ATE261300T1 - Direktverpressbare, ultrafeine acetaminophenzusammensetzungen und verfahren zu ihrer herstellung - Google Patents
Direktverpressbare, ultrafeine acetaminophenzusammensetzungen und verfahren zu ihrer herstellungInfo
- Publication number
- ATE261300T1 ATE261300T1 AT00974090T AT00974090T ATE261300T1 AT E261300 T1 ATE261300 T1 AT E261300T1 AT 00974090 T AT00974090 T AT 00974090T AT 00974090 T AT00974090 T AT 00974090T AT E261300 T1 ATE261300 T1 AT E261300T1
- Authority
- AT
- Austria
- Prior art keywords
- granulation
- acetaminophen
- polyvinylpyrrolidone
- granulation composition
- lubricant
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/397,356 US6264983B1 (en) | 1999-09-16 | 1999-09-16 | Directly compressible, ultra fine acetaminophen compositions and process for producing same |
PCT/US2000/040864 WO2001019363A1 (en) | 1999-09-16 | 2000-09-11 | Directly compressible, ultra fine acetaminophen compositions and process for producing same |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE261300T1 true ATE261300T1 (de) | 2004-03-15 |
Family
ID=23570864
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT00974090T ATE261300T1 (de) | 1999-09-16 | 2000-09-11 | Direktverpressbare, ultrafeine acetaminophenzusammensetzungen und verfahren zu ihrer herstellung |
Country Status (11)
Country | Link |
---|---|
US (3) | US6264983B1 (de) |
EP (1) | EP1231911B1 (de) |
JP (1) | JP5080711B2 (de) |
CN (1) | CN1204882C (de) |
AT (1) | ATE261300T1 (de) |
AU (1) | AU767671B2 (de) |
DE (1) | DE60008912T2 (de) |
ES (1) | ES2213056T3 (de) |
MX (1) | MXPA02002669A (de) |
TR (1) | TR200200688T2 (de) |
WO (1) | WO2001019363A1 (de) |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6264983B1 (en) * | 1999-09-16 | 2001-07-24 | Rhodia, Inc. | Directly compressible, ultra fine acetaminophen compositions and process for producing same |
BRPI0015284B8 (pt) | 1999-10-29 | 2021-05-25 | Euro Celtique S/A | formulações de hidrocodona de liberação controlada |
US10179130B2 (en) | 1999-10-29 | 2019-01-15 | Purdue Pharma L.P. | Controlled release hydrocodone formulations |
DE19961897A1 (de) * | 1999-12-20 | 2001-06-28 | Basf Ag | Verwendung eines Filmüberzuges als geschmacksmaskierendes Coating von pharmazeutischen Darreichungsformen |
KR101045144B1 (ko) | 2000-10-30 | 2011-06-30 | 유로-셀티크 소시에떼 아노뉨 | 서방성 하이드로코돈 제형 |
US8101209B2 (en) | 2001-10-09 | 2012-01-24 | Flamel Technologies | Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles |
FR2830447B1 (fr) * | 2001-10-09 | 2004-04-16 | Flamel Tech Sa | Forme galenique orale microparticulaire pour la liberation retardee et controlee de principes actifs pharmaceutiques |
CN100577164C (zh) * | 2002-04-09 | 2010-01-06 | 弗拉梅技术公司 | 可改进释放阿莫西林的微囊含水混悬液形式的口服药物制剂 |
EP1492511B3 (de) | 2002-04-09 | 2012-05-02 | Flamel Technologies | Orale wässrige suspension, mikrokapseln enthaltend, zur kontrollierten freisetzung von wirkstoffen |
GB0209265D0 (en) | 2002-04-23 | 2002-06-05 | Novartis Ag | Organic compounds |
US20030203019A1 (en) * | 2002-04-30 | 2003-10-30 | Cornelius John Mark | Coated conditioners for use in foods and pharmaceuticals |
US20040086566A1 (en) * | 2002-11-04 | 2004-05-06 | Alpharma, Inc. | Waxy matrix dosage forms |
US7704528B2 (en) * | 2003-05-05 | 2010-04-27 | Isp Investments Inc. | Binder composition and method for processing poorly compressible drugs into tablets of predetermined hardness and friability |
DE10325989A1 (de) * | 2003-06-07 | 2005-01-05 | Glatt Gmbh | Verfahren zur Herstellung von und daraus resultierende Mikropellets sowie deren Verwendung |
MY148773A (en) * | 2004-03-17 | 2013-05-31 | Novartis Ag | Galenic formulations of organic compounds |
AU2006228947A1 (en) * | 2005-03-30 | 2006-10-05 | Mylan Pharmaceuticals Ulc | Combined-step process for pharmaceutical compositions |
US20060229689A1 (en) * | 2005-04-08 | 2006-10-12 | Led Technologies, Llc | LED therapy device |
CN1686089B (zh) * | 2005-05-08 | 2010-08-18 | 北京健健康康生物技术有限公司 | 一种可直接压片的木糖醇颗粒及其制备方法 |
WO2006133733A1 (en) * | 2005-06-13 | 2006-12-21 | Flamel Technologies | Oral dosage form comprising an antimisuse system |
US20080085318A1 (en) * | 2005-07-16 | 2008-04-10 | Cherukuri S R | Coated compositions and methods for preparing same |
US8652529B2 (en) * | 2005-11-10 | 2014-02-18 | Flamel Technologies | Anti-misuse microparticulate oral pharmaceutical form |
US8865743B2 (en) | 2006-01-06 | 2014-10-21 | Acelrx Pharmaceuticals, Inc. | Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain |
US8252328B2 (en) * | 2006-01-06 | 2012-08-28 | Acelrx Pharmaceuticals, Inc. | Bioadhesive drug formulations for oral transmucosal delivery |
US8202535B2 (en) | 2006-01-06 | 2012-06-19 | Acelrx Pharmaceuticals, Inc. | Small-volume oral transmucosal dosage forms |
US8535714B2 (en) | 2006-01-06 | 2013-09-17 | Acelrx Pharmaceuticals, Inc. | Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain |
US8252329B2 (en) * | 2007-01-05 | 2012-08-28 | Acelrx Pharmaceuticals, Inc. | Bioadhesive drug formulations for oral transmucosal delivery |
US20080069889A1 (en) * | 2006-03-07 | 2008-03-20 | Cherukuri S R | Compressible resilient granules and formulations prepared therefrom |
US20070212417A1 (en) * | 2006-03-07 | 2007-09-13 | Cherukuri S R | Compressible resilient granules and formulations prepared therefrom |
WO2007103528A2 (en) * | 2006-03-07 | 2007-09-13 | Capricorn Pharma, Inc | Compressible resilient granules and formulations prepared therefrom |
GB2443793B (en) * | 2006-04-05 | 2010-12-01 | Reckitt Benckiser Healthcare | Product, method of manufacture and use |
EP3269346A1 (de) * | 2007-08-07 | 2018-01-17 | Acelrx Pharmaceuticals, Inc. | Vorrichtung zur oralen medikamentengabe |
US20100055180A1 (en) * | 2007-10-10 | 2010-03-04 | Mallinckrodt Baker, Inc. | Directly Compressible Granular Microcrystalline Cellulose Based Excipient, Manufacturing Process and Use Thereof |
AU2008311289A1 (en) * | 2007-10-10 | 2009-04-16 | Avantor Performance Materials, Inc. | Directly compressible high functionality granular microcrystalline cellulose based excipient, manufacturing process and use thereof |
GB0813929D0 (en) * | 2008-07-30 | 2008-09-03 | Glaxo Group Ltd | Novel method |
US8945592B2 (en) * | 2008-11-21 | 2015-02-03 | Acelrx Pharmaceuticals, Inc. | Sufentanil solid dosage forms comprising oxygen scavengers and methods of using the same |
US20110091544A1 (en) * | 2009-10-16 | 2011-04-21 | Acelrx Pharmaceuticals, Inc. | Compositions and Methods for Mild Sedation, Anxiolysis and Analgesia in the Procedural Setting |
CA3042642A1 (en) | 2013-08-12 | 2015-02-19 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded immediate release abuse deterrent pill |
JP2015063521A (ja) * | 2013-09-02 | 2015-04-09 | 科研製薬株式会社 | 高い薬物含有率を有する錠剤及びその製造方法 |
US9492444B2 (en) | 2013-12-17 | 2016-11-15 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
US10172797B2 (en) | 2013-12-17 | 2019-01-08 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
PL3154528T3 (pl) * | 2014-06-11 | 2023-07-10 | SpecGx LLC | Suszone rozpyłowo kompozycje o różnych profilach rozpuszczania i sposoby ich wytwarzania |
JP6371463B2 (ja) | 2014-07-17 | 2018-08-08 | ファーマシューティカル マニュファクチュアリング リサーチ サービシズ,インコーポレーテッド | 即時放出性乱用抑止性液体充填剤形 |
US20160106737A1 (en) | 2014-10-20 | 2016-04-21 | Pharmaceutical Manufacturing Research Services, Inc. | Extended Release Abuse Deterrent Liquid Fill Dosage Form |
CN105310990B (zh) * | 2014-12-04 | 2018-01-19 | 蚌埠丰原涂山制药有限公司 | 一种防止粘冲和裂片的对乙酰氨酚片及其制备方法 |
EP3456324B1 (de) * | 2016-05-10 | 2023-04-05 | Nippon Zoki Pharmaceutical Co., Ltd. | Verfahren zur herstellung eines acetaminophenpräparats |
CA3081181A1 (en) * | 2017-11-09 | 2019-05-16 | Nippon Zoki Pharmaceutical Co., Ltd. | Acetaminophen preparation, and method for producing same |
CN109602709B (zh) * | 2018-10-08 | 2021-05-04 | 江西济民可信药业有限公司 | 一种提高小儿氨酚黄那敏颗粒得率和均一性的制备方法 |
CN111374953A (zh) * | 2018-12-31 | 2020-07-07 | 上海鼎雅药物化学科技有限公司 | 对乙酰氨基酚片及其制备工艺 |
CN111920774B (zh) * | 2020-08-06 | 2022-08-12 | 河北君临药业有限公司 | 一种对乙酰氨基酚片及其制备方法 |
Family Cites Families (31)
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US3279998A (en) | 1962-06-22 | 1966-10-18 | Smith Kline French Lab | Method of preparing sustained release tablets |
US3400197A (en) | 1965-01-26 | 1968-09-03 | Robins Co Inc A H | Compressible sustained release pharmaceutical tablet lipid-colloidal silica gel matrix fragment granules |
US4117116A (en) * | 1973-09-10 | 1978-09-26 | William H. Rorer, Inc. | Method for lowering the viscosity of certain agents |
US4013785A (en) | 1975-03-21 | 1977-03-22 | Bristol-Myers Company | Apap tablet containing fumed silica and process for manufacturing same |
US4439453A (en) | 1980-12-22 | 1984-03-27 | Monsanto Company | Directly compressible acetaminophen granulation |
US4401665A (en) | 1981-04-14 | 1983-08-30 | Bristol-Myers Company | Sleep-aid composition containing an analgesic and diphenhydramine dihydrogencitrate, and method of use |
US4882167A (en) | 1983-05-31 | 1989-11-21 | Jang Choong Gook | Dry direct compression compositions for controlled release dosage forms |
US4600579A (en) | 1983-06-07 | 1986-07-15 | Mallinckrodt, Inc. | N-acetyl-p-aminophenol compositions containing partially gelatinized starch and method for preparing same |
US4661521A (en) | 1984-04-30 | 1987-04-28 | Mallinckrodt, Inc. | Direct tableting acetaminophen compositions |
US4631284A (en) | 1984-11-19 | 1986-12-23 | Mallinckrodt, Inc. | Acetaminophen compositions containing low doses of chlorpheniramine maleate, method for preparing same and tablets formed therefrom |
US4710519A (en) | 1985-09-30 | 1987-12-01 | Basf Corporation | Process for preparing spray dried acetaminophen powder and the powder prepared thereby |
US4757090A (en) | 1986-07-14 | 1988-07-12 | Mallinckrodt, Inc. | Direct tableting acetaminophen compositions |
US4820522A (en) | 1987-07-27 | 1989-04-11 | Mcneilab, Inc. | Oral sustained release acetaminophen formulation and process |
US4968509A (en) | 1987-07-27 | 1990-11-06 | Mcneilab, Inc. | Oral sustained release acetaminophen formulation and process |
US5073380A (en) | 1987-07-27 | 1991-12-17 | Mcneil-Ppc, Inc. | Oral sustained release pharmaceutical formulation and process |
US4894236A (en) | 1988-01-12 | 1990-01-16 | Choong-Gook Jang | Direct compression tablet binders for acetaminophen |
US4990535A (en) * | 1989-05-03 | 1991-02-05 | Schering Corporation | Pharmaceutical composition comprising loratadine, ibuprofen and pseudoephedrine |
US5198228A (en) | 1989-09-14 | 1993-03-30 | Hoechst-Roussel Pharmaceuticals Inc. | Direct dry compressible acetaminophen tablet |
US5130140A (en) | 1989-09-14 | 1992-07-14 | Hoeschst-Roussel Pharmaceuticals Inc. | Method of making direct dry compressible acetaminophen composition |
US5037658A (en) | 1989-09-14 | 1991-08-06 | Hoechst-Roussel Pharmaceuticals, Inc. | Direct dry compressible acetaminophen composition |
US4983399A (en) | 1989-10-18 | 1991-01-08 | Eastman Kodak Company | Direct compression carrier composition |
JPH044297A (ja) | 1990-04-23 | 1992-01-08 | Tokai Rika Co Ltd | 電気摺動接触器用潤滑剤 |
US5453281A (en) | 1992-03-17 | 1995-09-26 | Lafayette Applied Chemistry, Inc. | Compositions utilizing small granule starch |
JPH0656659A (ja) * | 1992-06-10 | 1994-03-01 | Natl Sci Council | 直接打錠できる薬学組成物及びその錠剤の製造法 |
US5635208A (en) * | 1993-07-20 | 1997-06-03 | Mcneil-Ppc, Inc. | Granulation process for producing an acetaminophen and diphenhydramine hydrochloride composition and composition produced by same |
US5895664A (en) | 1993-09-10 | 1999-04-20 | Fuisz Technologies Ltd. | Process for forming quickly dispersing comestible unit and product therefrom |
US5370878A (en) | 1993-09-30 | 1994-12-06 | Hallmark Pharmaceuticals, Inc. | Method for preparing a direct compression granulated acetaminophen composition |
JP2994956B2 (ja) * | 1994-05-31 | 1999-12-27 | 信越化学工業株式会社 | 低置換度ヒドロキシプロピルセルロース、その組成物およびその錠剤 |
US5965164A (en) * | 1994-10-28 | 1999-10-12 | Fuisz Technologies Ltd. | Recipient-dosage delivery system |
US5733578A (en) | 1995-11-15 | 1998-03-31 | Edward Mendell Co., Inc. | Directly compressible high load acetaminophen formulations |
US6264983B1 (en) * | 1999-09-16 | 2001-07-24 | Rhodia, Inc. | Directly compressible, ultra fine acetaminophen compositions and process for producing same |
-
1999
- 1999-09-16 US US09/397,356 patent/US6264983B1/en not_active Expired - Lifetime
-
2000
- 2000-09-11 DE DE60008912T patent/DE60008912T2/de not_active Expired - Lifetime
- 2000-09-11 AT AT00974090T patent/ATE261300T1/de not_active IP Right Cessation
- 2000-09-11 MX MXPA02002669A patent/MXPA02002669A/es active IP Right Grant
- 2000-09-11 ES ES00974090T patent/ES2213056T3/es not_active Expired - Lifetime
- 2000-09-11 TR TR2002/00688T patent/TR200200688T2/xx unknown
- 2000-09-11 CN CN00812944.4A patent/CN1204882C/zh not_active Expired - Lifetime
- 2000-09-11 EP EP00974090A patent/EP1231911B1/de not_active Expired - Lifetime
- 2000-09-11 WO PCT/US2000/040864 patent/WO2001019363A1/en active IP Right Grant
- 2000-09-11 AU AU12513/01A patent/AU767671B2/en not_active Expired
- 2000-09-11 JP JP2001522997A patent/JP5080711B2/ja not_active Expired - Lifetime
-
2001
- 2001-03-14 US US09/808,374 patent/US6607750B2/en not_active Expired - Lifetime
-
2003
- 2003-06-18 US US10/464,629 patent/US20030215504A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US6607750B2 (en) | 2003-08-19 |
ES2213056T3 (es) | 2004-08-16 |
CN1374862A (zh) | 2002-10-16 |
US6264983B1 (en) | 2001-07-24 |
US20030215504A1 (en) | 2003-11-20 |
DE60008912D1 (de) | 2004-04-15 |
DE60008912T2 (de) | 2004-08-19 |
TR200200688T2 (tr) | 2002-06-21 |
EP1231911B1 (de) | 2004-03-10 |
JP5080711B2 (ja) | 2012-11-21 |
CN1204882C (zh) | 2005-06-08 |
AU1251301A (en) | 2001-04-17 |
US20010044472A1 (en) | 2001-11-22 |
MXPA02002669A (es) | 2002-10-23 |
AU767671B2 (en) | 2003-11-20 |
EP1231911A1 (de) | 2002-08-21 |
JP2003509368A (ja) | 2003-03-11 |
WO2001019363A1 (en) | 2001-03-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |