ATE249228T1 - Verwendung von polyallylamin-polymeren zur herstellung eines medikamentes zur behandlung von hypercholesterolemia - Google Patents

Verwendung von polyallylamin-polymeren zur herstellung eines medikamentes zur behandlung von hypercholesterolemia

Info

Publication number
ATE249228T1
ATE249228T1 AT98930234T AT98930234T ATE249228T1 AT E249228 T1 ATE249228 T1 AT E249228T1 AT 98930234 T AT98930234 T AT 98930234T AT 98930234 T AT98930234 T AT 98930234T AT E249228 T1 ATE249228 T1 AT E249228T1
Authority
AT
Austria
Prior art keywords
polyallylamin
medication
polymers
producing
treating hypercholesterolemia
Prior art date
Application number
AT98930234T
Other languages
English (en)
Inventor
Stephen Randall Holmes-Farley
W Harry Mandeville Iii
Steven K Burke
Dennis I Goldberg
Original Assignee
Genzyme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genzyme Corp filed Critical Genzyme Corp
Application granted granted Critical
Publication of ATE249228T1 publication Critical patent/ATE249228T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/74Synthetic polymeric materials
    • A61K31/785Polymers containing nitrogen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
AT98930234T 1997-06-18 1998-06-15 Verwendung von polyallylamin-polymeren zur herstellung eines medikamentes zur behandlung von hypercholesterolemia ATE249228T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US87842297A 1997-06-18 1997-06-18
US92724797A 1997-09-11 1997-09-11
US08/979,096 US6423754B1 (en) 1997-06-18 1997-11-26 Method for treating hypercholesterolemia with polyallylamine polymers
PCT/US1998/012422 WO1998057652A1 (en) 1997-06-18 1998-06-15 Polyallylamine polymers for treating hypercholesterolemia

Publications (1)

Publication Number Publication Date
ATE249228T1 true ATE249228T1 (de) 2003-09-15

Family

ID=27420493

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98930234T ATE249228T1 (de) 1997-06-18 1998-06-15 Verwendung von polyallylamin-polymeren zur herstellung eines medikamentes zur behandlung von hypercholesterolemia

Country Status (16)

Country Link
US (3) US6423754B1 (de)
EP (1) EP0996454B1 (de)
JP (1) JP4420143B2 (de)
KR (1) KR100567751B1 (de)
CN (1) CN1211091C (de)
AT (1) ATE249228T1 (de)
AU (1) AU735260C (de)
CA (1) CA2294036C (de)
DE (1) DE69818058T2 (de)
HK (1) HK1029920A1 (de)
IL (1) IL133434A (de)
MX (1) MXPA99011826A (de)
MY (1) MY125874A (de)
NZ (1) NZ501719A (de)
TW (1) TW526063B (de)
WO (1) WO1998057652A1 (de)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW568788B (en) * 1998-10-12 2004-01-01 Chugai Pharmaceutical Co Ltd Polymer combining with phosphoric acid and preparation containing the same
EP1293211A1 (de) * 1998-12-23 2003-03-19 G.D. Searle LLC. Kombination von Ileumgallensäuretransport-Inhibitoren und Gallensäure-Sequestriermittel für kardiovaskuläre Indikationen
JP4634618B2 (ja) * 1999-04-16 2011-02-16 アボット・ラボラトリーズ 架橋ポリアリルアミン塩酸塩の製造方法
US6362266B1 (en) 1999-09-03 2002-03-26 The Dow Chemical Company Process for reducing cohesiveness of polyallylamine polymer gels during drying
US6180754B1 (en) 1999-09-03 2001-01-30 The Dow Chemical Company Process for producing cross-linked polyallylamine polymer
US20020054903A1 (en) * 1999-10-19 2002-05-09 Joseph Tyler Direct compression polymer tablet core
US6733780B1 (en) 1999-10-19 2004-05-11 Genzyme Corporation Direct compression polymer tablet core
EP1911462A3 (de) 2001-01-26 2011-11-30 Schering Corporation Zusammensetzungen enthaltend einen Sterolabsorptionshemmer
DK1392331T3 (da) 2001-04-18 2008-06-23 Genzyme Corp Anvendelse af colesevelam eller sevelamer, hydrogenchlorid til sænkning af serumglucoseniveauet
WO2002085379A1 (en) * 2001-04-18 2002-10-31 Geltex Pharmaceuticals, Inc. Method for improving vascular access in patients with vascular shunts
CN1509180A (zh) * 2001-04-18 2004-06-30 ԭ���ø� 用脂肪族聚胺治疗综合症x的方法
WO2002085378A1 (en) * 2001-04-18 2002-10-31 Genzyme Corporation Low salt forms of polyallylamine
US7030126B2 (en) * 2001-11-16 2006-04-18 Als Therapy Development Foundation, Inc. Use of polyamine analogs for amyotrophic lateral sclerosis
WO2004037274A1 (en) * 2002-10-22 2004-05-06 Genzyme Corporation Amine polymers for promoting bone formation
US7608674B2 (en) * 2003-11-03 2009-10-27 Ilypsa, Inc. Pharmaceutical compositions comprising cross-linked small molecule amine polymers
US7385012B2 (en) * 2003-11-03 2008-06-10 Ilypsa, Inc. Polyamine polymers
US7335795B2 (en) * 2004-03-22 2008-02-26 Ilypsa, Inc. Crosslinked amine polymers
US7449605B2 (en) * 2003-11-03 2008-11-11 Ilypsa, Inc. Crosslinked amine polymers
US7767768B2 (en) * 2003-11-03 2010-08-03 Ilypsa, Inc. Crosslinked amine polymers
US7459502B2 (en) * 2003-11-03 2008-12-02 Ilypsa, Inc. Pharmaceutical compositions comprising crosslinked polyamine polymers
WO2005051298A2 (en) 2003-11-19 2005-06-09 Metabasis Therapeutics, Inc. Novel phosphorus-containing thyromimetics
DE602005018619D1 (de) 2004-03-30 2010-02-11 Relypsa Inc Ionenbindende zusammensetzungen
US20050244367A1 (en) * 2004-05-03 2005-11-03 Ilypsa, Inc. Phospholipase inhibitors localized in the gastrointestinal lumen
US20050276781A1 (en) * 2004-06-09 2005-12-15 Ross Edward A Molecularly imprinted phosphate binders for therapeutic use
US7985418B2 (en) * 2004-11-01 2011-07-26 Genzyme Corporation Aliphatic amine polymer salts for tableting
US20060177415A1 (en) * 2004-11-01 2006-08-10 Burke Steven K Once a day formulation for phosphate binders
JP2008533272A (ja) * 2005-03-16 2008-08-21 ユーエスヴィー リミテッド 架橋ポリアリルアミンポリマーの調製のための改良された方法
CA2606498C (en) 2005-05-26 2016-08-09 Metabasis Therapeutics, Inc. Novel phosphinic acid-containing thyromimetics
CA2620406A1 (en) 2005-09-02 2007-03-08 Genzyme Corporation Method for removing phosphate and polymer used therefore
AR056499A1 (es) * 2005-09-06 2007-10-10 Serapis Farmaceuticals Ltd Compuestos
ES2556217T3 (es) 2005-09-15 2016-01-14 Genzyme Corporation Formulación en bolsa para polímeros de amina
US20080085259A1 (en) * 2006-05-05 2008-04-10 Huval Chad C Amine condensation polymers as phosphate sequestrants
BRPI0715053A2 (pt) * 2006-07-18 2013-03-19 Genzyme Corp composiÇço farmacÊutica, mÉtodo para tratar doenÇas, e, polÍmero
JP2010504975A (ja) 2006-09-29 2010-02-18 ゲンズイメ コーポレーション アミドデンドリマー組成物
BRPI0716319A8 (pt) * 2006-10-25 2019-02-05 Aovatechnologies Inc método para reduzir a absorção de fosfato em um indivíduo animal humano ou não-humano correndo o risco de desenvolver ou que desenvolveu hiperfosfatomia e método para reduzir os efeitos colaterais da terapia de vitamina d em um ser humano
US8877198B2 (en) 2006-10-26 2014-11-04 Wisconsin Alumni Research Foundation Methods of reducing phosphate absorption
JP2010513271A (ja) * 2006-12-14 2010-04-30 ゲンズイメ コーポレーション アミド−アミンポリマー組成物
JP2010514702A (ja) 2006-12-22 2010-05-06 アイロンウッド ファーマシューティカルズ,インコーポレーテッド 食道障害の治療方法および治療用組成物
US20100129309A1 (en) * 2007-02-23 2010-05-27 Dhal Pradeep K Amine polymer compositions
US20100196305A1 (en) * 2007-03-08 2010-08-05 Dhal Pradeep K Sulfone polymer compositions
EP2152277A1 (de) * 2007-04-27 2010-02-17 Genzyme Corporation Amido-amin-dendrimer-zusammensetzungen
PA8807201A1 (es) * 2007-12-14 2009-07-23 Genzyme Corp Composiciones farmaceuticas
JP2011506449A (ja) * 2007-12-14 2011-03-03 ジェンザイム コーポレーション コーティング医薬組成物
US20110142952A1 (en) * 2008-06-20 2011-06-16 Harris David J Pharmaceutical Compositions
US8404784B2 (en) * 2008-12-03 2013-03-26 Navinta Llc Manufacturing process of making polymeric amine salts
WO2010093601A1 (en) 2009-02-10 2010-08-19 Metabasis Therapeutics, Inc. Novel sulfonic acid-containing thyromimetics, and methods for their use
IT1394299B1 (it) * 2009-05-12 2012-06-06 Chimico Internaz Spa Lab Procedimento per la preparazione di sevelamer
JP5285000B2 (ja) * 2010-02-23 2013-09-11 富士フイルム株式会社 低密度リポ蛋白コレステロールの測定方法
US20130156720A1 (en) 2010-08-27 2013-06-20 Ironwood Pharmaceuticals, Inc. Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders
WO2014057522A1 (en) 2012-10-12 2014-04-17 Mochida Pharmaceutical Co., Ltd. Compositions and methods for treating non-alcoholic steatohepatitis
SG11201507288UA (en) 2013-03-15 2015-10-29 Mochida Pharm Co Ltd Compositions and methods for treating non-alcoholic steatohepatitis
US10441560B2 (en) 2013-03-15 2019-10-15 Mochida Pharmaceutical Co., Ltd. Compositions and methods for treating non-alcoholic steatohepatitis
CN112047854B (zh) * 2020-10-20 2021-07-02 中国科学院长春应用化学研究所 一种n-乙烯基烷基酰胺的制备方法

Family Cites Families (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB798488A (en) 1956-01-09 1958-07-23 Nat Aluminate Corp Quaternary ammonium compounds and method for the preparation thereof
US2874132A (en) 1956-11-02 1959-02-17 Rohm & Haas Anion-exchange resins for sugar decolorization and their preparation
BE580490A (fr) 1958-07-15 1960-01-08 Merck & Co Inc Compositions et procédés pour abaisser la teneur en cholestérol du sang
US3383281A (en) 1961-09-22 1968-05-14 Merck & Co Inc Method for binding bile acids in vivo
US3308020A (en) 1961-09-22 1967-03-07 Merck & Co Inc Compositions and method for binding bile acids in vivo including hypocholesteremics
US3288770A (en) 1962-12-14 1966-11-29 Peninsular Chem Res Inc Water soluble quaternary ammonium polymers
CH486202A (de) 1966-05-31 1970-02-28 Agripat Sa Mikrobizides Mittel
US3562266A (en) 1969-05-26 1971-02-09 Montedison Spa Quaternary ammonium halides having a 2-chloro cyclohexyl or 2-chloro alkyl substituent
BE756035A (fr) 1969-09-12 1971-03-11 Inveresk Res Int Polymeres pontes
US3803237A (en) 1969-11-03 1974-04-09 Upjohn Co Reaction products of polyethylenepolyamines and chlorohydrins or epoxy containing compounds
NL7017227A (de) 1969-12-27 1971-06-29
US3692895A (en) 1970-09-08 1972-09-19 Norman A Nelson Method of reducing hypercholesteremia in humans employing a copolymer of polyethylenepolyamine and a bifunctional substance, such as epichlorohydria
US3980770A (en) 1971-06-04 1976-09-14 Pharmacia Aktiebolag Polymerization products containing amino groups useful in serum cholesterol level control
US4027009A (en) 1973-06-11 1977-05-31 Merck & Co., Inc. Compositions and methods for depressing blood serum cholesterol
US4217429A (en) 1973-06-11 1980-08-12 Merck & Co., Inc. Poly-[(methylimino)trimethylene]
US4205064A (en) 1973-06-11 1980-05-27 Merck & Co., Inc. Bile acid sequestering composition containing poly[{alkyl-(3-ammoniopropyl)imino}-trimethylenedihalides]
CS187563B1 (en) 1974-02-08 1979-02-28 Petr Strop Method of preparation of the hydrophilic homogeneous or macroporous annexes
CS173201B1 (de) 1974-02-13 1977-02-28
US4016209A (en) 1975-04-23 1977-04-05 Merck & Co., Inc. 3-[N'-(3-Halopropyl)-N-'-methylamino]-N,N,N-trimethyl-1-propanaminium halide and acid addition salts thereof
US4071478A (en) 1976-06-07 1978-01-31 Merck & Co., Inc. Controlled partially cross-linked 3,3-ionenes
FI67483C (fi) 1977-02-17 1985-04-10 Merck & Co Inc Foerfarande foer framstaellning av ett icke adhesivt friflytande farmakologiskt godtagbart gallsyrakomplexbildande adsorbatpreparat
IT1106718B (it) 1978-12-21 1985-11-18 Alfa Farmaceutici Spa Composizioni a base di resine anioniche salificate farmacologicamente attive
US4426489A (en) 1980-02-21 1984-01-17 The Dow Chemical Company Surface active polymeric surfactants containing side chain hydrophobes
ATE12511T1 (de) 1980-12-12 1985-04-15 Smith & Nephew Ass Polymere, deren herstellung und verwendungen.
JPS5879022A (ja) 1981-11-04 1983-05-12 Bitamin Kenkyusho:Kk 第四級窒素原子を含有する新規な金属架橋高分子化合物、その製法及び該高分子化合物を有効成分とする高脂血症治療剤
EP0098884B1 (de) 1982-01-18 1986-07-23 Mitsubishi Petrochemical Co., Ltd. Heilmittel zum absenken cholesterolspiegels
JPS6090243A (ja) 1983-10-25 1985-05-21 Nitto Boseki Co Ltd 小球状モノアリルアミン橋かけ重合体の製造方法
CA1220896A (en) 1983-11-10 1987-04-21 Susumu Harada Process for producing polymers of monoallylamine
JPS60106803A (ja) 1983-11-14 1985-06-12 Nitto Boseki Co Ltd アリル尿素重合体の製造方法
AU551886B2 (en) 1983-11-14 1986-05-15 Nitto Boseki Co. Ltd. Poly(allylamine) derivatives
CA1220897A (en) 1984-01-11 1987-04-21 Kiyoshi Shimizu Process for producing polymers of monoallylamine
OA08092A (fr) 1984-05-11 1987-03-31 Bristol Myers Co Novel bile sequestrant resin and uses.
US4759923A (en) 1987-06-25 1988-07-26 Hercules Incorporated Process for lowering serum cholesterol using poly(diallylmethylamine) derivatives
DE3800199A1 (de) 1988-01-07 1989-07-20 Sandoz Ag Seitenkettenhaltige vinylpolymere
GB8829088D0 (en) 1988-12-13 1989-01-25 Smith Kline French Lab Compounds
US5236701A (en) 1989-07-19 1993-08-17 Lowchol Scientific Inc. Ingestible hydrophilic polymeric amines useful for lowering blood cholesterol
GB8928278D0 (en) 1989-12-14 1990-02-21 Smith Kline French Lab Compounds
CA2040996A1 (en) 1990-05-02 1991-11-03 Robert L. Albright Composition and method for controlling cholesterol
GB9011332D0 (en) 1990-05-21 1990-07-11 Smith Kline French Lab Compounds
IE914179A1 (en) 1990-12-07 1992-06-17 Ici Plc Nitrogen derivatives
US5055197A (en) 1991-04-05 1991-10-08 Rohm And Haas Company Process for removing residual monomers and oligemers from amine-containing polymers
JP3247435B2 (ja) 1992-07-11 2002-01-15 日産アルティア株式会社 芯材添設型樹脂製車両用ルーフレールの製造方法及び車両用ルーフレール
EP0580078B1 (de) 1992-07-22 1997-10-15 Hoechst Aktiengesellschaft Hydrophile Zentren aufweisende Polyvinylamin-Derivate, Verfahren zu ihrer Herstellung sowie die Verwendung der Verbindungen als Arzneimittel, Wirkstoffträger und Nahrungsmittelhilfsstoff
DK0580079T3 (da) 1992-07-22 1997-06-30 Hoechst Ag Tværbundne, nitrogenholdige vinylcopolymerer, fremgangsmåde til deres fremstilling samt anvendelse af disse forbindelser
US5633344A (en) 1992-08-20 1997-05-27 E. I. Du Pont De Nemours & Company Crosslinked polymeric ammonium salts
US5451397A (en) 1992-12-21 1995-09-19 Rohm And Haas Company Bile acid sequestrant
JPH06321786A (ja) * 1993-05-12 1994-11-22 Sekisui Chem Co Ltd 胆汁酸腸管吸収抑制剤
US5487888A (en) 1993-05-20 1996-01-30 Geltex, Inc. Iron-binding polymers for oral administration
US5624963A (en) 1993-06-02 1997-04-29 Geltex Pharmaceuticals, Inc. Process for removing bile salts from a patient and compositions therefor
US5607669A (en) * 1994-06-10 1997-03-04 Geltex Pharmaceuticals, Inc. Amine polymer sequestrant and method of cholesterol depletion
WO1994027620A1 (en) 1993-06-02 1994-12-08 Geltex Pharmaceuticals, Inc. Compositions and process for removing bile salts
US5618530A (en) 1994-06-10 1997-04-08 Geltex Pharmaceuticals, Inc. Hydrophobic amine polymer sequestrant and method of cholesterol depletion
US5496545A (en) 1993-08-11 1996-03-05 Geltex Pharmaceuticals, Inc. Phosphate-binding polymers for oral administration
US5414068A (en) 1994-01-24 1995-05-09 Rohm And Haas Company Crosslinked anion exchange particles and method for producing the particles
TW474813B (en) 1994-06-10 2002-02-01 Geltex Pharma Inc Alkylated composition for removing bile salts from a patient
US5792749A (en) * 1997-01-09 1998-08-11 Virginia Commonwealth University Method and composition for lowering low density lipoprotein cholesterol

Also Published As

Publication number Publication date
HK1029920A1 (en) 2001-04-20
DE69818058D1 (de) 2003-10-16
AU735260B2 (en) 2001-07-05
JP2002516613A (ja) 2002-06-04
CN1263468A (zh) 2000-08-16
EP0996454A1 (de) 2000-05-03
JP4420143B2 (ja) 2010-02-24
WO1998057652A1 (en) 1998-12-23
US6423754B1 (en) 2002-07-23
KR20010013943A (ko) 2001-02-26
MXPA99011826A (es) 2002-07-02
US20030086898A1 (en) 2003-05-08
CN1211091C (zh) 2005-07-20
IL133434A0 (en) 2001-04-30
EP0996454B1 (de) 2003-09-10
TW526063B (en) 2003-04-01
CA2294036A1 (en) 1998-12-23
AU735260C (en) 2002-03-28
IL133434A (en) 2005-09-25
CA2294036C (en) 2007-08-21
DE69818058T2 (de) 2004-07-08
US20060239959A1 (en) 2006-10-26
KR100567751B1 (ko) 2006-04-05
MY125874A (en) 2006-08-30
NZ501719A (en) 2001-10-26
AU7967598A (en) 1999-01-04

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