ATE349699T1 - Verfahren zur identifizierung von modulatoren von proteaseaktivierten rezeptoren (par) - Google Patents

Verfahren zur identifizierung von modulatoren von proteaseaktivierten rezeptoren (par)

Info

Publication number
ATE349699T1
ATE349699T1 AT00991185T AT00991185T ATE349699T1 AT E349699 T1 ATE349699 T1 AT E349699T1 AT 00991185 T AT00991185 T AT 00991185T AT 00991185 T AT00991185 T AT 00991185T AT E349699 T1 ATE349699 T1 AT E349699T1
Authority
AT
Austria
Prior art keywords
par
protease
activated receptors
identifying modulators
molecule
Prior art date
Application number
AT00991185T
Other languages
English (en)
Inventor
Ludger Altrogge
Denis Monard
Original Assignee
Novartis Forschungsstiftung
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Forschungsstiftung filed Critical Novartis Forschungsstiftung
Application granted granted Critical
Publication of ATE349699T1 publication Critical patent/ATE349699T1/de

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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/975Kit

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Gyroscopes (AREA)
  • Optical Communication System (AREA)
  • Holo Graphy (AREA)
AT00991185T 1999-12-15 2000-12-13 Verfahren zur identifizierung von modulatoren von proteaseaktivierten rezeptoren (par) ATE349699T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9929674.1A GB9929674D0 (en) 1999-12-15 1999-12-15 Protease-activated receptor (PAR) modulator assays

Publications (1)

Publication Number Publication Date
ATE349699T1 true ATE349699T1 (de) 2007-01-15

Family

ID=10866389

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00991185T ATE349699T1 (de) 1999-12-15 2000-12-13 Verfahren zur identifizierung von modulatoren von proteaseaktivierten rezeptoren (par)

Country Status (11)

Country Link
US (1) US7148018B2 (de)
EP (1) EP1238283B1 (de)
AT (1) ATE349699T1 (de)
AU (1) AU3158501A (de)
CY (1) CY1106384T1 (de)
DE (1) DE60032632T2 (de)
DK (1) DK1238283T3 (de)
ES (1) ES2277866T3 (de)
GB (1) GB9929674D0 (de)
PT (1) PT1238283E (de)
WO (1) WO2001044496A2 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6346510B1 (en) 1995-10-23 2002-02-12 The Children's Medical Center Corporation Therapeutic antiangiogenic endostatin compositions
WO2006023844A2 (en) * 2004-08-20 2006-03-02 Entremed, Inc. Compositions and methods comprising proteinase activated receptor antagonists
CA2733041A1 (en) * 2008-08-05 2010-02-11 Boehringer Ingelheim International Gmbh Effectors of par-2 activation and their use in the modulation of inflammation
EP2776458B1 (de) * 2011-11-07 2018-07-25 The Scripps Research Institute Proteaseaktivierte aus einem rezeptor-1 (par1) gewonnene zellschützende polypeptide und verfahren dafür
WO2017194716A1 (en) * 2016-05-12 2017-11-16 Astrazeneca Ab Inhibitors of protease-activated receptor-2

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0535007T3 (da) 1990-06-01 1995-09-25 Lepetit Spa Monoklonalt antistof med GAG-proteinforstadiet p55 fra humant immunodefekt virus
US5235039A (en) * 1991-06-10 1993-08-10 Eli Lilly And Company Substrates for hiv protease
US5605809A (en) 1994-10-28 1997-02-25 Oncoimmunin, Inc. Compositions for the detection of proteases in biological samples and methods of use thereof
AU4904397A (en) 1996-10-17 1998-05-11 Chiron Corporation Protease regulator screening assay
US5892014A (en) 1996-10-30 1999-04-06 The Regents Of The University Of California DNA encoding a protease-activated receptor 3
JP2001514506A (ja) 1997-03-07 2001-09-11 トロピックス・インコーポレーテッド プロテアーゼ阻害剤分析
US6111075A (en) 1998-04-01 2000-08-29 Zymogenetics, Inc. Protese-activated receptor PAR4 (ZCHEMR2)

Also Published As

Publication number Publication date
AU3158501A (en) 2001-06-25
US20030148921A1 (en) 2003-08-07
DK1238283T3 (da) 2007-04-02
EP1238283B1 (de) 2006-12-27
CY1106384T1 (el) 2011-10-12
WO2001044496A3 (en) 2002-05-10
ES2277866T3 (es) 2007-08-01
DE60032632D1 (de) 2007-02-08
GB9929674D0 (en) 2000-02-09
PT1238283E (pt) 2007-03-30
US7148018B2 (en) 2006-12-12
EP1238283A2 (de) 2002-09-11
DE60032632T2 (de) 2007-11-15
WO2001044496A2 (en) 2001-06-21

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