ATE272074T1 - An neuropeptide gebundenes rgd (arg-gly-asp) - Google Patents

An neuropeptide gebundenes rgd (arg-gly-asp)

Info

Publication number: ATE272074T1
Authority: AT; Austria
Prior art keywords: gly; asp; arg; neuropeptides; rgd
Prior art date: 2000-04-26

Application number

AT01947245T

Other languages

English (en)

Inventor

Jong Marion De

Eric Paul Krenning

Hagen Petrus Martinus Van

Original Assignee

Biosynthema Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-04-26

Filing date

2001-04-26

Publication date

2004-08-15

2001-04-26 Application filed by Biosynthema Inc filed Critical Biosynthema Inc

2004-08-15 Application granted granted Critical

2004-08-15 Publication of ATE272074T1 publication Critical patent/ATE272074T1/de

Links

IYMAXBFPHPZYIK-BQBZGAKWSA-N Arg-Gly-Asp Chemical group NC(N)=NCCC[C@H](N)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(O)=O IYMAXBFPHPZYIK-BQBZGAKWSA-N 0.000 title abstract 3
108010072041 arginyl-glycyl-aspartic acid Proteins 0.000 title abstract 2
108090000189 Neuropeptides Proteins 0.000 title 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 2
238000004519 manufacturing process Methods 0.000 abstract 2
206010028980 Neoplasm Diseases 0.000 abstract 1
125000003275 alpha amino acid group Chemical group 0.000 abstract 1
230000004071 biological effect Effects 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
239000008177 pharmaceutical agent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1019—Tetrapeptides with the first amino acid being basic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/082—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being a RGD-containing peptide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/083—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being octreotide or a somatostatin-receptor-binding peptide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57563—Vasoactive intestinal peptide [VIP]; Related peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/595—Gastrins; Cholecystokinins [CCK]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
- C07K14/6555—Somatostatins at least 1 amino acid in D-form
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/75—Fibrinogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0815—Tripeptides with the first amino acid being basic
- C07K5/0817—Tripeptides with the first amino acid being basic the first amino acid being Arg
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
- C07K7/086—Bombesin; Related peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/22—Tachykinins, e.g. Eledoisins, Substance P; Related peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Toxicology (AREA)
Endocrinology (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Optics & Photonics (AREA)
Physics & Mathematics (AREA)
Hematology (AREA)
Vascular Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

AT01947245T 2000-04-26 2001-04-26 An neuropeptide gebundenes rgd (arg-gly-asp) ATE272074T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP00201499		2000-04-26
PCT/EP2001/004764 WO2001081426A2 (en)	2000-04-26	2001-04-26	Rgd (arg-gly-asp) coupled to (neuro)peptides

Publications (1)

Publication Number	Publication Date
ATE272074T1 true ATE272074T1 (de)	2004-08-15

Family

ID=8171409

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT01947245T ATE272074T1 (de)	2000-04-26	2001-04-26	An neuropeptide gebundenes rgd (arg-gly-asp)

Country Status (15)

Country	Link
US (1)	US7202330B2 (de)
EP (2)	EP1452543A3 (de)
JP (1)	JP2004517034A (de)
AT (1)	ATE272074T1 (de)
AU (2)	AU6898201A (de)
CA (1)	CA2407514C (de)
CZ (1)	CZ20023539A3 (de)
DE (1)	DE60104552T2 (de)
ES (1)	ES2225570T3 (de)
HU (1)	HUP0301571A2 (de)
IL (1)	IL152466A0 (de)
NO (1)	NO20025064L (de)
NZ (1)	NZ522200A (de)
PL (1)	PL202279B1 (de)
WO (1)	WO2001081426A2 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CZ20023539A3 (cs)	2000-04-26	2003-09-17	Biosynthema, Inc.	Sloučeniny s vaznou afinitou pro alfa v beta3 - receptory a pro (neuro)peptidové receptory
US7122622B2 (en)	2002-04-16	2006-10-17	Biosynthema Inc.	Peptide compounds having improved binding affinity to somatostatin receptors
EP1358890A1 (de)	2002-05-03	2003-11-05	BioSynthema, Inc	Benzothienyl-Analoge von Somatostatine, selectiv für bestimmte Somatostatinrezeptoren
CN100410276C (zh)	2003-03-31	2008-08-13	株式会社林原生物化学研究所	多肽
US20070025910A1 (en)	2005-07-29	2007-02-01	Norenberg Jeffrey P	Anticancer therapy
JP2009541302A (ja)	2006-07-24	2009-11-26	ザプロクターアンドギャンブルカンパニー	シクロヘキセニルケトンのエピマー化方法及びアルドール縮合プロセスにおけるその利用
KR100987592B1 (ko) *	2008-03-10	2010-10-12	경북대학교 산학협력단	암진단용 ｍｒ 조영제와 그 제조방법
US9517201B2 (en) *	2008-04-04	2016-12-13	Rutgers, The State University Of New Jersey	Nanocarrier and nanogel compositions
US8263133B2 (en) *	2009-02-18	2012-09-11	The Regents Of The University Of California	Multivalent clustering targeting strategy for drug carriers
CN102260352B (zh) *	2010-05-28	2013-11-20	山东先声麦得津生物制药有限公司	靶向性白细胞介素融合蛋白及其制备方法与应用
US9775803B2 (en)	2011-10-19	2017-10-03	Samsung Electronics Co., Ltd.	Liposome comprising elastin-like polypeptide and tumor cell targeting material and use thereof
WO2014081655A1 (en) *	2012-11-21	2014-05-30	Serene Oncology, Llc	Tin-1 17m comprising somatostatin receptor binding compounds
EP3568205B1 (de)	2017-01-12	2023-08-16	Radiomedix Inc.	Behandlung von somatostatin rezeptoren überexprimierenden krebszellen mit mit radioisotope chelatgebundene octreotidderivaten
CN106967149A (zh) *	2017-05-04	2017-07-21	苏州强耀生物科技有限公司	一种棕榈酰化修饰的半胱氨酸多肽的制备方法
PL238941B1 (pl) *	2018-04-04	2021-10-25	Gdanski Univ Medyczny	Związki chemiczne o działaniu przeciwuszkodzeniowym i/lub neuroprotekcyjnym
CN116510033B (zh) *	2023-03-09	2024-03-19	哈尔滨吉象隆生物技术有限公司	一种抗肿瘤的ppc药物及其制备方法与应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2878341B2 (ja) *	1989-03-03	1999-04-05	学校法人藤田学園	人工機能性ポリペプチド
US5843903A (en) *	1995-11-27	1998-12-01	The Administrators Of The Tulane Educational Fund	Targeted cytotoxic anthracycline analogs
CZ20023539A3 (cs)	2000-04-26	2003-09-17	Biosynthema, Inc.	Sloučeniny s vaznou afinitou pro alfa v beta3 - receptory a pro (neuro)peptidové receptory

2001
- 2001-04-26 CZ CZ20023539A patent/CZ20023539A3/cs unknown
- 2001-04-26 ES ES01947245T patent/ES2225570T3/es not_active Expired - Lifetime
- 2001-04-26 JP JP2001578513A patent/JP2004517034A/ja active Pending
- 2001-04-26 US US10/258,766 patent/US7202330B2/en not_active Expired - Lifetime
- 2001-04-26 AT AT01947245T patent/ATE272074T1/de not_active IP Right Cessation
- 2001-04-26 IL IL15246601A patent/IL152466A0/xx unknown
- 2001-04-26 NZ NZ522200A patent/NZ522200A/en unknown
- 2001-04-26 CA CA2407514A patent/CA2407514C/en not_active Expired - Lifetime
- 2001-04-26 AU AU6898201A patent/AU6898201A/xx active Pending
- 2001-04-26 AU AU2001268982A patent/AU2001268982B8/en not_active Ceased
- 2001-04-26 HU HU0301571A patent/HUP0301571A2/hu unknown
- 2001-04-26 EP EP04101401A patent/EP1452543A3/de not_active Withdrawn
- 2001-04-26 EP EP01947245A patent/EP1301540B1/de not_active Expired - Lifetime
- 2001-04-26 DE DE60104552T patent/DE60104552T2/de not_active Expired - Lifetime
- 2001-04-26 PL PL357246A patent/PL202279B1/pl not_active IP Right Cessation
- 2001-04-26 WO PCT/EP2001/004764 patent/WO2001081426A2/en active IP Right Grant
2002
- 2002-10-22 NO NO20025064A patent/NO20025064L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
CZ20023539A3 (cs)	2003-09-17
AU6898201A (en)	2001-11-07
PL357246A1 (en)	2004-07-26
NO20025064L (no)	2002-12-20
AU2001268982B2 (en)	2006-06-15
WO2001081426A2 (en)	2001-11-01
WO2001081426A3 (en)	2002-06-27
EP1452543A3 (de)	2005-08-03
PL202279B1 (pl)	2009-06-30
IL152466A0 (en)	2003-05-29
DE60104552D1 (de)	2004-09-02
EP1301540A2 (de)	2003-04-16
CA2407514A1 (en)	2001-11-01
JP2004517034A (ja)	2004-06-10
EP1301540B1 (de)	2004-07-28
EP1452543A2 (de)	2004-09-01
NO20025064D0 (no)	2002-10-22
HUP0301571A2 (hu)	2003-09-29
US20040136907A1 (en)	2004-07-15
DE60104552T2 (de)	2005-09-01
AU2001268982B8 (en)	2006-08-03
CA2407514C (en)	2011-03-29
ES2225570T3 (es)	2005-03-16
NZ522200A (en)	2004-07-30
US7202330B2 (en)	2007-04-10

Legal Events

Date	Code	Title	Description
2005-01-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE272074T1 (de)	2004-08-15	An neuropeptide gebundenes rgd (arg-gly-asp)
CA2064473C (en)	2001-04-17	Chimeric amino acids and peptides containing these analogues
ATE297219T1 (de)	2005-06-15	Antikörper als arzneimittel gegen lymphocytische tumore (ausschliesslich myelome)
DK1105409T3 (da)	2006-07-03	Beskyttelse af endogene terapeutiske peptider fra peptidaseaktivitet ved konjugering med blodkomponenter
ATA14642003A (de)	2005-11-15	Impfstoff für die alzheimer-krankheit
EP2298331A3 (de)	2011-04-13	Verwendung von Transthyretinpeptid-/-proteinfusionen zur Erhöhung der Serumshalbwertszeit von pharmakologisch aktiven Peptiden/Proteinen
DE69435105D1 (de)	2008-08-07	Derivate therapeutischer Peptide
AT500379B8 (de)	2009-08-15	Tau-proteine
DK0771209T3 (da)	2002-10-07	Hidtil ukendte peptider
RS51157B (sr)	2010-10-31	Baff receptor (bcma), imunoregulatorni agens
ATE463260T1 (de)	2010-04-15	Ortspezifische duale pegylation von proteine
ATE383375T1 (de)	2008-01-15	Wti-modifiziertes peptid
EA200400392A1 (ru)	2004-10-28	Связывающий каспазу-8 белок, его получение и применение
BR0007499A (pt)	2001-10-23	Composto
DK1219299T3 (da)	2007-05-21	Allergivacciner og fremstilling deraf
AU2003222944A1 (en)	2003-09-09	Novel coupling agents, the active intermediates and the conjugates thereof and the use of said conjugates in diagnostic methods
WO2002014346A8 (en)	2002-07-11	Antimicrobial peptides isolated from fish
PT1150716E (pt)	2004-08-31	Composicao farmaceutica de proteinas hedgehog hidrofobicamente modificadas e sua utilizacao
FR2797632B1 (fr)	2003-01-24	Fonctionnalisation d'un peptide par un groupement alpha- hydrazinoacetique