ATE260103T1 - Ortho-anthranilamide derivate als antikoagulantien - Google Patents
Ortho-anthranilamide derivate als antikoagulantienInfo
- Publication number
- ATE260103T1 ATE260103T1 AT98963519T AT98963519T ATE260103T1 AT E260103 T1 ATE260103 T1 AT E260103T1 AT 98963519 T AT98963519 T AT 98963519T AT 98963519 T AT98963519 T AT 98963519T AT E260103 T1 ATE260103 T1 AT E260103T1
- Authority
- AT
- Austria
- Prior art keywords
- anticoagulants
- ortho
- anthranilamide derivatives
- anthranilamide
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D333/70—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US99428497A | 1997-12-19 | 1997-12-19 | |
| US09/187,459 US6140351A (en) | 1997-12-19 | 1998-11-05 | Ortho-anthranilamide derivatives as anti-coagulants |
| PCT/EP1998/007650 WO1999032477A1 (en) | 1997-12-19 | 1998-11-27 | Ortho-anthranilamide derivatives as anti-coagulants |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE260103T1 true ATE260103T1 (de) | 2004-03-15 |
Family
ID=26883056
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98963519T ATE260103T1 (de) | 1997-12-19 | 1998-11-27 | Ortho-anthranilamide derivate als antikoagulantien |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US6380221B1 (de) |
| EP (1) | EP1040108B1 (de) |
| JP (1) | JP3811006B2 (de) |
| CN (1) | CN1143855C (de) |
| AT (1) | ATE260103T1 (de) |
| AU (1) | AU751856B2 (de) |
| CA (1) | CA2315070A1 (de) |
| DE (1) | DE69821985T2 (de) |
| DK (1) | DK1040108T3 (de) |
| ES (1) | ES2215337T3 (de) |
| HU (1) | HUP0101172A3 (de) |
| IL (1) | IL135536A0 (de) |
| NO (1) | NO20003111L (de) |
| NZ (1) | NZ503809A (de) |
| PL (1) | PL341044A1 (de) |
| PT (1) | PT1040108E (de) |
| RU (1) | RU2226529C2 (de) |
| SK (1) | SK9432000A3 (de) |
| WO (1) | WO1999032477A1 (de) |
Families Citing this family (79)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2208737T3 (es) | 1995-03-10 | 2004-06-16 | Berlex Laboratories, Inc. | Derivados de benzamidina, su preparacion y su utilizacion como anticoagulantes. |
| SK29599A3 (en) | 1996-09-12 | 1999-08-06 | Schering Ag | Benzamidine derivatives substituted by cyclic amino acid or cyclic hydroxy acid derivatives and their use as anti-coagulants |
| US6004985A (en) | 1996-10-09 | 1999-12-21 | Berlex Laboratories, Inc. | Thio acid derived monocylic N-heterocyclics as anticoagulants |
| US6313122B1 (en) | 1997-06-26 | 2001-11-06 | Eli Lilly And Company | Antithrombotic agents |
| JP2002510313A (ja) | 1997-06-26 | 2002-04-02 | イーライ・リリー・アンド・カンパニー | 抗血栓物質 |
| ES2241151T3 (es) | 1997-06-26 | 2005-10-16 | Eli Lilly And Company | Agentes antitromboticos. |
| EP0999834B1 (de) * | 1997-06-26 | 2005-10-12 | Eli Lilly And Company | Antithrombosemittel |
| US6291514B1 (en) | 1998-02-09 | 2001-09-18 | 3-Dimensional Pharmaceuticals, Inc. | Heteroaryl amidines, methylamidines and guanidines, preparation thereof, and use thereof as protease inhibitors |
| GB9824579D0 (en) | 1998-11-10 | 1999-01-06 | Novartis Ag | Organic compounds |
| US6127376A (en) | 1998-12-04 | 2000-10-03 | Berlex Laboratories, Inc. | Aryl and heterocyclyl substituted pyrimidine derivatives as anti-coagulants |
| JP2002533454A (ja) | 1998-12-23 | 2002-10-08 | イーライ・リリー・アンド・カンパニー | 芳香族アミド類 |
| WO2000039111A1 (en) | 1998-12-23 | 2000-07-06 | Eli Lilly And Company | Antithrombotic amides |
| US6689780B1 (en) | 1998-12-23 | 2004-02-10 | Eli Lilly And Company | Heteroroaromatic amides as inhibitor of factor Xa |
| AU3742100A (en) * | 1999-03-16 | 2000-10-04 | Glaxo Group Limited | Nuclear receptor arylating compounds |
| ES2248084T3 (es) | 1999-06-14 | 2006-03-16 | Eli Lilly And Company | Inhibidores de serinproteasa. |
| US6720317B1 (en) | 1999-09-17 | 2004-04-13 | Millennium Pharmaceuticals, Inc. | Inhibitors of factor Xa |
| US6844367B1 (en) | 1999-09-17 | 2005-01-18 | Millennium Pharmaceuticals, Inc. | Benzamides and related inhibitors of factor Xa |
| EP1235807A1 (de) * | 1999-11-24 | 2002-09-04 | Millennium Pharmaceuticals, Inc. | Auf b-aminosäure, asparaginsäure und diaminopropionsäure basierende inhibitoren von faktor xa |
| ES2254385T3 (es) | 2000-02-29 | 2006-06-16 | Millennium Pharmaceuticals, Inc. | Benzamidas e inhibidores relacionados del factor xa. |
| MY138097A (en) * | 2000-03-22 | 2009-04-30 | Du Pont | Insecticidal anthranilamides |
| AU776053B2 (en) | 2000-03-31 | 2004-08-26 | Astellas Pharma Inc. | Diazepan derivatives or salts thereof |
| DE60130771T2 (de) | 2000-07-27 | 2008-07-17 | Eli Lilly And Co., Indianapolis | Substituierte heterocyclische amide |
| AU2002211281A1 (en) * | 2000-09-29 | 2002-04-08 | Millenium Pharmaceuticals, Inc. | Quaternary amidino based inhibitors of factor xa |
| WO2002026712A2 (en) * | 2000-09-29 | 2002-04-04 | Millennium Pharmaceuticals, Inc. | Quaternary amines and related inhibitors of factor xa |
| US6710058B2 (en) | 2000-11-06 | 2004-03-23 | Bristol-Myers Squibb Pharma Company | Monocyclic or bicyclic carbocycles and heterocycles as factor Xa inhibitors |
| ATE323071T1 (de) | 2000-11-22 | 2006-04-15 | Astellas Pharma Inc | Substituierte phenolderivate und deren salze als hemmstoffe von koagulations faktor x |
| AU2001297648A1 (en) * | 2000-11-28 | 2002-08-28 | Eli Lilly And Company | Substituted carboxamides as inhibitors of factor xa |
| DE10061876A1 (de) * | 2000-12-12 | 2002-06-20 | Aventis Pharma Gmbh | Arylierte Furan- und Thiophencarbonsäureamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen |
| US7105682B2 (en) | 2001-01-12 | 2006-09-12 | Amgen Inc. | Substituted amine derivatives and methods of use |
| US20030134836A1 (en) | 2001-01-12 | 2003-07-17 | Amgen Inc. | Substituted arylamine derivatives and methods of use |
| US7102009B2 (en) | 2001-01-12 | 2006-09-05 | Amgen Inc. | Substituted amine derivatives and methods of use |
| US6878714B2 (en) | 2001-01-12 | 2005-04-12 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
| US6995162B2 (en) * | 2001-01-12 | 2006-02-07 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
| US6998408B2 (en) | 2001-03-23 | 2006-02-14 | Bristol-Myers Squibb Pharma Company | 6-5, 6-6, or 6-7 Heterobicycles as factor Xa inhibitors |
| US6864255B2 (en) | 2001-04-11 | 2005-03-08 | Amgen Inc. | Substituted triazinyl amide derivatives and methods of use |
| DE10121003A1 (de) * | 2001-04-28 | 2002-12-19 | Aventis Pharma Gmbh | Anthranilsäureamide, Verfahren zur Herstellung, ihrer Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen |
| SE0102764D0 (sv) | 2001-08-17 | 2001-08-17 | Astrazeneca Ab | Compounds |
| JP4249621B2 (ja) | 2001-09-21 | 2009-04-02 | ブリストル−マイヤーズ スクイブ カンパニー | 第Ｘａ因子阻害剤としてのラクタム含有化合物およびその誘導体 |
| TWI320039B (en) | 2001-09-21 | 2010-02-01 | Lactam-containing compounds and derivatives thereof as factor xa inhibitors | |
| TW200302225A (en) | 2001-12-04 | 2003-08-01 | Bristol Myers Squibb Co | Substituted amino methyl factor Xa inhibitors |
| US7449457B2 (en) | 2001-12-07 | 2008-11-11 | Eli Lilly And Company | Substituted heterocyclic carboxamides with antithrombotic activity |
| TW200307667A (en) | 2002-05-06 | 2003-12-16 | Bristol Myers Squibb Co | Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors |
| EP1505966A4 (de) | 2002-05-10 | 2006-08-30 | Bristol Myers Squibb Co | 1,1-disubstituierte cycloalkyl-derivate als faktor xa hemmer |
| SE0201937D0 (sv) | 2002-06-20 | 2002-06-20 | Astrazeneca Ab | Therapeutic agents |
| ATE386013T1 (de) | 2002-06-20 | 2008-03-15 | Astrazeneca Ab | Ortho-substituierte benzoesäurederivate zur behandlung von insulinresistenz |
| US7351858B2 (en) | 2002-06-20 | 2008-04-01 | Astrazeneca Ab | Ortho-substituted benzoic acid derivatives for the treatment of insulin resistance |
| US7307088B2 (en) | 2002-07-09 | 2007-12-11 | Amgen Inc. | Substituted anthranilic amide derivatives and methods of use |
| WO2004050637A2 (en) | 2002-12-03 | 2004-06-17 | Axys Pharmaceuticals, Inc. | 2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine derivatives as factor viia inhibitors |
| US7696225B2 (en) | 2003-01-06 | 2010-04-13 | Osi Pharmaceuticals, Inc. | (2-carboxamido)(3-Amino) thiophene compounds |
| TWI299664B (en) | 2003-01-06 | 2008-08-11 | Osi Pharm Inc | (2-carboxamido)(3-amino)thiophene compounds |
| US7122557B2 (en) | 2003-03-18 | 2006-10-17 | Bristol-Myers Squibb Company | Sulfonyl-amidino-containing and tetrahydropyrimidino-containing compounds as factor Xa inhibitors |
| US7205318B2 (en) | 2003-03-18 | 2007-04-17 | Bristol-Myers Squibb Company | Lactam-containing cyclic diamines and derivatives as a factor Xa inhibitors |
| EP1479680A1 (de) * | 2003-05-19 | 2004-11-24 | Aventis Pharma Deutschland GmbH | Azaindole-Derivative als Faktor Xa Hemmer |
| PL1651612T3 (pl) | 2003-07-22 | 2012-09-28 | Astex Therapeutics Ltd | Związki 3,4-pochodne 1h-pirazolu i ich zastosowanie jako kinazy zależne od cyklin (cdk) i modulatory kinazy syntazy glikogenu-3 (gsk-3) |
| TW200524915A (en) * | 2003-09-26 | 2005-08-01 | Tanabe Seiyaku Co | Carbamoyl-type benzofuran derivatives |
| TW200512181A (en) * | 2003-09-26 | 2005-04-01 | Tanabe Seiyaku Co | Amide-type carboxamide derivatives |
| US7199149B2 (en) | 2003-10-01 | 2007-04-03 | Bristol Myers Squibb Company | Monocyclic and bicyclic lactams as factor Xa inhibitors |
| US7507748B2 (en) * | 2004-07-22 | 2009-03-24 | Amgen Inc. | Substituted aryl-amine derivatives and methods of use |
| AR054425A1 (es) | 2005-01-21 | 2007-06-27 | Astex Therapeutics Ltd | Sales de adicion de piperidin 4-il- amida de acido 4-(2,6-dicloro-benzoilamino) 1h-pirazol-3-carboxilico. |
| US8404718B2 (en) | 2005-01-21 | 2013-03-26 | Astex Therapeutics Limited | Combinations of pyrazole kinase inhibitors |
| ES2323244T3 (es) * | 2005-05-13 | 2009-07-09 | Qosmos | Analisis del trafico en redes de alta velocidad. |
| US8247556B2 (en) | 2005-10-21 | 2012-08-21 | Amgen Inc. | Method for preparing 6-substituted-7-aza-indoles |
| ES2550057T3 (es) | 2006-11-02 | 2015-11-04 | Millennium Pharmaceuticals, Inc. | Métodos para sintetizar sales farmacéuticas de un inhibidor del Factor Xa |
| JP2010120852A (ja) * | 2007-03-09 | 2010-06-03 | Daiichi Sankyo Co Ltd | 新規なジアミド誘導体 |
| WO2008135524A2 (en) * | 2007-05-02 | 2008-11-13 | Boehringer Ingelheim International Gmbh | Substituted anthranilamides and analogues, manufacturing and use thereof as medicaments |
| AU2008266954A1 (en) * | 2007-06-20 | 2008-12-24 | Merck Sharp & Dohme Corp. | CETP inhibitors derived from benzoxazole arylamides |
| AR067182A1 (es) | 2007-06-29 | 2009-09-30 | Gilead Sciences Inc | Moduladores del receptor 7 tipo toll |
| ES2467108T3 (es) | 2008-12-09 | 2014-06-11 | Gilead Sciences, Inc. | Moduladores de receptores tipo toll |
| IN2012DN02984A (de) | 2009-10-22 | 2015-07-31 | Gilead Sciences Inc | |
| WO2012014109A1 (en) | 2010-07-30 | 2012-02-02 | Ranbaxy Laboratories Limited | Heterocyclic sulfonamides as inhibitors of transfer rna synthetase for use as antibacterial agents |
| AU2011323245B2 (en) | 2010-11-05 | 2016-01-21 | Senomyx, Inc. | Compounds useful as modulators of TRPM8 |
| US8883819B2 (en) | 2011-09-01 | 2014-11-11 | Irm Llc | Bicyclic heterocycle derivatives for the treatment of pulmonary arterial hypertension |
| US9073921B2 (en) | 2013-03-01 | 2015-07-07 | Novartis Ag | Salt forms of bicyclic heterocyclic derivatives |
| US10266488B2 (en) | 2013-10-10 | 2019-04-23 | Eastern Virginia Medical School | 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase |
| EA201790024A1 (ru) | 2014-07-11 | 2017-07-31 | Джилид Сайэнс, Инк. | Модуляторы toll-подобных рецепторов для лечения вич |
| EA201790369A1 (ru) | 2014-09-16 | 2017-10-31 | Джилид Сайэнс, Инк. | Твердые формы модулятора толл-подобного рецептора |
| JP6865743B2 (ja) | 2015-10-01 | 2021-04-28 | フィルメニッヒ インコーポレイテッドＦｉｒｍｅｎｉｃｈ Ｉｎｃｏｒｐｏｒａｔｅｄ | Ｔｒｐｍ８の活性調節因子として有用な化合物 |
| EP3849979A1 (de) | 2018-09-12 | 2021-07-21 | Novartis AG | Antivirale pyridopyrazindionverbindungen |
| US11667613B2 (en) | 2019-09-26 | 2023-06-06 | Novartis Ag | Antiviral pyrazolopyridinone compounds |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB824908A (en) | 1958-06-03 | 1959-12-09 | May & Baker Ltd | Improvements in or relating to triazine derivatives |
| JPS5922697B2 (ja) | 1976-01-13 | 1984-05-28 | エーザイ株式会社 | ビス−（メタ−アミジノフエノキシ）−化合物 |
| ATE167473T1 (de) * | 1990-08-20 | 1998-07-15 | Eisai Co Ltd | Sulfonamid-derivate |
| EP0518818A3 (en) | 1991-06-11 | 1993-04-28 | Ciba-Geigy Ag | Arylethers, their manufacture and use as medicament |
| US5451700A (en) | 1991-06-11 | 1995-09-19 | Ciba-Geigy Corporation | Amidino compounds, their manufacture and methods of treatment |
| ZA928276B (en) * | 1991-10-31 | 1993-05-06 | Daiichi Seiyaku Co | Aromatic amidine derivates and salts thereof. |
| WO1993015756A1 (en) | 1992-02-14 | 1993-08-19 | Corvas International, Inc. | Inhibitors of thrombosis |
| DE4213919A1 (de) | 1992-04-28 | 1993-11-04 | Thomae Gmbh Dr K | Cyclische iminoderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| AU675981B2 (en) | 1992-12-02 | 1997-02-27 | Bristol-Myers Squibb Company | Guanidinyl-substituted heterocyclic thrombin inhibitors |
| WO1994013693A1 (en) | 1992-12-15 | 1994-06-23 | Corvas International, Inc. | NOVEL INHIBITORS OF FACTOR Xa |
| US5332822A (en) | 1992-12-24 | 1994-07-26 | Bristol-Myers Squibb Company | Heteroaromatic and thioheteroaromatic substituted sulfonamide thrombin inhibitors |
| EP0684830B1 (de) | 1993-02-12 | 1999-06-16 | Corvas International, Inc. | Inhibitoren gegen thrombose |
| US5633381A (en) | 1994-07-05 | 1997-05-27 | Berlex Laboratories, Inc. | (Z,Z), (Z,E) and (E,Z) isomers of substituted bis(phenylmethylene)cycloketones |
| IL115420A0 (en) | 1994-09-26 | 1995-12-31 | Zeneca Ltd | Aminoheterocyclic derivatives |
| ES2208737T3 (es) | 1995-03-10 | 2004-06-16 | Berlex Laboratories, Inc. | Derivados de benzamidina, su preparacion y su utilizacion como anticoagulantes. |
| US5691364A (en) | 1995-03-10 | 1997-11-25 | Berlex Laboratories, Inc. | Benzamidine derivatives and their use as anti-coagulants |
| US5612363A (en) | 1995-06-02 | 1997-03-18 | Berlex Laboratories, Inc. | N,N-di(aryl) cyclic urea derivatives as anti-coagulants |
| US5721214A (en) | 1995-06-07 | 1998-02-24 | Cor Therapeutics, Inc. | Inhibitors of factor Xa |
| US5849759A (en) | 1995-12-08 | 1998-12-15 | Berlex Laboratories, Inc. | Naphthyl-substituted benzimidazole derivatives as anti-coagulants |
| US5994375A (en) * | 1996-02-12 | 1999-11-30 | Berlex Laboratories, Inc. | Benzamidine derivatives substituted by amino acid and hydroxy acid derivatives and their use as anti-coagulants |
| US5753635A (en) | 1996-08-16 | 1998-05-19 | Berlex Laboratories, Inc. | Purine derivatives and their use as anti-coagulants |
| US5693641A (en) | 1996-08-16 | 1997-12-02 | Berlex Laboratories Inc. | Bicyclic pyrimidine derivatives and their use as anti-coagulants |
| SK29599A3 (en) | 1996-09-12 | 1999-08-06 | Schering Ag | Benzamidine derivatives substituted by cyclic amino acid or cyclic hydroxy acid derivatives and their use as anti-coagulants |
| US6004985A (en) | 1996-10-09 | 1999-12-21 | Berlex Laboratories, Inc. | Thio acid derived monocylic N-heterocyclics as anticoagulants |
| ES2241151T3 (es) | 1997-06-26 | 2005-10-16 | Eli Lilly And Company | Agentes antitromboticos. |
| JP2002510313A (ja) | 1997-06-26 | 2002-04-02 | イーライ・リリー・アンド・カンパニー | 抗血栓物質 |
| US6313122B1 (en) * | 1997-06-26 | 2001-11-06 | Eli Lilly And Company | Antithrombotic agents |
| US6140351A (en) * | 1997-12-19 | 2000-10-31 | Berlex Laboratories, Inc. | Ortho-anthranilamide derivatives as anti-coagulants |
| AU2364600A (en) | 1998-12-23 | 2000-07-31 | Eli Lilly And Company | Heteroroaromatic amides as inhibitor of factor xa |
-
1998
- 1998-11-27 ES ES98963519T patent/ES2215337T3/es not_active Expired - Lifetime
- 1998-11-27 SK SK943-2000A patent/SK9432000A3/sk unknown
- 1998-11-27 EP EP98963519A patent/EP1040108B1/de not_active Expired - Lifetime
- 1998-11-27 RU RU2000119756/04A patent/RU2226529C2/ru not_active IP Right Cessation
- 1998-11-27 WO PCT/EP1998/007650 patent/WO1999032477A1/en not_active Application Discontinuation
- 1998-11-27 HU HU0101172A patent/HUP0101172A3/hu unknown
- 1998-11-27 PT PT98963519T patent/PT1040108E/pt unknown
- 1998-11-27 NZ NZ503809A patent/NZ503809A/en unknown
- 1998-11-27 AU AU18759/99A patent/AU751856B2/en not_active Ceased
- 1998-11-27 AT AT98963519T patent/ATE260103T1/de not_active IP Right Cessation
- 1998-11-27 DK DK98963519T patent/DK1040108T3/da active
- 1998-11-27 CN CNB988124173A patent/CN1143855C/zh not_active Expired - Fee Related
- 1998-11-27 DE DE69821985T patent/DE69821985T2/de not_active Expired - Fee Related
- 1998-11-27 JP JP2000525414A patent/JP3811006B2/ja not_active Expired - Fee Related
- 1998-11-27 PL PL98341044A patent/PL341044A1/xx not_active Application Discontinuation
- 1998-11-27 CA CA002315070A patent/CA2315070A1/en not_active Abandoned
- 1998-11-27 IL IL13553698A patent/IL135536A0/xx unknown
-
2000
- 2000-06-16 NO NO20003111A patent/NO20003111L/no not_active Application Discontinuation
- 2000-08-03 US US09/631,450 patent/US6380221B1/en not_active Expired - Fee Related
- 2000-08-03 US US09/631,452 patent/US6498185B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| NZ503809A (en) | 2002-04-26 |
| JP2001526283A (ja) | 2001-12-18 |
| DE69821985D1 (de) | 2004-04-01 |
| PL341044A1 (en) | 2001-03-26 |
| ES2215337T3 (es) | 2004-10-01 |
| WO1999032477B1 (en) | 1999-09-10 |
| CN1282329A (zh) | 2001-01-31 |
| CA2315070A1 (en) | 1999-07-01 |
| EP1040108A1 (de) | 2000-10-04 |
| SK9432000A3 (en) | 2001-02-12 |
| US6380221B1 (en) | 2002-04-30 |
| NO20003111L (no) | 2000-08-18 |
| RU2226529C2 (ru) | 2004-04-10 |
| HUP0101172A3 (en) | 2002-12-28 |
| US6498185B1 (en) | 2002-12-24 |
| DE69821985T2 (de) | 2005-05-04 |
| AU1875999A (en) | 1999-07-12 |
| NO20003111D0 (no) | 2000-06-16 |
| JP3811006B2 (ja) | 2006-08-16 |
| DK1040108T3 (da) | 2004-05-24 |
| WO1999032477A1 (en) | 1999-07-01 |
| AU751856B2 (en) | 2002-08-29 |
| PT1040108E (pt) | 2004-06-30 |
| EP1040108B1 (de) | 2004-02-25 |
| CN1143855C (zh) | 2004-03-31 |
| IL135536A0 (en) | 2001-05-20 |
| HUP0101172A1 (hu) | 2002-05-29 |
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