ATE259818T1 - Substituierte tricyclische verbindungen und deren verwendung zur behandlung von spla2-bedingten erkrankungen - Google Patents

Substituierte tricyclische verbindungen und deren verwendung zur behandlung von spla2-bedingten erkrankungen

Info

Publication number
ATE259818T1
ATE259818T1 AT01203116T AT01203116T ATE259818T1 AT E259818 T1 ATE259818 T1 AT E259818T1 AT 01203116 T AT01203116 T AT 01203116T AT 01203116 T AT01203116 T AT 01203116T AT E259818 T1 ATE259818 T1 AT E259818T1
Authority
AT
Austria
Prior art keywords
spla2
treating
related diseases
tricyclic compounds
substituted tricyclic
Prior art date
Application number
AT01203116T
Other languages
English (en)
Inventor
Nicholas James Bach
Jolie Anne Bastian
Douglas Wade Beight
Michael Dean Kinnick
Michael John Martinelli
Edward David Mihelich
John Michael Morlin Jr
Daniel Jon Sall
Jason Scott Sawyer
Edward C R Smith
Tulio Suarez
Quiping Wang
Thomas Michael Wilson
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of ATE259818T1 publication Critical patent/ATE259818T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyridine Compounds (AREA)
AT01203116T 1998-04-17 1999-04-16 Substituierte tricyclische verbindungen und deren verwendung zur behandlung von spla2-bedingten erkrankungen ATE259818T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US6216598A 1998-04-17 1998-04-17

Publications (1)

Publication Number Publication Date
ATE259818T1 true ATE259818T1 (de) 2004-03-15

Family

ID=22040624

Family Applications (2)

Application Number Title Priority Date Filing Date
AT01203116T ATE259818T1 (de) 1998-04-17 1999-04-16 Substituierte tricyclische verbindungen und deren verwendung zur behandlung von spla2-bedingten erkrankungen
AT99302969T ATE254128T1 (de) 1998-04-17 1999-04-16 Substituierte tricyclische verbindungen und deren verwendung zur behandlung von spla2-bedingten erkrankungen

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT99302969T ATE254128T1 (de) 1998-04-17 1999-04-16 Substituierte tricyclische verbindungen und deren verwendung zur behandlung von spla2-bedingten erkrankungen

Country Status (27)

Country Link
EP (2) EP0950661B1 (de)
JP (1) JP4435325B2 (de)
KR (1) KR19990083234A (de)
CN (1) CN1235968A (de)
AR (1) AR018185A1 (de)
AT (2) ATE259818T1 (de)
AU (1) AU757454B2 (de)
BR (1) BR9901275A (de)
CA (1) CA2269256A1 (de)
CO (1) CO5080728A1 (de)
CZ (1) CZ137199A3 (de)
DE (2) DE69914951T2 (de)
EA (1) EA003129B1 (de)
ES (2) ES2213668T3 (de)
HU (1) HUP9901219A1 (de)
ID (1) ID23219A (de)
IL (1) IL129484A0 (de)
NO (1) NO991823L (de)
NZ (1) NZ335252A (de)
PE (1) PE20000472A1 (de)
PL (1) PL332564A1 (de)
SG (1) SG106035A1 (de)
SV (1) SV1999000052A (de)
TR (1) TR199900842A2 (de)
TW (1) TW555760B (de)
YU (1) YU19099A (de)
ZA (1) ZA992773B (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU9123198A (en) * 1997-08-28 1999-03-16 Eli Lilly And Company Method for treatment of non-rheumatoid athritis
WO2001074817A1 (fr) * 2000-03-30 2001-10-11 Yamanouchi Pharmaceutical Co., Ltd. Derives d'hydrazide
BR0112460A (pt) * 2000-07-14 2003-07-22 Lilly Co Eli Método para tratamento de sépsis
AU2002239264A1 (en) * 2000-12-18 2002-07-01 Eli Lilly And Company Tetracyclic derivatives as spla2 inhibitors
DE60218155D1 (de) 2001-03-28 2007-03-29 Lilly Co Eli Substituierte carbazole als inhibitoren von spla2
JP2005527464A (ja) 2001-08-09 2005-09-15 イーライ・リリー・アンド・カンパニー ｓＰＬＡ２インヒビターとしてのシクロヘプタＢインドール誘導体
DE60208065T2 (de) 2001-08-09 2006-07-13 Eli Lilly And Co., Indianapolis Cyclohept'b! indolderivate als spla2-inhibitoren
US6992100B2 (en) 2001-12-06 2006-01-31 Eli Lilly And Company sPLA2 inhibitors
AU2005302559A1 (en) 2004-11-01 2006-05-11 Wyeth Substituted indolizines and derivatives as CNS agents
ES2523580T3 (es) 2008-01-11 2014-11-27 Albany Molecular Research, Inc. Piridoindoles substituidos con (1-Azinona)
WO2011003021A1 (en) 2009-07-01 2011-01-06 Albany Molecular Research, Inc. Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine mch-1 antagonists, methods of making, and use thereof
US8993765B2 (en) 2010-12-21 2015-03-31 Albany Molecular Research, Inc. Tetrahydro-azacarboline MCH-1 antagonists, methods of making, and uses thereof
PT2697223T (pt) * 2011-04-14 2016-10-14 Actelion Pharmaceuticals Ltd Derivados de ácido 7-(heteroaril-amino)-6,7,8,9-tetraidropirido[1,2-a]indolacético e utilização dos mesmos como moduladores do recetor d2 de prostaglandina
WO2013138565A1 (en) 2012-03-16 2013-09-19 Vitae Pharmaceuticals, Inc. Liver x receptor modulators
BR112014022780A8 (pt) 2012-03-16 2021-06-15 Vitae Pharmaceuticals Inc composto modulador de receptor de fígado x, composição farmacêutica que o compreende e seu uso

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3979391A (en) * 1972-11-22 1976-09-07 Sterling Drug Inc. 1,2,3,4-Tetrahydrocarbazoles
PT95692A (pt) * 1989-10-27 1991-09-13 American Home Prod Processo para a preparacao de derivados de acidos indole-,indeno-,piranoindole- e tetra-hidrocarbazole-alcanoicos, ou quais sao uteis como inibidores de pla2 e da lipoxigenase
IL109309A (en) * 1993-04-16 2000-06-29 Lilly Co Eli 1-H-indole-3-acetic acid hydrazide SPLA2 inhibitors and pharmaceutical compositions containing them
IL109311A0 (en) * 1993-04-16 1994-07-31 Lilly Co Eli 1H-indole-3-acetamide sPla2 inhibitors
EP0772596B1 (de) * 1994-07-21 2003-10-01 Eli Lilly And Company Indolizin spal2 inhibitoren
ATE203744T1 (de) * 1995-12-13 2001-08-15 Lilly Co Eli Naphthyl-acetamide als spla2-inhibitoren
IL129481A0 (en) * 1996-10-30 2000-02-29 Lilly Co Eli Substituted tricyclics
EP1007056A1 (de) * 1997-09-26 2000-06-14 Eli Lilly And Company Verfahren zur behandlung von zystischer fibrose
EP1043991A4 (de) * 1997-11-14 2005-02-02 Lilly Co Eli Behandlung der alzheimer-erkrankung

Also Published As

Publication number Publication date
JPH11322745A (ja) 1999-11-24
EP1156050A3 (de) 2001-11-28
NO991823L (no) 1999-10-18
TR199900842A2 (xx) 2000-09-21
SV1999000052A (es) 2000-03-14
DE69914951D1 (de) 2004-03-25
EA199900304A2 (ru) 1999-10-28
DE69912670T2 (de) 2004-08-12
EP1156050B1 (de) 2004-02-18
AR018185A1 (es) 2001-10-31
SG106035A1 (en) 2004-09-30
EP0950661A1 (de) 1999-10-20
BR9901275A (pt) 2000-05-02
ATE254128T1 (de) 2003-11-15
EA003129B1 (ru) 2003-02-27
IL129484A0 (en) 2000-02-29
AU2381899A (en) 1999-10-28
EA199900304A3 (ru) 2000-04-24
NO991823D0 (no) 1999-04-16
TW555760B (en) 2003-10-01
JP4435325B2 (ja) 2010-03-17
CO5080728A1 (es) 2001-09-25
AU757454B2 (en) 2003-02-20
CA2269256A1 (en) 1999-10-17
PL332564A1 (en) 1999-10-25
DE69912670D1 (de) 2003-12-18
CZ137199A3 (cs) 1999-11-17
HUP9901219A1 (hu) 2000-08-28
ES2213668T3 (es) 2004-09-01
HU9901219D0 (en) 1999-06-28
ID23219A (id) 2000-03-30
KR19990083234A (ko) 1999-11-25
EP0950661B1 (de) 2003-11-12
NZ335252A (en) 2000-11-24
DE69914951T2 (de) 2004-12-23
EP1156050A2 (de) 2001-11-21
ZA992773B (en) 2002-07-16
ES2210979T3 (es) 2004-07-01
CN1235968A (zh) 1999-11-24
YU19099A (sh) 2001-09-28
PE20000472A1 (es) 2000-06-02

Similar Documents

Publication Publication Date Title
ATE255888T1 (de) Tetrahydronaphtalene verbindungen und deren verwendung zur behandlung von neurodegenerativen krankheiten
DE69836752D1 (de) Prostaglandinagoniste und deren verwendung zur behandlung von knochenerkrankungen
ATE251903T1 (de) Verwendung von phosphororganischen verbindungen zur therapeutischen und prophylaktischen behandlung von infektionen
ATE236529T1 (de) Antiparasitäre zusammensetzung zur behandlung und zum schutz von haustieren
DE69920019D1 (de) Behandlung von mineralfüllstoffen mit phosphaten, diese füllstoffe und deren verwendung
DE69812603D1 (de) Substituierte benzopyranderivate zur behandlung von entzündungen
ATE267015T1 (de) Verbindungen und verfahren zur behandlung von krebs
DE69831222D1 (de) Verbindungen zur immundiagnose von prostatakrebs und deren verwendung
DE69612649D1 (de) Indolinonverbindungen zur behandlung von krankheiten
ATE241977T1 (de) Verwendung von anti-mikrotubuli mitteln zur behandlung von entzündlichen darmerkrankungen
ATE230617T1 (de) Verfahren und methode zur behandlung von abfällen
DE69906671D1 (de) Substituierte 2-Phenyl-1-(3,4-dihydroxy-5-nitrophenyl)-1-ethanone, deren Verwendung zur Behandlung von Erkrankungen des zentralen und periphären Nervensystems und diese enthaltende pharmazeutische Zusammensetzungen
DE60013859D1 (de) Indolderivate und deren verwendung zur behandlung von u.a. osteoporosis
ATE254128T1 (de) Substituierte tricyclische verbindungen und deren verwendung zur behandlung von spla2-bedingten erkrankungen
ATE227127T1 (de) Hochdosiertes chromtripicolinat zur behandlung von typ-ii-diabetes
DE69841984D1 (de) Zusammensetzung aus nanokapseln zur behandlung von intraarticulaeren erkrankungen
DE69734296D1 (de) Neue dikaffeoylchinasäurederivate und deren verwendung zur behandlung von hepatitis b
DE69835419D1 (de) Verfahren zur Behandlung von organischem Abwasser
DE69840752D1 (de) Verwendung von coumarine zur behandlung von lebererkrankungen und pankreaserkrankungen
DE60027429D1 (de) Dihydrobenzodiazepinen und deren verwendung zur behandlung von dyslipidämien
ATE258062T1 (de) Verwendung von wachstumshormon freisetzenden stoffen und ihren antagonisten zur behandlung von tumoren
ATE222910T1 (de) Triptolid-derivate nützlich zur behandlung von autoimmunkrankheiten
DE69925578D1 (de) Pharmazeutische zusammenstellung zur vorbeugung und behandlung von mit zellkrankheiten des augenhintergrundes zusammenhängenden krankheiten
DE69729735D1 (de) Verwendung von benzopyranolen zur behandlung von neurologischen erkrankungen
DE69913380D1 (de) Zusammensetzung zur behandlung von periodontalen erkrankungen

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties