastic generation of genetic vaccines and enzymes |
US6740506B2 (en) | 1995-12-07 | 2004-05-25 | Diversa Corporation | End selection in directed evolution |
US6492325B1 (en) | 1998-05-22 | 2002-12-10 | Boys Town National Research Hospital | Use of α1β1 integrin receptor inhibitors and TGF-β1 inhibitors in the treatment of kidney disease |
AU4572899A (en) * | 1998-06-16 | 2000-01-05 | Biogen, Inc. | Variant type ii tgf-beta receptor fusion proteins and methods |
CA2385538C (en) | 1999-09-17 | 2007-11-06 | Tgt Laboratories, S.A. De C.V. | Recombinant adenoviral vectors and their utilization in the treatment of various types of hepatic, renal and pulmonary fibrosis and hypertrophic scars |
US6808902B1 (en) * | 1999-11-12 | 2004-10-26 | Amgen Inc. | Process for correction of a disulfide misfold in IL-1Ra Fc fusion molecules |
MXPA00011713A (es) * | 2000-11-28 | 2002-05-31 | Tgt Lab S A De C V | Vectores recombinantes virales y no virales conteniendo el gen humano del activador de plasminogeno derivado de urocinasa y su utilidad en el tratamiento de diversos tipos de fibrosis hepatica, renal, pulmonar, pancreatica, cardiaca y cicatrices hipe |
DK1436003T3 (da) * | 2001-05-24 | 2010-03-15 | Zymogenetics Inc | TACI-immunoglobulin-fusionsproteiner |
US8597646B2 (en) | 2005-10-25 | 2013-12-03 | The Johns Hopkins University | Methods and compositons featuring TGF-beta antagonists for the treatment of marfan syndrome and associated disorders |
EP1998810A4 (de) | 2006-03-13 | 2009-09-02 | Univ Johns Hopkins | Erhöhung der endothelialen thromboresistenz |
WO2008067025A2 (en) * | 2006-09-29 | 2008-06-05 | Evanston Northwestern Healthcare | Oncolytic adenoviruses and uses thereof |
EP2083863B1 (de) | 2006-10-03 | 2015-03-18 | Genzyme Corporation | Anti-tgf-beta antikörper zur behandlung von kleinkindern, die gefahr laufen eine bronchopulmonäre dysplasie zu entwickeln |
EP2171062A1 (de) * | 2007-06-15 | 2010-04-07 | Genzyme Corporation | Fusionsproteine mit zwei tgf-beta-bindungsdomänen des tgf-beta-typ-ii-rezeptors |
WO2009152610A1 (en) | 2008-06-20 | 2009-12-23 | The Royal Institution For The Advancement Of Learning/Mcgill University | Interleukin-2/soluble tgf-beta type ii receptor b conjugates and methods and uses thereof |
WO2011100460A2 (en) * | 2010-02-11 | 2011-08-18 | Ecole Polytechnique Federale De Lausanne | Ccr7 ligand delivery and co-delivery in immunotherapy |
CA2807942C (en) | 2010-08-10 | 2021-07-27 | Ecole Polytechnique Federale De Lausanne | Erythrocyte-binding therapeutics |
US9517257B2 (en) | 2010-08-10 | 2016-12-13 | Ecole Polytechnique Federale De Lausanne (Epfl) | Erythrocyte-binding therapeutics |
US9850296B2 (en) | 2010-08-10 | 2017-12-26 | Ecole Polytechnique Federale De Lausanne (Epfl) | Erythrocyte-binding therapeutics |
WO2012090997A1 (ja) | 2010-12-27 | 2012-07-05 | 京都府公立大学法人 | iPS細胞とその製造法 |
CN102175501A (zh) * | 2011-01-07 | 2011-09-07 | 山东省农业科学院作物研究所 | 用于显微镜观察的植物样品的前处理方法 |
EP2737083A1 (de) | 2011-07-27 | 2014-06-04 | INSERM (Institut National de la Santé et de la Recherche Scientifique) | Verfahren zur diagnose und behandlung des myhre-syndroms |
CN102898508B (zh) * | 2011-08-12 | 2014-04-30 | 北京大学第一医院 | 封闭TGF-β受体或IL-10受体的多肽、其药物组合物及其用途 |
AU2011379972B2 (en) | 2011-10-26 | 2016-05-12 | Seattle Children's Research Institute | Cysteamine in the treatment of fibrotic disease |
WO2013100208A1 (ja) | 2011-12-28 | 2013-07-04 | 京都府公立大学法人 | 角膜内皮細胞の培養正常化 |
SG11201404943PA (en) | 2012-02-15 | 2014-10-30 | Ecole Polytech | Erythrocyte-binding therapeutics |
CN105658672A (zh) | 2013-08-22 | 2016-06-08 | 阿塞勒隆制药公司 | TGF-β受体II型变体及其用途 |
JPWO2015064768A1 (ja) | 2013-10-31 | 2017-03-09 | 京都府公立大学法人 | 角膜内皮の小胞体細胞死関連疾患治療薬 |
EP3071215B1 (de) | 2013-11-21 | 2020-01-08 | The Brigham and Women's Hospital, Inc. | Zusammensetzungen und verfahren zur behandlung pulmonaler hypertonie |
AR098827A1 (es) * | 2013-12-19 | 2016-06-15 | Consejo Nac De Investig Científicas Y Técnicas (Conicet) | ISOFORMA DEL RECEPTOR II DE TGF-b, POLINUCLEÓTIDOS QUE LA CODIFICAN VECTORES, CÉLULAS TRANSFORMADAS, PÉPTIDOS Y DE FUSIÓN, MÉTODO Y USOS |
BR112016014952A2 (pt) * | 2014-02-10 | 2017-09-19 | Merck Patent Gmbh | Inibição direcionada de tgfbeta |
AU2015233084B2 (en) | 2014-02-21 | 2020-12-17 | Anokion Sa | Glycotargeting therapeutics |
US10946079B2 (en) | 2014-02-21 | 2021-03-16 | Ecole Polytechnique Federale De Lausanne | Glycotargeting therapeutics |
US10953101B2 (en) | 2014-02-21 | 2021-03-23 | École Polytechnique Fédérale De Lausanne (Epfl) | Glycotargeting therapeutics |
US10046056B2 (en) | 2014-02-21 | 2018-08-14 | École Polytechnique Fédérale De Lausanne (Epfl) | Glycotargeting therapeutics |
CA2956256A1 (en) | 2014-08-01 | 2016-02-04 | The Brigham And Women's Hospital, Inc. | Methods and compositions relating to treatment of pulmonary arterial hypertension |
WO2016187312A1 (en) | 2015-05-18 | 2016-11-24 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Methods and compositions for treating an alphavirus infection |
AU2016301380B2 (en) * | 2015-08-04 | 2021-07-01 | Acceleron Pharma Inc. | Methods for treating myeloproliferative disorders |
EP3344660A4 (de) * | 2015-08-31 | 2019-07-03 | National Research Council of Canada | Tgf-beta-rezeptor-ektodomänenfusionsmoleküle und verwendungen davon |
CA3025020A1 (en) * | 2016-05-20 | 2017-11-23 | President And Fellows Of Harvard College | Gene therapy methods for age-related diseases and conditions |
CN110546168B (zh) * | 2016-09-27 | 2024-03-15 | 埃皮辛特瑞柯斯公司 | 免疫调节性融合蛋白 |
IL305536A (en) | 2017-03-02 | 2023-10-01 | Nat Res Council Canada | TGF–B receptor ectodomain fusion compounds and their uses |
SI3628049T1 (sl) * | 2017-05-04 | 2023-10-30 | Acceleron Pharma Inc. | Fuzijske beljakovine receptorja TGF-beta tipa II in njihova uporaba |
WO2018232176A1 (en) | 2017-06-16 | 2018-12-20 | The University Of Chicago | Compositions and methods for inducing immune tolerance |
US11834492B2 (en) | 2017-09-27 | 2023-12-05 | Epicentrx, Inc. | Human IL-10 receptor alpha fusion proteins |
CN112119157A (zh) | 2018-03-06 | 2020-12-22 | 宾夕法尼亚大学董事会 | ***特异性膜抗原car及其使用方法 |
KR20200130403A (ko) | 2018-03-09 | 2020-11-18 | 아게누스 인코포레이티드 | 항-cd73 항체 및 그의 사용 방법 |
EP3773657A4 (de) | 2018-03-26 | 2021-12-08 | Altor Bioscience LLC | Anti-pdl1, il-15- und tgf-beta-rezeptor-kombinationsmoleküle |
JP2021531754A (ja) | 2018-07-09 | 2021-11-25 | プレシゲン,インコーポレイテッド | 融合構築物およびその使用法 |
JP2022527972A (ja) | 2019-04-02 | 2022-06-07 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 前悪性病変を有する患者において癌を予測及び予防する方法 |
CA3147430A1 (en) * | 2019-07-26 | 2021-02-04 | Board Of Trustees Of Michigan State University | Methods of preventing or treating fatty degeneration of skeletal muscle |
WO2021041886A1 (en) * | 2019-08-29 | 2021-03-04 | Nantbio, Inc. | Modified n-810 and methods therefor |
US20240226235A1 (en) * | 2019-11-05 | 2024-07-11 | Acceleron Pharma Inc. | Treatments for systemic sclerosis |
CN113968903A (zh) * | 2020-07-24 | 2022-01-25 | 迈威(上海)生物科技股份有限公司 | TGF-β RII突变体及其融合蛋白 |
WO2023141724A1 (en) | 2022-01-28 | 2023-08-03 | 35Pharma Inc. | Activin receptor type iib variants and uses thereof |
WO2023206188A1 (en) * | 2022-04-28 | 2023-11-02 | Wenzhou Prarucom Bio-Chemical Technology Co. | Method for alleviating pulmonary fibrosis using epidermal growth factor |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3773919A (en) * | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
US4874702A (en) * | 1980-09-08 | 1989-10-17 | Biogen, Inc. | Vectors and methods for making such vectors and for expressive cloned genes |
US4588585A (en) * | 1982-10-19 | 1986-05-13 | Cetus Corporation | Human recombinant cysteine depleted interferon-β muteins |
US4797368A (en) * | 1985-03-15 | 1989-01-10 | The United States Of America As Represented By The Department Of Health And Human Services | Adeno-associated virus as eukaryotic expression vector |
US4683195A (en) * | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
US5399346A (en) * | 1989-06-14 | 1995-03-21 | The United States Of America As Represented By The Department Of Health And Human Services | Gene therapy |
US6129914A (en) * | 1992-03-27 | 2000-10-10 | Protein Design Labs, Inc. | Bispecific antibody effective to treat B-cell lymphoma and cell line |
AU669256B2 (en) * | 1992-10-29 | 1996-05-30 | Celtrix Pharmaceuticals, Inc. | Uses of TGF-beta receptor fragment as a therapeutic agent |
NZ262615A (en) * | 1993-02-09 | 1996-02-27 | Biogen Inc | Treating insulin dependent diabetes (type i) with anti vla4 (very late antigen) antibodies |
US5925351A (en) * | 1995-07-21 | 1999-07-20 | Biogen, Inc. | Soluble lymphotoxin-β receptors and anti-lymphotoxin receptor and ligand antibodies as therapeutic agents for the treatment of immunological disease |
-
1998
- 1998-04-16 DK DK98918247T patent/DK0975771T3/da active
- 1998-04-16 EP EP98918247A patent/EP0975771B1/de not_active Expired - Lifetime
- 1998-04-16 CA CA002286933A patent/CA2286933A1/en not_active Abandoned
- 1998-04-16 EA EA199900947A patent/EA199900947A1/ru unknown
- 1998-04-16 NZ NZ500284A patent/NZ500284A/en unknown
- 1998-04-16 PL PL98336306A patent/PL336306A1/xx unknown
- 1998-04-16 PT PT98918247T patent/PT975771E/pt unknown
- 1998-04-16 DE DE69838061T patent/DE69838061T2/de not_active Expired - Fee Related
- 1998-04-16 JP JP54615098A patent/JP2001515360A/ja not_active Withdrawn
- 1998-04-16 AU AU71208/98A patent/AU737106B2/en not_active Ceased
- 1998-04-16 CN CN98805473A patent/CN1257545A/zh active Pending
- 1998-04-16 BR BR9808934-0A patent/BR9808934A/pt not_active IP Right Cessation
- 1998-04-16 EE EEP199900492A patent/EE9900492A/xx unknown
- 1998-04-16 TR TR1999/02878T patent/TR199902878T2/xx unknown
- 1998-04-16 WO PCT/US1998/007587 patent/WO1998048024A1/en active IP Right Grant
- 1998-04-16 AT AT98918247T patent/ATE366816T1/de not_active IP Right Cessation
- 1998-04-16 ES ES98918247T patent/ES2289778T3/es not_active Expired - Lifetime
- 1998-04-16 IL IL13224998A patent/IL132249A0/xx unknown
- 1998-04-16 KR KR1019997009624A patent/KR20010006534A/ko not_active Application Discontinuation
-
1999
- 1999-10-14 NO NO994998A patent/NO994998L/no not_active Application Discontinuation
- 1999-10-15 IS IS5217A patent/IS5217A/is unknown
-
2005
- 2005-04-18 US US11/108,597 patent/US20050203022A1/en not_active Abandoned
-
2008
- 2008-01-11 JP JP2008005068A patent/JP2008106076A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
PL336306A1 (en) | 2000-06-19 |
TR199902878T2 (xx) | 2000-02-21 |
BR9808934A (pt) | 2000-08-01 |
JP2008106076A (ja) | 2008-05-08 |
KR20010006534A (ko) | 2001-01-26 |
CN1257545A (zh) | 2000-06-21 |
DE69838061T2 (de) | 2008-03-13 |
PT975771E (pt) | 2007-10-01 |
WO1998048024A1 (en) | 1998-10-29 |
EP0975771A1 (de) | 2000-02-02 |
EE9900492A (et) | 2000-06-15 |
US20050203022A1 (en) | 2005-09-15 |
IS5217A (is) | 1999-10-15 |
DK0975771T3 (da) | 2007-10-22 |
EP0975771B1 (de) | 2007-07-11 |
DE69838061D1 (de) | 2007-08-23 |
IL132249A0 (en) | 2001-03-19 |
CA2286933A1 (en) | 1998-10-29 |
EA199900947A1 (ru) | 2000-04-24 |
ES2289778T3 (es) | 2008-02-01 |
JP2001515360A (ja) | 2001-09-18 |
AU7120898A (en) | 1998-11-13 |
AU737106B2 (en) | 2001-08-09 |
NZ500284A (en) | 2001-09-28 |
NO994998D0 (no) | 1999-10-14 |
NO994998L (no) | 1999-12-20 |
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