ATE264107T1 - Cyclooxygenaseinhibitor und salze von amidinderivaten, verfahren zu deren herstellung, deren verwendung als arzneiwirkstoffe sowie diese salze enthaltende arzneimittel - Google Patents
Cyclooxygenaseinhibitor und salze von amidinderivaten, verfahren zu deren herstellung, deren verwendung als arzneiwirkstoffe sowie diese salze enthaltende arzneimittelInfo
- Publication number
- ATE264107T1 ATE264107T1 AT96925786T AT96925786T ATE264107T1 AT E264107 T1 ATE264107 T1 AT E264107T1 AT 96925786 T AT96925786 T AT 96925786T AT 96925786 T AT96925786 T AT 96925786T AT E264107 T1 ATE264107 T1 AT E264107T1
- Authority
- AT
- Austria
- Prior art keywords
- salts
- medicinal
- amideine
- hibitor
- cyclooxygenase
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/606—Salicylic acid; Derivatives thereof having amino groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Surgery (AREA)
- Pulmonology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9514518.1A GB9514518D0 (en) | 1995-07-15 | 1995-07-15 | Guanidine salt inhibitors of NO synthase and cyclooxygenase |
PCT/FR1996/001095 WO1997003678A1 (fr) | 1995-07-15 | 1996-07-15 | Sels de derives d'amidine et d'inhibiteur de cyclooxygenase, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE264107T1 true ATE264107T1 (de) | 2004-04-15 |
Family
ID=10777740
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT96925786T ATE264107T1 (de) | 1995-07-15 | 1996-07-15 | Cyclooxygenaseinhibitor und salze von amidinderivaten, verfahren zu deren herstellung, deren verwendung als arzneiwirkstoffe sowie diese salze enthaltende arzneimittel |
Country Status (24)
Country | Link |
---|---|
US (1) | US6063807A (de) |
EP (1) | EP0839041B1 (de) |
JP (1) | JPH11509540A (de) |
CN (1) | CN1187056C (de) |
AT (1) | ATE264107T1 (de) |
AU (1) | AU704373B2 (de) |
CA (1) | CA2227034A1 (de) |
CZ (1) | CZ293676B6 (de) |
DE (1) | DE69632193T2 (de) |
DK (1) | DK0839041T3 (de) |
ES (1) | ES2219690T3 (de) |
GB (1) | GB9514518D0 (de) |
HU (1) | HUP9901331A3 (de) |
IL (1) | IL122737A (de) |
MX (1) | MX9800408A (de) |
NO (1) | NO980178D0 (de) |
NZ (1) | NZ313654A (de) |
PL (1) | PL185375B1 (de) |
PT (1) | PT839041E (de) |
RU (1) | RU2167856C2 (de) |
TW (1) | TW474908B (de) |
UA (1) | UA53624C2 (de) |
WO (1) | WO1997003678A1 (de) |
ZA (1) | ZA965969B (de) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5925351A (en) | 1995-07-21 | 1999-07-20 | Biogen, Inc. | Soluble lymphotoxin-β receptors and anti-lymphotoxin receptor and ligand antibodies as therapeutic agents for the treatment of immunological disease |
US7255854B1 (en) | 1996-10-25 | 2007-08-14 | Biogen, Inc. | Use of lymphotoxin-β receptor blocking agents for the treatment of antibody mediated immunological diseases |
NZ513960A (en) * | 1999-12-08 | 2004-02-27 | Pharmacia Corp | Cyclooxygenase-2 inhibitor compositions having rapid onset of therapeutic effect |
US20020147216A1 (en) * | 2000-01-31 | 2002-10-10 | Yuhong Zhou | Mucin synthesis inhibitors |
PE20020146A1 (es) * | 2000-07-13 | 2002-03-31 | Upjohn Co | Formulacion oftalmica que comprende un inhibidor de ciclooxigenasa-2 (cox-2) |
ATE366569T1 (de) | 2000-07-20 | 2007-08-15 | Lauras As | Verwendung von cox-2 inhibitoren als immunostimulantien zur behandlung von hiv oder aids |
US7115565B2 (en) * | 2001-01-18 | 2006-10-03 | Pharmacia & Upjohn Company | Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability |
MY137736A (en) | 2001-04-03 | 2009-03-31 | Pharmacia Corp | Reconstitutable parenteral composition |
UA80682C2 (en) * | 2001-08-06 | 2007-10-25 | Pharmacia Corp | Orally deliverable stabilized oral suspension formulation and process for the incresaing physical stability of thixotropic pharmaceutical composition |
AR038957A1 (es) | 2001-08-15 | 2005-02-02 | Pharmacia Corp | Terapia de combinacion para el tratamiento del cancer |
WO2003088958A2 (en) * | 2002-04-18 | 2003-10-30 | Pharmacia Corporation | Combinations of cox-2 inhibitors and other agents for the treatment of parkinson’s disease |
JP2005532293A (ja) * | 2002-04-18 | 2005-10-27 | ファルマシア・コーポレーション | シクロオキシゲナーゼ−2(cox2)阻害剤を用いたパーキンソン病の治療のための単剤療法 |
US8338376B2 (en) | 2006-10-20 | 2012-12-25 | Biogen Idec Ma Inc. | Compositions comprising variant LT-B-R-IG fusion proteins |
SG154441A1 (en) | 2006-10-20 | 2009-08-28 | Biogen Idec Inc | Treatment of demyelinating disorders |
US20090155430A1 (en) * | 2007-12-14 | 2009-06-18 | E.I. Du Pont De Nemours And Company | Films comprising liquid smoke and flavorants |
RU2478618C2 (ru) | 2010-03-15 | 2013-04-10 | Закрытое Акционерное Общество "Инфарма" | Новое биологически активное соединение n-[3-(4-нитрофениламино)-индол-2-илметилен] аминогуанидина гидрохлорид с противовоспалительной активностью |
RU2480452C1 (ru) * | 2012-01-11 | 2013-04-27 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Санкт-Петербургская государственная химико-фармацевтическая академия" Министерства здравоохранения Российской Федерации (ГБОУ ВПО СПХФА Минздрава России) | Способ получения n-4-нитрофенилбензамидина |
RU2684117C1 (ru) * | 2018-10-29 | 2019-04-04 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Санкт-Петербургский государственный химико-фармацевтический университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО СПХФУ Минздрава России) | Способ получения N-(нафталин-2-ил)бензамидина |
CN109678715B (zh) * | 2018-11-28 | 2019-11-12 | 中国药科大学 | 2-(1-酰氧正戊基)苯甲酸与碱性氨基酸或氨基胍形成的盐、其制备方法及用途 |
RU2694263C1 (ru) * | 2019-02-14 | 2019-07-11 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Санкт-Петербургский государственный химико-фармацевтический университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО СПХФУ Минздрава России) | Анальгезирующее и противовоспалительное средство с противомикробной активностью |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS56147761A (en) * | 1980-04-15 | 1981-11-16 | Banyu Pharmaceut Co Ltd | Salt compound consisting of acetylsalicylic acid and diguanidine, its preparation and agent containing the same as active constitutent |
US4324801A (en) * | 1981-04-21 | 1982-04-13 | Banyu Pharmaceutical Co. Ltd. | Phenylguanidine acetylsalicylate compounds, process for production thereof, and pharmaceutical composition thereof |
JPS61143320A (ja) * | 1985-11-08 | 1986-07-01 | Banyu Pharmaceut Co Ltd | 微小循環器系改善剤 |
GB9200114D0 (en) * | 1992-01-04 | 1992-02-26 | Scras | Dual inhibitors of no synthase and cyclooxygenase |
-
1995
- 1995-07-15 GB GBGB9514518.1A patent/GB9514518D0/en active Pending
-
1996
- 1996-07-12 ZA ZA965969A patent/ZA965969B/xx unknown
- 1996-07-15 PT PT96925786T patent/PT839041E/pt unknown
- 1996-07-15 JP JP9506344A patent/JPH11509540A/ja active Pending
- 1996-07-15 IL IL12273796A patent/IL122737A/xx not_active IP Right Cessation
- 1996-07-15 HU HU9901331A patent/HUP9901331A3/hu unknown
- 1996-07-15 PL PL96324490A patent/PL185375B1/pl not_active IP Right Cessation
- 1996-07-15 WO PCT/FR1996/001095 patent/WO1997003678A1/fr active IP Right Grant
- 1996-07-15 CZ CZ199873A patent/CZ293676B6/cs not_active IP Right Cessation
- 1996-07-15 MX MX9800408A patent/MX9800408A/es not_active IP Right Cessation
- 1996-07-15 UA UA98010194A patent/UA53624C2/uk unknown
- 1996-07-15 EP EP96925786A patent/EP0839041B1/de not_active Expired - Lifetime
- 1996-07-15 AU AU66175/96A patent/AU704373B2/en not_active Ceased
- 1996-07-15 CA CA002227034A patent/CA2227034A1/fr not_active Abandoned
- 1996-07-15 AT AT96925786T patent/ATE264107T1/de not_active IP Right Cessation
- 1996-07-15 ES ES96925786T patent/ES2219690T3/es not_active Expired - Lifetime
- 1996-07-15 RU RU98102777/04A patent/RU2167856C2/ru not_active IP Right Cessation
- 1996-07-15 DE DE69632193T patent/DE69632193T2/de not_active Expired - Fee Related
- 1996-07-15 US US08/981,682 patent/US6063807A/en not_active Expired - Fee Related
- 1996-07-15 CN CNB961955627A patent/CN1187056C/zh not_active Expired - Fee Related
- 1996-07-15 NZ NZ313654A patent/NZ313654A/en unknown
- 1996-07-15 DK DK96925786T patent/DK0839041T3/da active
- 1996-07-30 TW TW085109268A patent/TW474908B/zh not_active IP Right Cessation
-
1998
- 1998-01-14 NO NO980178A patent/NO980178D0/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
PL324490A1 (en) | 1998-05-25 |
PT839041E (pt) | 2004-09-30 |
NZ313654A (en) | 1999-10-28 |
MX9800408A (es) | 1998-04-30 |
PL185375B1 (pl) | 2003-04-30 |
ES2219690T3 (es) | 2004-12-01 |
HUP9901331A2 (hu) | 1999-08-30 |
EP0839041B1 (de) | 2004-04-14 |
ZA965969B (en) | 1997-10-31 |
NO980178L (no) | 1998-01-14 |
WO1997003678A1 (fr) | 1997-02-06 |
DE69632193D1 (de) | 2004-05-19 |
DK0839041T3 (da) | 2004-08-09 |
CA2227034A1 (fr) | 1997-02-06 |
CN1190890A (zh) | 1998-08-19 |
UA53624C2 (uk) | 2003-02-17 |
JPH11509540A (ja) | 1999-08-24 |
EP0839041A1 (de) | 1998-05-06 |
US6063807A (en) | 2000-05-16 |
CZ7398A3 (cs) | 1998-06-17 |
HUP9901331A3 (en) | 1999-11-29 |
NO980178D0 (no) | 1998-01-14 |
RU2167856C2 (ru) | 2001-05-27 |
IL122737A0 (en) | 1998-08-16 |
AU704373B2 (en) | 1999-04-22 |
AU6617596A (en) | 1997-02-18 |
GB9514518D0 (en) | 1995-09-13 |
DE69632193T2 (de) | 2005-05-04 |
CZ293676B6 (cs) | 2004-06-16 |
IL122737A (en) | 2003-01-12 |
CN1187056C (zh) | 2005-02-02 |
TW474908B (en) | 2002-02-01 |
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Legal Events
Date | Code | Title | Description |
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UEP | Publication of translation of european patent specification |
Ref document number: 0839041 Country of ref document: EP |
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REN | Ceased due to non-payment of the annual fee |