ATE312661T1 - Vorrichtung und verfahren zum herstellen von kristallinen teilchen - Google Patents

Vorrichtung und verfahren zum herstellen von kristallinen teilchen

Info

Publication number
ATE312661T1
ATE312661T1 AT03701533T AT03701533T ATE312661T1 AT E312661 T1 ATE312661 T1 AT E312661T1 AT 03701533 T AT03701533 T AT 03701533T AT 03701533 T AT03701533 T AT 03701533T AT E312661 T1 ATE312661 T1 AT E312661T1
Authority
AT
Austria
Prior art keywords
crystalline particles
producing crystalline
producing
particles
crystalline
Prior art date
Application number
AT03701533T
Other languages
English (en)
Inventor
Hardev Singh
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Application granted granted Critical
Publication of ATE312661T1 publication Critical patent/ATE312661T1/de

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/80—Mixing by means of high-frequency vibrations above one kHz, e.g. ultrasonic vibrations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/005—Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/005—Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
    • B01D9/0054—Use of anti-solvent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/0059—General arrangements of crystallisation plant, e.g. flow sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/0081—Use of vibrations, e.g. ultrasound
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/20—Jet mixers, i.e. mixers using high-speed fluid streams
    • B01F25/25—Mixing by jets impinging against collision plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/80—Mixing by means of high-frequency vibrations above one kHz, e.g. ultrasonic vibrations
    • B01F31/85—Mixing by means of high-frequency vibrations above one kHz, e.g. ultrasonic vibrations with a vibrating element inside the receptacle
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/712—Feed mechanisms for feeding fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
    • B01F35/7174—Feed mechanisms characterised by the means for feeding the components to the mixer using pistons, plungers or syringes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
    • B01F35/7176—Feed mechanisms characterised by the means for feeding the components to the mixer using pumps
    • B01F35/717611—Peristaltic pumps
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
    • B01F35/71805—Feed mechanisms characterised by the means for feeding the components to the mixer using valves, gates, orifices or openings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/75—Discharge mechanisms
    • B01F35/754—Discharge mechanisms characterised by the means for discharging the components from the mixer
    • B01F35/7547—Discharge mechanisms characterised by the means for discharging the components from the mixer using valves, gates, orifices or openings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/18—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic using a vibrating apparatus

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Mixers With Rotating Receptacles And Mixers With Vibration Mechanisms (AREA)
AT03701533T 2002-01-22 2003-01-21 Vorrichtung und verfahren zum herstellen von kristallinen teilchen ATE312661T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0201400.9A GB0201400D0 (en) 2002-01-22 2002-01-22 Novel apparatus and process
PCT/EP2003/000558 WO2003061816A1 (en) 2002-01-22 2003-01-21 Apparatus and process for preparing crystalline particles

Publications (1)

Publication Number Publication Date
ATE312661T1 true ATE312661T1 (de) 2005-12-15

Family

ID=9929515

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03701533T ATE312661T1 (de) 2002-01-22 2003-01-21 Vorrichtung und verfahren zum herstellen von kristallinen teilchen

Country Status (22)

Country Link
US (1) US7384478B2 (de)
EP (1) EP1469938B1 (de)
JP (1) JP4408700B2 (de)
KR (1) KR20040082395A (de)
CN (1) CN1620333A (de)
AR (1) AR038200A1 (de)
AT (1) ATE312661T1 (de)
BR (1) BR0306738A (de)
CA (1) CA2473059A1 (de)
CO (1) CO5611178A2 (de)
DE (1) DE60302765T2 (de)
ES (1) ES2253656T3 (de)
GB (1) GB0201400D0 (de)
IL (1) IL162751A0 (de)
IS (1) IS7335A (de)
MX (1) MXPA04007073A (de)
NO (1) NO20043444L (de)
PL (1) PL372897A1 (de)
RU (1) RU2004120549A (de)
TW (1) TW200302129A (de)
WO (1) WO2003061816A1 (de)
ZA (1) ZA200405143B (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005177746A (ja) * 2003-11-28 2005-07-07 Mitsubishi Chemicals Corp 有機化合物微粒子の製造方法
CN1878602A (zh) * 2003-11-28 2006-12-13 三菱化学株式会社 有机化合物微粒的制造方法
GB0406069D0 (en) * 2004-03-17 2004-04-21 Thompson James Process
GB0507165D0 (en) * 2005-04-08 2005-05-18 Glaxo Group Ltd Novel crystalline pharmaceutical product
DE102005053862A1 (de) * 2005-11-04 2007-05-10 Pharmasol Gmbh Verfahren und Vorrichtung zur Herstellung hochfeiner Partikel sowie zur Beschichtung solcher Partikel
JP4597107B2 (ja) * 2006-03-02 2010-12-15 三井金属鉱業株式会社 砒素含有体からの砒素除去方法及び砒素除去装置
MX2008012794A (es) * 2006-04-03 2008-10-15 Teva Pharma Microparticulas de farmacos.
GB0705159D0 (en) 2007-03-19 2007-04-25 Prosonix Ltd Process for making crystals
GB0711680D0 (en) * 2007-06-18 2007-07-25 Prosonix Ltd Process
GB0900080D0 (en) 2009-01-06 2009-02-11 Prosonix Ltd An apparatus and process for producing crystals
GB0918150D0 (en) * 2009-10-16 2009-12-02 Jagotec Ag Improved formulations
GB0918149D0 (en) 2009-10-16 2009-12-02 Jagotec Ag Improved medicinal aerosol formulation
EP2500072A1 (de) * 2011-03-15 2012-09-19 LEK Pharmaceuticals d.d. Neuartiges Verfahren zum Entfernen von Restlösemittel
CN103649104A (zh) * 2011-07-08 2014-03-19 辉瑞股份有限公司 用于制备氟替卡松丙酸酯形式1的方法
ES2634699T3 (es) * 2011-07-14 2017-09-28 Covaris, Inc. Métodos para preparar composiciones nanocristalinas usando acústica enfocada
JP5848621B2 (ja) * 2012-01-25 2016-01-27 浜松ホトニクス株式会社 薬物評価方法及び薬物評価装置
CN104350063B (zh) 2012-05-08 2018-01-05 尼科斯眼药公司 疏水性治疗剂的制剂、其制备方法及应用
US8765725B2 (en) 2012-05-08 2014-07-01 Aciex Therapeutics, Inc. Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof
US9815865B2 (en) 2013-01-07 2017-11-14 Nicox Ophthalmics, Inc. Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof
WO2014118532A1 (en) 2013-01-31 2014-08-07 Prosonix Limited Pharmaceutical compositions comprising multi-component crystalline particles suitable for use in inhalation therapy
US9855538B2 (en) 2013-03-08 2018-01-02 The Board Of Trustees Of The University Of Illinois Ultrasonic method and apparatus for producing particles having a controlled size distribution
CN103977593B (zh) * 2014-05-19 2017-01-04 中国工程物理研究院化工材料研究所 制备纳米共晶含能材料的方法及装置
DE102021121631A1 (de) 2021-08-20 2023-02-23 Dionex Softron Gmbh Mischanordnung

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4930820B1 (de) * 1966-02-10 1974-08-16
US3749318A (en) 1971-03-01 1973-07-31 E Cottell Combustion method and apparatus burning an intimate emulsion of fuel and water
JPS5756031A (en) 1980-09-19 1982-04-03 Toshiba Corp Ultrasonic emulsifier
JPS58163425A (ja) 1982-03-25 1983-09-28 Toshiba Corp 超音波乳化装置
US5032027A (en) 1989-10-19 1991-07-16 Heat Systems Incorporated Ultrasonic fluid processing method
HUT59692A (en) * 1990-11-15 1992-06-29 Puetter Medice Chem Pharm Process for producing complexes containing s/+/-phenyl-alkanoic acids and aminosugars
JP3178873B2 (ja) 1991-12-20 2001-06-25 第一高周波工業株式会社 超音波を利用した液体混合方法
US5471001A (en) * 1994-12-15 1995-11-28 E. I. Du Pont De Nemours And Company Crystallization of adipic acid
JP3630834B2 (ja) 1995-04-24 2005-03-23 株式会社リコー 二種以上の樹脂原料液体の混合法及びその混合装置
DE19712488A1 (de) * 1997-03-25 1998-10-01 Knoell Hans Forschung Ev Steroidsulfamate, Verfahren zu ihrer Herstellung und Anwendung derselben
US20010023252A1 (en) * 1998-07-02 2001-09-20 Smithkline Beecham Plc Novel compound
GB9828721D0 (en) * 1998-12-24 1999-02-17 Glaxo Group Ltd Novel apparatus and process
TR200101891T2 (tr) 1999-01-29 2001-12-21 Bristol-Myers Squibb Company Sonik etkili jet kristalleşme aparat ve cihazı.

Also Published As

Publication number Publication date
CA2473059A1 (en) 2003-07-31
MXPA04007073A (es) 2004-10-29
ES2253656T3 (es) 2006-06-01
PL372897A1 (en) 2005-08-08
EP1469938B1 (de) 2005-12-14
GB0201400D0 (en) 2002-03-13
DE60302765T2 (de) 2006-07-06
WO2003061816A1 (en) 2003-07-31
CO5611178A2 (es) 2006-02-28
BR0306738A (pt) 2004-12-28
TW200302129A (en) 2003-08-01
EP1469938A1 (de) 2004-10-27
DE60302765D1 (de) 2006-01-19
CN1620333A (zh) 2005-05-25
RU2004120549A (ru) 2005-05-10
US7384478B2 (en) 2008-06-10
AR038200A1 (es) 2005-01-05
ZA200405143B (en) 2005-12-28
IS7335A (is) 2004-06-28
KR20040082395A (ko) 2004-09-24
NO20043444L (no) 2004-08-18
US20060096522A1 (en) 2006-05-11
IL162751A0 (en) 2005-11-20
JP4408700B2 (ja) 2010-02-03
JP2005525216A (ja) 2005-08-25

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Legal Events

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