ATE231128T1 - Verbindungen mit kondensierten ringen, verfahren zu ihrer herstellung und ihre anwendung - Google Patents
Verbindungen mit kondensierten ringen, verfahren zu ihrer herstellung und ihre anwendungInfo
- Publication number
- ATE231128T1 ATE231128T1 AT98904386T AT98904386T ATE231128T1 AT E231128 T1 ATE231128 T1 AT E231128T1 AT 98904386 T AT98904386 T AT 98904386T AT 98904386 T AT98904386 T AT 98904386T AT E231128 T1 ATE231128 T1 AT E231128T1
- Authority
- AT
- Austria
- Prior art keywords
- substituted
- group
- joints
- production
- application
- Prior art date
Links
- 201000011510 cancer Diseases 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 206010027476 Metastases Diseases 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 125000005678 ethenylene group Chemical group [H]C([*:1])=C([H])[*:2] 0.000 abstract 1
- 125000005677 ethinylene group Chemical group [*:2]C#C[*:1] 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000009401 metastasis Effects 0.000 abstract 1
- 125000001434 methanylylidene group Chemical group [H]C#[*] 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 150000003431 steroids Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
- C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3792797 | 1997-02-21 | ||
| PCT/JP1998/000688 WO1998037070A1 (fr) | 1997-02-21 | 1998-02-19 | Composes a anneaux condenses, leur procede de production et leur utilisation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE231128T1 true ATE231128T1 (de) | 2003-02-15 |
Family
ID=12511197
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98904386T ATE231128T1 (de) | 1997-02-21 | 1998-02-19 | Verbindungen mit kondensierten ringen, verfahren zu ihrer herstellung und ihre anwendung |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6420375B1 (de) |
| EP (1) | EP0974584B1 (de) |
| CN (1) | CN1251577A (de) |
| AT (1) | ATE231128T1 (de) |
| AU (1) | AU6229698A (de) |
| CA (1) | CA2281598A1 (de) |
| DE (1) | DE69810760T2 (de) |
| WO (1) | WO1998037070A1 (de) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW407153B (en) * | 1997-10-27 | 2000-10-01 | Nippon Kayaku Kk | Imidazole compounds and their use |
| JP2002533476A (ja) * | 1998-12-23 | 2002-10-08 | アストラゼネカ アクチボラグ | 化学化合物 |
| JP4865129B2 (ja) | 1999-01-13 | 2012-02-01 | ザ・リサーチ・ファウンデーション・オブ・ステイト・ユニバーシティ・オブ・ニューヨーク | タンパク質キナーゼ阻害剤を設計するための新規の方法 |
| US6417366B2 (en) | 1999-06-24 | 2002-07-09 | Abbott Laboratories | Preparation of quinoline-substituted carbonate and carbamate derivatives |
| TWI262791B (en) * | 1999-10-27 | 2006-10-01 | Nobex Corp | 6-methoxy-2-naphthylacetic acid prodrugs |
| US6436990B1 (en) | 1999-10-27 | 2002-08-20 | Nobex Corporation | 6-methoxy-2-naphthylacetic acid prodrugs |
| US6552078B2 (en) | 1999-10-27 | 2003-04-22 | Nobex Corp | 6-methoxy-2-naphthylacetic acid prodrugs |
| KR100809899B1 (ko) | 2000-11-17 | 2008-03-10 | 다케다 야쿠힌 고교 가부시키가이샤 | 신규 이미다졸 유도체, 이의 제조 방법 및 이의 용도 |
| AU2002214320A1 (en) | 2000-11-20 | 2002-05-27 | Takeda Chemical Industries Ltd. | Imidazole derivatives, process for their preparation and their use |
| EP1348706B1 (de) | 2000-12-08 | 2009-08-19 | Takeda Pharmaceutical Company Limited | Substituierte thiazolderivate mit 3-pyridylgruppen, verfahren zu deren herstellung und deren verwendung |
| EP1444204A4 (de) * | 2001-10-22 | 2009-11-04 | Univ New York State Res Found | Proteinkinase- und -phosphataseinhibitoren, verfahren zu deren entwicklung und verfahren zu deren verwendung |
| US7005445B2 (en) | 2001-10-22 | 2006-02-28 | The Research Foundation Of State University Of New York | Protein kinase and phosphatase inhibitors and methods for designing them |
| GB2405146A (en) * | 2002-06-07 | 2005-02-23 | Cortical Pty Ltd | Napthalene derivatives which inhibit the cytokine or biological activity of macrophage migration inhibitory factor (MIF) |
| US7838542B2 (en) | 2006-06-29 | 2010-11-23 | Kinex Pharmaceuticals, Llc | Bicyclic compositions and methods for modulating a kinase cascade |
| EP2330909B1 (de) * | 2008-08-12 | 2013-09-18 | GlaxoSmithKline LLC | Chemische verbindungen |
| JP5993742B2 (ja) | 2009-10-29 | 2016-09-14 | ジェノスコ | キナーゼ阻害剤 |
| ES2805031T3 (es) | 2016-02-10 | 2021-02-10 | Sumitomo Chemical Co | Método de producción de 1-metilpirrolidin-3-ol |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3642781A (en) * | 1968-10-15 | 1972-02-15 | Warner Lambert Co | Substituted acrylic acids and process for their production |
| US4237133A (en) * | 1977-11-14 | 1980-12-02 | Pfizer Inc. | 1,9-Dihydroxyoctahydrophenanthrenes |
| GB8417559D0 (en) * | 1984-07-10 | 1984-08-15 | Pfizer Ltd | Anti-diarrhoeal agents |
| LU86022A1 (fr) * | 1985-07-25 | 1987-02-04 | Cird | Derives aromatiques polycyliques,leur procede de preparation et leur application dans les domaines pharmaceutique et cosmetique |
| NZ221729A (en) * | 1986-09-15 | 1989-07-27 | Janssen Pharmaceutica Nv | Imidazolyl methyl-substituted benzimidazole derivatives and pharmaceutical compositions |
| JP2852659B2 (ja) * | 1988-03-03 | 1999-02-03 | 富山化学工業株式会社 | ピペラジン誘導体およびその塩 |
| JPH07121933B2 (ja) | 1988-03-28 | 1995-12-25 | キッセイ薬品工業株式会社 | ジヒドロベンゾフラノン誘導体 |
| US5273977A (en) * | 1990-11-05 | 1993-12-28 | Warner-Lambert Company | Substituted tetrahydropyridines and hydroxypiperidines as central nervous system agents |
| JP3157882B2 (ja) * | 1991-11-15 | 2001-04-16 | 帝国臓器製薬株式会社 | 新規なベンゾチオフエン誘導体 |
| GB9220735D0 (en) * | 1992-10-02 | 1992-11-18 | British Tech Group | Heterocyclic amines |
| JPH06293640A (ja) | 1993-02-15 | 1994-10-21 | Shin Nippon Yakuhin Kk | 肝疾患治療剤および１，３−ベンゾキサチオール誘導体 |
| JPH06239856A (ja) | 1993-02-15 | 1994-08-30 | Shin Nippon Yakuhin Kk | １，３−ベンゾオキサチオール−２−チオン誘導体 |
| GB9310635D0 (en) * | 1993-05-21 | 1993-07-07 | Glaxo Group Ltd | Chemical compounds |
| WO1995009157A1 (fr) | 1993-09-30 | 1995-04-06 | Yamanouchi Pharmaceutical Co., Ltd. | Derive d'azole et composition pharmaceutique le contenant |
| JPH07173120A (ja) | 1993-10-08 | 1995-07-11 | Banyu Pharmaceut Co Ltd | 置換芳香族カルボン酸誘導体 |
| CZ217697A3 (cs) | 1995-01-10 | 1998-03-18 | Smithkline Beecham S. P. A. | Indolové deriváty, kterých je možno použít pro léčení osteoporózy, způsob jejich přípravy, farmaceutický prostředek obsahující tyto deriváty a použití |
| WO1996023773A1 (fr) | 1995-02-03 | 1996-08-08 | Banyu Pharmaceutical Co., Ltd. | Derives d'acide 4-oxo-2-butenoique |
| AU7505196A (en) | 1995-11-07 | 1997-05-29 | Banyu Pharmaceutical Co., Ltd. | Cyclic amic acid derivatives |
| EE9800172A (et) * | 1995-12-06 | 1998-12-15 | Astra Pharmaceuticals Limited | Ühendid |
| EP0887340A4 (de) * | 1996-02-06 | 2000-03-29 | Japan Tobacco Inc | Chemische verbindungen und deren pharmazeutische verwendungen |
| FR2746098B1 (fr) | 1996-03-14 | 1998-04-30 | Composes propynyl biaromatiques | |
| CO4780021A1 (es) | 1996-03-29 | 1999-05-26 | Tanabe Seiyaku Co | Derivados de butadieno y procedimiento para la preparacion de los mismos |
| CZ3799A3 (cs) * | 1996-07-09 | 1999-08-11 | Smithkline Beecham S. P. A. | Indolový derivát k ošetřování osteoporézy |
| US6005000A (en) * | 1996-08-22 | 1999-12-21 | Oxis International, Inc. | 5,5-Disubstituted-3, 4-dihydroxy-2(5H)-furanones and methods of use therefor |
-
1998
- 1998-02-19 EP EP98904386A patent/EP0974584B1/de not_active Expired - Lifetime
- 1998-02-19 CN CN98803784.XA patent/CN1251577A/zh active Pending
- 1998-02-19 AT AT98904386T patent/ATE231128T1/de not_active IP Right Cessation
- 1998-02-19 US US09/367,896 patent/US6420375B1/en not_active Expired - Fee Related
- 1998-02-19 DE DE69810760T patent/DE69810760T2/de not_active Expired - Fee Related
- 1998-02-19 AU AU62296/98A patent/AU6229698A/en not_active Abandoned
- 1998-02-19 WO PCT/JP1998/000688 patent/WO1998037070A1/ja active IP Right Grant
- 1998-02-19 CA CA002281598A patent/CA2281598A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN1251577A (zh) | 2000-04-26 |
| EP0974584A4 (de) | 2000-05-17 |
| WO1998037070A1 (fr) | 1998-08-27 |
| EP0974584A1 (de) | 2000-01-26 |
| CA2281598A1 (en) | 1998-08-27 |
| DE69810760D1 (de) | 2003-02-20 |
| EP0974584B1 (de) | 2003-01-15 |
| AU6229698A (en) | 1998-09-09 |
| DE69810760T2 (de) | 2003-11-20 |
| US6420375B1 (en) | 2002-07-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |