ATE249228T1 - Verwendung von polyallylamin-polymeren zur herstellung eines medikamentes zur behandlung von hypercholesterolemia - Google Patents
Verwendung von polyallylamin-polymeren zur herstellung eines medikamentes zur behandlung von hypercholesterolemiaInfo
- Publication number
- ATE249228T1 ATE249228T1 AT98930234T AT98930234T ATE249228T1 AT E249228 T1 ATE249228 T1 AT E249228T1 AT 98930234 T AT98930234 T AT 98930234T AT 98930234 T AT98930234 T AT 98930234T AT E249228 T1 ATE249228 T1 AT E249228T1
- Authority
- AT
- Austria
- Prior art keywords
- polyallylamin
- medication
- polymers
- producing
- treating hypercholesterolemia
- Prior art date
Links
- 229920000642 polymer Polymers 0.000 title abstract 2
- 208000035150 Hypercholesterolemia Diseases 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 239000003833 bile salt Substances 0.000 abstract 1
- 229940093761 bile salts Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US87842297A | 1997-06-18 | 1997-06-18 | |
US92724797A | 1997-09-11 | 1997-09-11 | |
US08/979,096 US6423754B1 (en) | 1997-06-18 | 1997-11-26 | Method for treating hypercholesterolemia with polyallylamine polymers |
PCT/US1998/012422 WO1998057652A1 (en) | 1997-06-18 | 1998-06-15 | Polyallylamine polymers for treating hypercholesterolemia |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE249228T1 true ATE249228T1 (de) | 2003-09-15 |
Family
ID=27420493
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT98930234T ATE249228T1 (de) | 1997-06-18 | 1998-06-15 | Verwendung von polyallylamin-polymeren zur herstellung eines medikamentes zur behandlung von hypercholesterolemia |
Country Status (16)
Country | Link |
---|---|
US (3) | US6423754B1 (de) |
EP (1) | EP0996454B1 (de) |
JP (1) | JP4420143B2 (de) |
KR (1) | KR100567751B1 (de) |
CN (1) | CN1211091C (de) |
AT (1) | ATE249228T1 (de) |
AU (1) | AU735260C (de) |
CA (1) | CA2294036C (de) |
DE (1) | DE69818058T2 (de) |
HK (1) | HK1029920A1 (de) |
IL (1) | IL133434A (de) |
MX (1) | MXPA99011826A (de) |
MY (1) | MY125874A (de) |
NZ (1) | NZ501719A (de) |
TW (1) | TW526063B (de) |
WO (1) | WO1998057652A1 (de) |
Families Citing this family (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW568788B (en) * | 1998-10-12 | 2004-01-01 | Chugai Pharmaceutical Co Ltd | Polymer combining with phosphoric acid and preparation containing the same |
EP1293211A1 (de) * | 1998-12-23 | 2003-03-19 | G.D. Searle LLC. | Kombination von Ileumgallensäuretransport-Inhibitoren und Gallensäure-Sequestriermittel für kardiovaskuläre Indikationen |
JP4634618B2 (ja) * | 1999-04-16 | 2011-02-16 | アボット・ラボラトリーズ | 架橋ポリアリルアミン塩酸塩の製造方法 |
US6362266B1 (en) | 1999-09-03 | 2002-03-26 | The Dow Chemical Company | Process for reducing cohesiveness of polyallylamine polymer gels during drying |
US6180754B1 (en) | 1999-09-03 | 2001-01-30 | The Dow Chemical Company | Process for producing cross-linked polyallylamine polymer |
US20020054903A1 (en) * | 1999-10-19 | 2002-05-09 | Joseph Tyler | Direct compression polymer tablet core |
US6733780B1 (en) | 1999-10-19 | 2004-05-11 | Genzyme Corporation | Direct compression polymer tablet core |
EP1911462A3 (de) | 2001-01-26 | 2011-11-30 | Schering Corporation | Zusammensetzungen enthaltend einen Sterolabsorptionshemmer |
DK1392331T3 (da) | 2001-04-18 | 2008-06-23 | Genzyme Corp | Anvendelse af colesevelam eller sevelamer, hydrogenchlorid til sænkning af serumglucoseniveauet |
WO2002085379A1 (en) * | 2001-04-18 | 2002-10-31 | Geltex Pharmaceuticals, Inc. | Method for improving vascular access in patients with vascular shunts |
CN1509180A (zh) * | 2001-04-18 | 2004-06-30 | ԭ���ø� | 用脂肪族聚胺治疗综合症x的方法 |
WO2002085378A1 (en) * | 2001-04-18 | 2002-10-31 | Genzyme Corporation | Low salt forms of polyallylamine |
US7030126B2 (en) * | 2001-11-16 | 2006-04-18 | Als Therapy Development Foundation, Inc. | Use of polyamine analogs for amyotrophic lateral sclerosis |
WO2004037274A1 (en) * | 2002-10-22 | 2004-05-06 | Genzyme Corporation | Amine polymers for promoting bone formation |
US7608674B2 (en) * | 2003-11-03 | 2009-10-27 | Ilypsa, Inc. | Pharmaceutical compositions comprising cross-linked small molecule amine polymers |
US7385012B2 (en) * | 2003-11-03 | 2008-06-10 | Ilypsa, Inc. | Polyamine polymers |
US7335795B2 (en) * | 2004-03-22 | 2008-02-26 | Ilypsa, Inc. | Crosslinked amine polymers |
US7449605B2 (en) * | 2003-11-03 | 2008-11-11 | Ilypsa, Inc. | Crosslinked amine polymers |
US7767768B2 (en) * | 2003-11-03 | 2010-08-03 | Ilypsa, Inc. | Crosslinked amine polymers |
US7459502B2 (en) * | 2003-11-03 | 2008-12-02 | Ilypsa, Inc. | Pharmaceutical compositions comprising crosslinked polyamine polymers |
WO2005051298A2 (en) | 2003-11-19 | 2005-06-09 | Metabasis Therapeutics, Inc. | Novel phosphorus-containing thyromimetics |
DE602005018619D1 (de) | 2004-03-30 | 2010-02-11 | Relypsa Inc | Ionenbindende zusammensetzungen |
US20050244367A1 (en) * | 2004-05-03 | 2005-11-03 | Ilypsa, Inc. | Phospholipase inhibitors localized in the gastrointestinal lumen |
US20050276781A1 (en) * | 2004-06-09 | 2005-12-15 | Ross Edward A | Molecularly imprinted phosphate binders for therapeutic use |
US7985418B2 (en) * | 2004-11-01 | 2011-07-26 | Genzyme Corporation | Aliphatic amine polymer salts for tableting |
US20060177415A1 (en) * | 2004-11-01 | 2006-08-10 | Burke Steven K | Once a day formulation for phosphate binders |
JP2008533272A (ja) * | 2005-03-16 | 2008-08-21 | ユーエスヴィー リミテッド | 架橋ポリアリルアミンポリマーの調製のための改良された方法 |
CA2606498C (en) | 2005-05-26 | 2016-08-09 | Metabasis Therapeutics, Inc. | Novel phosphinic acid-containing thyromimetics |
CA2620406A1 (en) | 2005-09-02 | 2007-03-08 | Genzyme Corporation | Method for removing phosphate and polymer used therefore |
AR056499A1 (es) * | 2005-09-06 | 2007-10-10 | Serapis Farmaceuticals Ltd | Compuestos |
ES2556217T3 (es) | 2005-09-15 | 2016-01-14 | Genzyme Corporation | Formulación en bolsa para polímeros de amina |
US20080085259A1 (en) * | 2006-05-05 | 2008-04-10 | Huval Chad C | Amine condensation polymers as phosphate sequestrants |
BRPI0715053A2 (pt) * | 2006-07-18 | 2013-03-19 | Genzyme Corp | composiÇço farmacÊutica, mÉtodo para tratar doenÇas, e, polÍmero |
JP2010504975A (ja) | 2006-09-29 | 2010-02-18 | ゲンズイメ コーポレーション | アミドデンドリマー組成物 |
BRPI0716319A8 (pt) * | 2006-10-25 | 2019-02-05 | Aovatechnologies Inc | método para reduzir a absorção de fosfato em um indivíduo animal humano ou não-humano correndo o risco de desenvolver ou que desenvolveu hiperfosfatomia e método para reduzir os efeitos colaterais da terapia de vitamina d em um ser humano |
US8877198B2 (en) | 2006-10-26 | 2014-11-04 | Wisconsin Alumni Research Foundation | Methods of reducing phosphate absorption |
JP2010513271A (ja) * | 2006-12-14 | 2010-04-30 | ゲンズイメ コーポレーション | アミド−アミンポリマー組成物 |
JP2010514702A (ja) | 2006-12-22 | 2010-05-06 | アイロンウッド ファーマシューティカルズ,インコーポレーテッド | 食道障害の治療方法および治療用組成物 |
US20100129309A1 (en) * | 2007-02-23 | 2010-05-27 | Dhal Pradeep K | Amine polymer compositions |
US20100196305A1 (en) * | 2007-03-08 | 2010-08-05 | Dhal Pradeep K | Sulfone polymer compositions |
EP2152277A1 (de) * | 2007-04-27 | 2010-02-17 | Genzyme Corporation | Amido-amin-dendrimer-zusammensetzungen |
PA8807201A1 (es) * | 2007-12-14 | 2009-07-23 | Genzyme Corp | Composiciones farmaceuticas |
JP2011506449A (ja) * | 2007-12-14 | 2011-03-03 | ジェンザイム コーポレーション | コーティング医薬組成物 |
US20110142952A1 (en) * | 2008-06-20 | 2011-06-16 | Harris David J | Pharmaceutical Compositions |
US8404784B2 (en) * | 2008-12-03 | 2013-03-26 | Navinta Llc | Manufacturing process of making polymeric amine salts |
WO2010093601A1 (en) | 2009-02-10 | 2010-08-19 | Metabasis Therapeutics, Inc. | Novel sulfonic acid-containing thyromimetics, and methods for their use |
IT1394299B1 (it) * | 2009-05-12 | 2012-06-06 | Chimico Internaz Spa Lab | Procedimento per la preparazione di sevelamer |
JP5285000B2 (ja) * | 2010-02-23 | 2013-09-11 | 富士フイルム株式会社 | 低密度リポ蛋白コレステロールの測定方法 |
US20130156720A1 (en) | 2010-08-27 | 2013-06-20 | Ironwood Pharmaceuticals, Inc. | Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders |
WO2014057522A1 (en) | 2012-10-12 | 2014-04-17 | Mochida Pharmaceutical Co., Ltd. | Compositions and methods for treating non-alcoholic steatohepatitis |
SG11201507288UA (en) | 2013-03-15 | 2015-10-29 | Mochida Pharm Co Ltd | Compositions and methods for treating non-alcoholic steatohepatitis |
US10441560B2 (en) | 2013-03-15 | 2019-10-15 | Mochida Pharmaceutical Co., Ltd. | Compositions and methods for treating non-alcoholic steatohepatitis |
CN112047854B (zh) * | 2020-10-20 | 2021-07-02 | 中国科学院长春应用化学研究所 | 一种n-乙烯基烷基酰胺的制备方法 |
Family Cites Families (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB798488A (en) | 1956-01-09 | 1958-07-23 | Nat Aluminate Corp | Quaternary ammonium compounds and method for the preparation thereof |
US2874132A (en) | 1956-11-02 | 1959-02-17 | Rohm & Haas | Anion-exchange resins for sugar decolorization and their preparation |
BE580490A (fr) | 1958-07-15 | 1960-01-08 | Merck & Co Inc | Compositions et procédés pour abaisser la teneur en cholestérol du sang |
US3383281A (en) | 1961-09-22 | 1968-05-14 | Merck & Co Inc | Method for binding bile acids in vivo |
US3308020A (en) | 1961-09-22 | 1967-03-07 | Merck & Co Inc | Compositions and method for binding bile acids in vivo including hypocholesteremics |
US3288770A (en) | 1962-12-14 | 1966-11-29 | Peninsular Chem Res Inc | Water soluble quaternary ammonium polymers |
CH486202A (de) | 1966-05-31 | 1970-02-28 | Agripat Sa | Mikrobizides Mittel |
US3562266A (en) | 1969-05-26 | 1971-02-09 | Montedison Spa | Quaternary ammonium halides having a 2-chloro cyclohexyl or 2-chloro alkyl substituent |
BE756035A (fr) | 1969-09-12 | 1971-03-11 | Inveresk Res Int | Polymeres pontes |
US3803237A (en) | 1969-11-03 | 1974-04-09 | Upjohn Co | Reaction products of polyethylenepolyamines and chlorohydrins or epoxy containing compounds |
NL7017227A (de) | 1969-12-27 | 1971-06-29 | ||
US3692895A (en) | 1970-09-08 | 1972-09-19 | Norman A Nelson | Method of reducing hypercholesteremia in humans employing a copolymer of polyethylenepolyamine and a bifunctional substance, such as epichlorohydria |
US3980770A (en) | 1971-06-04 | 1976-09-14 | Pharmacia Aktiebolag | Polymerization products containing amino groups useful in serum cholesterol level control |
US4027009A (en) | 1973-06-11 | 1977-05-31 | Merck & Co., Inc. | Compositions and methods for depressing blood serum cholesterol |
US4217429A (en) | 1973-06-11 | 1980-08-12 | Merck & Co., Inc. | Poly-[(methylimino)trimethylene] |
US4205064A (en) | 1973-06-11 | 1980-05-27 | Merck & Co., Inc. | Bile acid sequestering composition containing poly[{alkyl-(3-ammoniopropyl)imino}-trimethylenedihalides] |
CS187563B1 (en) | 1974-02-08 | 1979-02-28 | Petr Strop | Method of preparation of the hydrophilic homogeneous or macroporous annexes |
CS173201B1 (de) | 1974-02-13 | 1977-02-28 | ||
US4016209A (en) | 1975-04-23 | 1977-04-05 | Merck & Co., Inc. | 3-[N'-(3-Halopropyl)-N-'-methylamino]-N,N,N-trimethyl-1-propanaminium halide and acid addition salts thereof |
US4071478A (en) | 1976-06-07 | 1978-01-31 | Merck & Co., Inc. | Controlled partially cross-linked 3,3-ionenes |
FI67483C (fi) | 1977-02-17 | 1985-04-10 | Merck & Co Inc | Foerfarande foer framstaellning av ett icke adhesivt friflytande farmakologiskt godtagbart gallsyrakomplexbildande adsorbatpreparat |
IT1106718B (it) | 1978-12-21 | 1985-11-18 | Alfa Farmaceutici Spa | Composizioni a base di resine anioniche salificate farmacologicamente attive |
US4426489A (en) | 1980-02-21 | 1984-01-17 | The Dow Chemical Company | Surface active polymeric surfactants containing side chain hydrophobes |
ATE12511T1 (de) | 1980-12-12 | 1985-04-15 | Smith & Nephew Ass | Polymere, deren herstellung und verwendungen. |
JPS5879022A (ja) | 1981-11-04 | 1983-05-12 | Bitamin Kenkyusho:Kk | 第四級窒素原子を含有する新規な金属架橋高分子化合物、その製法及び該高分子化合物を有効成分とする高脂血症治療剤 |
EP0098884B1 (de) | 1982-01-18 | 1986-07-23 | Mitsubishi Petrochemical Co., Ltd. | Heilmittel zum absenken cholesterolspiegels |
JPS6090243A (ja) | 1983-10-25 | 1985-05-21 | Nitto Boseki Co Ltd | 小球状モノアリルアミン橋かけ重合体の製造方法 |
CA1220896A (en) | 1983-11-10 | 1987-04-21 | Susumu Harada | Process for producing polymers of monoallylamine |
JPS60106803A (ja) | 1983-11-14 | 1985-06-12 | Nitto Boseki Co Ltd | アリル尿素重合体の製造方法 |
AU551886B2 (en) | 1983-11-14 | 1986-05-15 | Nitto Boseki Co. Ltd. | Poly(allylamine) derivatives |
CA1220897A (en) | 1984-01-11 | 1987-04-21 | Kiyoshi Shimizu | Process for producing polymers of monoallylamine |
OA08092A (fr) | 1984-05-11 | 1987-03-31 | Bristol Myers Co | Novel bile sequestrant resin and uses. |
US4759923A (en) | 1987-06-25 | 1988-07-26 | Hercules Incorporated | Process for lowering serum cholesterol using poly(diallylmethylamine) derivatives |
DE3800199A1 (de) | 1988-01-07 | 1989-07-20 | Sandoz Ag | Seitenkettenhaltige vinylpolymere |
GB8829088D0 (en) | 1988-12-13 | 1989-01-25 | Smith Kline French Lab | Compounds |
US5236701A (en) | 1989-07-19 | 1993-08-17 | Lowchol Scientific Inc. | Ingestible hydrophilic polymeric amines useful for lowering blood cholesterol |
GB8928278D0 (en) | 1989-12-14 | 1990-02-21 | Smith Kline French Lab | Compounds |
CA2040996A1 (en) | 1990-05-02 | 1991-11-03 | Robert L. Albright | Composition and method for controlling cholesterol |
GB9011332D0 (en) | 1990-05-21 | 1990-07-11 | Smith Kline French Lab | Compounds |
IE914179A1 (en) | 1990-12-07 | 1992-06-17 | Ici Plc | Nitrogen derivatives |
US5055197A (en) | 1991-04-05 | 1991-10-08 | Rohm And Haas Company | Process for removing residual monomers and oligemers from amine-containing polymers |
JP3247435B2 (ja) | 1992-07-11 | 2002-01-15 | 日産アルティア株式会社 | 芯材添設型樹脂製車両用ルーフレールの製造方法及び車両用ルーフレール |
EP0580078B1 (de) | 1992-07-22 | 1997-10-15 | Hoechst Aktiengesellschaft | Hydrophile Zentren aufweisende Polyvinylamin-Derivate, Verfahren zu ihrer Herstellung sowie die Verwendung der Verbindungen als Arzneimittel, Wirkstoffträger und Nahrungsmittelhilfsstoff |
DK0580079T3 (da) | 1992-07-22 | 1997-06-30 | Hoechst Ag | Tværbundne, nitrogenholdige vinylcopolymerer, fremgangsmåde til deres fremstilling samt anvendelse af disse forbindelser |
US5633344A (en) | 1992-08-20 | 1997-05-27 | E. I. Du Pont De Nemours & Company | Crosslinked polymeric ammonium salts |
US5451397A (en) | 1992-12-21 | 1995-09-19 | Rohm And Haas Company | Bile acid sequestrant |
JPH06321786A (ja) * | 1993-05-12 | 1994-11-22 | Sekisui Chem Co Ltd | 胆汁酸腸管吸収抑制剤 |
US5487888A (en) | 1993-05-20 | 1996-01-30 | Geltex, Inc. | Iron-binding polymers for oral administration |
US5624963A (en) | 1993-06-02 | 1997-04-29 | Geltex Pharmaceuticals, Inc. | Process for removing bile salts from a patient and compositions therefor |
US5607669A (en) * | 1994-06-10 | 1997-03-04 | Geltex Pharmaceuticals, Inc. | Amine polymer sequestrant and method of cholesterol depletion |
WO1994027620A1 (en) | 1993-06-02 | 1994-12-08 | Geltex Pharmaceuticals, Inc. | Compositions and process for removing bile salts |
US5618530A (en) | 1994-06-10 | 1997-04-08 | Geltex Pharmaceuticals, Inc. | Hydrophobic amine polymer sequestrant and method of cholesterol depletion |
US5496545A (en) | 1993-08-11 | 1996-03-05 | Geltex Pharmaceuticals, Inc. | Phosphate-binding polymers for oral administration |
US5414068A (en) | 1994-01-24 | 1995-05-09 | Rohm And Haas Company | Crosslinked anion exchange particles and method for producing the particles |
TW474813B (en) | 1994-06-10 | 2002-02-01 | Geltex Pharma Inc | Alkylated composition for removing bile salts from a patient |
US5792749A (en) * | 1997-01-09 | 1998-08-11 | Virginia Commonwealth University | Method and composition for lowering low density lipoprotein cholesterol |
-
1997
- 1997-11-26 US US08/979,096 patent/US6423754B1/en not_active Expired - Lifetime
-
1998
- 1998-06-15 MX MXPA99011826A patent/MXPA99011826A/es active IP Right Grant
- 1998-06-15 WO PCT/US1998/012422 patent/WO1998057652A1/en active IP Right Grant
- 1998-06-15 CN CNB988071118A patent/CN1211091C/zh not_active Expired - Lifetime
- 1998-06-15 DE DE69818058T patent/DE69818058T2/de not_active Expired - Lifetime
- 1998-06-15 JP JP50464599A patent/JP4420143B2/ja not_active Expired - Lifetime
- 1998-06-15 IL IL13343498A patent/IL133434A/xx not_active IP Right Cessation
- 1998-06-15 CA CA002294036A patent/CA2294036C/en not_active Expired - Lifetime
- 1998-06-15 AU AU79675/98A patent/AU735260C/en not_active Expired
- 1998-06-15 KR KR1019997011968A patent/KR100567751B1/ko not_active IP Right Cessation
- 1998-06-15 NZ NZ501719A patent/NZ501719A/en not_active IP Right Cessation
- 1998-06-15 AT AT98930234T patent/ATE249228T1/de not_active IP Right Cessation
- 1998-06-15 EP EP98930234A patent/EP0996454B1/de not_active Expired - Lifetime
- 1998-06-17 MY MYPI98002704A patent/MY125874A/en unknown
- 1998-07-09 TW TW087109749A patent/TW526063B/zh not_active IP Right Cessation
-
2001
- 2001-01-22 HK HK01100549A patent/HK1029920A1/xx not_active IP Right Cessation
-
2002
- 2002-05-29 US US10/158,207 patent/US20030086898A1/en not_active Abandoned
-
2006
- 2006-02-01 US US11/344,862 patent/US20060239959A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
HK1029920A1 (en) | 2001-04-20 |
DE69818058D1 (de) | 2003-10-16 |
AU735260B2 (en) | 2001-07-05 |
JP2002516613A (ja) | 2002-06-04 |
CN1263468A (zh) | 2000-08-16 |
EP0996454A1 (de) | 2000-05-03 |
JP4420143B2 (ja) | 2010-02-24 |
WO1998057652A1 (en) | 1998-12-23 |
US6423754B1 (en) | 2002-07-23 |
KR20010013943A (ko) | 2001-02-26 |
MXPA99011826A (es) | 2002-07-02 |
US20030086898A1 (en) | 2003-05-08 |
CN1211091C (zh) | 2005-07-20 |
IL133434A0 (en) | 2001-04-30 |
EP0996454B1 (de) | 2003-09-10 |
TW526063B (en) | 2003-04-01 |
CA2294036A1 (en) | 1998-12-23 |
AU735260C (en) | 2002-03-28 |
IL133434A (en) | 2005-09-25 |
CA2294036C (en) | 2007-08-21 |
DE69818058T2 (de) | 2004-07-08 |
US20060239959A1 (en) | 2006-10-26 |
KR100567751B1 (ko) | 2006-04-05 |
MY125874A (en) | 2006-08-30 |
NZ501719A (en) | 2001-10-26 |
AU7967598A (en) | 1999-01-04 |
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