ATE303382T1 - Benzo(c)quinolizinderivative und deren verwendung als 5 alpha-reduktase-hemmer - Google Patents

Benzo(c)quinolizinderivative und deren verwendung als 5 alpha-reduktase-hemmer

Info

Publication number
ATE303382T1
ATE303382T1 AT98966711T AT98966711T ATE303382T1 AT E303382 T1 ATE303382 T1 AT E303382T1 AT 98966711 T AT98966711 T AT 98966711T AT 98966711 T AT98966711 T AT 98966711T AT E303382 T1 ATE303382 T1 AT E303382T1
Authority
AT
Austria
Prior art keywords
benzo
alpha
reductase inhibitors
quinolizine derivatives
quinolizine
Prior art date
Application number
AT98966711T
Other languages
English (en)
Inventor
Antonio Guarna
Mario Serio
Original Assignee
Applied Research Systems
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems filed Critical Applied Research Systems
Application granted granted Critical
Publication of ATE303382T1 publication Critical patent/ATE303382T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Dermatology (AREA)
  • Environmental Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Zoology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
AT98966711T 1997-12-23 1998-12-21 Benzo(c)quinolizinderivative und deren verwendung als 5 alpha-reduktase-hemmer ATE303382T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97122733A EP0926148A1 (de) 1997-12-23 1997-12-23 Benzo (c)quinolizine-derivate,deren herstellung und verwendung als 5-alpha-reduktase-hemmer
PCT/EP1998/008582 WO1999033828A1 (en) 1997-12-23 1998-12-21 Benzo[c]quinolizine derivatives and their use as 5 alpha-reductases inhibitors

Publications (1)

Publication Number Publication Date
ATE303382T1 true ATE303382T1 (de) 2005-09-15

Family

ID=8227866

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98966711T ATE303382T1 (de) 1997-12-23 1998-12-21 Benzo(c)quinolizinderivative und deren verwendung als 5 alpha-reduktase-hemmer

Country Status (22)

Country Link
US (1) US6962925B1 (de)
EP (2) EP0926148A1 (de)
JP (1) JP2001527074A (de)
KR (1) KR100580742B1 (de)
CN (1) CN1144804C (de)
AR (1) AR017964A1 (de)
AT (1) ATE303382T1 (de)
AU (1) AU744105B2 (de)
BR (1) BR9813836A (de)
CA (1) CA2315055A1 (de)
DE (1) DE69831427T2 (de)
EA (1) EA002831B1 (de)
EE (1) EE04615B1 (de)
ES (1) ES2245053T3 (de)
HK (1) HK1033128A1 (de)
IL (1) IL136919A0 (de)
NO (1) NO326034B1 (de)
PT (1) PT1066284E (de)
SI (1) SI1066284T1 (de)
UA (1) UA66371C2 (de)
WO (1) WO1999033828A1 (de)
ZA (1) ZA9811762B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0926148A1 (de) * 1997-12-23 1999-06-30 Applied Research Systems Ars Holding N.V. Benzo (c)quinolizine-derivate,deren herstellung und verwendung als 5-alpha-reduktase-hemmer
CA2338298A1 (en) * 1998-07-29 2000-02-10 Merck & Co., Inc. Tricyclic compounds
KR100785088B1 (ko) 2006-05-23 2007-12-12 한국과학기술연구원 두 개의 엑소 메틸렌을 가지는 고리가 접합된 락탐화합물과이의 제조방법
WO2008007778A1 (fr) * 2006-07-13 2008-01-17 Nihon Nohyaku Co., Ltd. agent de RÉGULATION de plante parasite et son emploi
GB201506894D0 (en) * 2015-04-23 2015-06-10 Galapagos Nv Novel dihydropyridoisoquinolinones and pharmaceutical compositions thereof for the treatment of inflammatory disorders
CN106008423B (zh) * 2016-06-24 2018-02-02 云南民族大学 一种苯丙素类化合物及其制备方法和应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5239075A (en) * 1991-08-21 1993-08-24 Eli Lilly And Company Process for the preparation of benzo (f) quinolinones
EP0591583B1 (de) * 1991-08-21 2001-12-19 Eli Lilly And Company Benzo(f)quinolinone als 5-Alpha-reduktase Inhibitoren
EP0591582B1 (de) * 1991-08-21 1999-01-20 Eli Lilly And Company Hexahydrobenzo(f)quinolinone als 5-Alpha-reduktase Inhibitoren
US5250539A (en) * 1991-08-21 1993-10-05 Eli Lilly And Company Hexahydrobenzo[f]quinolinones
WO1994021614A1 (en) * 1993-03-24 1994-09-29 Merck & Co., Inc. SUBSTITUTED 3-PHENANTHRIDINONE DERIVATIVES AS 5α-REDUCTASE INHIBITORS
US5578724A (en) * 1994-09-20 1996-11-26 Eli Lilly And Company Process for preparation of benzo[f]quinolinones
IT1286545B1 (it) * 1996-02-09 1998-07-15 Antonio Guarna Derivati benzo(c) chinolizinici,loro preparazione ed uso come inibitori delle 5-alfa-riduttasi
ITFI970193A1 (it) * 1997-08-01 1999-02-01 Applied Research Systems Uso di derivati benzo(c) chinolizinici come regolatori della crescita delle piante e composizioni ad uso agricolo che contengono tali
EP0926148A1 (de) * 1997-12-23 1999-06-30 Applied Research Systems Ars Holding N.V. Benzo (c)quinolizine-derivate,deren herstellung und verwendung als 5-alpha-reduktase-hemmer

Also Published As

Publication number Publication date
ES2245053T3 (es) 2005-12-16
JP2001527074A (ja) 2001-12-25
DE69831427T2 (de) 2006-06-08
DE69831427D1 (de) 2005-10-06
EP0926148A1 (de) 1999-06-30
ZA9811762B (en) 1999-06-23
EE04615B1 (et) 2006-04-17
SI1066284T1 (sl) 2005-12-31
CA2315055A1 (en) 1999-07-08
PT1066284E (pt) 2005-11-30
AU744105B2 (en) 2002-02-14
EP1066284A1 (de) 2001-01-10
US6962925B1 (en) 2005-11-08
KR100580742B1 (ko) 2006-05-15
NO20003199D0 (no) 2000-06-20
NO20003199L (no) 2000-08-23
AR017964A1 (es) 2001-10-24
KR20010033432A (ko) 2001-04-25
EA200000697A1 (ru) 2000-12-25
EA002831B1 (ru) 2002-10-31
NO326034B1 (no) 2008-09-01
CN1284954A (zh) 2001-02-21
AU2419499A (en) 1999-07-19
HK1033128A1 (en) 2001-08-17
WO1999033828A1 (en) 1999-07-08
EE200000387A (et) 2001-12-17
BR9813836A (pt) 2000-10-10
CN1144804C (zh) 2004-04-07
IL136919A0 (en) 2001-06-14
UA66371C2 (en) 2004-05-17
EP1066284B1 (de) 2005-08-31

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