ATE235956T1 - Verfahren zur herstellung von partikeln - Google Patents
Verfahren zur herstellung von partikelnInfo
- Publication number
- ATE235956T1 ATE235956T1 AT00942295T AT00942295T ATE235956T1 AT E235956 T1 ATE235956 T1 AT E235956T1 AT 00942295 T AT00942295 T AT 00942295T AT 00942295 T AT00942295 T AT 00942295T AT E235956 T1 ATE235956 T1 AT E235956T1
- Authority
- AT
- Austria
- Prior art keywords
- vehicles
- vehicle
- solvent
- target substance
- dispersion
- Prior art date
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
- B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
- B01J2/04—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a gaseous medium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/04—Solvent extraction of solutions which are liquid
- B01D11/0403—Solvent extraction of solutions which are liquid with a supercritical fluid
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/04—Solvent extraction of solutions which are liquid
- B01D11/0403—Solvent extraction of solutions which are liquid with a supercritical fluid
- B01D11/0407—Solvent extraction of solutions which are liquid with a supercritical fluid the supercritical fluid acting as solvent for the solute
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/04—Solvent extraction of solutions which are liquid
- B01D11/0403—Solvent extraction of solutions which are liquid with a supercritical fluid
- B01D11/0411—Solvent extraction of solutions which are liquid with a supercritical fluid the supercritical fluid acting as solvent for the solvent and as anti-solvent for the solute, e.g. formation of particles from solutions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/04—Solvent extraction of solutions which are liquid
- B01D11/0488—Flow sheets
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Extraction Or Liquid Replacement (AREA)
- Medicinal Preparation (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
- Glass Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9915975.8A GB9915975D0 (en) | 1999-07-07 | 1999-07-07 | Method for the formation of particles |
PCT/GB2000/002606 WO2001003821A1 (en) | 1999-07-07 | 2000-07-07 | Method of particle formation |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE235956T1 true ATE235956T1 (de) | 2003-04-15 |
Family
ID=10856857
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT00942295T ATE235956T1 (de) | 1999-07-07 | 2000-07-07 | Verfahren zur herstellung von partikeln |
Country Status (12)
Country | Link |
---|---|
US (2) | US6860907B1 (de) |
EP (1) | EP1191999B1 (de) |
JP (1) | JP4490016B2 (de) |
AT (1) | ATE235956T1 (de) |
AU (1) | AU773548B2 (de) |
CA (1) | CA2376593C (de) |
DE (1) | DE60001944T2 (de) |
DK (1) | DK1191999T3 (de) |
ES (1) | ES2195908T3 (de) |
GB (2) | GB9915975D0 (de) |
MX (1) | MXPA01013259A (de) |
WO (1) | WO2001003821A1 (de) |
Families Citing this family (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9703673D0 (en) * | 1997-02-21 | 1997-04-09 | Bradford Particle Design Ltd | Method and apparatus for the formation of particles |
GB9810559D0 (en) * | 1998-05-15 | 1998-07-15 | Bradford Particle Design Ltd | Method and apparatus for particle formation |
GB9915975D0 (en) * | 1999-07-07 | 1999-09-08 | Bradford Particle Design Ltd | Method for the formation of particles |
GB9920558D0 (en) * | 1999-08-31 | 1999-11-03 | Bradford Particle Design Ltd | Methods for particle formation and their products |
GB9927011D0 (en) | 1999-11-16 | 2000-01-12 | Advanced Phytonics Ltd | Method for the production of particles |
FR2815540B1 (fr) † | 2000-10-19 | 2005-06-10 | Separex Sa | Procede de fabrication de tres fines particules constituees d'un principe insere dans une molecule hote |
GB0027357D0 (en) | 2000-11-09 | 2000-12-27 | Bradford Particle Design Plc | Particle formation methods and their products |
IL156618A0 (en) * | 2000-12-28 | 2004-01-04 | Altus Biologics Inc | Crystals of whole antibodies and fragments thereof, methods for the preparation thereof and diagnostic kits utilizing the same |
GB0102075D0 (en) | 2001-01-26 | 2001-03-14 | Astrazeneca Ab | Process |
CA2438275C (en) * | 2001-02-26 | 2010-05-25 | Dompe S.P.A. | Apparatus and method for micron and submicron particle formation |
IL159475A0 (en) * | 2001-06-21 | 2004-06-01 | Altus Biologics Inc | Spherical protein particles, compositions containing the same and methods for the production thereof |
EP1414633A4 (de) | 2001-07-10 | 2005-01-26 | Univ Technology Corp | Vorrichtung und verfahren zur herstellung von teilchen |
GB0208742D0 (en) | 2002-04-17 | 2002-05-29 | Bradford Particle Design Ltd | Particulate materials |
GB0117696D0 (en) * | 2001-07-20 | 2001-09-12 | Bradford Particle Design Plc | Particle information |
EP1440082B1 (de) | 2001-10-22 | 2011-09-28 | Dompé S.P.A. | Verfahren durch gebrauch von überkritischen flüssigkeiten: herstellung von proteinmikropartikeln und ihre stabilisierung |
GB0126716D0 (en) * | 2001-11-07 | 2002-01-02 | Advanced Phytonics Ltd | Method for the production of particles |
US7582284B2 (en) * | 2002-04-17 | 2009-09-01 | Nektar Therapeutics | Particulate materials |
GB0216562D0 (en) * | 2002-04-25 | 2002-08-28 | Bradford Particle Design Ltd | Particulate materials |
US9339459B2 (en) | 2003-04-24 | 2016-05-17 | Nektar Therapeutics | Particulate materials |
GB0216780D0 (en) * | 2002-07-19 | 2002-08-28 | Bradford Particle Design Ltd | Methods of particle formation |
JP2006516958A (ja) * | 2002-12-19 | 2006-07-13 | バクスター・インターナショナル・インコーポレイテッド | 超臨界流体を用いた組み合わせ薬学的処方物を調製するためのプロセス |
GB0229714D0 (en) * | 2002-12-20 | 2003-01-29 | Glaxo Group Ltd | Novel apparatus and method |
MXPA05007154A (es) * | 2002-12-30 | 2005-09-21 | Nektar Therapeutics | Atomizador prepeliculizacion. |
CA2524773C (en) | 2003-05-08 | 2014-04-08 | Nektar Therapeutics Uk Ltd | Particulate coformulations of active substances with excipients |
SE0303476D0 (sv) | 2003-12-22 | 2003-12-22 | Censdelivery Ab | Device, method and use for the formation of small particles |
JP4545467B2 (ja) * | 2004-03-26 | 2010-09-15 | 株式会社大川原製作所 | 超臨界微粒子製造装置 |
US7507823B2 (en) | 2004-05-06 | 2009-03-24 | Bristol-Myers Squibb Company | Process of making aripiprazole particles |
GB0418447D0 (en) * | 2004-08-19 | 2004-09-22 | Advanced Phytonics Ltd | Process for preparing particles and apparatus |
JP5016785B2 (ja) * | 2004-12-28 | 2012-09-05 | 株式会社奈良機械製作所 | 微細粒子の生成装置 |
US20090053314A1 (en) * | 2005-03-22 | 2009-02-26 | Regeron, Inc. | Submicronization of proteins using supercritical fluids |
EP1904219A4 (de) * | 2005-07-15 | 2011-07-27 | Map Pharmaceuticals Inc | Teilchenbildungsverfahren |
ES2472699T3 (es) * | 2006-10-11 | 2014-07-02 | Crititech, Inc. | Aparato para precipitación de partículas pequeñas de medicamento en recipientes de uso |
GB0702402D0 (en) | 2007-02-08 | 2007-03-21 | Thar Pharmaceuticals Inc | Method of creating crystalline substances |
PL2425820T3 (pl) | 2007-02-11 | 2015-08-31 | Map Pharmaceuticals Inc | Sposób terapeutycznego stosowania dhe w celu umożliwienia szybkiego złagodzenia migreny przy jednoczesnym zminimalizowaniu profilu działań niepożądanych |
US7827822B2 (en) * | 2007-07-25 | 2010-11-09 | Schott Corporation | Method and apparatus for spray-forming melts of glass and glass-ceramic compositions |
US8585943B2 (en) * | 2007-12-07 | 2013-11-19 | Xspray Microparticles Ab | Method and arrangement for the production of particles |
US20110171141A1 (en) * | 2009-06-26 | 2011-07-14 | Kellerman Donald J | Administration of dihydroergotamine mesylate particles using a metered dose inhaler |
GB201016433D0 (en) * | 2010-09-30 | 2010-11-17 | Q Chip Ltd | Apparatus and method for making solid beads |
GB201016436D0 (en) | 2010-09-30 | 2010-11-17 | Q Chip Ltd | Method of making solid beads |
US9808030B2 (en) | 2011-02-11 | 2017-11-07 | Grain Processing Corporation | Salt composition |
US8778181B1 (en) | 2013-03-14 | 2014-07-15 | Crititech, Inc. | Equipment assembly for and method of processing particles |
US9925512B2 (en) | 2013-03-14 | 2018-03-27 | Crititech, Inc. | Equipment assembly for and method of processing particles |
US20170050337A1 (en) * | 2013-05-02 | 2017-02-23 | Melior Innovations, Inc. | Formation apparatus, systems and methods for manufacturing polymer derived ceramic structures |
GB201402556D0 (en) | 2014-02-13 | 2014-04-02 | Crystec Ltd | Improvements relating to inhalable particles |
US10252270B2 (en) * | 2014-09-08 | 2019-04-09 | Arizona Board Of Regents On Behalf Of Arizona State University | Nozzle apparatus and methods for use thereof |
DK3212212T3 (da) | 2014-10-31 | 2020-12-21 | Univ Monash | Pulverformulering |
DE102015007604A1 (de) * | 2015-06-12 | 2016-12-29 | Messer France S.A.S | Vorrichtung und Verfahren zum Kühlen und Zerstäuben flüssiger oder pastöser Stoffe |
CN108026059A (zh) | 2015-07-22 | 2018-05-11 | 阿纳韦克斯生命科学公司 | 四氢-n,n-二甲基-2,2-二苯基-3-呋喃甲胺盐酸盐的晶型,制备这样晶型的方法,及其药物组合物 |
CN108969555B (zh) * | 2017-09-25 | 2021-08-10 | 安徽九鑫药业有限公司 | 一种补肾、益精血、增强免疫力的淫羊藿中药组合物的制备方法 |
EP3752282A1 (de) | 2018-02-15 | 2020-12-23 | Cambridge Enterprise Limited | Kontinuierliche reaktorvorrichtung mit konstanter scherung |
CN112657301A (zh) * | 2020-12-01 | 2021-04-16 | 大连理工大学 | 一种超临界气固分离装置及方法 |
EP4190437A1 (de) * | 2021-12-03 | 2023-06-07 | SiTec PharmaBio SL | Verfahren und vorrichtung zur herstellung von festen mikropartikeln |
Family Cites Families (39)
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DE1078283B (de) | 1958-06-12 | 1960-03-24 | Bayer Ag | Verfahren zur Umhuellung oder Einbettung von pharmazeutischen Wirkstoffen |
US4361285A (en) | 1980-06-03 | 1982-11-30 | Fluid Kinetics, Inc. | Mixing nozzle |
US4328107A (en) | 1980-11-28 | 1982-05-04 | Synergo, Inc. | Process and apparatus for forming dispersions |
US4582731A (en) | 1983-09-01 | 1986-04-15 | Battelle Memorial Institute | Supercritical fluid molecular spray film deposition and powder formation |
US4702799A (en) | 1985-09-03 | 1987-10-27 | Nestec S.A. | Dryer and drying method |
US4737384A (en) | 1985-11-01 | 1988-04-12 | Allied Corporation | Deposition of thin films using supercritical fluids |
EP0321607B1 (de) | 1987-12-21 | 1993-09-22 | Union Carbide Corporation | Verwendung von superkritischen Flüssigkeiten als Verdünner beim Aufsprühen von Überzügen |
DE3744329A1 (de) | 1987-12-28 | 1989-07-06 | Schwarz Pharma Gmbh | Verfahren zur herstellung einer mindestens einen wirkstoff und einen traeger umfassenden zubereitung |
JPH01176437A (ja) | 1987-12-29 | 1989-07-12 | Ono Pharmaceut Co Ltd | 有機物質の微粒化方法 |
US4919853A (en) | 1988-01-21 | 1990-04-24 | The United States Of America As Represented By The United States Department Of Energy | Apparatus and method for spraying liquid materials |
US4977785A (en) | 1988-02-19 | 1990-12-18 | Extrel Corporation | Method and apparatus for introduction of fluid streams into mass spectrometers and other gas phase detectors |
US5707634A (en) | 1988-10-05 | 1998-01-13 | Pharmacia & Upjohn Company | Finely divided solid crystalline powders via precipitation into an anti-solvent |
JP2843857B2 (ja) | 1988-10-05 | 1999-01-06 | ファルマシア・アンド・アップジョン・カンパニー | 反溶剤への沈澱を介する微細分化固体結晶性粉末 |
US5009367A (en) | 1989-03-22 | 1991-04-23 | Union Carbide Chemicals And Plastics Technology Corporation | Methods and apparatus for obtaining wider sprays when spraying liquids by airless techniques |
US5106659A (en) | 1989-10-04 | 1992-04-21 | Nordson Corporation | Method and apparatus for spraying a liquid coating containing supercritical fluid or liquified gas |
US4970093A (en) | 1990-04-12 | 1990-11-13 | University Of Colorado Foundation | Chemical deposition methods using supercritical fluid solutions |
US5264536A (en) * | 1990-12-06 | 1993-11-23 | Exxon Research And Engineering Company | Supercritical mixed-solvent separation of polymer mixtures |
DE4118230A1 (de) | 1990-12-20 | 1992-06-25 | Bayer Ag | Verfahren zur isolierung von polymeren aus ihren loesungsmitteln mit kohlendioxid-haltigen fluessigkeiten |
DE4041563A1 (de) | 1990-12-22 | 1992-06-25 | Sanol Arznei Schwarz Gmbh | Verfahren zur herstellung wirkstoffhaltiger mikropartikel aus hydrolytisch abbaubaren polymeren |
DE4117751A1 (de) | 1991-05-30 | 1992-12-03 | Bayer Ag | Verfahren zur isolierung von polycarbonaten |
JPH0557166A (ja) | 1991-08-31 | 1993-03-09 | Kobe Steel Ltd | 被覆微粒子の製造方法 |
US6063910A (en) | 1991-11-14 | 2000-05-16 | The Trustees Of Princeton University | Preparation of protein microparticles by supercritical fluid precipitation |
US5639441A (en) | 1992-03-06 | 1997-06-17 | Board Of Regents Of University Of Colorado | Methods for fine particle formation |
AU5171293A (en) | 1992-10-14 | 1994-05-09 | Regents Of The University Of Colorado, The | Ion-pairing of drugs for improved efficacy and delivery |
AU678788B2 (en) | 1992-11-02 | 1997-06-12 | Ferro Corporation | Method of preparing coating materials |
EP0612697B1 (de) | 1993-02-24 | 1998-01-21 | Sulzer Chemtech AG | Reinigung von salzbeladenem Abwasser durch Nassoxidation bei superkritischen Bedingungen |
US5554382A (en) | 1993-05-28 | 1996-09-10 | Aphios Corporation | Methods and apparatus for making liposomes |
GB9313642D0 (en) | 1993-07-01 | 1993-08-18 | Glaxo Group Ltd | Method and apparatus for the formation of particles |
GB9313650D0 (en) * | 1993-07-01 | 1993-08-18 | Glaxo Group Ltd | Method and apparatus for the formation of particles |
SI9400079B (sl) | 1994-02-15 | 2003-02-28 | Dr. Weidner Eckhard, Dipl. Ing. | Postopek in naprava za pridobivanje in frakcioniranje majhnih delcev iz raztopin nasičenih s plinom |
GB9413202D0 (en) * | 1994-06-30 | 1994-08-24 | Univ Bradford | Method and apparatus for the formation of particles |
US5716558A (en) | 1994-11-14 | 1998-02-10 | Union Carbide Chemicals & Plastics Technology Corporation | Method for producing coating powders catalysts and drier water-borne coatings by spraying compositions with compressed fluids |
MX9504934A (es) | 1994-12-12 | 1997-01-31 | Morton Int Inc | Revestimientos en polvo de pelicula delgada lisa. |
US5833891A (en) | 1996-10-09 | 1998-11-10 | The University Of Kansas | Methods for a particle precipitation and coating using near-critical and supercritical antisolvents |
AU709384B2 (en) * | 1996-03-01 | 1999-08-26 | University Of Kansas, The | Methods and apparatus for particle precipitation and coating using near-critical and supercritical antisolvents |
GB9703673D0 (en) | 1997-02-21 | 1997-04-09 | Bradford Particle Design Ltd | Method and apparatus for the formation of particles |
GB9804379D0 (en) * | 1998-03-02 | 1998-04-22 | Bradford Particle Design Ltd | Method of particle formation |
GB9810559D0 (en) * | 1998-05-15 | 1998-07-15 | Bradford Particle Design Ltd | Method and apparatus for particle formation |
GB9915975D0 (en) * | 1999-07-07 | 1999-09-08 | Bradford Particle Design Ltd | Method for the formation of particles |
-
1999
- 1999-07-07 GB GBGB9915975.8A patent/GB9915975D0/en not_active Ceased
-
2000
- 2000-07-07 EP EP00942295A patent/EP1191999B1/de not_active Expired - Lifetime
- 2000-07-07 DE DE60001944T patent/DE60001944T2/de not_active Expired - Lifetime
- 2000-07-07 MX MXPA01013259A patent/MXPA01013259A/es active IP Right Grant
- 2000-07-07 JP JP2001509286A patent/JP4490016B2/ja not_active Expired - Lifetime
- 2000-07-07 AT AT00942295T patent/ATE235956T1/de not_active IP Right Cessation
- 2000-07-07 AU AU56990/00A patent/AU773548B2/en not_active Ceased
- 2000-07-07 US US10/030,392 patent/US6860907B1/en not_active Expired - Lifetime
- 2000-07-07 WO PCT/GB2000/002606 patent/WO2001003821A1/en active IP Right Grant
- 2000-07-07 GB GB0016618A patent/GB2354968B/en not_active Expired - Lifetime
- 2000-07-07 DK DK00942295T patent/DK1191999T3/da active
- 2000-07-07 CA CA002376593A patent/CA2376593C/en not_active Expired - Lifetime
- 2000-07-07 ES ES00942295T patent/ES2195908T3/es not_active Expired - Lifetime
-
2004
- 2004-12-07 US US11/006,464 patent/US7150766B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
MXPA01013259A (es) | 2002-12-13 |
AU773548B2 (en) | 2004-05-27 |
WO2001003821A1 (en) | 2001-01-18 |
US6860907B1 (en) | 2005-03-01 |
DK1191999T3 (da) | 2003-07-21 |
GB2354968A (en) | 2001-04-11 |
EP1191999A1 (de) | 2002-04-03 |
DE60001944T2 (de) | 2003-12-24 |
EP1191999B1 (de) | 2003-04-02 |
US7150766B2 (en) | 2006-12-19 |
JP2003504178A (ja) | 2003-02-04 |
ES2195908T3 (es) | 2003-12-16 |
AU5699000A (en) | 2001-01-30 |
GB9915975D0 (en) | 1999-09-08 |
US20050206023A1 (en) | 2005-09-22 |
GB2354968B (en) | 2001-09-12 |
JP4490016B2 (ja) | 2010-06-23 |
GB0016618D0 (en) | 2000-08-23 |
CA2376593A1 (en) | 2001-01-18 |
CA2376593C (en) | 2009-12-01 |
DE60001944D1 (de) | 2003-05-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |