ATE342729T1 - Modifizierter tumor-nekrosefaktor - Google Patents
Modifizierter tumor-nekrosefaktorInfo
- Publication number
- ATE342729T1 ATE342729T1 AT98904563T AT98904563T ATE342729T1 AT E342729 T1 ATE342729 T1 AT E342729T1 AT 98904563 T AT98904563 T AT 98904563T AT 98904563 T AT98904563 T AT 98904563T AT E342729 T1 ATE342729 T1 AT E342729T1
- Authority
- AT
- Austria
- Prior art keywords
- tnf
- necrosis factor
- tumor necrosis
- modified tumor
- range
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/525—Tumour necrosis factor [TNF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/14—Lymphokine; related peptides
- Y10S930/144—Tumor necrosis factor
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3552197P | 1997-01-15 | 1997-01-15 | |
US681098A | 1998-01-14 | 1998-01-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE342729T1 true ATE342729T1 (de) | 2006-11-15 |
Family
ID=26676095
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT98904563T ATE342729T1 (de) | 1997-01-15 | 1998-01-15 | Modifizierter tumor-nekrosefaktor |
Country Status (11)
Country | Link |
---|---|
US (1) | US7785579B2 (de) |
EP (1) | EP1007082B1 (de) |
JP (1) | JP4295831B2 (de) |
CN (1) | CN1168495C (de) |
AT (1) | ATE342729T1 (de) |
AU (1) | AU725133B2 (de) |
CA (1) | CA2277757C (de) |
DE (1) | DE69836222T2 (de) |
DK (1) | DK1007082T3 (de) |
ES (1) | ES2275300T3 (de) |
WO (1) | WO1998031383A1 (de) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2158923B1 (de) | 1998-08-06 | 2013-02-27 | Mountain View Pharmaceuticals, Inc. | Peg-uricase Konjugate und Verwendung davon |
US6783965B1 (en) | 2000-02-10 | 2004-08-31 | Mountain View Pharmaceuticals, Inc. | Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates |
WO2001062827A2 (en) | 2000-02-22 | 2001-08-30 | Shearwater Corporation | N-maleimidyl polymer derivatives |
CN1315351A (zh) * | 2000-03-24 | 2001-10-03 | 上海博德基因开发有限公司 | 一种新的多肽——人一种组织或发育阶段特异转录因子相关因子11和编码这种多肽的多核苷酸 |
US7635680B2 (en) | 2001-02-21 | 2009-12-22 | Alavita Pharmaceuticals, Inc. | Attenuation of reperfusion injury |
US7635676B2 (en) | 2001-02-21 | 2009-12-22 | Alavita Pharmaccuticals, Inc. | Modified annexin proteins and methods for their use in organ transplantation |
ES2286247T3 (es) * | 2001-02-21 | 2007-12-01 | Alavita Pharmaceuticals, Inc. | Proteinas anexinicas modificacdas y tratamiento de la trombosis. |
US7645739B2 (en) | 2001-02-21 | 2010-01-12 | Alavita Pharmaceuticals, Inc. | Modified annexin compositions and methods of using same |
EP1234583A1 (de) * | 2001-02-23 | 2002-08-28 | F. Hoffmann-La Roche Ag | PEG-Konjugate des HGF-NK4 |
NZ541365A (en) | 2002-12-27 | 2009-09-25 | Diobex Inc | Compositions and methods for the prevention and control of insulin-induced hypoglycemia |
US7655618B2 (en) | 2002-12-27 | 2010-02-02 | Diobex, Inc. | Compositions and methods for the prevention and control of insulin-induced hypoglycemia |
US7432331B2 (en) | 2002-12-31 | 2008-10-07 | Nektar Therapeutics Al, Corporation | Hydrolytically stable maleimide-terminated polymers |
KR101025143B1 (ko) | 2002-12-31 | 2011-04-01 | 넥타르 테라퓨틱스 | 가수분해상으로 안정한 말레이미드-종결 중합체 |
WO2005056636A2 (en) | 2003-12-03 | 2005-06-23 | Nektar Therapeutics Al, Corporation | Method of preparing maleimide functionalized polymers |
JP4877225B2 (ja) * | 2005-02-18 | 2012-02-15 | 日油株式会社 | ポリオキシアルキレン誘導体 |
US8148123B2 (en) | 2005-04-11 | 2012-04-03 | Savient Pharmaceuticals, Inc. | Methods for lowering elevated uric acid levels using intravenous injections of PEG-uricase |
PL3321359T3 (pl) | 2005-04-11 | 2021-06-28 | Horizon Pharma Rheumatology Llc | Wariantowe postacie oksydazy moczanowej i ich zastosowanie |
RU2435847C2 (ru) | 2005-04-11 | 2011-12-10 | Савиент Фармасьютикалз, Инк. | Вариантная форма урат-оксидазы и ее использование |
ES2532804T3 (es) | 2006-04-12 | 2015-03-31 | Crealta Pharmaceuticals Llc | Purificación de proteínas con tensioactivo catiónico |
KR100886783B1 (ko) * | 2006-06-12 | 2009-03-04 | 성균관대학교산학협력단 | N-말단이 수식된 peg-trail 결합체, 이의 제조방법 및 이의 용도 |
CN101837130B (zh) * | 2009-03-20 | 2013-10-23 | 北京大学 | 聚乙二醇-二肽-抗肿瘤药物复合物及其用途 |
US20100284962A1 (en) * | 2009-05-06 | 2010-11-11 | Oncopharmacologics, Inc. | Modified tumor necrosis factor-beta |
KR101861547B1 (ko) | 2009-06-25 | 2018-07-02 | 크레알타 파마슈티칼스 엘엘씨 | 페길화된 유리카아제 치료 중에 혈청 요산을 모니터링하여 주입 반응의 위험성 및 반응의 항체매개 상실을 예측하는 방법 및 키트 |
WO2014151836A1 (en) * | 2013-03-14 | 2014-09-25 | Ran Biotechnologies, Inc. | Methods and materials for microorganism capture |
KR102352614B1 (ko) | 2013-03-14 | 2022-01-18 | 랜 바이오테크놀러지스, 인크. | 생물제제의 검출을 위한 방법 및 물질 |
CN105294852B (zh) * | 2015-10-27 | 2019-06-07 | 岳阳新华达制药有限公司 | 聚乙二醇与肿瘤坏死因子α或其类似物的偶联物及其医药用途 |
WO2017106627A1 (en) | 2015-12-17 | 2017-06-22 | The Johns Hopkins University | Ameliorating systemic sclerosis with death receptor agonists |
WO2017177148A1 (en) | 2016-04-07 | 2017-10-12 | The Johns Hopkins University | Compositions and methods for treating pancreatitis and pain with death receptor agonists |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
US4640835A (en) * | 1981-10-30 | 1987-02-03 | Nippon Chemiphar Company, Ltd. | Plasminogen activator derivatives |
US4609546A (en) | 1982-06-24 | 1986-09-02 | Japan Chemical Research Co., Ltd. | Long-acting composition |
US5447722A (en) | 1983-12-12 | 1995-09-05 | University Of Manitoba | Method for the suppression of an immune response with antigen-MPEG conjugates in nonsensitized individuals |
EP0229108B1 (de) * | 1985-06-26 | 1990-12-27 | Cetus Corporation | Solubilisierung von proteinen für pharmazeutische zusammensetzungen mittels polymerkonjugierung |
US5080891A (en) | 1987-08-03 | 1992-01-14 | Ddi Pharmaceuticals, Inc. | Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols |
JP3040121B2 (ja) | 1988-01-12 | 2000-05-08 | ジェネンテク,インコーポレイテッド | 増殖因子レセプターの機能を阻害することにより腫瘍細胞を処置する方法 |
US5162430A (en) | 1988-11-21 | 1992-11-10 | Collagen Corporation | Collagen-polymer conjugates |
AU4660789A (en) | 1988-11-23 | 1990-06-12 | Genentech Inc. | Polypeptide derivatives |
EP0401384B1 (de) | 1988-12-22 | 1996-03-13 | Kirin-Amgen, Inc. | Chemisch modifizierte granulocytenkolonie erregender faktor |
JPH04218000A (ja) * | 1990-02-13 | 1992-08-07 | Kirin Amgen Inc | 修飾ポリペプチド |
WO1994005332A2 (en) | 1992-09-01 | 1994-03-17 | Berlex Laboratories, Inc. | Glycolation of glycosylated macromolecules |
KR970005042B1 (ko) | 1993-02-09 | 1997-04-11 | 한일합성섬유공업 주식회사 | 종양괴사인자-알파 뮤테인 |
US5695760A (en) | 1995-04-24 | 1997-12-09 | Boehringer Inglehiem Pharmaceuticals, Inc. | Modified anti-ICAM-1 antibodies and their use in the treatment of inflammation |
US5747639A (en) * | 1996-03-06 | 1998-05-05 | Amgen Boulder Inc. | Use of hydrophobic interaction chromatography to purify polyethylene glycols |
-
1998
- 1998-01-15 ES ES98904563T patent/ES2275300T3/es not_active Expired - Lifetime
- 1998-01-15 CN CNB988018373A patent/CN1168495C/zh not_active Expired - Lifetime
- 1998-01-15 DK DK98904563T patent/DK1007082T3/da active
- 1998-01-15 AT AT98904563T patent/ATE342729T1/de active
- 1998-01-15 CA CA002277757A patent/CA2277757C/en not_active Expired - Lifetime
- 1998-01-15 WO PCT/US1998/000683 patent/WO1998031383A1/en active IP Right Grant
- 1998-01-15 DE DE69836222T patent/DE69836222T2/de not_active Expired - Lifetime
- 1998-01-15 JP JP53448898A patent/JP4295831B2/ja not_active Expired - Lifetime
- 1998-01-15 EP EP98904563A patent/EP1007082B1/de not_active Expired - Lifetime
- 1998-01-15 AU AU62410/98A patent/AU725133B2/en not_active Expired
-
2006
- 2006-02-27 US US11/363,863 patent/US7785579B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DE69836222D1 (de) | 2006-11-30 |
CA2277757C (en) | 2008-09-16 |
DK1007082T3 (da) | 2007-02-19 |
CN1243444A (zh) | 2000-02-02 |
US20060222626A1 (en) | 2006-10-05 |
JP2001511784A (ja) | 2001-08-14 |
EP1007082B1 (de) | 2006-10-18 |
WO1998031383A1 (en) | 1998-07-23 |
CA2277757A1 (en) | 1998-07-23 |
EP1007082A4 (de) | 2004-05-12 |
DE69836222T2 (de) | 2007-11-15 |
EP1007082A1 (de) | 2000-06-14 |
ES2275300T3 (es) | 2007-06-01 |
CN1168495C (zh) | 2004-09-29 |
JP4295831B2 (ja) | 2009-07-15 |
AU6241098A (en) | 1998-08-07 |
US7785579B2 (en) | 2010-08-31 |
AU725133B2 (en) | 2000-10-05 |
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Legal Events
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