ATE354096T1 - Synthese und screening von liganden mit hilfe von röntgenkristallographie - Google Patents
Synthese und screening von liganden mit hilfe von röntgenkristallographieInfo
- Publication number
- ATE354096T1 ATE354096T1 AT03782663T AT03782663T ATE354096T1 AT E354096 T1 ATE354096 T1 AT E354096T1 AT 03782663 T AT03782663 T AT 03782663T AT 03782663 T AT03782663 T AT 03782663T AT E354096 T1 ATE354096 T1 AT E354096T1
- Authority
- AT
- Austria
- Prior art keywords
- macromolecule
- crystal
- ligands
- screening
- synthesis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B30/00—Methods of screening libraries
- C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N23/00—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00
- G01N23/20—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by using diffraction of the radiation by the materials, e.g. for investigating crystal structure; by using scattering of the radiation by the materials, e.g. for investigating non-crystalline materials; by using reflection of the radiation by the materials
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43534902P | 2002-12-23 | 2002-12-23 | |
| GB0230172A GB0230172D0 (en) | 2002-12-24 | 2002-12-24 | Synthesis and screening of macromolecules |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE354096T1 true ATE354096T1 (de) | 2007-03-15 |
Family
ID=32683994
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03782663T ATE354096T1 (de) | 2002-12-23 | 2003-12-22 | Synthese und screening von liganden mit hilfe von röntgenkristallographie |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7149280B2 (de) |
| EP (1) | EP1576375B1 (de) |
| AT (1) | ATE354096T1 (de) |
| AU (1) | AU2003290304A1 (de) |
| DE (1) | DE60311879T2 (de) |
| WO (1) | WO2004057340A1 (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040265909A1 (en) * | 2003-04-11 | 2004-12-30 | Jeff Blaney | Compound libraries and methods for drug discovery |
| ATE527542T1 (de) | 2005-04-27 | 2011-10-15 | Siemens Medical Solutions | Verfahren zur herstellung von abbildungssonden unter verwendung von click chemie |
| JP2021081369A (ja) * | 2019-11-21 | 2021-05-27 | キリンホールディングス株式会社 | 求核基を有する化合物の結晶スポンジ法による構造解析のための結晶構造解析用試料の調製方法 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5958702A (en) * | 1995-02-06 | 1999-09-28 | Benner; Steven Albert | Receptor-assisted combinatorial chemistry |
| DE19619373A1 (de) | 1996-05-14 | 1997-11-20 | Hoechst Ag | Neue Substanzbibliothek und damit hergestellte supramolekulare Komplexe |
| GB9718913D0 (en) | 1997-09-05 | 1997-11-12 | Glaxo Group Ltd | Substituted oxindole derivatives |
| WO1999045389A2 (en) * | 1998-03-06 | 1999-09-10 | Abbott Lab | Ligand screening and design by x-ray crystallography |
| US6344330B1 (en) | 1998-03-27 | 2002-02-05 | The Regents Of The University Of California | Pharmacophore recombination for the identification of small molecule drug lead compounds |
| US6335155B1 (en) | 1998-06-26 | 2002-01-01 | Sunesis Pharmaceuticals, Inc. | Methods for rapidly identifying small organic molecule ligands for binding to biological target molecules |
| CA2355215A1 (en) | 1998-12-28 | 2000-07-06 | Jim Wells | Identifying small organic molecule ligands for binding |
| GB9904933D0 (en) * | 1999-03-04 | 1999-04-28 | Glaxo Group Ltd | Compounds |
| US6404849B1 (en) * | 1999-08-11 | 2002-06-11 | Abbott Laboratories | Automated sample handling for X-ray crystallography |
| EP1130009A1 (de) | 2000-03-01 | 2001-09-05 | Therascope AG | Erzeugung und Screenen einer dynamischen kombinatorischen Verbindungsbibliothek |
| US6947844B2 (en) | 2000-08-09 | 2005-09-20 | Yale University | Modulators of ribosomal function and identification thereof |
| EP1184359A1 (de) | 2000-09-04 | 2002-03-06 | Therascope AG | Erzeugung von dynamischen kombinatorischen Verbindungsbibliotheken und deren Bewertung durch Dekonvolution |
| AU2002225731B2 (en) | 2000-11-21 | 2005-04-14 | Sunesis Pharmaceuticals, Inc. | An extended tethering approach for rapid identification of ligands |
| US6546074B1 (en) | 2001-03-27 | 2003-04-08 | Astex Technology Limited | Protein crystal structure and method for identifying protein modulators |
| AU2002258787A1 (en) * | 2001-04-11 | 2002-10-28 | Emerald Biostructures, Inc. | Screening methods for identifying ligands |
| EP1308716A1 (de) * | 2001-10-03 | 2003-05-07 | Avantium International B.V. | Verfahren und Vorrichtung zur Durchführung einer Transmissions- Diffraktionsanalyse |
| WO2003033437A2 (en) | 2001-10-15 | 2003-04-24 | Therascope Ag | A method of forming neuraminidase inhibitors by dynamic combinatorial chemistry and compounds obtained |
| AU2003219337A1 (en) | 2002-04-10 | 2003-10-27 | Ufc Limited | Method of producing dynamic combinatorial libraries |
-
2003
- 2003-12-22 AT AT03782663T patent/ATE354096T1/de not_active IP Right Cessation
- 2003-12-22 EP EP03782663A patent/EP1576375B1/de not_active Expired - Lifetime
- 2003-12-22 US US10/539,447 patent/US7149280B2/en not_active Expired - Fee Related
- 2003-12-22 WO PCT/GB2003/005595 patent/WO2004057340A1/en active IP Right Grant
- 2003-12-22 DE DE60311879T patent/DE60311879T2/de not_active Expired - Fee Related
- 2003-12-22 AU AU2003290304A patent/AU2003290304A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20060159226A1 (en) | 2006-07-20 |
| DE60311879T2 (de) | 2007-12-20 |
| EP1576375A1 (de) | 2005-09-21 |
| DE60311879D1 (de) | 2007-03-29 |
| US7149280B2 (en) | 2006-12-12 |
| EP1576375B1 (de) | 2007-02-14 |
| AU2003290304A1 (en) | 2004-07-14 |
| WO2004057340A1 (en) | 2004-07-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |