ATE364704T1 - Mutanten von op-1 - Google Patents

Mutanten von op-1

Info

Publication number: ATE364704T1
Authority: AT; Austria
Prior art keywords: proteins; finger; domain; sub; tgf
Prior art date: 1998-10-07

Application number

AT99954771T

Other languages

English (en)

Inventor

Hermann Oppermann

Mei-Sheng Tai

John Mccartney

Original Assignee

Stryker Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-10-07

Filing date

1999-10-07

Publication date

2007-07-15

1999-10-07 Application filed by Stryker Corp filed Critical Stryker Corp

2007-07-15 Application granted granted Critical

2007-07-15 Publication of ATE364704T1 publication Critical patent/ATE364704T1/de

Links

102000004887 Transforming Growth Factor beta Human genes 0.000 abstract 3
108090001012 Transforming Growth Factor beta Proteins 0.000 abstract 3
ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 abstract 3
102000035118 modified proteins Human genes 0.000 abstract 2
108091005573 modified proteins Proteins 0.000 abstract 2
102000004169 proteins and genes Human genes 0.000 abstract 2
108090000623 proteins and genes Proteins 0.000 abstract 2
150000001413 amino acids Chemical class 0.000 abstract 1
230000000921 morphogenic effect Effects 0.000 abstract 1
238000006467 substitution reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Biomedical Technology (AREA)
Molecular Biology (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Wood Science & Technology (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
Medicinal Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Physics & Mathematics (AREA)
Toxicology (AREA)
Gastroenterology & Hepatology (AREA)
Plant Pathology (AREA)
Microbiology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

AT99954771T 1998-10-07 1999-10-07 Mutanten von op-1 ATE364704T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US10341898P	1998-10-07	1998-10-07
US09/374,958 US6677432B1 (en)	1998-10-07	1999-08-16	Mutations of the C-terminal portion of TGF-β superfamily proteins

Publications (1)

Publication Number	Publication Date
ATE364704T1 true ATE364704T1 (de)	2007-07-15

Family

ID=26800441

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99954771T ATE364704T1 (de)	1998-10-07	1999-10-07	Mutanten von op-1

Country Status (8)

Country	Link
US (1)	US6677432B1 (de)
EP (1)	EP1117804B1 (de)
JP (3)	JP3971107B2 (de)
AT (1)	ATE364704T1 (de)
AU (1)	AU772930B2 (de)
CA (1)	CA2344974C (de)
DE (1)	DE69936312T2 (de)
WO (1)	WO2000020607A2 (de)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1225225A3 (de) *	1988-04-08	2003-01-08	Stryker Corporation	Osteogene Vorrichtungen
US6586388B2 (en) *	1988-04-08	2003-07-01	Stryker Corporation	Method of using recombinant osteogenic protein to repair bone or cartilage defects
US6919308B2 (en) *	1988-04-08	2005-07-19	Stryker Corporation	Osteogenic devices
EP0876401B1 (de) *	1996-01-22	2007-06-13	Curis, Inc.	Methoden zur herstellung von op-1 morphogen analoge
US20030185792A1 (en) *	1996-01-22	2003-10-02	Curis, Inc.	Morphogen analogs of bone morphogenic proteins
US7211644B1 (en) *	1996-08-27	2007-05-01	University Of South Florida	Diagnostic markers of human female infertility
US8106001B2 (en) *	1996-08-27	2012-01-31	University Of South Florida	Diagnostic markers of human female infertility
US6683156B1 (en)	1996-08-27	2004-01-27	University Of South Florida	Method for diagnosing selected adenocarcinomas
US6294662B1 (en)	1996-08-27	2001-09-25	University Of South Florida	Nucleic acids encoding an endometrial bleeding associated factor (ebaf)
EP2128260A3 (de) *	1998-10-07	2010-06-16	STRYKER CORPORATION (a Michigan corporation)	Modifizierte TGF-beta-Superfamilienproteine
DE10026713A1 (de) *	2000-05-30	2001-12-06	Walter Sebald	Mutein einer Kette eines Proteins aus der Superfamilie des Wachstumsfaktors TGF-beta
JP4685294B2 (ja) *	2001-09-18	2011-05-18	株式会社カネカ	新規ペプチド、生産方法、新規吸着体、吸着器および吸着方法
EP2392659B1 (de) *	2002-06-17	2015-01-14	Thrasos Innovation, Inc.	TDF-zugehörige Einzeldomänenverbindungen und Analoge davon
AU2003283155A1 (en)	2002-11-14	2004-06-03	Adherex Technologies Inc.	Compounds and methods for modulating functions of classical cadherins
CA2561809A1 (en) *	2004-03-31	2005-10-20	Xencor, Inc.	Bmp-7 variants with improved properties
US7795389B2 (en)	2004-09-28	2010-09-14	The Board Of Regents Of The University Of Texas System	Antagonizing TGF-beta activity with various ectodomains TGF-beta receptors used in combination or as fusion proteins
EP1698691A1 (de) *	2005-03-04	2006-09-06	Biopharm Gesellschaft zur biotechnologischen Entwicklung von Pharmaka mbH	Mutanten von Wachstumsfaktoren mit verbesserter biologischer Eigenschaft
ATE520711T1 (de) *	2005-05-27	2011-09-15	Bbs Bioactive Bone Substitutes Oy	Knochenmorphogenetisches protein 4 und osteogene vorrichtungen und pharmazeutische produkte, die dieses enthalten
US7659250B2 (en) *	2005-12-22	2010-02-09	Centocor, Inc.	BMP-7 variant compositions, methods and uses
GB0604938D0 (en) *	2006-03-11	2006-04-19	Renovo Ltd	Proteins, nucleic acids and medicaments
GB0604966D0 (en)	2006-03-11	2006-04-19	Renovo Ltd	Medicaments and proteins
GB0604964D0 (en)	2006-03-11	2006-04-19	Renovo Ltd	Protein folding
WO2008014054A2 (en) *	2006-07-27	2008-01-31	Centocor, Inc.	Bmp-7 variant compositions, methods and uses
CA2671925A1 (en)	2006-12-21	2008-07-10	Stryker Corporation	Sustained-release formulations comprising crystals, macromolecular gels, and particulate suspensions of biologic agents
EP2396026A2 (de)	2009-02-12	2011-12-21	Stryker Corporation	Zusammensetzungen und verfahren für die minimal invasive systemische abgabe von proteinen einschliesslich mitglieder der tgf-superfamilie
EP2396025A2 (de)	2009-02-12	2011-12-21	Stryker Corporation	Periphere verabreichung von proteinen einschliesslich mitglieder der tgf-beta-superfamilie zur systemischen behandlung von störungen und erkrankungen
EP2401293B1 (de)	2009-02-24	2016-02-10	The Salk Institute For Biological Studies	Designer-liganden der tgf-beta-superfamilie
WO2010110974A1 (en)	2009-03-24	2010-09-30	Stryker Corporation	Methods and compositions for tissue engineering
WO2011031856A1 (en)	2009-09-09	2011-03-17	Stryker Corporation	Bmp -7 for use in treating pain induced by injuries and diseases of an articular joint
AU2010295509A1 (en)	2009-09-17	2012-04-19	Stryker Corporation	Buffers for controlling the pH of bone morphogenetic proteins
JP2013514811A (ja)	2009-12-22	2013-05-02	ストライカーコーポレイション	免疫原性が抑制されたｂｍｐ−７変異体
CU24181B1 (es) *	2012-11-09	2016-04-25	Ct De Inmunología Molecular	POLIPÉPTIDOS DERIVADOS DEL TGFß
CN107847638A (zh)	2014-12-29	2018-03-27	佰欧维恩图斯有限责任公司	用于骨修复中改善骨诱导性分子递送的***和方法
CA2995310A1 (en)	2015-08-25	2017-03-02	Histide Ag	Compounds for inducing tissue formation and uses thereof
US20190016770A1 (en) *	2015-08-25	2019-01-17	Histide Ag	Compounds for inducing tissue formation and uses thereof
EP3464337A4 (de)	2016-05-31	2019-12-18	Mogam Institute for Biomedical Research	Ab6-familie-designerliganden der tgf-beta-superfamilie
JPWO2020095894A1 (ja) *	2018-11-05	2021-10-07	味の素株式会社	フローマイクロリアクターを用いるリフォールディングされたタンパク質の製造方法及びタンパク質のリフォールディング装置

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5250302A (en)	1988-04-08	1993-10-05	Stryker Corporation	Osteogenic devices
US5011691A (en)	1988-08-15	1991-04-30	Stryker Corporation	Osteogenic devices
US5266683A (en)	1988-04-08	1993-11-30	Stryker Corporation	Osteogenic proteins
DK0448704T3 (da)	1989-10-17	1999-04-06	Stryker Corp	Osteogene anordninger
JPH05501500A (ja)	1989-10-18	1993-03-25	クリエイティブ・バイオマリキュールズ・インコーポレーテッド	ＴＧＦ―βの生合成構築物
GB8927546D0 (en)	1989-12-06	1990-02-07	Ciba Geigy	Process for the production of biologically active tgf-beta
US5071655A (en) *	1990-01-12	1991-12-10	Baylink David J	Pharmaceutical combination for treatment of bone-wasting diseases
WO1992015323A1 (en)	1991-03-11	1992-09-17	Creative Biomolecules, Inc.	Protein-induced morphogenesis
DE4131545C2 (de)	1991-09-21	1995-02-02	Krupp Industrietech	Federbein für hydraulischen Radantrieb
WO1994015949A1 (en)	1993-01-12	1994-07-21	Johns Hopkins University School Of Medicine	Growth differentiation factor-5
CA2165776A1 (en)	1993-07-09	1995-01-19	Se-Jin Lee	Growth differentiation factor-6
US5399677A (en)	1993-12-07	1995-03-21	Genetics Institute, Inc.	Mutants of bone morphogenetic proteins
ES2255059T3 (es)	1993-12-07	2006-06-16	Genetics Institute, Llc	Bmp-12, bmp-13 y composiciones suyas inductoras de tendon.
FR2720069A1 (fr)	1994-05-19	1995-11-24	Inst Nat Sante Rech Med	Dérivés de facteurs de croissance et d'hormones de la superfamille des TGFB, procédé pour leur obtention et leurs applications biologiques.
US5674292A (en)	1995-06-07	1997-10-07	Stryker Corporation	Terminally sterilized osteogenic devices and preparation thereof

1999
- 1999-08-16 US US09/374,958 patent/US6677432B1/en not_active Expired - Lifetime
- 1999-10-07 AU AU11038/00A patent/AU772930B2/en not_active Ceased
- 1999-10-07 WO PCT/US1999/023371 patent/WO2000020607A2/en active IP Right Grant
- 1999-10-07 CA CA2344974A patent/CA2344974C/en not_active Expired - Fee Related
- 1999-10-07 DE DE69936312T patent/DE69936312T2/de not_active Expired - Lifetime
- 1999-10-07 JP JP2000574702A patent/JP3971107B2/ja not_active Expired - Fee Related
- 1999-10-07 AT AT99954771T patent/ATE364704T1/de not_active IP Right Cessation
- 1999-10-07 EP EP99954771A patent/EP1117804B1/de not_active Expired - Lifetime
2005
- 2005-06-17 JP JP2005178654A patent/JP4294010B2/ja not_active Expired - Fee Related
2008
- 2008-05-20 JP JP2008132454A patent/JP5149070B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
WO2000020607A9 (en)	2001-03-29
CA2344974A1 (en)	2000-04-13
AU772930B2 (en)	2004-05-13
WO2000020607A2 (en)	2000-04-13
AU1103800A (en)	2000-04-26
WO2000020607A3 (en)	2000-07-06
JP2002526115A (ja)	2002-08-20
JP5149070B2 (ja)	2013-02-20
JP2008237223A (ja)	2008-10-09
JP2005290016A (ja)	2005-10-20
EP1117804B1 (de)	2007-06-13
DE69936312D1 (de)	2007-07-26
CA2344974C (en)	2011-03-29
DE69936312T2 (de)	2008-02-14
JP4294010B2 (ja)	2009-07-08
EP1117804A2 (de)	2001-07-25
JP3971107B2 (ja)	2007-09-05
US6677432B1 (en)	2004-01-13

Legal Events

Date	Code	Title	Description
2007-12-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69936312D1 (de)	2007-07-26	Mutanten von op-1
EP2128260A3 (de)	2010-06-16	Modifizierte TGF-beta-Superfamilienproteine
ATE339507T1 (de)	2006-10-15	Erythropoietin-analog-menschliches serum-albumin fusionsprotein
DE69434299D1 (de)	2005-04-21	Nukleoside und oligonukleoside mit thiol-gruppe
ATE332368T1 (de)	2006-07-15	Selektion von proteinen mittels rns-protein fusionen
EE9800306A (et)	1999-02-15	Isoleeritud dimeerne fibroblastide aktivatsioonivalk alfa ja selle kasutusalad
DE69937291D1 (de)	2007-11-22	Antikörper varianten und fragmente davon
DE69931507D1 (de)	2006-06-29	Interferon-beta fusionsproteine und deren verwendungen
WO2003000853A3 (en)	2003-12-04	Protein aggregation assays and uses thereof
DE69839444D1 (de)	2008-06-19	Smad 6 und dessen anwendungen
DE69932845D1 (de)	2006-09-28	Methoden zur quantifizierung von hla-dr und cd11b
ATE348159T1 (de)	2007-01-15	Mutierte mitglieder der tgf-beta-superfamilie, einschliesslich morphogenetischer proteine
SE8902532L (sv)	1991-01-15	Bestaemning av plasmaproteiner
FR2766193B1 (fr)	2001-09-14	Polypeptide chimerique comprenant le fragment b de la toxine shiga et des peptides d'interet therapeutique
DE69800720T2 (de)	2002-04-18	Reagenz zur Färbung von Blutzellen
ES2173471T3 (es)	2002-10-16	Analisis para homocisteina y homocisteina desulfurasa a partir de tricomonas viginalis de protozoos.
DE69634489D1 (de)	2005-04-21	Adenovirus dodekahedrischer proteinkomplex, dieser enthaltende zusammensetzung und verwendungen davon
ATE363070T1 (de)	2007-06-15	Auswertung von biologischen mitteln in lebenden zielzellen
EP0749312A4 (de)	1999-04-28	DIROFILARIA IMMITIS - Gp29 - PROTEINE, NUKLEINSÄUREMOLEKÜLE UND IHRE VERWENDUNGEN
AU7147898A (en)	1998-11-13	(dirofilaria) and (brugia) ankyrin proteins, nucleic acid molecules, and uses thereof
TR200000416T2 (tr)	2000-07-21	Neisseria loctoferrin bağlayıcı protein.
PT723552E (pt)	2003-02-28	Oligopeptidos derivados de fragmentos de proteina reactiva c
PT929299E (pt)	2004-02-27	1,2,3,4-tetra-hidro-2-dibenzofuranaminas e 2-aminociclo-hepta ¬b\| benzofuranos substituidos
TR199902434T2 (xx)	2000-01-21	Bakteriyel plazmidler.
AU4981093A (en)	1994-03-15	Nucleotide sequences coding for cryptosporidium proteins, polypeptides coded by said sequences and kits for the use thereof