ATE293590T1 - Bicyclische aminosäuren als pharmazeutische mittel - Google Patents

Bicyclische aminosäuren als pharmazeutische mittel

Info

Publication number: ATE293590T1
Authority: AT; Austria
Prior art keywords: amino acids; pharmaceutical agents; bicyclic amino; bicyclic; pharmaceutical
Prior art date: 1999-10-20

Application number

AT00972226T

Other languages

English (en)

Inventor

Justin Stephen Bryans

David Clive Blakemore

Simon Osborne

Jean-Marie Residence Receveur

Original Assignee

Warner Lambert Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-10-20

Filing date

2000-10-17

Publication date

2005-05-15

2000-10-17 Application filed by Warner Lambert Co filed Critical Warner Lambert Co

2005-05-15 Application granted granted Critical

2005-05-15 Publication of ATE293590T1 publication Critical patent/ATE293590T1/de

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/28—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and containing rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/18—All rings being cycloaliphatic the ring system containing six carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/20—All rings being cycloaliphatic the ring system containing seven carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/22—All rings being cycloaliphatic the ring system containing eight carbon atoms, e.g. pentalene
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/24—All rings being cycloaliphatic the ring system containing nine carbon atoms, e.g. perhydroindane
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/26—All rings being cycloaliphatic the ring system containing ten carbon atoms
- C07C2602/28—Hydrogenated naphthalenes

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Diabetes (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Cardiology (AREA)
Physical Education & Sports Medicine (AREA)
Endocrinology (AREA)
Orthopedic Medicine & Surgery (AREA)
Anesthesiology (AREA)
Psychology (AREA)
Hematology (AREA)
Epidemiology (AREA)
Psychiatry (AREA)
Urology & Nephrology (AREA)
Immunology (AREA)
Vascular Medicine (AREA)
Obesity (AREA)
Reproductive Health (AREA)
Dermatology (AREA)
Pulmonology (AREA)
Hospice & Palliative Care (AREA)
Rheumatology (AREA)
Emergency Medicine (AREA)

AT00972226T 1999-10-20 2000-10-17 Bicyclische aminosäuren als pharmazeutische mittel ATE293590T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US16072599P	1999-10-20	1999-10-20
PCT/US2000/028687 WO2001028978A1 (en)	1999-10-20	2000-10-17	Bicyclic amino acids as pharmaceutical agents

Publications (1)

Publication Number	Publication Date
ATE293590T1 true ATE293590T1 (de)	2005-05-15

Family

ID=22578159

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT04027485T ATE358116T1 (de)	1999-10-20	2000-10-17	Bicyclische aminosäuren als pharmazeutische mittel
AT00972226T ATE293590T1 (de)	1999-10-20	2000-10-17	Bicyclische aminosäuren als pharmazeutische mittel

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AT04027485T ATE358116T1 (de)	1999-10-20	2000-10-17	Bicyclische aminosäuren als pharmazeutische mittel

Country Status (50)

Country	Link
US (2)	US6689906B1 (de)
EP (2)	EP1226110B1 (de)
JP (2)	JP3632191B2 (de)
KR (2)	KR100593349B1 (de)
CN (1)	CN1165518C (de)
AP (2)	AP2002002517A0 (de)
AR (2)	AR026087A1 (de)
AT (2)	ATE358116T1 (de)
AU (2)	AU778871B2 (de)
BG (2)	BG106719A (de)
BR (1)	BR0014972B1 (de)
CA (1)	CA2386297C (de)
CO (1)	CO5280060A1 (de)
CR (1)	CR6620A (de)
CU (1)	CU23112A3 (de)
CZ (1)	CZ295960B6 (de)
DE (2)	DE60034157T2 (de)
DO (1)	DOP2000000083A (de)
DZ (1)	DZ3197A1 (de)
EA (1)	EA005206B1 (de)
EC (1)	ECSP045393A (de)
EE (1)	EE200200211A (de)
ES (2)	ES2237464T3 (de)
GE (1)	GEP20043297B (de)
GT (2)	GT200000183A (de)
HK (1)	HK1049826B (de)
HN (1)	HN2000000224A (de)
HR (2)	HRP20020428B1 (de)
HU (1)	HUP0203325A3 (de)
IL (3)	IL149143A0 (de)
IS (2)	IS6348A (de)
MA (1)	MA26842A1 (de)
MX (1)	MXPA02003229A (de)
MY (1)	MY127678A (de)
NO (2)	NO20021780L (de)
NZ (1)	NZ517961A (de)
OA (1)	OA12070A (de)
PA (1)	PA8505201A1 (de)
PE (1)	PE20010740A1 (de)
PL (1)	PL354607A1 (de)
PT (1)	PT1226110E (de)
SI (1)	SI1226110T1 (de)
SK (1)	SK5232002A3 (de)
SV (1)	SV2001000188A (de)
TR (2)	TR200500221T2 (de)
TW (2)	TW200505824A (de)
UA (1)	UA72931C2 (de)
WO (1)	WO2001028978A1 (de)
YU (2)	YU73004A (de)
ZA (1)	ZA200202543B (de)

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US7164034B2 (en)	1999-06-10	2007-01-16	Pfizer Inc.	Alpha2delta ligands for fibromyalgia and other disorders
MXPA02010668A (es) *	2000-06-26	2003-03-10	Warner Lambert Co	Analogos de gabapentina para alteraciones del sueno.
US6620829B2 (en)	2000-10-17	2003-09-16	Warner-Lambert Company	Method of treating noninflammatory cartilage damage
EP1226820A1 (de) *	2001-01-26	2002-07-31	Warner-Lambert Company	Verwendung von bicyclische Aminosäuren zur Prophylaxe und Behandlung von Eingeweideschmerzen und gastrointestinalen Erkrankungen
EA006396B1 (ru) *	2001-04-19	2005-12-29	УОРНЕР-ЛАМБЕРТ КОМПАНИ Эл Эл Си	Конденсированные бициклические аминокислоты
GB2375109A (en) *	2001-05-04	2002-11-06	Warner Lambert Co	Process for preparing bicyclic amino acid
GB2375108A (en) *	2001-05-04	2002-11-06	Warner Lambert Co	Production of a bicycloheptanone
US8048917B2 (en)	2005-04-06	2011-11-01	Xenoport, Inc.	Prodrugs of GABA analogs, compositions and uses thereof
US7186855B2 (en)	2001-06-11	2007-03-06	Xenoport, Inc.	Prodrugs of GABA analogs, compositions and uses thereof
KR20040016882A (ko) *	2001-06-11	2004-02-25	제노포트 인코포레이티드	감소된 독성을 가진 ｇａｂａ 유사체 프로드러그의 구강투여용 투여 형태물
US6818787B2 (en)	2001-06-11	2004-11-16	Xenoport, Inc.	Prodrugs of GABA analogs, compositions and uses thereof
MXPA04004105A (es)	2002-01-31	2004-11-29	Warner Lambert Co	Metodo de tratamiento de tinnitus.
BR0307906A (pt) *	2002-02-22	2004-12-21	Warner Lambert Co	Combinações de um ligando alfa-2-delta com um inibidor seletivo de ciclooxigenase-2
AU2003239752A1 (en) *	2002-06-27	2004-01-19	Warner-Lambert Company Llc	Use of an alpha2delta ligand such as gabapentin or pregabalin for treating ttention deficit hyperactivity disorder
MXPA05001643A (es) *	2002-08-15	2005-04-25	Pfizer	Uso terapeutico de aminoacidos biciclicos y triciclicos condensados.
US7419981B2 (en)	2002-08-15	2008-09-02	Pfizer Inc.	Synergistic combinations of an alpha-2-delta ligand and a cGMP phosphodieterse 5 inhibitor
GB0219024D0 (en) *	2002-08-15	2002-09-25	Pfizer Ltd	Synergistic combinations
GB0223072D0 (en)	2002-10-04	2002-11-13	Pfizer Ltd	Cyclic nitromethyl acetic acid derivatives
US7018818B2 (en)	2002-10-04	2006-03-28	Pfizer Inc.	Intermediates in the preparation of therapeutic fused bicyclic amino acids
US7060727B2 (en)	2002-12-11	2006-06-13	Xenoport, Inc.	Prodrugs of fused GABA analogs, pharmaceutical compositions and uses thereof
CA2451267A1 (en)	2002-12-13	2004-06-13	Warner-Lambert Company Llc	Pharmaceutical uses for alpha2delta ligands
RU2331438C2 (ru)	2002-12-13	2008-08-20	Уорнер-Ламберт Компани Ллс	Альфа-2-дельта лиганд для лечения симптомов нижних мочевыводящих путей
WO2004054566A1 (en)	2002-12-13	2004-07-01	Warner-Lambert Company Llc	Pregabalin derivatives for the treatment of fibromyalgia and other disorders
NZ545494A (en)	2003-09-12	2009-10-30	Pfizer	Combinations comprising alpha-2-delta ligands and serotonin / noradrenaline re-uptake inhibitors
WO2006092692A1 (en) *	2005-03-01	2006-09-08	Pfizer Limited	Use of combinations of pde7 inhibitors and alpha-2-delty ligands for the treatment of neuropathic pain
AR061728A1 (es) *	2006-06-30	2008-09-17	Pfizer Prod Inc	Composicion para tratamiento usando compuestos selectivos alfa-2-delta-1
WO2008077599A1 (en)	2006-12-22	2008-07-03	Recordati Ireland Limited	COMBINATION THERAPY OF LOWER URINARY TRACT DISORDERS WITH α2δ LIGANDS AND NSAIDS
RU2446148C2 (ru)	2007-09-28	2012-03-27	Дайити Санкио Компани, Лимитед	Бициклическое производное гамма-аминокислоты
CA2756750C (en)	2009-03-26	2014-05-13	Daiichi Sankyo Company, Limited	A method for producing bicyclic .gamma.-amino acid derivative
WO2012169475A1 (ja)	2011-06-08	2012-12-13	第一三共株式会社	クライゼン転位反応による二環性化合物の製造方法
JP5922118B2 (ja)	2011-06-08	2016-05-24	第一三共株式会社	イミニウム塩を経由する二環性化合物の製造方法
CA2859003C (en)	2011-12-15	2016-11-01	Daiichi Sankyo Company, Limited	Optical resolution method for bicyclic compound using asymmetric catalyst
IN2014DN07923A (de)	2012-04-10	2015-05-01	Daiichi Sankyo Companyltd
US9066853B2 (en)	2013-01-15	2015-06-30	Warsaw Orthopedic, Inc.	Clonidine compounds in a biodegradable fiber
TWI635071B (zh)	2013-07-08	2018-09-11	第一三共股份有限公司	光學活性二環γ－胺基酸衍生物及其製造方法
WO2018166855A1 (en)	2017-03-16	2018-09-20	Basf Se	Heterobicyclic substituted dihydroisoxazoles
CN113045410A (zh) *	2021-03-29	2021-06-29	华东理工大学	一种双环降二萜类化合物及其合成基因及制备方法

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US3641129A (en)	1969-06-17	1972-02-08	Merck & Co Inc	Antifibrinolytic compounds
DE2460891C2 (de)	1974-12-21	1982-09-23	Gödecke AG, 1000 Berlin	1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
US4087544A (en) *	1974-12-21	1978-05-02	Warner-Lambert Company	Treatment of cranial dysfunctions using novel cyclic amino acids
DE69834204T2 (de)	1997-10-27	2007-03-29	Warner-Lambert Co. Llc	Zyklische aminosäuren und deren derivate als arzneimittel

2000
- 2000-10-05 HN HN2000000224A patent/HN2000000224A/es unknown
- 2000-10-06 SV SV2000000188A patent/SV2001000188A/es not_active Application Discontinuation
- 2000-10-17 AT AT04027485T patent/ATE358116T1/de not_active IP Right Cessation
- 2000-10-17 UA UA2002032434A patent/UA72931C2/uk unknown
- 2000-10-17 CZ CZ20021310A patent/CZ295960B6/cs not_active IP Right Cessation
- 2000-10-17 HU HU0203325A patent/HUP0203325A3/hu unknown
- 2000-10-17 AP APAP/P/2002/002517A patent/AP2002002517A0/en unknown
- 2000-10-17 TR TR2005/00221T patent/TR200500221T2/xx unknown
- 2000-10-17 PT PT00972226T patent/PT1226110E/pt unknown
- 2000-10-17 IL IL14914300A patent/IL149143A0/xx not_active IP Right Cessation
- 2000-10-17 OA OA1200200117A patent/OA12070A/en unknown
- 2000-10-17 EE EEP200200211A patent/EE200200211A/xx unknown
- 2000-10-17 EP EP00972226A patent/EP1226110B1/de not_active Expired - Lifetime
- 2000-10-17 DE DE60034157T patent/DE60034157T2/de not_active Expired - Lifetime
- 2000-10-17 EP EP04027485A patent/EP1506955B1/de not_active Expired - Lifetime
- 2000-10-17 EA EA200200293A patent/EA005206B1/ru unknown
- 2000-10-17 PL PL00354607A patent/PL354607A1/xx not_active Application Discontinuation
- 2000-10-17 KR KR1020027005036A patent/KR100593349B1/ko not_active IP Right Cessation
- 2000-10-17 KR KR1020067002249A patent/KR100566462B1/ko not_active IP Right Cessation
- 2000-10-17 YU YU73004A patent/YU73004A/sh unknown
- 2000-10-17 AT AT00972226T patent/ATE293590T1/de not_active IP Right Cessation
- 2000-10-17 ES ES00972226T patent/ES2237464T3/es not_active Expired - Lifetime
- 2000-10-17 IL IL16406000A patent/IL164060A0/xx unknown
- 2000-10-17 DZ DZ003197A patent/DZ3197A1/xx active
- 2000-10-17 DE DE60019628T patent/DE60019628T2/de not_active Expired - Lifetime
- 2000-10-17 TR TR2002/01094T patent/TR200201094T2/xx unknown
- 2000-10-17 BR BRPI0014972-1A patent/BR0014972B1/pt not_active IP Right Cessation
- 2000-10-17 US US10/130,023 patent/US6689906B1/en not_active Expired - Fee Related
- 2000-10-17 NZ NZ517961A patent/NZ517961A/xx unknown
- 2000-10-17 ES ES04027485T patent/ES2282785T3/es not_active Expired - Lifetime
- 2000-10-17 AP AP2004003186A patent/AP2004003186A0/xx unknown
- 2000-10-17 AU AU10920/01A patent/AU778871B2/en not_active Ceased
- 2000-10-17 GE GE4783A patent/GEP20043297B/en unknown
- 2000-10-17 CN CNB008145644A patent/CN1165518C/zh not_active Expired - Fee Related
- 2000-10-17 JP JP2001531783A patent/JP3632191B2/ja not_active Expired - Fee Related
- 2000-10-17 SI SI200030670T patent/SI1226110T1/xx unknown
- 2000-10-17 WO PCT/US2000/028687 patent/WO2001028978A1/en active IP Right Grant
- 2000-10-17 YU YU29302A patent/YU29302A/sh unknown
- 2000-10-17 MX MXPA02003229A patent/MXPA02003229A/es active IP Right Grant
- 2000-10-17 SK SK523-2002A patent/SK5232002A3/sk unknown
- 2000-10-17 CA CA2386297A patent/CA2386297C/en not_active Expired - Fee Related
- 2000-10-18 MY MYPI20004896A patent/MY127678A/en unknown
- 2000-10-18 PA PA20008505201A patent/PA8505201A1/es unknown
- 2000-10-19 CO CO00079741A patent/CO5280060A1/es not_active Application Discontinuation
- 2000-10-19 DO DO2000000083A patent/DOP2000000083A/es unknown
- 2000-10-19 AR ARP000105497A patent/AR026087A1/es unknown
- 2000-10-19 GT GT200000183A patent/GT200000183A/es unknown
- 2000-10-19 PE PE2000001116A patent/PE20010740A1/es not_active Application Discontinuation
- 2000-10-19 GT GT200000183AK patent/GT200000183AA/es unknown
- 2000-10-20 TW TW093125953A patent/TW200505824A/zh unknown
- 2000-10-20 TW TW089122115A patent/TWI225855B/zh not_active IP Right Cessation
2002
- 2002-03-28 ZA ZA200202543A patent/ZA200202543B/xx unknown
- 2002-04-15 IL IL149143A patent/IL149143A/en unknown
- 2002-04-16 CU CU78A patent/CU23112A3/es unknown
- 2002-04-16 NO NO20021780A patent/NO20021780L/no not_active Application Discontinuation
- 2002-04-17 IS IS6348A patent/IS6348A/is unknown
- 2002-04-18 CR CR6620A patent/CR6620A/es not_active Application Discontinuation
- 2002-05-10 MA MA26634A patent/MA26842A1/fr unknown
- 2002-05-15 HR HR20020428A patent/HRP20020428B1/xx not_active IP Right Cessation
- 2002-05-20 BG BG106719A patent/BG106719A/bg unknown
- 2002-05-20 BG BG108860A patent/BG108860A/en unknown
2003
- 2003-03-14 HK HK03101868.4A patent/HK1049826B/zh not_active IP Right Cessation
2004
- 2004-01-21 US US10/762,026 patent/US6835751B2/en not_active Expired - Fee Related
- 2004-07-28 EC EC2004005393A patent/ECSP045393A/es unknown
- 2004-08-04 HR HRP20040709 patent/HRP20040709A2/xx not_active Application Discontinuation
- 2004-08-17 AR ARP040102937A patent/AR045456A2/es unknown
- 2004-09-01 NO NO20043663A patent/NO20043663L/no not_active Application Discontinuation
- 2004-09-14 JP JP2004266488A patent/JP3744928B2/ja not_active Expired - Fee Related
- 2004-10-08 IS IS7497A patent/IS7497A/is unknown
2005
- 2005-03-23 AU AU2005201268A patent/AU2005201268A1/en not_active Abandoned

Also Published As

Publication number	Publication date
EP1226110B1 (de)	2005-04-20
CN1165518C (zh)	2004-09-08
US6835751B2 (en)	2004-12-28
PL354607A1 (en)	2004-01-26
JP3632191B2 (ja)	2005-03-23
NZ517961A (en)	2002-12-20
TR200500221T2 (tr)	2005-03-21
KR100593349B1 (ko)	2006-06-26
BR0014972A (pt)	2002-07-16
JP3744928B2 (ja)	2006-02-15
AR026087A1 (es)	2002-12-26
CA2386297A1 (en)	2001-04-26
TW200505824A (en)	2005-02-16
EA005206B1 (ru)	2004-12-30
KR20020040900A (ko)	2002-05-30
CR6620A (es)	2004-02-02
KR100566462B1 (ko)	2006-03-31
DE60034157D1 (de)	2007-05-10
US20040152779A1 (en)	2004-08-05
CO5280060A1 (es)	2003-05-30
BR0014972B1 (pt)	2011-09-06
SK5232002A3 (en)	2003-07-01
KR20060013701A (ko)	2006-02-13
IL149143A0 (en)	2002-11-10
WO2001028978A1 (en)	2001-04-26
HRP20020428B1 (en)	2006-02-28
IL164060A0 (en)	2005-12-18
AP2004003186A0 (en)	2004-12-31
CZ295960B6 (cs)	2005-12-14
OA12070A (en)	2003-11-10
DE60019628T2 (de)	2006-01-19
ATE358116T1 (de)	2007-04-15
YU73004A (sh)	2005-11-28
ECSP045393A (es)	2004-10-23
AU1092001A (en)	2001-04-30
JP2005036009A (ja)	2005-02-10
HRP20040709A2 (en)	2004-12-31
MA26842A1 (fr)	2004-12-20
TR200201094T2 (tr)	2002-09-23
ZA200202543B (en)	2003-09-23
ES2237464T3 (es)	2005-08-01
EA200200293A1 (ru)	2002-10-31
ES2282785T3 (es)	2007-10-16
GEP20043297B (en)	2004-01-12
GT200000183A (es)	2000-10-19
AR045456A2 (es)	2005-10-26
HK1049826A1 (en)	2003-05-30
DZ3197A1 (fr)	2001-04-26
EE200200211A (et)	2003-06-16
HK1049826B (zh)	2005-02-25
HUP0203325A3 (en)	2003-12-29
PA8505201A1 (es)	2002-08-29
EP1506955B1 (de)	2007-03-28
DE60019628D1 (de)	2005-05-25
DOP2000000083A (es)	2002-03-30
AU2005201268A1 (en)	2005-04-21
CZ20021310A3 (cs)	2003-05-14
SV2001000188A (es)	2001-09-07
NO20021780D0 (no)	2002-04-16
CN1382118A (zh)	2002-11-27
MXPA02003229A (es)	2002-09-30
EP1226110A1 (de)	2002-07-31
HRP20020428A2 (en)	2005-02-28
JP2003512348A (ja)	2003-04-02
MY127678A (en)	2006-12-29
BG108860A (en)	2006-03-31
IS7497A (is)	2004-10-08
HN2000000224A (es)	2001-04-11
NO20021780L (no)	2002-04-16
PE20010740A1 (es)	2001-07-27
EP1506955A1 (de)	2005-02-16
HUP0203325A2 (hu)	2003-02-28
IL149143A (en)	2007-02-11
TWI225855B (en)	2005-01-01
IS6348A (is)	2002-04-17
GT200000183AA (es)	2005-06-17
AP2002002517A0 (en)	2002-06-30
SI1226110T1 (en)	2005-08-31
AU778871B2 (en)	2004-12-23
YU29302A (sh)	2005-06-10
US6689906B1 (en)	2004-02-10
UA72931C2 (uk)	2005-05-16
BG106719A (bg)	2003-02-28
CU23112A3 (es)	2006-02-27
CA2386297C (en)	2010-02-09
PT1226110E (pt)	2005-07-29
DE60034157T2 (de)	2007-12-13
NO20043663L (no)	2002-04-16

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