ATE282695T1 - Pseudo-halbknoten ausbildende rna durch hybridisierung von antisenseoligonnukleotiden an gezielte rna sekundärstrukturen - Google Patents
Pseudo-halbknoten ausbildende rna durch hybridisierung von antisenseoligonnukleotiden an gezielte rna sekundärstrukturenInfo
- Publication number
- ATE282695T1 ATE282695T1 AT93917122T AT93917122T ATE282695T1 AT E282695 T1 ATE282695 T1 AT E282695T1 AT 93917122 T AT93917122 T AT 93917122T AT 93917122 T AT93917122 T AT 93917122T AT E282695 T1 ATE282695 T1 AT E282695T1
- Authority
- AT
- Austria
- Prior art keywords
- rna
- antiseseoligon
- hybridization
- nucleotides
- secondary structures
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
- C12N15/1132—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses against retroviridae, e.g. HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
- C12N2310/3521—Methyl
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- AIDS & HIV (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US91676492A | 1992-07-20 | 1992-07-20 | |
PCT/US1993/006546 WO1994002637A1 (en) | 1992-07-20 | 1993-07-12 | Pseudo-half-knot rna formation by hybridization of antisense oligonucleotides to target rna's secondary structure |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE282695T1 true ATE282695T1 (de) | 2004-12-15 |
Family
ID=25437800
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT93917122T ATE282695T1 (de) | 1992-07-20 | 1993-07-12 | Pseudo-halbknoten ausbildende rna durch hybridisierung von antisenseoligonnukleotiden an gezielte rna sekundärstrukturen |
Country Status (9)
Country | Link |
---|---|
US (1) | US5512438A (de) |
EP (1) | EP0652972B1 (de) |
JP (1) | JP3113280B2 (de) |
AT (1) | ATE282695T1 (de) |
AU (1) | AU4674393A (de) |
CA (1) | CA2140669A1 (de) |
DE (1) | DE69333698T2 (de) |
IL (1) | IL106396A (de) |
WO (1) | WO1994002637A1 (de) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6339066B1 (en) | 1990-01-11 | 2002-01-15 | Isis Pharmaceuticals, Inc. | Antisense oligonucleotides which have phosphorothioate linkages of high chiral purity and which modulate βI, βII, γ, δ, Ε, ζ and η isoforms of human protein kinase C |
US6537973B1 (en) | 1992-03-16 | 2003-03-25 | Isis Pharmaceuticals, Inc. | Oligonucleotide inhibition of protein kinase C |
US5985558A (en) * | 1997-04-14 | 1999-11-16 | Isis Pharmaceuticals Inc. | Antisense oligonucleotide compositions and methods for the inibition of c-Jun and c-Fos |
US6291438B1 (en) | 1993-02-24 | 2001-09-18 | Jui H. Wang | Antiviral anticancer poly-substituted phenyl derivatized oligoribonucleotides and methods for their use |
US6776986B1 (en) | 1996-06-06 | 2004-08-17 | Novartis Ag | Inhibition of HIV-1 replication by antisense RNA expression |
US20040266706A1 (en) * | 2002-11-05 | 2004-12-30 | Muthiah Manoharan | Cross-linked oligomeric compounds and their use in gene modulation |
US7235653B2 (en) * | 1996-12-31 | 2007-06-26 | Isis Pharmaceuticals, Inc. | Oligonucleotide compositions and methods for the modulation of the expression of B7 protein |
US6319906B1 (en) | 1996-12-31 | 2001-11-20 | Isis Pharmaceuticals | Oligonucleotide compositions and methods for the modulation of the expression of B7 protein |
US20040023917A1 (en) * | 1996-12-31 | 2004-02-05 | Bennett C. Frank | Oligonucleotide compositions and methods for the modulation of the expression of B7 protein |
US6077833A (en) * | 1996-12-31 | 2000-06-20 | Isis Pharmaceuticals, Inc. | Oligonucleotide compositions and methods for the modulation of the expression of B7 protein |
US5902881A (en) * | 1997-03-03 | 1999-05-11 | Isis Pharmaceuticals, Inc. | Reagent useful for synthesizing sulfurized oligonucleotide analogs |
US5760209A (en) * | 1997-03-03 | 1998-06-02 | Isis Pharmaceuticals, Inc. | Protecting group for synthesizing oligonucleotide analogs |
US5972639A (en) * | 1997-07-24 | 1999-10-26 | Irori | Fluorescence-based assays for measuring cell proliferation |
US6809193B2 (en) | 1997-08-13 | 2004-10-26 | Isis Pharmaceuticals, Inc. | Antisense oligonucleotide compositions and methods for the modulation of JNK proteins |
US6133246A (en) * | 1997-08-13 | 2000-10-17 | Isis Pharmaceuticals Inc. | Antisense oligonucleotide compositions and methods for the modulation of JNK proteins |
US20070149472A1 (en) * | 1997-08-13 | 2007-06-28 | Mckay Robert | Antisense oligonucleotide compositions and methods for the modulation of jnk proteins |
US5877309A (en) * | 1997-08-13 | 1999-03-02 | Isis Pharmaceuticals, Inc. | Antisense oligonucleotides against JNK |
US6251588B1 (en) * | 1998-02-10 | 2001-06-26 | Agilent Technologies, Inc. | Method for evaluating oligonucleotide probe sequences |
EP1829856A3 (de) | 1998-11-12 | 2009-02-25 | Invitrogen Corporation | Transfektionsreagenzien |
US6492111B1 (en) * | 1998-11-25 | 2002-12-10 | Isis Pharmaceuticals, Inc. | In situ binary synthesis of biologically effective molecules |
US7205129B1 (en) * | 2000-02-28 | 2007-04-17 | Qiagen Gmbh | Method for reducing artifacts in nucleic acid amplification |
GB0012497D0 (en) * | 2000-05-23 | 2000-07-12 | Syngenix Ltd | Antiviral therapy |
CN1274072C (zh) * | 2000-08-03 | 2006-09-06 | 松下电器产业株式会社 | 无刷电机及其制造方法 |
AU2002232387A1 (en) * | 2000-10-27 | 2002-05-06 | Invitrogen Corporation | Method for introducing antisense oligonucleotides into eucaryotic cells |
US20050222063A1 (en) * | 2001-12-03 | 2005-10-06 | Rima Rozen | Methylenetetrahydrofolate reductase inhibitors and use thereof |
US7319145B2 (en) * | 2001-12-03 | 2008-01-15 | Rima Rozen | Methylenetetrahydrofolate reductase inhibitors and use thereof |
US20040063109A2 (en) | 2002-01-25 | 2004-04-01 | Applera Corporation | Single-tube, ready-to-use assay kits, and methods using same |
US20040002083A1 (en) * | 2002-01-29 | 2004-01-01 | Ye Ding | Statistical algorithms for folding and target accessibility prediction and design of nucleic acids |
AU2003245575A1 (en) * | 2002-06-19 | 2004-01-06 | University Of Rochester | Oligonucleotide directed misfolding of rna |
AU2003291884A1 (en) * | 2002-12-10 | 2004-06-30 | Ottawa Health Research Institute | Modulation of stem cell differentiation by modulation of caspase-3 activity |
US7960355B2 (en) * | 2003-05-23 | 2011-06-14 | Isis Pharmaceuticals, Inc. | Compositions and methods for the modulation of the expression of B7 protein |
US7897582B2 (en) * | 2003-05-23 | 2011-03-01 | Isis Pharmaceuticals, Inc. | Oligonucleotide compositions and methods for the modulation of the expression of B7 protein |
US7683036B2 (en) | 2003-07-31 | 2010-03-23 | Regulus Therapeutics Inc. | Oligomeric compounds and compositions for use in modulation of small non-coding RNAs |
US20050240357A1 (en) * | 2004-04-26 | 2005-10-27 | Minor James M | Methods and systems for differential clustering |
US20050282174A1 (en) * | 2004-06-19 | 2005-12-22 | Webb Peter G | Methods and systems for selecting nucleic acid probes for microarrays |
EP3169310A1 (de) | 2014-07-15 | 2017-05-24 | Life Technologies Corporation | Zusammensetzungen mit lipidaggregaten und verfahren zur effizienten bereitstellung von molekülen an zellen |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5034506A (en) * | 1985-03-15 | 1991-07-23 | Anti-Gene Development Group | Uncharged morpholino-based polymers having achiral intersubunit linkages |
US4806463A (en) * | 1986-05-23 | 1989-02-21 | Worcester Foundation For Experimental Biology | Inhibition of HTLV-III by exogenous oligonucleotides |
DE3907562A1 (de) * | 1989-03-09 | 1990-09-13 | Bayer Ag | Antisense-oligonukleotide zur inhibierung der transaktivatorzielsequenz (tar) und der synthese des transaktivatorproteins (tat) aus hiv-1 und deren verwendung |
US5220014A (en) * | 1989-11-13 | 1993-06-15 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Rrna specific oligonucleotides |
CA2082044C (en) * | 1990-05-04 | 1999-08-24 | David J. Ecker | Modulation of gene expression through interference with rna secondary structure |
-
1993
- 1993-07-12 AU AU46743/93A patent/AU4674393A/en not_active Abandoned
- 1993-07-12 AT AT93917122T patent/ATE282695T1/de not_active IP Right Cessation
- 1993-07-12 DE DE69333698T patent/DE69333698T2/de not_active Expired - Fee Related
- 1993-07-12 CA CA002140669A patent/CA2140669A1/en not_active Abandoned
- 1993-07-12 WO PCT/US1993/006546 patent/WO1994002637A1/en active IP Right Grant
- 1993-07-12 EP EP93917122A patent/EP0652972B1/de not_active Expired - Lifetime
- 1993-07-12 JP JP06504517A patent/JP3113280B2/ja not_active Expired - Fee Related
- 1993-07-19 IL IL10639693A patent/IL106396A/en not_active IP Right Cessation
-
1994
- 1994-01-03 US US08/176,314 patent/US5512438A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JPH07508656A (ja) | 1995-09-28 |
US5512438A (en) | 1996-04-30 |
EP0652972A4 (de) | 1995-09-20 |
IL106396A (en) | 2004-07-25 |
EP0652972A1 (de) | 1995-05-17 |
DE69333698D1 (de) | 2004-12-23 |
JP3113280B2 (ja) | 2000-11-27 |
AU4674393A (en) | 1994-02-14 |
CA2140669A1 (en) | 1994-02-03 |
EP0652972B1 (de) | 2004-11-17 |
IL106396A0 (en) | 1993-11-15 |
DE69333698T2 (de) | 2005-12-01 |
WO1994002637A1 (en) | 1994-02-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |