ATE275543T1 - Zelladhäsion inhibierende entzündungshemmende und immunsuppressive verbindungen - Google Patents

Zelladhäsion inhibierende entzündungshemmende und immunsuppressive verbindungen

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Publication number
ATE275543T1
ATE275543T1 AT00921654T AT00921654T ATE275543T1 AT E275543 T1 ATE275543 T1 AT E275543T1 AT 00921654 T AT00921654 T AT 00921654T AT 00921654 T AT00921654 T AT 00921654T AT E275543 T1 ATE275543 T1 AT E275543T1
Authority
AT
Austria
Prior art keywords
compounds
inflammatory
immunosupressive
cell adhesion
adhesion inhibiting
Prior art date
Application number
AT00921654T
Other languages
English (en)
Inventor
James Link
Gang Liu
Zhonghua Pei
Geldern Thomas W Von
Martin Winn
Zhili Xin
Sheldon Wang
Steven A Boyd
Gui-Dong Zhu
Jennifer C Freeman
Indrani W Gunawardana
Michael A Staeger
Hwan-Soo Jae
John K Lynch
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/541,795 external-priority patent/US6878700B1/en
Application filed by Abbott Lab filed Critical Abbott Lab
Application granted granted Critical
Publication of ATE275543T1 publication Critical patent/ATE275543T1/de

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    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
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    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/66—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Measurement Of Force In General (AREA)
  • Pyrrole Compounds (AREA)
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  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
AT00921654T 1999-04-02 2000-04-03 Zelladhäsion inhibierende entzündungshemmende und immunsuppressive verbindungen ATE275543T1 (de)

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US28664599A 1999-04-02 1999-04-02
US47451799A 1999-12-29 1999-12-29
US09/541,795 US6878700B1 (en) 1998-12-29 2000-03-31 Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds
PCT/US2000/008895 WO2000059880A1 (en) 1999-04-02 2000-04-03 Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds

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PE20020354A1 (es) 2000-09-01 2002-06-12 Novartis Ag Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda)
EP1347959A1 (de) 2000-12-27 2003-10-01 Bayer Aktiengesellschaft Indol-derivate
KR100854424B1 (ko) * 2001-01-29 2008-08-27 3-디멘져널 파마슈티칼즈 인코오포레이티드 치환된 인돌 및 인테그린 길항제로서의 이들의 용도
FR2829766A1 (fr) * 2001-09-14 2003-03-21 Lipha Derives d'oxamates comportant un heterocycle azote diversement substitue
AR037097A1 (es) 2001-10-05 2004-10-20 Novartis Ag Compuestos acilsulfonamidas, composiciones farmaceuticas y el uso de dichos compuestos para la preparacion de un medicamento
US7217701B2 (en) 2001-10-11 2007-05-15 Katsuhiko Mikoshiba Intracellular calcium concentration increase inhibitors
KR100941197B1 (ko) * 2001-11-29 2010-02-10 테라코스, 인코포레이티드 염증, 당뇨병 및 관련된 다른 질환의 치료 화합물
US7101898B2 (en) 2002-02-01 2006-09-05 Novo Nordisk A/S Amides of aminoalkyl-substituted azetidines, pyrrolidines, piperidines and azepanes
CA2473468C (en) * 2002-02-01 2011-06-21 Novo Nordisk A/S Amides of aminoalkyl-substituted azetidines, pyrrolidines, piperidines and azepanes
KR101011373B1 (ko) 2002-07-11 2011-01-28 비큐론 파마슈티컬스 인코포레이티드 항균작용을 갖는 ｎ-히드록시아미드 유도체
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WO2005016883A2 (en) * 2003-08-14 2005-02-24 Icos Corporation Acrylamide derivatives as vla-1 integrin antagonists and uses thereof
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JP5271540B2 (ja) 2005-01-20 2013-08-21 インスティチュート フォー モレキュラー メディスン インコーポレイテッド メチルフェニデート誘導体を含む治療剤及び医薬組成物
ZA200803939B (en) * 2005-11-24 2009-10-28 Eisai R&D Man Co Ltd Morpholine type cinnamide compound
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JP6784069B2 (ja) * 2015-07-07 2020-11-11 Jnc株式会社 液晶性化合物、液晶組成物および液晶表示素子
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EA009052B1 (ru) 2007-10-26
KR20010108439A (ko) 2001-12-07
EP1481968A2 (de) 2004-12-01
EA200101036A1 (ru) 2002-06-27
EA005563B1 (ru) 2005-04-28
IL145529A0 (en) 2002-12-01
HK1040985A1 (en) 2002-06-28
EE200100513A (et) 2002-12-16
AU4194400A (en) 2000-10-23
IS7616A (is) 2004-12-23
SK14012001A3 (sk) 2002-06-04
UA74781C2 (en) 2006-02-15
NZ515237A (en) 2004-11-26
ZA200108944B (en) 2003-07-02
NO20014767D0 (no) 2001-10-01
EP1481968A3 (de) 2005-01-19
MXPA01009766A (es) 2002-06-21
CA2369238A1 (en) 2000-10-12
EP1165505B1 (de) 2004-09-08
KR100678999B1 (ko) 2007-02-28
JP2004513063A (ja) 2004-04-30
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NO20014767L (no) 2001-11-30
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BR0009426A (pt) 2002-04-09
CN1353691A (zh) 2002-06-12
AU774564B2 (en) 2004-07-01
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