ATE254122T1 - Indolderivate als 5-ht1b und 5-ht1d agonisten - Google Patents

Indolderivate als 5-ht1b und 5-ht1d agonisten

Info

Publication number
ATE254122T1
ATE254122T1 AT98942759T AT98942759T ATE254122T1 AT E254122 T1 ATE254122 T1 AT E254122T1 AT 98942759 T AT98942759 T AT 98942759T AT 98942759 T AT98942759 T AT 98942759T AT E254122 T1 ATE254122 T1 AT E254122T1
Authority
AT
Austria
Prior art keywords
ht1b
indole derivatives
ht1d agonists
ht1d
agonists
Prior art date
Application number
AT98942759T
Other languages
English (en)
Inventor
Michel Perez
Serge Halazy
Original Assignee
Pf Medicament
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pf Medicament filed Critical Pf Medicament
Application granted granted Critical
Publication of ATE254122T1 publication Critical patent/ATE254122T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cardiology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
AT98942759T 1997-08-25 1998-08-20 Indolderivate als 5-ht1b und 5-ht1d agonisten ATE254122T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9710606A FR2767527B1 (fr) 1997-08-25 1997-08-25 Derives de piperazines indoliques, utiles comme medicaments et procede de preparation
PCT/FR1998/001826 WO1999010344A1 (fr) 1997-08-25 1998-08-20 Derives d'indole comme agonistes de 5-ht1b et 5-ht1d

Publications (1)

Publication Number Publication Date
ATE254122T1 true ATE254122T1 (de) 2003-11-15

Family

ID=9510463

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98942759T ATE254122T1 (de) 1997-08-25 1998-08-20 Indolderivate als 5-ht1b und 5-ht1d agonisten

Country Status (11)

Country Link
US (2) US6277853B1 (de)
EP (1) EP1007524B1 (de)
JP (1) JP2001514180A (de)
CN (1) CN1272108A (de)
AT (1) ATE254122T1 (de)
AU (1) AU736074B2 (de)
BR (1) BR9811348A (de)
CA (1) CA2301750A1 (de)
DE (1) DE69819742D1 (de)
FR (1) FR2767527B1 (de)
WO (1) WO1999010344A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1482931B1 (de) * 2002-03-05 2011-10-19 TransTech Pharma, Inc. Mono- und bicyclische azolderivate die die interaktion von liganden mit rage hemmen
SI1587821T1 (sl) * 2002-12-19 2009-02-28 Scripps Research Inst Sestavki in postopki za stabiliziranje transtiretina in zaviranje napaäśnega zvijanja transtiretina
JP2006518738A (ja) * 2003-02-12 2006-08-17 トランス　テック　ファーマ，インコーポレイテッド 治療薬としての置換アゾール誘導体
EP1635823A1 (de) * 2003-05-20 2006-03-22 TransTech Pharma Inc. Rage antagonisten in der behandlung amyloidosis und anderer assoziierten krankheiten
JP4898458B2 (ja) * 2004-02-12 2012-03-14 トランス テック ファーマ，インコーポレイテッド 置換アゾール誘導体、組成物及び使用方法
WO2005112913A1 (en) 2004-05-20 2005-12-01 The Scripps Research Institute Transthyretin stabilization
WO2007078335A2 (en) * 2005-12-21 2007-07-12 Decode Genetics, Ehf. Biaryl nitrogen heterocycle inhibitors of lta4h for treating inflammation
EP1991544B1 (de) 2006-01-30 2018-08-15 vTv Therapeutics LLC Substituierte imidazol- derivate und ihre verwendung als ptpase inhibitoren
WO2008034016A2 (en) * 2006-09-15 2008-03-20 Foldrx Pharmaceuticals, Inc. Assays for detecting native-state proteins and identifying compounds that modulate the stability of native-state proteins
WO2011002067A1 (ja) * 2009-07-02 2011-01-06 武田薬品工業株式会社 複素環化合物およびその用途
EP2470510B1 (de) 2009-09-30 2014-05-14 TransTech Pharma, LLC Substituierte imidazol-derivate für die behandlung von alzheimers krankheit.
CN103781770B (zh) 2011-09-16 2016-04-13 辉瑞公司 转甲状腺素蛋白解离抑制剂的固体形式

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2699918B1 (fr) * 1992-12-30 1995-03-17 Pf Medicament Ligands sélectifs des récepteurs 5HY1D-5HT1B dérivés d'indole-pipérazine utiles comme médicaments.
FR2712591B1 (fr) * 1993-11-19 1996-02-09 Pf Medicament Nouvelles arylpipérazines dérivées d'indole, leur préparation et leur utilisation thérapeutique.

Also Published As

Publication number Publication date
AU9077498A (en) 1999-03-16
US20020061891A1 (en) 2002-05-23
WO1999010344A1 (fr) 1999-03-04
US6589953B2 (en) 2003-07-08
FR2767527B1 (fr) 1999-11-12
CN1272108A (zh) 2000-11-01
FR2767527A1 (fr) 1999-02-26
EP1007524A1 (de) 2000-06-14
US6277853B1 (en) 2001-08-21
BR9811348A (pt) 2000-09-12
AU736074B2 (en) 2001-07-26
JP2001514180A (ja) 2001-09-11
CA2301750A1 (fr) 1999-03-04
DE69819742D1 (de) 2003-12-18
EP1007524B1 (de) 2003-11-12

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Legal Events

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