ATE222126T1 - Minocyclin und edta enthaltende beschichtungszusammensetzung für medizinische geräte - Google Patents

Minocyclin und edta enthaltende beschichtungszusammensetzung für medizinische geräte

Info

Publication number
ATE222126T1
ATE222126T1 AT94901405T AT94901405T ATE222126T1 AT E222126 T1 ATE222126 T1 AT E222126T1 AT 94901405 T AT94901405 T AT 94901405T AT 94901405 T AT94901405 T AT 94901405T AT E222126 T1 ATE222126 T1 AT E222126T1
Authority
AT
Austria
Prior art keywords
edta
glycocalyx
minocycline
formation
methods
Prior art date
Application number
AT94901405T
Other languages
English (en)
Inventor
Issam Raad
Robert J Sherertz
Original Assignee
Univ Texas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Texas filed Critical Univ Texas
Application granted granted Critical
Publication of ATE222126T1 publication Critical patent/ATE222126T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A61L29/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/08—Materials for coatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/21—Acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/42—Anti-thrombotic agents, anticoagulants, anti-platelet agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/45—Mixtures of two or more drugs, e.g. synergistic mixtures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0043—Catheters; Hollow probes characterised by structural features
    • A61M2025/0056—Catheters; Hollow probes characterised by structural features provided with an antibacterial agent, e.g. by coating, residing in the polymer matrix or releasing an agent out of a reservoir

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Materials For Medical Uses (AREA)
  • Paints Or Removers (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT94901405T 1992-11-12 1993-11-12 Minocyclin und edta enthaltende beschichtungszusammensetzung für medizinische geräte ATE222126T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/975,486 US5362754A (en) 1992-11-12 1992-11-12 M-EDTA pharmaceutical preparations and uses thereof
PCT/US1993/010893 WO1994010838A1 (en) 1992-11-12 1993-11-12 M-edta pharmaceutical preparations and uses thereof

Publications (1)

Publication Number Publication Date
ATE222126T1 true ATE222126T1 (de) 2002-08-15

Family

ID=25523080

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94901405T ATE222126T1 (de) 1992-11-12 1993-11-12 Minocyclin und edta enthaltende beschichtungszusammensetzung für medizinische geräte

Country Status (7)

Country Link
US (1) US5362754A (de)
EP (1) EP0668720B1 (de)
JP (1) JPH08503400A (de)
AT (1) ATE222126T1 (de)
AU (1) AU673400B2 (de)
DE (1) DE69332204T2 (de)
WO (1) WO1994010838A1 (de)

Families Citing this family (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5055455A (en) 1988-09-28 1991-10-08 Brigham And Women's Hospital Capsular polysaccharide adhesin antigen, preparation, purification and use
US5688516A (en) * 1992-11-12 1997-11-18 Board Of Regents, The University Of Texas System Non-glycopeptide antimicrobial agents in combination with an anticoagulant, an antithrombotic or a chelating agent, and their uses in, for example, the preparation of medical devices
US5624704A (en) * 1995-04-24 1997-04-29 Baylor College Of Medicine Antimicrobial impregnated catheters and other medical implants and method for impregnating catheters and other medical implants with an antimicrobial agent
US5820607A (en) * 1995-06-05 1998-10-13 Board Of Regents, University Of Texas Systems Multipurpose anti-microbial silastic sheath system for the prevention of device-related infections
US6558686B1 (en) 1995-11-08 2003-05-06 Baylor College Of Medicine Method of coating medical devices with a combination of antiseptics and antiseptic coating therefor
US5756145A (en) * 1995-11-08 1998-05-26 Baylor College Of Medicine Durable, Resilient and effective antimicrobial coating for medical devices and method of coating therefor
US6599714B1 (en) 1996-03-13 2003-07-29 University Technologies International Inc. Method of growing and analyzing a biofilm
US20040068241A1 (en) * 1996-06-04 2004-04-08 Fischer Frank J. Implantable medical device
US20050124608A1 (en) * 2001-04-03 2005-06-09 Redmond H. P. Treatment of cancers
US8304390B2 (en) * 1997-07-31 2012-11-06 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Method of treatment for preventing or reducing tumor growth in the liver of patient
US7132413B1 (en) 1997-07-31 2006-11-07 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Anticoagulant/sterilizing compositions and methods
US6165484A (en) 1997-08-26 2000-12-26 Wake Forest University EDTA and other chelators with or without antifungal antimicrobial agents for the prevention and treatment of fungal infections
US6166007A (en) 1998-07-02 2000-12-26 Sodemann; Klaus Antimicrobial locks comprising taurinamide derivatives and carboxylic acids and/or salts thereof
US7252828B2 (en) 1998-07-15 2007-08-07 The Brigham And Women's Hospital, Inc. Polysaccharide vaccine for staphylococcal infections
US6174537B1 (en) 1998-09-25 2001-01-16 Becton, Dickinson And Company Catheter flush solution and method for its use
CA2302720C (en) * 1999-03-29 2009-07-14 Ed Geistlich Sohne Ag Fur Chemische Industrie Anticoagulant/sterilizing compositions and methods
US6187768B1 (en) 1999-06-01 2001-02-13 Becton, Dickinson And Company Kit for flushing medical devices and method of preparation
US7345039B2 (en) * 1999-06-04 2008-03-18 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Enhancement of effectiveness of 5-fluorouracil in treatment of tumor metastases and cancer
US8030301B2 (en) * 1999-06-04 2011-10-04 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Treatment of cancers with methylol-containing compounds and at least one electrolyte
US7892530B2 (en) * 1999-06-04 2011-02-22 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Treatment of tumor metastases and cancer
US6679870B1 (en) 1999-07-23 2004-01-20 Vasca, Inc. Methods and kits for locking and disinfecting implanted catheters
US6685694B2 (en) 1999-07-23 2004-02-03 Vasca, Inc. Methods and kits for locking and disinfecting implanted catheters
US6596505B2 (en) 2000-04-17 2003-07-22 University Technologies International, Inc. Apparatus and methods for testing effects of materials and surface coatings on the formation of biofilms
US6599696B2 (en) 2000-04-17 2003-07-29 University Technologies International, Inc. Effects of materials and surface coatings on encrustation and biofilm formation
ATE368380T1 (de) * 2001-01-12 2007-08-15 Univ Texas Neue antiseptische derivate mit breitem antimikrobiellem wirkungsspektrum zur imprägnierung von oberflächen
CA2457234A1 (en) * 2001-03-14 2002-09-19 Mark L. Nelson Substituted tetracycline compounds as antifungal agents
JP2005504722A (ja) 2001-03-14 2005-02-17 パラテック ファーマシューティカルズ インコーポレイテッド 相乗的抗真菌薬剤としての置換テトラサイクリン化合物
EP2332548A1 (de) * 2001-07-13 2011-06-15 Paratek Pharmaceuticals, Inc. Tetracyclinverbindungen zur Behandlung von Schlaganfall
IL162083A0 (en) * 2001-11-26 2005-11-20 Genentech Inc Catheter composition and uses thereof
JP4165754B2 (ja) * 2001-12-05 2008-10-15 タイコ・ヘルスケアー・グループ・エルピー 抗菌性システムおよび方法
US8541472B2 (en) * 2001-12-05 2013-09-24 Aseptica, Inc. Antiseptic compositions, methods and systems
US6716200B2 (en) 2002-01-18 2004-04-06 C.R. Bard, Inc. Antimicrobial urine collection system and methods of manufacturing the same
US8133501B2 (en) 2002-02-08 2012-03-13 Boston Scientific Scimed, Inc. Implantable or insertable medical devices for controlled drug delivery
US7993390B2 (en) * 2002-02-08 2011-08-09 Boston Scientific Scimed, Inc. Implantable or insertable medical device resistant to microbial growth and biofilm formation
US6887270B2 (en) 2002-02-08 2005-05-03 Boston Scientific Scimed, Inc. Implantable or insertable medical device resistant to microbial growth and biofilm formation
US8685427B2 (en) 2002-07-31 2014-04-01 Boston Scientific Scimed, Inc. Controlled drug delivery
US20030208166A1 (en) * 2002-05-06 2003-11-06 Schwartz Anthony H. Implantable device with free-flowing exit and uses thereof
US8920826B2 (en) 2002-07-31 2014-12-30 Boston Scientific Scimed, Inc. Medical imaging reference devices
WO2004043407A2 (en) * 2002-11-12 2004-05-27 The Brigham And Women's Hospital, Inc. Methods and products for treating staphylococcal infections
CA2501077C (en) 2002-11-12 2016-06-21 Gerald B. Pier Polysaccharide vaccine for staphylococcal infections
US7306580B2 (en) * 2003-04-16 2007-12-11 Cook Incorporated Medical device with therapeutic agents
EP1644024B1 (de) * 2003-06-06 2019-07-31 Board of Regents, The University of Texas System Antimikrobielle spüllösungen
EA009259B1 (ru) * 2003-06-19 2007-12-28 Янссен Фармацевтика Н.В. Аминосульфонилзамещенные 4-(аминометил)пиперидинбензамиды в качестве 5ht-антагонистов
AU2004296178B2 (en) * 2003-12-04 2011-03-24 The United States Of America As Represented By The Department Of Veterans Affairs Gallium inhibits biofilm formation
US20050197634A1 (en) * 2004-01-20 2005-09-08 Board Of Regents, The University Of Texas System Methods for coating and impregnating medical devices with antiseptic compositions
US7144992B2 (en) * 2004-04-01 2006-12-05 Kane Biotech Inc. Synergistic antimicrobial compositions and methods for reducing biofilm formation
AU2005236068C1 (en) 2004-04-21 2012-08-30 Beth Israel Deaconess Medical Center, Inc. Poly-N-acetyl glucosamine (PNAG/DPNAG)-binding peptides and methods of use thereof
AU2005244988C1 (en) 2004-05-21 2012-06-28 President And Fellows Of Harvard College Synthesis of tetracyclines and analogues thereof
US7696182B2 (en) 2004-11-02 2010-04-13 Nd Partners, Llc Antimicrobial locking solutions comprising taurinamide derivatives and biologically acceptable salts and acids, with the addition of small concentrations of heparin
US20080139450A1 (en) * 2005-07-01 2008-06-12 Srinivasa Madhyastha Antimicrobial Compositions and Uses Thereof
WO2007003028A1 (en) 2005-07-01 2007-01-11 Kane Biotech Inc. Antimicrobial compositions for inhibiting growth and proliferation of a microbial biofilm on medical devices
US20070244449A1 (en) * 2005-10-06 2007-10-18 Novacal Pharmaceuticals, Inc. System and method for the prevention of bacterial and fungal infections including Urinary Tract Infections (UTI) using N-halogenated amino acids
WO2007062306A2 (en) 2005-11-18 2007-05-31 The Board Of Regents Of The University Of Texas System Methods for coating surfaces with antimicrobial agents
EP2114298B1 (de) 2006-02-08 2022-10-19 Medtronic, Inc. Vorübergehend versteifte maschenprothesen
US8591531B2 (en) 2006-02-08 2013-11-26 Tyrx, Inc. Mesh pouches for implantable medical devices
AU2007235279B2 (en) * 2006-04-07 2012-12-06 President And Fellows Of Harvard College Synthesis of tetracyclines and analogues thereof
WO2007120608A2 (en) * 2006-04-11 2007-10-25 Tyco Healthcare Group Lp Wound dressings with anti-microbial and chelating agents
US8167847B2 (en) 2006-06-22 2012-05-01 Excelsior Medical Corporation Antiseptic cap and antiseptic cap equipped plunger and syringe barrel assembly
EP3056487B1 (de) 2006-10-11 2018-02-21 President and Fellows of Harvard College Synthese eines enon-zwischenprodukts
US9023114B2 (en) 2006-11-06 2015-05-05 Tyrx, Inc. Resorbable pouches for implantable medical devices
US8916148B2 (en) 2006-11-07 2014-12-23 Genentech, Inc. Tissue plasminogen activator variant uses
ES2524792T3 (es) * 2008-05-30 2014-12-12 University Of Cincinnati Uso de quelantes de zinc que comprenden dtpa para inhibir la formación de biopelículas
RU2532911C2 (ru) * 2008-07-21 2014-11-20 Дзе Брихэм Энд Уимен'З Хоспитал, Инк. Способы и композиции, относящиеся к синтетическим бета-1,6-глюкозаминолигосахаридам
US20100055437A1 (en) * 2008-08-28 2010-03-04 Tyco Healthcare Group Lp Anti-microbial fibers and related articles and methods
JP5752051B2 (ja) 2009-01-23 2015-07-22 ケーン バイオテク インコーポレーテッド バイオフィルム除去用抗菌性組成物およびその使用
US9622481B2 (en) 2009-01-23 2017-04-18 Kane Biotech Inc. Biofilm-removing antimicrobial compositions and uses thereof
US9073829B2 (en) 2009-04-30 2015-07-07 President And Fellows Of Harvard College Synthesis of tetracyclines and intermediates thereto
US20110066141A1 (en) * 2009-09-11 2011-03-17 Cook Incorporated Implantable medical device having an anti-gastric distress agent
WO2012034032A2 (en) 2010-09-10 2012-03-15 The Board Of Regents Of Unbiversity Of Texas System Antimicrobial solutions
CA2846891C (en) 2011-08-31 2017-10-24 Organic Medical Ventures, L.L.C. Transdermal venous access locking solutions
CA2909283C (en) 2013-04-16 2022-08-30 University Of Cincinnati Antimicrobial compositions of aminoglycosidic antibiotics and zinc ion chelators
JP6820921B2 (ja) 2015-11-05 2021-01-27 ボード オブ リージェンツ, ザ ユニバーシティ オブ テキサス システムBoard Of Regents, The University Of Texas System 安定性を増強させた抗菌溶液
WO2017134049A1 (en) 2016-02-01 2017-08-10 Schierholz Jörg Michael Implantable medical products, a process for the preparation thereof, and use thereof
JP6947756B2 (ja) 2016-02-22 2021-10-13 ボード オブ リージェンツ, ザ ユニバーシティ オブ テキサス システムBoard Of Regents, The University Of Texas System 抗菌組成物およびその使用
GB201607814D0 (en) 2016-05-04 2016-06-15 5D Health Prot Group Ltd Anti-microbial compositions
WO2018226334A1 (en) * 2017-06-06 2018-12-13 St. Jude Medical, Cardiology Division, Inc. Electrophysiology Device with Ion-Selective Electrodes
US11738120B1 (en) 2022-04-14 2023-08-29 Cormedix Inc. Synthesis of taurolidine, purity profiles and polymorphs

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS179567B1 (en) * 1974-11-25 1977-11-30 Vladimir Stoy Ionogennic hydrophilic in water insoluble gels based on partial saponificated polymers or copolymers acrylonitrile and method of preparing them
US4442133A (en) * 1982-02-22 1984-04-10 Greco Ralph S Antibiotic bonding of vascular prostheses and other implants
DK119884A (da) * 1983-03-18 1984-09-19 Lilly Co Eli Fast, cylindrisk, subkutan implantation og dens anvendelse
US4678660A (en) * 1984-12-07 1987-07-07 Deseret Medical, Inc. Thermoplastic polyurethane anticoagulant alloy coating
US4917686A (en) * 1985-12-16 1990-04-17 Colorado Biomedical, Inc. Antimicrobial device and method
US4749585A (en) * 1986-04-11 1988-06-07 University Of Medicine And Dentistry Of New Jersey Antibiotic bonded prosthesis and process for producing same
US4895566A (en) * 1986-07-25 1990-01-23 C. R. Bard, Inc. Coating medical devices with cationic antibiotics
US5202449A (en) * 1987-07-28 1993-04-13 Nippon Kayaku Kabushiki Kaisha Process for purifying 7-dimethylamino-6-demethyl-6-deoxytetracycline
US4846844A (en) * 1987-08-31 1989-07-11 Eli Lilly And Company Antimicrobial coated implants
US5013306A (en) * 1989-01-18 1991-05-07 Becton, Dickinson And Company Anti-infective and antithrombogenic medical articles and method for their preparation
US5217493A (en) * 1992-03-11 1993-06-08 Board Of Regents, The University Of Texas System Antibacterial coated medical implants
FR2698025B1 (fr) * 1992-11-13 1994-12-16 Innovation Ingenierie Integrat Dispositif de récupération et de stockage de déchets.

Also Published As

Publication number Publication date
DE69332204T2 (de) 2002-12-12
JPH08503400A (ja) 1996-04-16
WO1994010838A1 (en) 1994-05-26
EP0668720A1 (de) 1995-08-30
DE69332204D1 (de) 2002-09-19
AU5600394A (en) 1994-06-08
EP0668720A4 (de) 1999-09-01
EP0668720B1 (de) 2002-08-14
AU673400B2 (en) 1996-11-07
US5362754A (en) 1994-11-08

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