ATE278693T1 - Zyklische verbindungen welche nukleotidebasen- spezifische wechselwirkung mit doppelsträngiger nukleinsäure eingehen - Google Patents

Zyklische verbindungen welche nukleotidebasen- spezifische wechselwirkung mit doppelsträngiger nukleinsäure eingehen

Info

Publication number
ATE278693T1
ATE278693T1 AT00903143T AT00903143T ATE278693T1 AT E278693 T1 ATE278693 T1 AT E278693T1 AT 00903143 T AT00903143 T AT 00903143T AT 00903143 T AT00903143 T AT 00903143T AT E278693 T1 ATE278693 T1 AT E278693T1
Authority
AT
Austria
Prior art keywords
double
compounds
stranded nucleic
enter
nucleic acid
Prior art date
Application number
AT00903143T
Other languages
English (en)
Inventor
Eldon E Baird
Peter B Dervan
Original Assignee
California Inst Of Techn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by California Inst Of Techn filed Critical California Inst Of Techn
Application granted granted Critical
Publication of ATE278693T1 publication Critical patent/ATE278693T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
AT00903143T 1999-01-08 2000-01-06 Zyklische verbindungen welche nukleotidebasen- spezifische wechselwirkung mit doppelsträngiger nukleinsäure eingehen ATE278693T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11523299P 1999-01-08 1999-01-08
PCT/US2000/000298 WO2000040605A2 (en) 1999-01-08 2000-01-06 Compositions and methods relating to cyclic compounds that undergo nucleotide base pair-specific interactions with double-stranded nucleic acids

Publications (1)

Publication Number Publication Date
ATE278693T1 true ATE278693T1 (de) 2004-10-15

Family

ID=22360079

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00903143T ATE278693T1 (de) 1999-01-08 2000-01-06 Zyklische verbindungen welche nukleotidebasen- spezifische wechselwirkung mit doppelsträngiger nukleinsäure eingehen

Country Status (7)

Country Link
EP (1) EP1144414B1 (de)
JP (1) JP2002539077A (de)
AT (1) ATE278693T1 (de)
AU (1) AU2493100A (de)
CA (1) CA2358119A1 (de)
DE (1) DE60014579T2 (de)
WO (1) WO2000040605A2 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6528620B1 (en) 1999-11-08 2003-03-04 University Of Utah Research Foundation Sid-polyamide fusions: a potent method of regulating gene expression
US7078536B2 (en) 2001-03-14 2006-07-18 Genesoft Pharmaceuticals, Inc. Charged compounds comprising a nucleic acid binding moiety and uses therefor
DE60128551D1 (de) 2000-03-16 2007-07-05 Genesoft Inc Geladene verbindungen mit einer nukleinsäure-bindenden einheit sowie deren verwendungen
US7498349B2 (en) 2002-08-02 2009-03-03 Genesoft Pharmaceuticals, Inc. Biaryl compounds having anti-infective activity
EP1562931A2 (de) 2002-10-25 2005-08-17 Genesoft Pharmaceuticals, Inc. Biarylverbindungen mitantiinfektionswirkung
EP1587529A4 (de) 2002-12-10 2009-08-12 Oscient Pharmaceuticals Corp Antibakterielle verbindungen mit(pyrrolcarboxamid)-(benzamid)-(imidazolcarboxamid)-motiv
EP1599474B1 (de) * 2003-03-04 2013-04-24 California Institute Of Technology Heterocyclische oligomere Verbindungen zur DNS-Erkennung
CN1845733A (zh) * 2003-09-04 2006-10-11 学校法人日本大学 TGF－β基因表达抑制剂

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6090947A (en) * 1996-02-26 2000-07-18 California Institute Of Technology Method for the synthesis of pyrrole and imidazole carboxamides on a solid support
JP2002515897A (ja) * 1996-02-26 2002-05-28 カリフォルニア・インスティチュート・オブ・テクノロジー 特異的ポリアミドｄｎａ−結合リガンドの設計、合成、および使用
CN1260006A (zh) * 1996-02-26 2000-07-12 加利福尼亚州技术学院 双链dna和杂环低聚物之间复合物的形成
WO1998037066A1 (en) * 1996-02-26 1998-08-27 California Institute Of Technology Improved polyamides for binding in the minor groove of double stranded dna
EP1023288A1 (de) * 1996-02-26 2000-08-02 California Institute Of Technology Stereochemische kontrolle der dna-bindungsaffinität, sequenz-spezifität und orientierungspräferenz von chiralen hairinpolyamiden an den kleinen graben
JP2002515057A (ja) * 1996-08-01 2002-05-21 カリフォルニア・インスティチュート・オブ・テクノロジー ポリアミドｄｎａ結合リガンドによる遺伝子発現の阻害
CA2286232A1 (en) * 1997-04-06 1998-11-05 California Institute Of Technology Dna-binding pyrrole and imidazole polyamide derivatives

Also Published As

Publication number Publication date
JP2002539077A (ja) 2002-11-19
WO2000040605A9 (en) 2001-10-25
EP1144414B1 (de) 2004-10-06
EP1144414A2 (de) 2001-10-17
AU2493100A (en) 2000-07-24
WO2000040605A2 (en) 2000-07-13
CA2358119A1 (en) 2000-07-13
DE60014579T2 (de) 2006-03-09
WO2000040605A3 (en) 2000-11-30
DE60014579D1 (de) 2004-11-11

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