ATE274601T1 - Elektroerzeugte chemilumineszierende markierungsmittel zur analyse und/oder zur referenzbildung - Google Patents
Elektroerzeugte chemilumineszierende markierungsmittel zur analyse und/oder zur referenzbildungInfo
- Publication number
- ATE274601T1 ATE274601T1 AT96903716T AT96903716T ATE274601T1 AT E274601 T1 ATE274601 T1 AT E274601T1 AT 96903716 T AT96903716 T AT 96903716T AT 96903716 T AT96903716 T AT 96903716T AT E274601 T1 ATE274601 T1 AT E274601T1
- Authority
- AT
- Austria
- Prior art keywords
- coreactant
- produces
- ecl
- analysis
- electro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/001—Enzyme electrodes
- C12Q1/005—Enzyme electrodes involving specific analytes or enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6825—Nucleic acid detection involving sensors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Dental Preparations (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/385,864 US5786141A (en) | 1994-08-26 | 1995-02-09 | Electrogenerated chemiluminescence labels for analysis and/or referencing |
| PCT/US1996/001113 WO1996024690A1 (en) | 1995-02-09 | 1996-02-09 | Electrogenerated chemiluminescence labels for analysis and/or referencing |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE274601T1 true ATE274601T1 (de) | 2004-09-15 |
Family
ID=23523173
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96903716T ATE274601T1 (de) | 1995-02-09 | 1996-02-09 | Elektroerzeugte chemilumineszierende markierungsmittel zur analyse und/oder zur referenzbildung |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US5786141A (de) |
| EP (1) | EP0755458B1 (de) |
| JP (1) | JP3989019B2 (de) |
| AT (1) | ATE274601T1 (de) |
| AU (1) | AU709592B2 (de) |
| CA (1) | CA2186503C (de) |
| DE (1) | DE69633212T2 (de) |
| DK (1) | DK0755458T3 (de) |
| ES (1) | ES2227580T3 (de) |
| PT (1) | PT755458E (de) |
| WO (1) | WO1996024690A1 (de) |
Families Citing this family (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20010003647A1 (en) * | 1995-06-07 | 2001-06-14 | Ji Sun | Coreatant-including electrochemiluminescent compounds, methods, systems and kits utilizing same |
| US6319670B1 (en) | 1995-05-09 | 2001-11-20 | Meso Scale Technology Llp | Methods and apparatus for improved luminescence assays using microparticles |
| US7885697B2 (en) | 2004-07-13 | 2011-02-08 | Dexcom, Inc. | Transcutaneous analyte sensor |
| US6613583B1 (en) | 1997-06-27 | 2003-09-02 | Igen International, Inc. | Electrochemiluminescent label based on multimetallic assemblies |
| US6153674A (en) * | 1998-01-30 | 2000-11-28 | 3M Innovative Properties Company | Fire barrier material |
| US6200531B1 (en) * | 1998-05-11 | 2001-03-13 | Igen International, Inc. | Apparatus for carrying out electrochemiluminescence test measurements |
| US7186568B1 (en) | 2000-06-26 | 2007-03-06 | Lumigen Inc. | Electrochemiluminescence from acridan compounds |
| JP2006170615A (ja) * | 2001-01-19 | 2006-06-29 | Shigeori Takenaka | 遺伝子の検出方法、検出装置、並びに検出用チップ |
| CA2451789C (en) | 2001-06-29 | 2012-03-27 | Meso Scale Technologies, Llc. | Assay plates, reader systems and methods for luminescence test measurements |
| EP3021106B8 (de) | 2001-07-30 | 2019-03-27 | Meso Scale Technologies, LLC | Verwendung einer prüfelektrode mit immobilisierten lipid-/proteinschichten für lumineszenztestmessungen |
| JP4768224B2 (ja) | 2001-09-10 | 2011-09-07 | メソ スケイル テクノロジーズ，エルエルシー | １つの試料について複数の測定を実施する方法及び装置 |
| US7553448B2 (en) * | 2002-06-20 | 2009-06-30 | Bioveris Corporation | Electrochemiluminescence flow cell and flow cell components |
| US7920906B2 (en) | 2005-03-10 | 2011-04-05 | Dexcom, Inc. | System and methods for processing analyte sensor data for sensor calibration |
| US9247900B2 (en) | 2004-07-13 | 2016-02-02 | Dexcom, Inc. | Analyte sensor |
| US20060270922A1 (en) | 2004-07-13 | 2006-11-30 | Brauker James H | Analyte sensor |
| EP1830183A1 (de) * | 2004-12-21 | 2007-09-05 | Kyoto University | Sondeneinheit, vorrichtung zur identifizierung eines nukleinsäurebereichs und verfahren zur identifizierung eines nukleinsäurebereichs |
| WO2006076650A2 (en) * | 2005-01-12 | 2006-07-20 | Applera Corporation | Compositions, methods, and kits for selective amplification of nucleic acids |
| EP1893990B1 (de) | 2005-06-03 | 2018-05-02 | Board of Regents of the University of Texas System | Elektrochemie und elektrogenerierte chemolumineszenz mit einer faradayschen einzelelektrode |
| DK2271938T3 (da) | 2008-04-11 | 2014-05-12 | Univ Texas | Fremgangsmåde og apparat til nanopartikel-elektrogenereret kemiluminescens-amplifikation |
| AU2009244904B2 (en) * | 2008-05-08 | 2014-04-17 | Board Of Regents Of The University Of Texas System | Luminescent nanostructured materials for use in electrogenerated chemiluminescence |
| US20100261292A1 (en) | 2009-04-10 | 2010-10-14 | Meso Scale Technologies, Llc | Methods for Conducting Assays |
| US20110143947A1 (en) * | 2009-07-27 | 2011-06-16 | Meso Scale Technologies, Llc | Assay Apparatuses, Consumables and Methods |
| CA3139049A1 (en) | 2010-10-14 | 2012-04-19 | Meso Scale Technologies, Llc | Reagent storage in an assay device |
| WO2012055815A1 (en) | 2010-10-25 | 2012-05-03 | Roche Diagnostics Gmbh | Use of signal enhancing compounds in electrochemiluminescence detection |
| ES2700792T3 (es) | 2011-11-11 | 2019-02-19 | Eli N Glezer | Procedimientos de ensayo asistidos por coagente de unión |
| US9625465B2 (en) | 2012-05-15 | 2017-04-18 | Defined Diagnostics, Llc | Clinical diagnostic systems |
| US9075042B2 (en) | 2012-05-15 | 2015-07-07 | Wellstat Diagnostics, Llc | Diagnostic systems and cartridges |
| US9213043B2 (en) | 2012-05-15 | 2015-12-15 | Wellstat Diagnostics, Llc | Clinical diagnostic system including instrument and cartridge |
| EP2941633B1 (de) | 2013-01-04 | 2024-02-28 | Meso Scale Technologies, LLC | Assay-vorrichtungen, -verfahren und -reagenzien |
| CN105378477B9 (zh) | 2013-03-11 | 2021-08-06 | 梅索磅秤技术有限公司 | 用于进行多路测定法的改进方法 |
| KR20220038550A (ko) | 2013-03-13 | 2022-03-28 | 메소 스케일 테크놀러지즈, 엘엘시 | 개선된 분석 방법 |
| US10114015B2 (en) | 2013-03-13 | 2018-10-30 | Meso Scale Technologies, Llc. | Assay methods |
| BR112015023775B1 (pt) | 2013-03-15 | 2022-08-16 | Lubrizol Advanced Materials, Inc | Composições de cpvc isentas de metal pesado |
| CA3229509A1 (en) | 2014-05-09 | 2015-11-12 | Meso Scale Technologies, Llc. | Graphene-modified electrodes |
| AU2015259048B2 (en) | 2014-05-15 | 2021-09-09 | Meso Scale Technologies, Llc. | Improved assay methods |
| CN104297231A (zh) * | 2014-10-30 | 2015-01-21 | 中国科学院长春应用化学研究所 | 一种电化学发光光谱仪 |
| TR201909273T4 (tr) | 2015-08-20 | 2019-07-22 | Hoffmann La Roche | Bir pegile analit spesifik bağlanma ajanının kullanıldığı partikül bazlı immünolojik test. |
| KR102437995B1 (ko) | 2016-03-07 | 2022-08-29 | 에프. 호프만-라 로슈 아게 | 항-p53 항체의 검출 |
| JP7039481B2 (ja) | 2016-03-11 | 2022-03-22 | エフ．ホフマン－ラ ロシュ アーゲー | 電気化学発光検出における分枝鎖アミン |
| WO2018141768A1 (en) | 2017-02-02 | 2018-08-09 | Roche Diagnostics Gmbh | Immunoassay using at least two pegylated analyte-specific binding agents |
| FI127861B (en) | 2017-06-29 | 2019-04-15 | Labmaster Oy | Method and apparatus for dynamically generating hot electrons in aqueous solutions |
| EP4310184A3 (de) | 2018-02-23 | 2024-05-01 | Meso Scale Technologies, LLC. | Verfahren zum screenen von antigen-bindenden molekülen durch normalisierung auf die konzentration eines antigen-bindenden moleküls |
| EP3781600A1 (de) | 2018-04-18 | 2021-02-24 | F. Hoffmann-La Roche AG | Neuartige anti-thymidinkinase-antikörper |
| CN112639475A (zh) | 2018-08-31 | 2021-04-09 | 豪夫迈·罗氏有限公司 | Dlbcl的预后指数中的胸苷激酶(tk-1) |
| SG11202012634UA (en) * | 2018-12-17 | 2021-01-28 | Illumina Inc | Flow cells and sequencing kits |
| US20220018846A1 (en) | 2019-01-03 | 2022-01-20 | Meso Scale Technologies, Llc. | Compositions and methods for carrying out assay measurements |
| EP3931201A1 (de) | 2019-03-01 | 2022-01-05 | Meso Scale Technologies, LLC | Elektrochemilumineszente markierte sonden zur verwendung in immunoassay-verfahren, verfahren mit verwendung davon und kits damit |
| KR20220005571A (ko) | 2019-06-07 | 2022-01-13 | 에프. 호프만-라 로슈 아게 | 전부 lna 올리고뉴클레오티드 혼성화 |
| CN114144676A (zh) | 2019-07-22 | 2022-03-04 | 豪夫迈·罗氏有限公司 | S100a6作为血液生物标志物用于子宫内膜异位症的非侵入性诊断 |
| EP4004552A1 (de) | 2019-07-22 | 2022-06-01 | F. Hoffmann-La Roche AG | S100a12 als blutbiomarker zur nichtinvasiven diagnose von endometriose |
| CN114144675A (zh) | 2019-07-22 | 2022-03-04 | 豪夫迈·罗氏有限公司 | S100a9作为血液生物标志物用于子宫内膜异位症的非侵入性诊断 |
| EP4004551A1 (de) | 2019-07-22 | 2022-06-01 | F. Hoffmann-La Roche AG | Substanz p als blutbiomarker zur nichtinvasiven diagnose von endometriose |
| CN114144673A (zh) | 2019-07-22 | 2022-03-04 | 豪夫迈·罗氏有限公司 | S100a8作为血液生物标志物用于子宫内膜异位症的非侵入性诊断 |
| CN110501406B (zh) * | 2019-09-30 | 2021-11-19 | 青岛大学 | 一种基于石墨烯电极的亚精胺电化学发光检测法 |
| JP2023502360A (ja) | 2019-11-15 | 2023-01-24 | エフ．ホフマン－ラ ロシュ アーゲー | 患者試料における質量分析測定のためのβ－ラクタム抗生物質の誘導体化 |
| EP4154008A1 (de) | 2020-05-19 | 2023-03-29 | Meso Scale Technologies, LLC | Verfahren, zusammensetzungen und kits zum nachweis von nukleinsäuren |
| EP4176263A1 (de) | 2020-07-01 | 2023-05-10 | Meso Scale Technologies, LLC | Zusammensetzungen und verfahren für assay-messungen |
| WO2022090455A1 (en) | 2020-11-02 | 2022-05-05 | F. Hoffmann-La Roche Ag | Sars-cov-2 nucleocapsid antibodies |
| WO2022136234A1 (en) | 2020-12-22 | 2022-06-30 | F. Hoffmann-La Roche Ag | Method for detecting an analyte of interest in a sample |
| WO2022207628A1 (en) | 2021-03-30 | 2022-10-06 | F. Hoffmann-La Roche Ag | Scf as blood biomarker for the non-invasive diagnosis of endometriosis |
| JP2024511867A (ja) | 2021-04-01 | 2024-03-15 | エフ． ホフマン－ラ ロシュ アーゲー | 子宮内膜症の非侵襲的診断のための血液バイオマーカーとしてのｐｓｐ９４ |
| CN117337394A (zh) | 2021-05-17 | 2024-01-02 | 豪夫迈·罗氏有限公司 | sFRP4作为血液生物标志物用于子宫腺肌病的非侵入性诊断 |
| AU2022304570A1 (en) | 2021-06-28 | 2024-01-18 | Meso Scale Technologies, Llc. | Methods, compositions, and kits for assay signal amplification |
| WO2023072904A1 (en) | 2021-10-26 | 2023-05-04 | F. Hoffmann-La Roche Ag | Monoclonal antibodies specific for sars-cov-2 rbd |
| WO2023129884A1 (en) | 2021-12-30 | 2023-07-06 | Meso Scale Technologies, Llc. | Methods for electrochemiluminescence detection |
| WO2023131594A1 (en) | 2022-01-05 | 2023-07-13 | F. Hoffmann-La Roche Ag | Derivatization of compounds in patient samples for therapeutic drug monitoring (tdm) |
| WO2023156510A1 (en) | 2022-02-18 | 2023-08-24 | F. Hoffmann-La Roche Ag | Method for detecting an analyte of interest in a sample |
| WO2023196927A1 (en) | 2022-04-07 | 2023-10-12 | Meso Scale Technologies, Llc. | Methods and kits for assessing alzheimer's disease |
| WO2023247752A1 (en) | 2022-06-23 | 2023-12-28 | F. Hoffmann-La Roche Ag | Method for diagnosing endometriosis and for classifying the stage of endometriosis |
| WO2024017982A1 (en) | 2022-07-22 | 2024-01-25 | F. Hoffmann-La Roche Ag | Leukotriene a4 hydrolase (lta4h) as (blood) biomarker for the diagnosis of polycystic ovarian syndrome |
| WO2024017985A1 (en) | 2022-07-22 | 2024-01-25 | F. Hoffmann-La Roche Ag | Fibroblast growth factor binding protein 1 (fgfbp1) as (blood) biomarker for the diagnosis of polycystic ovarian syndrome |
| WO2024017983A1 (en) | 2022-07-22 | 2024-01-25 | F. Hoffmann-La Roche Ag | Meteorin-like protein (metrnl) as (blood) biomarker for the diagnosis of polycystic ovarian syndrome |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3442816A (en) * | 1966-02-23 | 1969-05-06 | American Cyanamid Co | Generation of light by the reaction of tetracyanoethylene or other electronegatively substituted ethylene,ethylene oxide and carbonyl compound with hydrogen peroxide in the presence of a fluorescer |
| US5238808A (en) * | 1984-10-31 | 1993-08-24 | Igen, Inc. | Luminescent metal chelate labels and means for detection |
| US5221605A (en) * | 1984-10-31 | 1993-06-22 | Igen, Inc. | Luminescent metal chelate labels and means for detection |
| US5310687A (en) * | 1984-10-31 | 1994-05-10 | Igen, Inc. | Luminescent metal chelate labels and means for detection |
| JPH01305069A (ja) * | 1988-05-31 | 1989-12-08 | Shionogi & Co Ltd | ベンゾトリアゾール誘導体およびそれを含有する発螢光試薬 |
| US5324457A (en) * | 1989-10-02 | 1994-06-28 | Board Of Regents, The University Of Tx System | Devices and methods for generating electrogenerated chemiluminescence |
| US5340714A (en) * | 1992-05-08 | 1994-08-23 | Monitor Diagnostics, Inc. | Use of nonmetallic tetrapyrrole molecules and novel signal solutions in chemiluminescent reactions and assays |
| AU703344B2 (en) * | 1994-08-26 | 1999-03-25 | Igen International, Inc. | Biosensor for and method of electrogenerated chemiluminescent detection of nucleic acid adsorbed to a solid surface |
-
1995
- 1995-02-09 US US08/385,864 patent/US5786141A/en not_active Expired - Lifetime
-
1996
- 1996-02-09 AT AT96903716T patent/ATE274601T1/de active
- 1996-02-09 PT PT96903716T patent/PT755458E/pt unknown
- 1996-02-09 CA CA002186503A patent/CA2186503C/en not_active Expired - Lifetime
- 1996-02-09 DE DE69633212T patent/DE69633212T2/de not_active Expired - Lifetime
- 1996-02-09 WO PCT/US1996/001113 patent/WO1996024690A1/en active IP Right Grant
- 1996-02-09 DK DK96903716T patent/DK0755458T3/da active
- 1996-02-09 ES ES96903716T patent/ES2227580T3/es not_active Expired - Lifetime
- 1996-02-09 JP JP52429396A patent/JP3989019B2/ja not_active Expired - Lifetime
- 1996-02-09 AU AU47708/96A patent/AU709592B2/en not_active Expired
- 1996-02-09 EP EP96903716A patent/EP0755458B1/de not_active Expired - Lifetime
-
1998
- 1998-05-20 US US09/082,273 patent/US6479233B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0755458A1 (de) | 1997-01-29 |
| US5786141A (en) | 1998-07-28 |
| AU4770896A (en) | 1996-08-27 |
| DE69633212T2 (de) | 2005-09-22 |
| US6479233B1 (en) | 2002-11-12 |
| ES2227580T3 (es) | 2005-04-01 |
| JP3989019B2 (ja) | 2007-10-10 |
| PT755458E (pt) | 2005-01-31 |
| EP0755458B1 (de) | 2004-08-25 |
| WO1996024690A1 (en) | 1996-08-15 |
| AU709592B2 (en) | 1999-09-02 |
| EP0755458A4 (de) | 2000-07-26 |
| DE69633212D1 (de) | 2004-09-30 |
| CA2186503C (en) | 2007-01-23 |
| JPH10502702A (ja) | 1998-03-10 |
| DK0755458T3 (da) | 2004-11-29 |
| CA2186503A1 (en) | 1996-08-15 |
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