ATE261278T1 - Mikrokapseln zum verabreichen von neuroaktiven wirkstoffen - Google Patents
Mikrokapseln zum verabreichen von neuroaktiven wirkstoffenInfo
- Publication number
- ATE261278T1 ATE261278T1 AT95924078T AT95924078T ATE261278T1 AT E261278 T1 ATE261278 T1 AT E261278T1 AT 95924078 T AT95924078 T AT 95924078T AT 95924078 T AT95924078 T AT 95924078T AT E261278 T1 ATE261278 T1 AT E261278T1
- Authority
- AT
- Austria
- Prior art keywords
- mum
- microspheres
- neuroactive
- microcapsules
- ingredients
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0085—Brain, e.g. brain implants; Spinal cord
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5063—Compounds of unknown constitution, e.g. material from plants or animals
- A61K9/5068—Cell membranes or bacterial membranes enclosing drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/906—Drug delivery
- Y10S977/907—Liposome
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Molecular Biology (AREA)
- Psychology (AREA)
- Botany (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/268,177 US6517859B1 (en) | 1990-05-16 | 1994-06-29 | Microcapsules for administration of neuroactive agents |
PCT/US1995/008123 WO1996000537A1 (en) | 1994-06-29 | 1995-06-28 | Microcapsules for administration of neuroactive agents |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE261278T1 true ATE261278T1 (de) | 2004-03-15 |
Family
ID=23021810
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT95924078T ATE261278T1 (de) | 1994-06-29 | 1995-06-28 | Mikrokapseln zum verabreichen von neuroaktiven wirkstoffen |
Country Status (8)
Country | Link |
---|---|
US (2) | US6517859B1 (de) |
EP (1) | EP0767634B1 (de) |
JP (1) | JPH10506373A (de) |
AT (1) | ATE261278T1 (de) |
DE (1) | DE69532673T2 (de) |
DK (1) | DK0767634T3 (de) |
ES (1) | ES2217281T3 (de) |
WO (1) | WO1996000537A1 (de) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5827819A (en) * | 1990-11-01 | 1998-10-27 | Oregon Health Sciences University | Covalent polar lipid conjugates with neurologically active compounds for targeting |
US5543390A (en) | 1990-11-01 | 1996-08-06 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University | Covalent microparticle-drug conjugates for biological targeting |
WO1999002139A1 (en) * | 1997-07-10 | 1999-01-21 | Keith Baker | Methods for universally distributing therapeutic agents to the brain |
US7045543B2 (en) | 2001-11-05 | 2006-05-16 | Enzrel Inc. | Covalent conjugates of biologically-active compounds with amino acids and amino acid derivatives for targeting to physiologically-protected sites |
US7378111B2 (en) * | 2002-02-20 | 2008-05-27 | The Trustees Of The University Of Pennsylvania | Regulation of GSK-3α activity for the treatment or prevention of Alzheimer's disease |
CN100363085C (zh) * | 2002-06-12 | 2008-01-23 | 创普太克公司 | 包封的活性颗粒及其制备和使用方法 |
KR101152183B1 (ko) | 2003-03-31 | 2012-06-15 | 타이탄 파머슈티컬즈 인코퍼레이티드 | 도파민 아고니스트의 지속 방출을 위한 이식가능한 폴리머디바이스 |
EP1730516A1 (de) * | 2004-03-30 | 2006-12-13 | Pfizer Products Incorporated | Verfahren und vorrichtung zur bewertung pharmazeutischer zusammensetzungen |
WO2006085149A2 (en) | 2004-12-22 | 2006-08-17 | Neurochem (International) Limited | Methods and compositions for treating amyloid-related diseases |
US20060228420A1 (en) * | 2005-03-15 | 2006-10-12 | Queen Mary & Westfield College | Pharmaceutical compositions comprising microparticles for delivery into neurons |
US7855279B2 (en) * | 2005-09-27 | 2010-12-21 | Amunix Operating, Inc. | Unstructured recombinant polymers and uses thereof |
US20090099031A1 (en) * | 2005-09-27 | 2009-04-16 | Stemmer Willem P | Genetic package and uses thereof |
EP1929073A4 (de) * | 2005-09-27 | 2010-03-10 | Amunix Inc | Proteinöse arzneimittel und ihre verwendung |
US7846445B2 (en) * | 2005-09-27 | 2010-12-07 | Amunix Operating, Inc. | Methods for production of unstructured recombinant polymers and uses thereof |
US20070142287A1 (en) * | 2005-12-20 | 2007-06-21 | Biomed Solutions, Llc | Compositions And Methods For Treatment Of Cancer |
EP3363455A1 (de) | 2005-12-30 | 2018-08-22 | Zensun (Shanghai) Science & Technology, Co., Ltd. | Verlängerte freisetzung von neuregulin für verbesserte herzfunktion |
US20070231360A1 (en) * | 2006-03-28 | 2007-10-04 | Minu, L.L.C. | Neural conduit agent dissemination |
US8945287B2 (en) * | 2006-05-09 | 2015-02-03 | Cocona, Inc. | Active particle-enhanced membrane and methods for making and using the same |
DK2089417T3 (en) | 2006-10-12 | 2015-03-23 | Bhi Ltd Partnership | Methods, Compounds, Compositions and Vehicles for Delivery of 3-Amion-1-Propanesulfonic Acid |
WO2008063557A2 (en) * | 2006-11-16 | 2008-05-29 | Gregory Haggquist | Exothermic-enhanced articles and methods for making the same |
WO2008065502A1 (en) * | 2006-11-29 | 2008-06-05 | Pfizer Products Inc. | Pharmaceutical compositions based on a) nanoparticles comprising enteric polymers and b) casein |
WO2008122044A2 (en) * | 2007-04-02 | 2008-10-09 | Georgia Tech Research Corporation | Implantable device for communicating with biological tissue |
US20100119612A1 (en) * | 2007-04-17 | 2010-05-13 | Bend Research, Inc | Nanoparticles comprising non-crystalline drug |
WO2008135828A2 (en) | 2007-05-03 | 2008-11-13 | Pfizer Products Inc. | Nanoparticles comprising a drug, ethylcellulose, and a bile salt |
US20100080852A1 (en) * | 2007-05-03 | 2010-04-01 | Ronald Arthur Beyerinck | Phamaceutical composition comprising nanoparticles and casein |
US8703204B2 (en) * | 2007-05-03 | 2014-04-22 | Bend Research, Inc. | Nanoparticles comprising a cholesteryl ester transfer protein inhibitor and anon-ionizable polymer |
EP2162120B1 (de) * | 2007-06-04 | 2016-05-04 | Bend Research, Inc | Nanopartikel mit nicht ionisierbarem zellulosepolymer und amphipilem nicht ionisierbarem blockcopolymer |
WO2008149230A2 (en) | 2007-06-04 | 2008-12-11 | Pfizer Products Inc. | Nanoparticles comprising drug, a non-ionizable cellulosic polymer and tocopheryl polyethylene glycol succinate |
EP2178518A2 (de) * | 2007-07-13 | 2010-04-28 | Bend Research, Inc | Nanopartikel mit ionisierbaren und schwach wasserlöslichen zellulose-polymeren |
US8933197B2 (en) * | 2007-08-15 | 2015-01-13 | Amunix Operating Inc. | Compositions comprising modified biologically active polypeptides |
WO2009073215A1 (en) * | 2007-12-06 | 2009-06-11 | Bend Research, Inc. | Pharmaceutical compositions comprising nanoparticles and a resuspending material |
US9233078B2 (en) * | 2007-12-06 | 2016-01-12 | Bend Research, Inc. | Nanoparticles comprising a non-ionizable polymer and an Amine-functionalized methacrylate copolymer |
EP2342356A4 (de) | 2008-09-29 | 2012-11-21 | Univ Ben Gurion | Amyloid-beta-peptidasen und verwendungsverfahren dafür |
WO2010091122A1 (en) | 2009-02-03 | 2010-08-12 | Amunix, Inc. | Extended recombinant polypeptides and compositions comprising same |
US20120263701A1 (en) | 2009-08-24 | 2012-10-18 | Volker Schellenberger | Coagulation factor vii compositions and methods of making and using same |
CA2778678A1 (en) | 2009-10-30 | 2011-05-05 | Cns Therapeutics, Inc. | Improved neurturin molecules |
LT2814840T (lt) | 2012-02-15 | 2020-02-25 | Bioverativ Therapeutics Inc. | Faktoriaus viii kompozicijos ir jų gavimo ir naudojimo būdai |
EP2822577B1 (de) | 2012-02-15 | 2019-02-06 | Bioverativ Therapeutics Inc. | Rekombinante faktor-viii-proteine |
EP3033097B1 (de) | 2013-08-14 | 2021-03-10 | Bioverativ Therapeutics Inc. | Faktor viii-xten fusionen sowie ihre verwendungen. |
AU2016301303B2 (en) | 2015-08-03 | 2021-10-07 | Bioverativ Therapeutics Inc. | Factor IX fusion proteins and methods of making and using same |
CN106519205B (zh) * | 2016-10-26 | 2018-04-10 | 河南工程学院 | 一种载药多孔phbv接枝多巴胺微球的制备方法及应用 |
HUE058207T2 (hu) | 2017-01-31 | 2022-07-28 | Veru Inc | Készítmények és módszerek gonadotropin felszabadító hormon (GNRH) antagonisták elnyújtott idejû felszabadítására |
CN110997693A (zh) | 2017-06-07 | 2020-04-10 | 阿德克斯公司 | τ聚集抑制剂 |
EP3668886A2 (de) | 2017-08-18 | 2020-06-24 | Adrx, Inc. | Peptidinhibitoren der tau-aggregation |
AU2019270184A1 (en) | 2018-05-18 | 2020-11-26 | Bioverativ Therapeutics Inc. | Methods of treating hemophilia A |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
JPS6048923A (ja) | 1983-08-25 | 1985-03-16 | Mitsui Toatsu Chem Inc | 微小粒子の製造方法 |
JPS60100516A (ja) | 1983-11-04 | 1985-06-04 | Takeda Chem Ind Ltd | 徐放型マイクロカプセルの製造法 |
US4962091A (en) * | 1986-05-23 | 1990-10-09 | Syntex (U.S.A.) Inc. | Controlled release of macromolecular polypeptides |
US4832686A (en) | 1986-06-24 | 1989-05-23 | Anderson Mark E | Method for administering interleukin-2 |
JPS63122620A (ja) * | 1986-11-12 | 1988-05-26 | Sanraku Inc | ポリ乳酸マイクロスフエア及びその製造方法 |
US4883666A (en) * | 1987-04-29 | 1989-11-28 | Massachusetts Institute Of Technology | Controlled drug delivery system for treatment of neural disorders |
US4882686A (en) * | 1987-06-22 | 1989-11-21 | Eastman Kodak Company | Printing apparatus with improved data formatting circuitry |
IL92344A0 (en) | 1989-01-04 | 1990-07-26 | Gist Brocades Nv | Microencapsulation of bioactive substances in biocompatible polymers,microcapsules obtained and pharmaceutical preparation comprising said microcapsules |
JP2738881B2 (ja) | 1989-06-21 | 1998-04-08 | ブラウン ユニバーシティ リサーチ ファウンデイション | 神経治療システム |
CH679207A5 (de) | 1989-07-28 | 1992-01-15 | Debiopharm Sa | |
US5225205A (en) | 1989-07-28 | 1993-07-06 | Debiopharm S.A. | Pharmaceutical composition in the form of microparticles |
JP3187410B2 (ja) | 1989-08-10 | 2001-07-11 | 住友製薬株式会社 | 脳内投与用徐放性製剤 |
ES2185615T3 (es) * | 1990-05-16 | 2003-05-01 | Southern Res Inst | Uso y liberacion controlada de las microcapsulas para estimular el crecimiento de la fibra nerviosa. |
-
1994
- 1994-06-29 US US08/268,177 patent/US6517859B1/en not_active Expired - Fee Related
-
1995
- 1995-06-28 WO PCT/US1995/008123 patent/WO1996000537A1/en active IP Right Grant
- 1995-06-28 JP JP8503413A patent/JPH10506373A/ja not_active Ceased
- 1995-06-28 ES ES95924078T patent/ES2217281T3/es not_active Expired - Lifetime
- 1995-06-28 DK DK95924078T patent/DK0767634T3/da active
- 1995-06-28 AT AT95924078T patent/ATE261278T1/de not_active IP Right Cessation
- 1995-06-28 EP EP95924078A patent/EP0767634B1/de not_active Expired - Lifetime
- 1995-06-28 DE DE69532673T patent/DE69532673T2/de not_active Expired - Fee Related
-
2001
- 2001-08-21 US US09/934,382 patent/US6565875B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US6517859B1 (en) | 2003-02-11 |
EP0767634B1 (de) | 2004-03-10 |
JPH10506373A (ja) | 1998-06-23 |
EP0767634A1 (de) | 1997-04-16 |
DE69532673T2 (de) | 2005-02-17 |
WO1996000537A1 (en) | 1996-01-11 |
DK0767634T3 (da) | 2004-07-19 |
US6565875B2 (en) | 2003-05-20 |
EP0767634A4 (de) | 1998-09-30 |
DE69532673D1 (de) | 2004-04-15 |
US20020094347A1 (en) | 2002-07-18 |
ES2217281T3 (es) | 2004-11-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification |
Ref document number: 0767634 Country of ref document: EP |
|
REN | Ceased due to non-payment of the annual fee |