ATE271385T1 - Verwendung von cyclooxygenase-2 inhibitoren zur behandlung und verbeugung von neoplasia - Google Patents

Verwendung von cyclooxygenase-2 inhibitoren zur behandlung und verbeugung von neoplasia

Info

Publication number
ATE271385T1
ATE271385T1 AT97911746T AT97911746T ATE271385T1 AT E271385 T1 ATE271385 T1 AT E271385T1 AT 97911746 T AT97911746 T AT 97911746T AT 97911746 T AT97911746 T AT 97911746T AT E271385 T1 ATE271385 T1 AT E271385T1
Authority
AT
Austria
Prior art keywords
cyclooxygenase
inhibitors
treat
prevent neoplasia
neoplasia
Prior art date
Application number
AT97911746T
Other languages
English (en)
Inventor
Karen Seibert
Jaime Masferrer
Gary B Gordon
Original Assignee
Searle Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21843754&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE271385(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Searle Llc filed Critical Searle Llc
Application granted granted Critical
Publication of ATE271385T1 publication Critical patent/ATE271385T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A61K31/10—Sulfides; Sulfoxides; Sulfones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
AT97911746T 1996-10-15 1997-10-14 Verwendung von cyclooxygenase-2 inhibitoren zur behandlung und verbeugung von neoplasia ATE271385T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2849496P 1996-10-15 1996-10-15
PCT/US1997/018670 WO1998016227A1 (en) 1996-10-15 1997-10-14 Method of using cyclooxygenase-2 inhibitors in the treatment and prevention of neoplasia

Publications (1)

Publication Number Publication Date
ATE271385T1 true ATE271385T1 (de) 2004-08-15

Family

ID=21843754

Family Applications (2)

Application Number Title Priority Date Filing Date
AT04011516T ATE399547T1 (de) 1996-10-15 1997-10-14 Verwendung von cyclooxygenase-2 inhibitoren zur behandlung und vorbeugung von neoplasia
AT97911746T ATE271385T1 (de) 1996-10-15 1997-10-14 Verwendung von cyclooxygenase-2 inhibitoren zur behandlung und verbeugung von neoplasia

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT04011516T ATE399547T1 (de) 1996-10-15 1997-10-14 Verwendung von cyclooxygenase-2 inhibitoren zur behandlung und vorbeugung von neoplasia

Country Status (25)

Country Link
EP (3) EP0932402B1 (de)
JP (1) JP2001503395A (de)
KR (1) KR20000049138A (de)
CN (2) CN1332661C (de)
AT (2) ATE399547T1 (de)
AU (1) AU742645B2 (de)
BR (1) BR9712314A (de)
CA (1) CA2267186C (de)
CZ (1) CZ298022B6 (de)
DE (2) DE69738815D1 (de)
DK (2) DK1479385T3 (de)
ES (2) ES2308068T3 (de)
HK (1) HK1025518A1 (de)
HU (1) HU227564B1 (de)
IL (3) IL154501A0 (de)
NO (1) NO326822B1 (de)
NZ (3) NZ506515A (de)
PT (2) PT932402E (de)
RO (1) RO120172B1 (de)
RU (1) RU2239429C2 (de)
SK (1) SK284788B6 (de)
TR (1) TR199900827T2 (de)
TW (1) TWI235060B (de)
UA (1) UA67732C2 (de)
WO (1) WO1998016227A1 (de)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6512121B2 (en) 1998-09-14 2003-01-28 G.D. Searle & Co. Heterocyclo substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors
AU5886296A (en) 1995-06-02 1996-12-18 G.D. Searle & Co. Heterocyclo substituted hydroxamic acid derivatives as cyclo oxygenase-2 and 5-lipoxygenase inhibitors
US20040072889A1 (en) 1997-04-21 2004-04-15 Pharmacia Corporation Method of using a COX-2 inhibitor and an alkylating-type antineoplastic agent as a combination therapy in the treatment of neoplasia
NZ333399A (en) 1997-12-24 2000-05-26 Sankyo Co Cyclooxygenase-2 inhibitors (COX-2) for the prevention and treatment of tumors, cachexia and tumor-metastasis
US6294558B1 (en) 1999-05-31 2001-09-25 Pfizer Inc. Sulfonylbenzene compounds as anti-inflammatory/analgesic agents
US6727238B2 (en) 1998-06-11 2004-04-27 Pfizer Inc. Sulfonylbenzene compounds as anti-inflammatory/analgesic agents
US20040053900A1 (en) * 1998-12-23 2004-03-18 Pharmacia Corporation Method of using a COX-2 inhibitor and an aromatase inhibitor as a combination therapy
US20020103141A1 (en) * 1998-12-23 2002-08-01 Mckearn John P. Antiangiogenic combination therapy for the treatment of cancer
US6833373B1 (en) 1998-12-23 2004-12-21 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6649645B1 (en) * 1998-12-23 2003-11-18 Pharmacia Corporation Combination therapy of radiation and a COX-2 inhibitor for treatment of neoplasia
AU2713600A (en) * 1998-12-23 2000-07-31 G.D. Searle & Co. Use of a matrix metalloproteinase inhibitor and an integrin antagonist in the treatment of neoplasia
US20040122011A1 (en) * 1998-12-23 2004-06-24 Pharmacia Corporation Method of using a COX-2 inhibitor and a TACE inhibitors as a combination therapy
US6403630B1 (en) * 1999-01-27 2002-06-11 Cornell Research Foundation, Inc. Treating cancers associated with overexpression of HER-2/neu
EP1189628A1 (de) * 1999-06-24 2002-03-27 Pharmacia Corporation Kombination von tumornekrosefaktor (tnf) antagonisten und von cox-2 inhibitoren für die behandlung der entzündung
CN1181819C (zh) * 1999-07-29 2004-12-29 图拉列克股份有限公司 使用五氟苯磺酰胺的综合疗法
DE60037597T2 (de) 1999-11-22 2008-12-11 Smithkline Beecham P.L.C., Brentford Imidazol- Derivate
WO2001054688A1 (en) * 2000-01-28 2001-08-02 Merck & Co., Inc. Treatment or prevention of prostate cancer with a cox-2 selective inhibiting drug
GB0003224D0 (en) 2000-02-11 2000-04-05 Glaxo Group Ltd Chemical compounds
GB0005357D0 (en) 2000-03-06 2000-04-26 Smithkline Beecham Plc Compounds
AU2001275004A1 (en) * 2000-06-01 2001-12-11 Pharmacia Corporation Use of cox2 inhibitors for treating skin injury from exposure to ultraviolet radiation
GB0021494D0 (en) 2000-09-01 2000-10-18 Glaxo Group Ltd Chemical comkpounds
DE60112312T2 (de) 2000-09-21 2005-12-29 Smithkline Beecham P.L.C., Brentford Imidazolderivate als raf-kinase-inhibitoren
AU2002234165A1 (en) 2000-11-03 2002-05-27 Tularik, Inc. Combination therapy using pentafluorobenzenesulfonamides and antineoplastic agents
WO2002089790A1 (en) * 2001-05-03 2002-11-14 Cornell Research Foundation, Inc. Treatment of hpv caused diseases
GB0112810D0 (en) 2001-05-25 2001-07-18 Glaxo Group Ltd Pyrimidine derivatives
GB0112802D0 (en) 2001-05-25 2001-07-18 Glaxo Group Ltd Pyrimidine derivatives
GB0119477D0 (en) 2001-08-09 2001-10-03 Glaxo Group Ltd Pyrimidine derivatives
MXPA04003878A (es) * 2001-10-25 2004-07-08 Novartis Ag Combinaciones que comprenden un inhibidor selectivo de cicloxigenasa-2.
FR2835433B1 (fr) * 2002-02-01 2006-02-17 Richard Lab M Utilisation de la 1-(-4-chlorobenzoyl)-5methoxy-2-methyl-1h- indole-3acetic 4-(acetylamino)phenylester pour la fabrication d'un medicament destine a inhiber exclusivement la cox2
JP2005522477A (ja) 2002-04-08 2005-07-28 グラクソ　グループ　リミテッド （２−（（２−アルコキシ）−フェニル）−シクロペント−１−エニル）芳香族炭素環式および複素環式酸および誘導体
AU2003258630A1 (en) 2002-08-19 2004-03-11 Glaxo Group Limited Pyrimidine derivatives as selective cox-2 inhibitors
GB0221443D0 (en) 2002-09-16 2002-10-23 Glaxo Group Ltd Pyridine derivates
KR100484525B1 (ko) * 2002-10-15 2005-04-20 씨제이 주식회사 이소티아졸 유도체, 그 제조방법 및 약제학적 조성물
GB0225548D0 (en) 2002-11-01 2002-12-11 Glaxo Group Ltd Compounds
PE20040844A1 (es) 2002-11-26 2004-12-30 Novartis Ag Acidos fenilaceticos y derivados como inhibidores de la cox-2
BRPI0407403B1 (pt) * 2003-02-11 2022-07-19 Cancer Research Technology Ltd Compostos de isoxazol e composição farmacêutica
GB0308466D0 (en) 2003-04-11 2003-05-21 Novartis Ag Organic compounds
NZ560712A (en) 2005-02-17 2010-12-24 Synta Pharmaceuticals Corp (3,4,5-trisubstituted-phenyl)isoxazole combretastin derivatives for the treatment of disorders
WO2006096778A2 (en) * 2005-03-08 2006-09-14 Mitsui Norin Co., Ltd Polyphenol coxib combinations and methods
KR20100122513A (ko) * 2008-07-17 2010-11-22 아사히 가세이 파마 가부시키가이샤 질소 함유 복소환 화합물
AU2009282901A1 (en) * 2008-08-22 2010-02-25 Novartis Ag Use of a COX-2 inhibitor for the treatment of a COX-2 dependent disorder in a patient not carrying HLA alleles associated with hepatotoxicity
EP3313399A4 (de) 2015-06-29 2019-07-24 NantBio, Inc. Zusammensetzungen und verfahren der rit1-hemmung

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU33730B (en) 1967-04-18 1978-02-28 Farmaceutici Italia Process for preparing a novel antibiotic substance and salts thereof
US4012448A (en) 1976-01-15 1977-03-15 Stanford Research Institute Synthesis of adriamycin and 7,9-epiadriamycin
KR0145953B1 (ko) 1991-07-19 1998-08-17 제임스 클리프튼 보올딩 슈퍼옥사이드의 불균화촉매로서 효과적인 질소를 포함하는 마크로사이클 릭리간드의 망간착물
US5604260A (en) 1992-12-11 1997-02-18 Merck Frosst Canada Inc. 5-methanesulfonamido-1-indanones as an inhibitor of cyclooxygenase-2
ATE160345T1 (de) 1993-01-15 1997-12-15 Searle & Co 3,4-diarylthiophene und analoga davon, sowie deren verwendung als entzündungshemmende mittel
US5409944A (en) 1993-03-12 1995-04-25 Merck Frosst Canada, Inc. Alkanesulfonamido-1-indanone derivatives as inhibitors of cyclooxygenase
AU6718494A (en) 1993-05-13 1994-12-12 Merck Frosst Canada Inc. 2-substituted-3,4-diarylthiophene derivatives as inhibitors of cyclooxygenase
US5380738A (en) 1993-05-21 1995-01-10 Monsanto Company 2-substituted oxazoles further substituted by 4-fluorophenyl and 4-methylsulfonylphenyl as antiinflammatory agents
US5474995A (en) 1993-06-24 1995-12-12 Merck Frosst Canada, Inc. Phenyl heterocycles as cox-2 inhibitors
US5344991A (en) 1993-10-29 1994-09-06 G.D. Searle & Co. 1,2 diarylcyclopentenyl compounds for the treatment of inflammation
RU2139281C1 (ru) 1993-11-30 1999-10-10 Джи Ди Сирл энд Компани Пиразолилзамещенный бензолсульфонамид или его фармацевтически приемлемая соль, фармацевтическая композиция, способ лечения от воспаления или связанного с воспалением заболевания
US5475018A (en) 1993-11-30 1995-12-12 G. D. Searle & Co. 1,5-diphenyl pyrazole compounds for treatment of inflammation
US5466823A (en) * 1993-11-30 1995-11-14 G.D. Searle & Co. Substituted pyrazolyl benzenesulfonamides
US5434178A (en) * 1993-11-30 1995-07-18 G.D. Searle & Co. 1,3,5 trisubstituted pyrazole compounds for treatment of inflammation
US5393790A (en) 1994-02-10 1995-02-28 G.D. Searle & Co. Substituted spiro compounds for the treatment of inflammation
US5486534A (en) 1994-07-21 1996-01-23 G. D. Searle & Co. 3,4-substituted pyrazoles for the treatment of inflammation
EP1125932A3 (de) 1994-07-27 2001-08-29 G.D. Searle & Co. Substituierte Thiazole zur Behandlung von Entzündungen
US5616601A (en) 1994-07-28 1997-04-01 Gd Searle & Co 1,2-aryl and heteroaryl substituted imidazolyl compounds for the treatment of inflammation
US5620999A (en) 1994-07-28 1997-04-15 Weier; Richard M. Benzenesulfonamide subtituted imidazolyl compounds for the treatment of inflammation
US5521213A (en) 1994-08-29 1996-05-28 Merck Frosst Canada, Inc. Diaryl bicyclic heterocycles as inhibitors of cyclooxygenase-2
US5739166A (en) 1994-11-29 1998-04-14 G.D. Searle & Co. Substituted terphenyl compounds for the treatment of inflammation
US5686470A (en) 1995-02-10 1997-11-11 Weier; Richard M. 2, 3-substituted pyridines for the treatment of inflammation
US5596008A (en) 1995-02-10 1997-01-21 G. D. Searle & Co. 3,4-Diaryl substituted pyridines for the treatment of inflammation
RO119946B1 (ro) 1995-02-13 2005-06-30 G.D. Searle & Co. Derivaţi de izoxazol, utilizaţi pentru tratamentul inflamaţiilor
US5510368A (en) 1995-05-22 1996-04-23 Merck Frosst Canada, Inc. N-benzyl-3-indoleacetic acids as antiinflammatory drugs
AU5886296A (en) * 1995-06-02 1996-12-18 G.D. Searle & Co. Heterocyclo substituted hydroxamic acid derivatives as cyclo oxygenase-2 and 5-lipoxygenase inhibitors
EP0859779A4 (de) 1995-08-31 2000-04-12 Smithkline Beecham Corp Interleukin-konvertierendes enzym und apoptosis
ATE225343T1 (de) 1995-12-20 2002-10-15 Hoffmann La Roche Matrix-metalloprotease inhibitoren

Also Published As

Publication number Publication date
CA2267186A1 (en) 1998-04-23
CZ298022B6 (cs) 2007-05-30
HU227564B1 (en) 2011-08-29
BR9712314A (pt) 1999-08-31
TR199900827T2 (xx) 1999-07-21
AU742645B2 (en) 2002-01-10
RO120172B1 (ro) 2005-10-28
HUP9904221A2 (hu) 2000-09-28
DK0932402T3 (da) 2004-11-08
ES2308068T3 (es) 2008-12-01
KR20000049138A (ko) 2000-07-25
IL165816A0 (en) 2006-01-15
SK46299A3 (en) 2000-03-13
EP1479385B1 (de) 2008-07-02
NZ509755A (en) 2002-09-27
HUP9904221A3 (en) 2000-12-28
JP2001503395A (ja) 2001-03-13
EP1479385A1 (de) 2004-11-24
NO991793L (no) 1999-04-15
NZ506515A (en) 2002-05-31
DE69738815D1 (de) 2008-08-14
AU4904897A (en) 1998-05-11
NZ334921A (en) 2001-03-30
DE69729946T2 (de) 2005-01-20
ES2224222T3 (es) 2005-03-01
UA67732C2 (uk) 2004-07-15
RU2239429C2 (ru) 2004-11-10
CN1660083A (zh) 2005-08-31
DE69729946D1 (de) 2004-08-26
TWI235060B (en) 2005-07-01
IL128568A0 (en) 2000-01-31
ATE399547T1 (de) 2008-07-15
SK284788B6 (sk) 2005-11-03
CA2267186C (en) 2002-05-14
IL154501A0 (en) 2003-09-17
PT1479385E (pt) 2008-09-02
HK1025518A1 (en) 2000-11-17
CN100558356C (zh) 2009-11-11
CZ117199A3 (cs) 1999-07-14
EP1977749A1 (de) 2008-10-08
DK1479385T3 (da) 2008-08-04
WO1998016227A1 (en) 1998-04-23
EP0932402B1 (de) 2004-07-21
EP0932402A1 (de) 1999-08-04
CN1332661C (zh) 2007-08-22
NO991793D0 (no) 1999-04-15
CN1244122A (zh) 2000-02-09
PT932402E (pt) 2004-11-30
NO326822B1 (no) 2009-02-23

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