ATE322513T1 - Milchsäurepolymer und verfahren zu dessen herstellung - Google Patents

Milchsäurepolymer und verfahren zu dessen herstellung

Info

Publication number
ATE322513T1
ATE322513T1 AT01954447T AT01954447T ATE322513T1 AT E322513 T1 ATE322513 T1 AT E322513T1 AT 01954447 T AT01954447 T AT 01954447T AT 01954447 T AT01954447 T AT 01954447T AT E322513 T1 ATE322513 T1 AT E322513T1
Authority
AT
Austria
Prior art keywords
weight
lactic acid
acid polymer
production
sustained
Prior art date
Application number
AT01954447T
Other languages
English (en)
Inventor
Kohei Yamamoto
Tsutomu Tani
Takashi Aoki
Yoshio Hata
Original Assignee
Wako Pure Chem Ind Ltd
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=18729814&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE322513(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wako Pure Chem Ind Ltd, Takeda Pharmaceutical filed Critical Wako Pure Chem Ind Ltd
Application granted granted Critical
Publication of ATE322513T1 publication Critical patent/ATE322513T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/88—Post-polymerisation treatment
    • C08G63/89—Recovery of the polymer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
    • C08G63/08—Lactones or lactides
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/88—Post-polymerisation treatment
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/91—Polymers modified by chemical after-treatment
    • C08G63/912—Polymers modified by chemical after-treatment derived from hydroxycarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Polymers & Plastics (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Biological Depolymerization Polymers (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT01954447T 2000-08-07 2001-08-06 Milchsäurepolymer und verfahren zu dessen herstellung ATE322513T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2000238051 2000-08-07

Publications (1)

Publication Number Publication Date
ATE322513T1 true ATE322513T1 (de) 2006-04-15

Family

ID=18729814

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01954447T ATE322513T1 (de) 2000-08-07 2001-08-06 Milchsäurepolymer und verfahren zu dessen herstellung

Country Status (15)

Country Link
US (3) US7019106B2 (de)
EP (2) EP1310517B2 (de)
JP (2) JP5046447B2 (de)
KR (1) KR100772950B1 (de)
CN (1) CN1269870C (de)
AT (1) ATE322513T1 (de)
AU (1) AU2001276733A1 (de)
CA (1) CA2419065C (de)
CY (1) CY1117889T1 (de)
DE (1) DE60118575T3 (de)
DK (1) DK1310517T4 (de)
ES (2) ES2256276T5 (de)
HK (1) HK1095526A1 (de)
PT (2) PT1693054T (de)
WO (1) WO2002012369A1 (de)

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TWI332407B (en) † 2001-06-29 2010-11-01 Takeda Chemical Industries Ltd Controlled release composition and method of producting the same
WO2004067756A1 (en) * 2003-01-29 2004-08-12 Biomatera Inc. Method for controlling molecular weight and distribution of biopolymers
JP4205497B2 (ja) * 2003-06-23 2009-01-07 帝人株式会社 リン脂質を含有するポリ乳酸樹脂組成物および成形体
WO2005023906A1 (ja) 2003-09-08 2005-03-17 Chugai Seiyaku Kabushiki Kaisha ヒアルロン酸修飾物、及びそれを用いた薬物担体
EP1749039A1 (de) * 2004-04-23 2007-02-07 Amgen Inc. Niedermolekulare polymilchsäurepolymere
CA2564605A1 (en) * 2004-05-12 2005-12-01 Massachusetts Institute Of Technology Manufacturing process, such as three-dimensional printing, including solvent vapor filming and the like
TW200613012A (en) * 2004-07-02 2006-05-01 Takeda Pharmaceuticals Co Sustained-release composition, process for producing the same and use of the same
ATE382337T1 (de) * 2005-04-28 2008-01-15 Nipro Corp Bioabsorbierbare pharmazeutische zusammensetzung enthaltend einen plga-copolymer
CN101400363B (zh) 2006-01-18 2012-08-29 昌达生物科技公司 具有增强的稳定性的药物组合物
US8076448B2 (en) * 2006-10-11 2011-12-13 Tolmar Therapeutics, Inc. Preparation of biodegradable polyesters with low-burst properties by supercritical fluid extraction
NL2000454C1 (nl) 2006-11-28 2008-01-02 Purac Biochem Bv Stabiele lactidedeeltjes.
ES2429291T3 (es) * 2006-11-28 2013-11-14 Purac Biochem N.V. Partículas de lactida estables
US20080146822A1 (en) 2006-11-28 2008-06-19 Purac Biochem B.V. Stable lactide particles
BRPI0720582B1 (pt) 2006-12-18 2021-08-24 Takeda Pharmaceutical Company Limited Composição de liberação prolongada, processo para a preparação da mesma, composição farmacêutica, agente profilático ou terapêutico, e, uso de uma substância fisiologicamente ativa
PT2115029E (pt) * 2007-02-15 2015-10-26 Tolmar Therapeutics Inc Poli-(lactido/glicolido) de efeito de libertação imediata reduzido e métodos de produção de polímeros
WO2008139658A1 (ja) * 2007-05-16 2008-11-20 National Institute Of Advanced Industrial Science And Technology 乳酸オリゴマーおよびその製造方法
WO2009148579A2 (en) 2008-06-03 2009-12-10 Qlt Usa, Inc. Dehydrated hydrogel inclusion complex of a bioactive agent with flowable drug delivery system
US8877225B2 (en) 2008-06-03 2014-11-04 Tolmar Therapeutics, Inc. Controlled release copolymer formulation with improved release kinetics
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US9956164B2 (en) 2014-04-16 2018-05-01 Veyx-Pharma Gmbh Veterinary pharmaceutical composition and use thereof
HRP20231453T1 (hr) 2015-11-16 2024-03-01 Medincell S.A. Postupak za morseliranje i/ili usmjeravanje farmaceutski aktivnih sastojaka na sinovijalno tkivo
SG11202001688WA (en) 2017-08-31 2020-03-30 Evonik Corp Improved resorbable polymer purification process
KR20230079071A (ko) 2020-09-30 2023-06-05 톨마 인터내셔날 리미티드 테스토스테론의 연장 전달을 위한 생분해성 폴리머 전달 시스템

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Also Published As

Publication number Publication date
ES2256276T5 (es) 2011-02-22
US20060128938A1 (en) 2006-06-15
US20070259036A1 (en) 2007-11-08
EP1693054A3 (de) 2007-07-11
HK1095526A1 (zh) 2007-05-11
WO2002012369A1 (fr) 2002-02-14
KR20030046405A (ko) 2003-06-12
DE60118575T3 (de) 2011-05-19
EP1693054A2 (de) 2006-08-23
CA2419065A1 (en) 2002-02-14
EP1310517B1 (de) 2006-04-05
PT1693054T (pt) 2016-07-07
DE60118575T2 (de) 2006-08-24
US7019106B2 (en) 2006-03-28
EP1310517B2 (de) 2010-11-17
JP2002121272A (ja) 2002-04-23
CY1117889T1 (el) 2017-05-17
CN1461321A (zh) 2003-12-10
JP2012107256A (ja) 2012-06-07
WO2002012369A9 (fr) 2003-04-24
JP5622760B2 (ja) 2014-11-12
AU2001276733A1 (en) 2002-02-18
PT1310517E (pt) 2006-05-31
DE60118575D1 (de) 2006-05-18
JP5046447B2 (ja) 2012-10-10
CN1269870C (zh) 2006-08-16
US20030153724A1 (en) 2003-08-14
KR100772950B1 (ko) 2007-11-02
EP1310517A4 (de) 2005-01-05
ES2256276T3 (es) 2006-07-16
CA2419065C (en) 2009-12-22
EP1310517A1 (de) 2003-05-14
DK1310517T3 (da) 2006-07-24
DK1310517T4 (da) 2011-01-17
ES2577389T3 (es) 2016-07-14
EP1693054B1 (de) 2016-05-25
US8092830B2 (en) 2012-01-10

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