ATE247116T1 - Arylthioxanthine - Google Patents

Arylthioxanthine

Info

Publication number
ATE247116T1
ATE247116T1 AT95943949T AT95943949T ATE247116T1 AT E247116 T1 ATE247116 T1 AT E247116T1 AT 95943949 T AT95943949 T AT 95943949T AT 95943949 T AT95943949 T AT 95943949T AT E247116 T1 ATE247116 T1 AT E247116T1
Authority
AT
Austria
Prior art keywords
pde
compounds
inhibition
hydrogen
independently
Prior art date
Application number
AT95943949T
Other languages
English (en)
Inventor
David J Cavalla
Peter Hofer
Mark Chasin
Original Assignee
Euro Celtique Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Euro Celtique Sa filed Critical Euro Celtique Sa
Application granted granted Critical
Publication of ATE247116T1 publication Critical patent/ATE247116T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, ***e
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/22—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one sulfur atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Lubricants (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
AT95943949T 1994-12-13 1995-12-12 Arylthioxanthine ATE247116T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35466494A 1994-12-13 1994-12-13
PCT/US1995/016723 WO1996018399A1 (en) 1994-12-13 1995-12-12 Aryl thioxanthines

Publications (1)

Publication Number Publication Date
ATE247116T1 true ATE247116T1 (de) 2003-08-15

Family

ID=23394396

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95943949T ATE247116T1 (de) 1994-12-13 1995-12-12 Arylthioxanthine

Country Status (11)

Country Link
US (3) US6066641A (de)
EP (1) EP0814809B1 (de)
JP (1) JPH10508032A (de)
AT (1) ATE247116T1 (de)
AU (1) AU4527896A (de)
CA (1) CA2206287C (de)
DE (1) DE69531506T2 (de)
IL (1) IL116381A0 (de)
TW (1) TW315369B (de)
WO (1) WO1996018399A1 (de)
ZA (2) ZA9510595B (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6746839B1 (en) * 1998-01-12 2004-06-08 Interleukin Genetics, Inc. Diagnostics and therapeutics for an obstructive airway disease
IL145701A0 (en) * 1999-04-02 2002-07-25 Euro Celtique Sa Purine derivatives having phosphodiesterase iv inhibition activity
CA2379356A1 (en) * 1999-08-12 2001-02-22 Mark Chasin Novel hypoxanthine and thiohypoxanthine compounds
US7057516B2 (en) * 2001-06-01 2006-06-06 Dimitri Donskoy Device and method for detecting localization, monitoring, and identification of living organisms in structures
AR039385A1 (es) * 2002-04-19 2005-02-16 Astrazeneca Ab Derivados de tioxantina como inhibidores de la mieloperoxidasa
SE0302756D0 (sv) * 2003-10-17 2003-10-17 Astrazeneca Ab Novel Compounds
SE0402591D0 (sv) * 2004-10-25 2004-10-25 Astrazeneca Ab Novel use
MY140748A (en) * 2004-12-06 2010-01-15 Astrazeneca Ab Novel pyrrolo [3,2-d] pyrimidin-4-one derivatives and their use in therapy
UY30267A1 (es) * 2006-04-13 2007-11-30 Astrazeneca Ab Nuevos derivados de la tioxantina , composiciones farmacéuticas que los contienen, procedimientos de preparacion y aplicaciones
WO2007120097A1 (en) * 2006-04-13 2007-10-25 Astrazeneca Ab Thioxanthine derivatives and their use as inhibitors of mpo
TW200804383A (en) * 2006-06-05 2008-01-16 Astrazeneca Ab New compounds
JP2012521411A (ja) * 2009-03-26 2012-09-13 マピ ファーマ リミテッド アログリプチンの調製プロセス
CN103360393B (zh) * 2013-07-29 2016-01-06 上海万巷制药有限公司 茶碱乙酸的制备方法

Family Cites Families (147)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2903455A (en) * 1959-09-08 Jdnviiiiaisnvhi jo
US2956998A (en) * 1960-10-18 Adenine derivatives and process
US2844577A (en) * 1958-07-22 Certificate of correction
US3215696A (en) * 1965-11-02 Substituted adenines -and preparation thereof
FR835818A (fr) 1938-03-28 1939-01-04 Système de soupape, spécialement pour moteurs à combustion
US2320654A (en) * 1940-08-08 1943-06-01 Riester Oskar Sensitization of photographic emulsions
US2691654A (en) * 1952-06-11 1954-10-12 Buroughs Wellcome & Co U S A I Amino heterocycles and method of making
US2966488A (en) * 1956-07-30 1960-12-27 Shive William Substituted alkylaminopurines
US2957875A (en) * 1957-11-18 1960-10-25 Upjohn Co Derivatives of purine
US3079378A (en) * 1960-02-01 1963-02-26 Upjohn Co Acylated psicofuranosyladenines
BE601946A (de) * 1960-03-31
US3135753A (en) * 1961-05-10 1964-06-02 Burroughs Wellcome Co Alkylthiopurines and method
US3129225A (en) * 1961-06-07 1964-04-14 Us Vitamin Pharm Corp Novel 4-oxy-3-maleimidyl betaines
GB967483A (de) * 1961-09-12
FR1548252A (de) 1961-10-13 1968-12-06
US3136771A (en) * 1962-03-09 1964-06-09 Ciba Ltd Bis-(2-benzoxazolyl) furylmethy-pyridinium chloride
US3491091A (en) * 1962-03-28 1970-01-20 Boehringer & Soehne Gmbh 5-nitrofuran derivatives
US3470164A (en) * 1962-05-04 1969-09-30 Dainippon Pharmaceutical Co 2-(2-(5-nitrofuryl)-vinyl)-azoles and process for producing thereof
US3494919A (en) * 1964-07-30 1970-02-10 American Cyanamid Co Preparation of styryloxazole compounds
IL24679A (en) 1965-11-24 1971-10-20 Yissum Res Dev Co Derivatives of 3-methyl purine and methods of preparing the same
CH465959A (de) * 1966-11-30 1969-01-15 Ciba Geigy Gebrauchsfertiges Mittel zur Bekämpfung von schädlichen Mikroorganismen auf textilem Material
CH527215A (de) * 1967-04-15 1972-08-31 Fujisawa Pharmaceutical Co Verfahren zur Herstellung von 3,7-disubstituierten Cephalosporinderivaten
US3681328A (en) * 1967-06-27 1972-08-01 Fujisawa Pharmaceutical Co Sydnone derivatives of 7-aminocephalosporanic acids
CH542853A (de) * 1967-07-26 1973-10-15 Agripat Sa Verfahren zur Herstellung neuer Isothiocyano-benzazol-Derivate
GB1241657A (en) * 1967-08-21 1971-08-04 Glaxo Lab Ltd Improvements in or relating to cephalosporin compounds
DE1670265A1 (de) * 1967-08-25 1971-01-28 Boehringer Mannheim Gmbh 2-Amino-Adenosinderivate und Verfahren zu deren Herstellung
US3669979A (en) * 1967-12-14 1972-06-13 Gaf Corp Novel process for the production of 2-benzothiazolyl-phenol and derivatives thereof employing phosphorus trichloride as a catalyst
US3541100A (en) * 1967-12-14 1970-11-17 American Cyanamid Co Benzheteroazolo(2,3-a)isoquinolium salts
US3491106A (en) * 1967-12-15 1970-01-20 Gaf Corp Sodium 3-(2-benzothiazolyl) - 4-hydroxy-benzenesulfonates and analogues thereof
US3626018A (en) * 1968-01-25 1971-12-07 Edward C Taylor Chemical processes using organothallium compounds
US3923833A (en) * 1968-05-01 1975-12-02 Hoffmann La Roche N-{8 (1-cyano-2-phenyl)ethyl{9 carbamates
US3551554A (en) * 1968-08-16 1970-12-29 Crown Zellerbach Corp Enhancing tissue penetration of physiologically active agents with dmso
US3647812A (en) * 1969-04-22 1972-03-07 Richard F Smith Halogenated 2(2'-hydroxyphenyl benzothiazoles
US3574218A (en) * 1969-08-11 1971-04-06 Egyt Gyogyszervegyeszeti Gyar 2-aryl- or aralkyl-substituted benzazole derivatives
US4146721A (en) * 1969-09-12 1979-03-27 Byk Gulden Lomberg Chemische Fabrik Gmbh Pyrazol-4-acetic acid compounds
US3666769A (en) * 1969-10-09 1972-05-30 Du Pont Thermally stable 2-perfluoro-substituted benzothiazoles
US3686238A (en) * 1970-01-19 1972-08-22 Syntex Corp Glycerol esterified with 2-naphthyl-acetic acids and fatty acids
US3636039A (en) * 1970-02-24 1972-01-18 Hoffmann La Roche Substituted benzylimidazolidinones
FR2104932A1 (en) 1970-09-08 1972-04-28 Ferlux O-hydroxyphenyl pyrazoles - hypocholesterolemics anti inflammatories analgesics etc
US3674781A (en) * 1970-09-15 1972-07-04 Hoechst Ag Optical brighteners of the benzoxazole series
US3962452A (en) * 1972-05-18 1976-06-08 Lilly Industries, Ltd. Benzoxazole derivatives as therapeutics
US3895028A (en) 1972-09-12 1975-07-15 Tokyo Tanabe Co Alpha-(2-phenylbenzothiazol-5-yl)propionic acid
CA994351A (en) 1973-01-11 1976-08-03 E.R. Squibb And Sons Tetrahydronaphthyloxy-amines and related compounds
US4107306A (en) * 1973-01-16 1978-08-15 The Regents Of The University Of Michigan Process for treating proliferative skin disease
US4025637A (en) * 1973-10-23 1977-05-24 Lilly Industries, Ltd. 2,5 OR 2,6 Disubstituted benzoxazoles
US4025636A (en) * 1973-10-23 1977-05-24 Lilly Industries, Ltd. 2-(Optionally substituted)phenyl-5 or 6-substituted benzoxazoles
DE2413935A1 (de) 1974-03-20 1975-10-16 Schering Ag 4-(polyalkoxy-phenyl)-2-pyrrolidone
JPS5120826A (en) * 1974-08-13 1976-02-19 Fuji Photo Film Co Ltd Shashinyokapuraa
US4020165A (en) * 1975-08-20 1977-04-26 Uniroyal Inc. Control of acarids using certain benzothiazoles or benzothiazolines
CA1077932A (en) 1976-03-31 1980-05-20 Berlex Laboratories, Inc. Xanthine compounds and method of treating bronchospastic and allergic diseases
LU76467A1 (de) * 1976-12-23 1978-07-10
DE2714953C2 (de) 1977-04-02 1986-09-25 Hoechst Ag, 6230 Frankfurt Arzneimittel
SE416810C (sv) * 1977-10-14 1982-07-19 Draco Ab Forfarande for framstellning av xantinderivat med antiallergisk aktivitet
HU179019B (en) * 1978-11-01 1982-08-28 Gyogyszekutato Intezet Process for preparing 4-//3,4-dialkoxy-phenyl/-alkyl/- 2imidazolidinone derivatives
GB2041359B (en) 1979-01-10 1982-12-15 Ici Ltd Purine derivatives and their use in the defoliation of cotton plants
US4684728A (en) * 1979-01-12 1987-08-04 Bayer Aktiengesellschaft Solubilizing biologically active compounds with reactive hydrogen atoms
IL59665A0 (en) * 1979-04-05 1980-06-30 Wuelfing J Kg Xanthine derivatives,process for their preparation and their use in pharmaceutical compositions
CH643260A5 (fr) * 1980-05-02 1984-05-30 Nestle Sa 1-allyl-3-butyl-8-methylxanthine, procede de preparation et utilisation dans un medicament.
GB2091249A (en) 1980-12-23 1982-07-28 Fordonal Sa Xanthine derivatives
US4416892A (en) * 1981-04-23 1983-11-22 Lilly Industries Limited Method of treating hypersensitivity disease with benzoxazole derivatives
DE3138397A1 (de) * 1981-09-26 1983-04-07 Hoechst Ag, 6230 Frankfurt "arzneimittel, darin enthaltene vicinale dihydroxyalkylxanthine und herstellungsverfahren fuer diese xanthinverbindungen"
US4361699A (en) * 1981-09-28 1982-11-30 Merck & Co., Inc. Novel process for the preparation of N6 -alkyl-arprinocid
US4495195A (en) * 1982-11-01 1985-01-22 Eli Lilly And Company Xanthine oxidase inhibiting 3(5)-phenyl-substituted-5(3)-pyrazole-carboxylic acid derivatives, compositions, and methods of use
US4769377A (en) * 1983-02-18 1988-09-06 The Johns Hopkins University Adenosine receptor antagonists
US4918074A (en) * 1984-03-12 1990-04-17 Yoshitomi Pharmaceutical Industries, Ltd. Polyazaheterocycle compounds
ATE49198T1 (de) * 1984-05-12 1990-01-15 Fisons Plc Antiinflammatorische 1,n-diarylpyrazol-3-amine, deren zusammensetzungen und verfahren zu deren herstellung.
JPS615071A (ja) * 1984-06-15 1986-01-10 Fuji Photo Film Co Ltd ベンゾオキサゾ−ル誘導体
IN165525B (de) * 1984-07-23 1989-11-04 Shinetsu Chemical Co
EP0178413A1 (de) 1984-08-17 1986-04-23 Beecham Group Plc Benzimidazole
US4883801A (en) * 1984-09-07 1989-11-28 The General Hospital Corporation Xanthine derivative pest control agents
WO1986001724A1 (en) * 1984-09-07 1986-03-27 The General Hospital Corporation Xanthine derivative pest control agents
IT1177017B (it) * 1984-10-22 1987-08-26 Ravizza Spa Processo per la preparazione dell'acido 2(4-flurofenil)alfa-metil-5-benzox azoloacetico
US4710503A (en) * 1985-02-07 1987-12-01 Euroceltique S.A. 6-thioxanthine derivatives
JPH0658512B2 (ja) * 1985-04-12 1994-08-03 富士写真フイルム株式会社 ハロゲン化銀写真感光材料
GB8510758D0 (en) 1985-04-27 1985-06-05 Wellcome Found Compounds
US4732978A (en) * 1985-10-03 1988-03-22 American Home Products Corporation Novel substituted naphthyloxymethyl quinoline derivatives as anti-inflammatory and antiallergy agents
US4684656A (en) * 1986-03-14 1987-08-04 E. R. Squibb & Sons, Inc. 1,2,3,4-tetrahydro-6-substituted-4-aryl-3-(substituted sulfonyl)-2-thioxo(or oxo)-5-pyrimidinecarboxylic acids and esters and method of using them to lower blood pressure
DE3773746D1 (en) * 1986-05-07 1991-11-21 Fisons Plc Pyrazole.
US4826868A (en) * 1986-05-29 1989-05-02 Ortho Pharmaceutical Corporation 1,5-Diaryl-3-substituted pyrazoles pharmaceutical compositions and use
US4868183A (en) * 1986-07-21 1989-09-19 Otsuka Pharmaceutical Factory, Inc. N-pyrazinyl substituted P-aminophenols
US4755517A (en) * 1986-07-31 1988-07-05 Warner-Lambert Company Derivatives of xanthine, pharmaceutical compositions and methods of use therefor
GB8618931D0 (en) * 1986-08-02 1986-09-10 Euro Celtique Sa 6-thioxanthines
DE3779374D1 (en) 1986-08-28 1992-07-02 Sandoz Ag Xanthinderivate.
JPH0612406B2 (ja) * 1986-11-14 1994-02-16 富士写真フイルム株式会社 超硬調ネガ型ハロゲン化銀写真感光材料
EP0583821B1 (de) * 1987-01-23 2000-03-29 The General Hospital Corporation Hydralazin zur topischen Behandlung von Glaukom
CA1340284C (en) * 1987-03-19 1998-12-22 Zeneca Inc. Herbicidal substituted cyclic diones
US4988689A (en) * 1987-07-01 1991-01-29 Janssen Pharmaceutica N.V. ((Pharmacologically active bicyclic heterocyclic)methyl and -heteroatom) substituted hexahydro-1H-azepines and pyrrolidines
JPH0670025B2 (ja) * 1987-08-07 1994-09-07 鐘紡株式会社 ベンゾチアゾ−ル誘導体および該化合物を有効成分とする抗リウマチ剤
JPH01156978A (ja) * 1987-09-24 1989-06-20 Kyowa Hakko Kogyo Co Ltd 新規なキサンチン誘導体
JPH01121854A (ja) * 1987-11-06 1989-05-15 Fuji Photo Film Co Ltd 高コントラストネガ画像形成方法
JPH07117726B2 (ja) * 1987-12-17 1995-12-18 富士写真フイルム株式会社 ハロゲン化銀感光材料
US5139921A (en) * 1988-01-11 1992-08-18 Fuji Photo Film Co., Ltd. Process for forming super high contrast negative images
JPH01213650A (ja) * 1988-02-20 1989-08-28 Fuji Photo Film Co Ltd ハロゲン化銀カラー写真感光材料の処理方法
JPH07113758B2 (ja) * 1988-03-28 1995-12-06 富士写真フイルム株式会社 ハロゲン化銀写真感光材料
IE62214B1 (en) 1988-05-25 1995-01-11 Warner Lambert Co Arylmethylenyl derivatives of thiazolidinones, imidazolidinones and oxazolidinones useful as antiallergy agents and antiinflammatory agents
GB8820231D0 (en) * 1988-08-25 1988-09-28 Fujisawa Pharmaceutical Co New benzazole compounds processes for preparation thereof & pharmaceutical composition comprising same
IL91418A (en) * 1988-09-01 1997-11-20 Rhone Poulenc Agrochimie (hetero) cyclic amide derivatives, process for their preparation and fungicidal compositions containing them
US5175290A (en) * 1988-09-16 1992-12-29 Marion Merrell Dow Inc. 8-(oxo-substituted cycloalkyl)xanthines
GB8826595D0 (en) 1988-11-14 1988-12-21 Beecham Wuelfing Gmbh & Co Kg Active compounds
DE8817122U1 (de) * 1988-12-22 1993-02-04 Boehringer Ingelheim Kg, 55218 Ingelheim Neue Xanthinderivate mit Adenosinantogenistischer Wirkung
JP2843634B2 (ja) * 1989-03-06 1999-01-06 協和醗酵工業株式会社 キサンチン誘導体
IT1229195B (it) 1989-03-10 1991-07-25 Poli Ind Chimica Spa Derivati xantinici ad attivita' broncodilatatrice e loro applicazioni terapeutiche.
GB8906792D0 (en) 1989-03-23 1989-05-10 Beecham Wuelfing Gmbh & Co Kg Treatment and compounds
US5290782A (en) * 1989-09-01 1994-03-01 Kyowa Hakko Kogyo Co., Ltd. Xanthine derivatives
JPH06102662B2 (ja) 1989-09-01 1994-12-14 協和醗酵工業株式会社 キサンチン誘導体
EP0417790B1 (de) * 1989-09-14 1996-12-04 Kyowa Hakko Kogyo Co., Ltd. 5-Triazolo(3,4-i)purinderivate
JPH03173874A (ja) * 1989-09-29 1991-07-29 Mitsubishi Kasei Corp 新規複素環化合物
JP2988711B2 (ja) 1989-10-20 1999-12-13 協和醗酵工業株式会社 縮合プリン誘導体
FR2654935B1 (fr) * 1989-11-28 1994-07-01 Lvmh Rech Utilisation de xanthines, eventuellement incorporees dans des liposomes, pour favoriser la pigmentation de la peau ou des cheveux.
GB8929208D0 (en) * 1989-12-27 1990-02-28 Almirall Lab New xanthine derivatives
US5124455A (en) 1990-08-08 1992-06-23 American Home Products Corporation Oxime-carbamates and oxime-carbonates as bronchodilators and anti-inflammatory agents
GB9020959D0 (en) * 1990-09-26 1990-11-07 Beecham Group Plc Novel compounds
GB9020921D0 (en) * 1990-09-26 1990-11-07 Beecham Group Plc Novel compounds
US5117830A (en) * 1990-11-08 1992-06-02 Whitby Research, Inc. Method of determining viability of tissue
JP3095413B2 (ja) * 1990-12-28 2000-10-03 帝人株式会社 ベンゾオキサ縮合環化合物
IE71647B1 (en) 1991-01-28 1997-02-26 Rhone Poulenc Rorer Ltd Benzamide derivatives
JPH0559056A (ja) * 1991-02-25 1993-03-09 Kyowa Hakko Kogyo Co Ltd キサンチン誘導体
US5190942A (en) * 1991-04-22 1993-03-02 E. R. Squibb & Sons, Inc. Benzoxazole and related heterocyclic substituted imidazole and benzimidazole derivatives
US5191084A (en) 1991-05-01 1993-03-02 American Home Products Corporation Phenyl pyrazolidinones as bronchodilators and anti-inflammatory agents
PT100441A (pt) * 1991-05-02 1993-09-30 Smithkline Beecham Corp Pirrolidinonas, seu processo de preparacao, composicoes farmaceuticas que as contem e uso
US5264589A (en) * 1991-06-06 1993-11-23 Miles Inc. Merocyanine protein error indicators
DE4129603A1 (de) * 1991-09-06 1993-03-11 Thomae Gmbh Dr K Kondensierte 5-gliedrige heterocyclen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
EP0642489A1 (de) * 1991-10-02 1995-03-15 Smithkline Beecham Corporation Cyclopentan- und cyclopenten-derivate mit antiallergischen, entzündungshemmendenund tumor necrose faktor inhibierenden eigenschaften
JPH05105631A (ja) * 1991-10-16 1993-04-27 Kyowa Hakko Kogyo Co Ltd 抗痴呆薬
DE69229257D1 (de) * 1991-11-08 1999-07-01 Kyowa Hakko Kogyo Kk Xanthinderivate zur Behandlung der Demenz
AU3592493A (en) * 1992-01-13 1993-08-03 Smithkline Beecham Corporation Pyridyl substituted imidazoles
AU3481593A (en) * 1992-01-29 1993-09-01 Smithkline Beecham Corporation N-(3-phenylpropyl)oxamic acid, oxamate, and oxamide derivatives
WO1993015044A1 (en) * 1992-01-29 1993-08-05 Smithkline Beecham Corporation N-benzyloxamic acid, oxamate, and oxamide derivatives and their use as tnf and pde iv inhibitors
US5602173A (en) * 1992-04-02 1997-02-11 Smithkline Beecham Corporation Compounds useful for treating allergic and inflammatory diseases
US5300298A (en) * 1992-05-06 1994-04-05 The Pennsylvania Research Corporation Methods of treating obesity with purine related compounds
DE69309030T2 (de) * 1992-06-15 1997-09-25 Celltech Therapeutics Ltd Trisubstituierte phenylderivate als selektive phosphodiesterase iv inhibitoren
NZ254881A (en) * 1992-07-28 1996-09-25 Rhone Poulenc Rorer Ltd Diether, dithioether or diether thioether derivatives of 1,2-dihydroxybenzenes substituted in position-4 by an (hetero)aryl-containing group;
TW252044B (de) * 1992-08-10 1995-07-21 Boehringer Ingelheim Kg
US5436258A (en) * 1992-09-09 1995-07-25 Eli Lilly And Company Prevention of bone resorption
US5422350A (en) * 1992-09-10 1995-06-06 Warner-Lambert Company Nitrogen substituted acridine and cytochrome P450 inhibitors and methods of use
JP2613355B2 (ja) 1992-09-28 1997-05-28 協和醗酵工業株式会社 パーキンソン氏病治療剤
US5322847A (en) * 1992-11-05 1994-06-21 Pfizer Inc. Azabenzimidazoles in the treatment of asthma, arthritis and related diseases
US5451596A (en) * 1992-12-29 1995-09-19 Rhone Poulenc Rorer Pharmaceuticals Inc. Cycloalkyl amine bis-aryl squalene synthase inhibitors
DE4309969A1 (de) * 1993-03-26 1994-09-29 Bayer Ag Substituierte heteroanellierte Imidazole
US5395836A (en) 1993-04-07 1995-03-07 Kyowa Hakko Kogyo Co., Ltd. 8-tricycloalkyl xanthine derivatives
AU6702894A (en) * 1993-04-09 1994-11-08 Cell Therapeutics, Inc. Ring-substituted cell signaling inhibitors
US5334596A (en) * 1993-05-11 1994-08-02 Merck & Co., Inc. Fibrinogen receptor antagonists
GB9312853D0 (en) * 1993-06-22 1993-08-04 Euro Celtique Sa Chemical compounds
US5446046A (en) 1993-10-28 1995-08-29 University Of Florida Research Foundation A1 adenosine receptor agonists and antagonists as diuretics
AU1868195A (en) * 1994-01-28 1995-08-15 Cell Therapeutics, Inc. Cell signaling inhibitors
CA2161011A1 (en) * 1994-02-23 1995-08-31 Fumio Suzuki Xanthine derivatives
CA2218548A1 (en) * 1995-05-19 1996-11-21 Chiroscience Limited Xanthines and their therapeutic use

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CA2206287C (en) 2001-03-20
IL116381A0 (en) 1996-03-31
AU4527896A (en) 1996-07-03
EP0814809A1 (de) 1998-01-07
ZA9510595B (en) 1996-06-19
WO1996018399A1 (en) 1996-06-20
TW315369B (de) 1997-09-11
US6440979B1 (en) 2002-08-27
DE69531506D1 (en) 2003-09-18
ZA9510594B (en) 1996-06-19
CA2206287A1 (en) 1996-06-20
DE69531506T2 (de) 2004-06-24
EP0814809A4 (de) 1998-04-01
EP0814809B1 (de) 2003-08-13
US6090816A (en) 2000-07-18
JPH10508032A (ja) 1998-08-04
US6066641A (en) 2000-05-23

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