ATE219087T1 - Verfahren zur herstellung von diisopinocampheylchloroboran - Google Patents

Verfahren zur herstellung von diisopinocampheylchloroboran

Info

Publication number: ATE219087T1
Authority: AT; Austria
Prior art keywords: diisopinocampheylchloroborane; producing; pinene; alpha; isolation
Prior art date: 1994-08-11

Application number

AT95928320T

Other languages

English (en)

Inventor

Anthony On-Ping King

Robert D Larsen

Thomas R Verhoeven

Mangzhu Zhao

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-08-11

Filing date

1995-08-07

Publication date

2002-06-15

1995-08-07 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

2002-06-15 Application granted granted Critical

2002-06-15 Publication of ATE219087T1 publication Critical patent/ATE219087T1/de

Links

238000004519 manufacturing process Methods 0.000 title 1
GRWFGVWFFZKLTI-UHFFFAOYSA-N α-pinene Chemical compound CC1=CCC2C(C)(C)C1C2 GRWFGVWFFZKLTI-UHFFFAOYSA-N 0.000 abstract 2
GRWFGVWFFZKLTI-IUCAKERBSA-N 1S,5S-(-)-alpha-Pinene Natural products CC1=CC[C@@H]2C(C)(C)[C@H]1C2 GRWFGVWFFZKLTI-IUCAKERBSA-N 0.000 abstract 1
150000001298 alcohols Chemical class 0.000 abstract 1
MVNCAPSFBDBCGF-UHFFFAOYSA-N alpha-pinene Natural products CC1=CCC23C1CC2C3(C)C MVNCAPSFBDBCGF-UHFFFAOYSA-N 0.000 abstract 1
238000011065 in-situ storage Methods 0.000 abstract 1
238000002955 isolation Methods 0.000 abstract 1
150000002576 ketones Chemical class 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
230000003287 optical effect Effects 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
229910000033 sodium borohydride Inorganic materials 0.000 abstract 1
239000012279 sodium borohydride Substances 0.000 abstract 1
FAQYAMRNWDIXMY-UHFFFAOYSA-N trichloroborane Chemical compound ClB(Cl)Cl FAQYAMRNWDIXMY-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D215/14—Radicals substituted by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/027—Organoboranes and organoborohydrides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Detergent Compositions (AREA)
Cephalosporin Compounds (AREA)
Medicinal Preparation (AREA)
Lock And Its Accessories (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Lubricants (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT95928320T 1994-08-11 1995-08-07 Verfahren zur herstellung von diisopinocampheylchloroboran ATE219087T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/289,077 US5545758A (en)	1994-08-11	1994-08-11	Process for the preparation of diisopinocampheylchloroborane
PCT/US1995/009921 WO1996005206A1 (en)	1994-08-11	1995-08-07	Novel process for the preparation of diisopinocampheylchloroborane

Publications (1)

Publication Number	Publication Date
ATE219087T1 true ATE219087T1 (de)	2002-06-15

Family

ID=23109960

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95928320T ATE219087T1 (de)	1994-08-11	1995-08-07	Verfahren zur herstellung von diisopinocampheylchloroboran

Country Status (23)

Country	Link
US (2)	US5545758A (de)
EP (1)	EP0775146B1 (de)
JP (1)	JPH10504307A (de)
KR (1)	KR100355916B1 (de)
CN (2)	CN1051087C (de)
AT (1)	ATE219087T1 (de)
AU (1)	AU693588B2 (de)
BR (1)	BR9508578A (de)
CA (1)	CA2195776C (de)
CZ (2)	CZ294311B6 (de)
DE (1)	DE69527070T2 (de)
DK (1)	DK0775146T3 (de)
ES (1)	ES2176335T3 (de)
FI (1)	FI120347B (de)
HU (1)	HU215183B (de)
MX (1)	MX9701087A (de)
NZ (1)	NZ291101A (de)
PT (1)	PT775146E (de)
RO (1)	RO115882B1 (de)
RU (1)	RU2150472C1 (de)
SI (1)	SI0775146T1 (de)
UA (1)	UA46741C2 (de)
WO (1)	WO1996005206A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL159632A0 (en) *	2001-07-17	2004-06-01	Upjohn Co	Process and intermediates to prepare latanoprost
WO2006021974A1 (en) *	2004-08-23	2006-03-02	Morepen Laboratories Limited	A process for synthesizing diol (viii)-an intermediate of montelukast sodium
US20060223999A1 (en) *	2006-05-10	2006-10-05	Chemagis Ltd.	Process for preparing montelukast and precursors thereof
CN101225089B (zh) *	2007-01-17	2011-06-15	上海迪赛诺医药发展有限公司	制备二异松蒎基氯甲硼烷的方法
WO2009042984A1 (en) *	2007-09-28	2009-04-02	Codexis, Inc.	Ketoreductase polypeptides and uses thereof
US20100055052A1 (en) *	2008-08-26	2010-03-04	James Albert Berta	Processing System for Oral Care Compositions
CN101525344B (zh) *	2009-04-09	2011-10-05	霸州市路德精细化工有限公司	异松蒎基硼烷氯化物的制备方法
CN103030658B (zh) *	2012-06-29	2015-08-19	山东威智医药工业有限公司	二异松蒎基氯甲硼烷的工业化生产方法
CN103601708B (zh) *	2013-12-11	2015-06-17	武汉武药科技有限公司	一种前列素药物杂质的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5043479A (en) *	1986-08-29	1991-08-27	Aldrich Chemical Company, Inc.	Chemically and optically pure diisopinocampheylhaloboranes
CA2050820A1 (en) *	1990-09-24	1992-03-25	Pamela M. Simpson	In-situ preparation of diisopinocamphenyl chloroborane
US5159116A (en) *	1991-07-15	1992-10-27	Aldrich Chemical Company, Inc.	Chemically and optically pure B-halodiiso-2-ethylapopinocampheylboranes
US5220072A (en) *	1991-07-15	1993-06-15	Aldrich Chemical Co., Inc.	Process of synthesizing chemically and optically pure B-halodiiso-2-ethylapopinocampheylboranes
US5270324A (en) *	1992-04-10	1993-12-14	Merck Frosst Canada, Inc.	Fluorinated hydroxyalkylquinoline acids as leukotriene antagonists
US5220077A (en) *	1992-08-19	1993-06-15	Vista Chemical Company	Alkoxylation process

1994
- 1994-08-11 US US08/289,077 patent/US5545758A/en not_active Expired - Lifetime
1995
- 1995-08-07 DE DE69527070T patent/DE69527070T2/de not_active Expired - Lifetime
- 1995-08-07 MX MX9701087A patent/MX9701087A/es unknown
- 1995-08-07 WO PCT/US1995/009921 patent/WO1996005206A1/en active IP Right Grant
- 1995-08-07 AT AT95928320T patent/ATE219087T1/de active
- 1995-08-07 KR KR1019970700854A patent/KR100355916B1/ko not_active IP Right Cessation
- 1995-08-07 SI SI9530597T patent/SI0775146T1/xx unknown
- 1995-08-07 DK DK95928320T patent/DK0775146T3/da active
- 1995-08-07 NZ NZ291101A patent/NZ291101A/en not_active IP Right Cessation
- 1995-08-07 EP EP95928320A patent/EP0775146B1/de not_active Expired - Lifetime
- 1995-08-07 AU AU32135/95A patent/AU693588B2/en not_active Ceased
- 1995-08-07 PT PT95928320T patent/PT775146E/pt unknown
- 1995-08-07 CZ CZ19993445A patent/CZ294311B6/cs not_active IP Right Cessation
- 1995-08-07 ES ES95928320T patent/ES2176335T3/es not_active Expired - Lifetime
- 1995-08-07 UA UA97031025A patent/UA46741C2/uk unknown
- 1995-08-07 HU HU9701953A patent/HU215183B/hu not_active IP Right Cessation
- 1995-08-07 JP JP8507416A patent/JPH10504307A/ja not_active Ceased
- 1995-08-07 CN CN95195485A patent/CN1051087C/zh not_active Expired - Fee Related
- 1995-08-07 RO RO97-00268A patent/RO115882B1/ro unknown
- 1995-08-07 BR BR9508578A patent/BR9508578A/pt not_active IP Right Cessation
- 1995-08-07 RU RU97103951/04A patent/RU2150472C1/ru not_active IP Right Cessation
- 1995-08-07 CA CA002195776A patent/CA2195776C/en not_active Expired - Fee Related
- 1995-08-07 CZ CZ1997387A patent/CZ286602B6/cs not_active IP Right Cessation
1996
- 1996-01-16 US US08/586,037 patent/US5693816A/en not_active Expired - Lifetime
1997
- 1997-02-10 FI FI970564A patent/FI120347B/fi not_active IP Right Cessation
1999
- 1999-06-28 CN CN99108855A patent/CN1122039C/zh not_active Expired - Fee Related

Also Published As

Publication number	Publication date
FI970564A0 (fi)	1997-02-10
WO1996005206A1 (en)	1996-02-22
US5693816A (en)	1997-12-02
ES2176335T3 (es)	2002-12-01
HU215183B (hu)	1998-10-28
CZ286602B6 (cs)	2000-05-17
CA2195776A1 (en)	1996-02-22
KR100355916B1 (ko)	2003-01-06
CN1122039C (zh)	2003-09-24
EP0775146A1 (de)	1997-05-28
PT775146E (pt)	2002-09-30
CZ38797A3 (en)	1997-10-15
UA46741C2 (uk)	2002-06-17
AU3213595A (en)	1996-03-07
BR9508578A (pt)	1997-11-25
MX9701087A (es)	1997-05-31
EP0775146A4 (de)	1998-01-07
RO115882B1 (ro)	2000-07-28
CA2195776C (en)	2005-05-31
JPH10504307A (ja)	1998-04-28
US5545758A (en)	1996-08-13
CN1159810A (zh)	1997-09-17
FI970564A (fi)	1997-02-10
AU693588B2 (en)	1998-07-02
CN1051087C (zh)	2000-04-05
HUT77238A (hu)	1998-03-02
DE69527070T2 (de)	2003-03-20
FI120347B (fi)	2009-09-30
EP0775146B1 (de)	2002-06-12
CN1240212A (zh)	2000-01-05
RU2150472C1 (ru)	2000-06-10
DK0775146T3 (da)	2002-07-15
SI0775146T1 (en)	2002-10-31
DE69527070D1 (de)	2002-07-18
NZ291101A (en)	1998-11-25
CZ294311B6 (cs)	2004-11-10

Legal Events

Date	Code	Title	Description
2011-12-15	EEFA	Change of the company name

Publication	Publication Date	Title
ATE174017T1 (de)	1998-12-15	Verfahren zur herstellung von faserverstärkten xerogelen, sowie ihre verwendung
ATE262319T1 (de)	2004-04-15	Mikrosphären aus polyvinylalkohol sowie verfahren zu deren herstellung
DE69716767D1 (de)	2002-12-05	Verfahren zur herstellung von tolterodin
DE59107901D1 (de)	1996-07-11	Verfahren zur herstellung gereinigter glycolipide durch membrantrennverfahren
DE69527070D1 (de)	2002-07-18	Verfahren zur herstellung von diisopinocampheylchloroboran
DE69522436D1 (de)	2001-10-04	Verfahren zur herstellung von äthylalkohol
DE59007250D1 (de)	1994-10-27	Verfahren zur Herstellung hochtemperaturbeständiger Schaum- stoffe.
ATE187440T1 (de)	1999-12-15	Verfahren zur herstellung von substituierten 3- aminobenzonitrilen
DE69415345D1 (de)	1999-01-28	Verfahren zur herstellung von bisnoraldehyden aus bisnoralkohol
DE59701191D1 (de)	2000-04-06	Verfahren zur herstellung von alkoxysilanen
DE59703792D1 (de)	2001-07-19	Verfahren zur gewinnung von glykolen mit niedrigem aldehydgehalt
ATE152722T1 (de)	1997-05-15	Verfahren zur herstellung von 9-(2-hydroxy)- ethoxy-guanin
DE69808771D1 (de)	2002-11-21	Ein verfahren zur herstellung von tetraaza makrocyclen
DE59305451D1 (de)	1997-03-27	Porzellan, Porzellanversatz sowie Verfahren zur Herstellung des Porzellans
DE69926223D1 (de)	2005-08-25	Verfahren zur herstellung von zwischenprodukten
ATE100420T1 (de)	1994-02-15	Verfahren zur herstellung von phosphaten durch schmelzen.
DE69500313D1 (de)	1997-06-26	Neues verfahren zur herstellung von clonidin-derivaten
ATE207139T1 (de)	2001-11-15	Verfahren zur herstellung von butantetracarbonsäure
ATE205473T1 (de)	2001-09-15	Neue borneolderivate, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung
ATE211716T1 (de)	2002-01-15	Verfahren zur herstellung von feinverteiltes metallisches kobalt enthaltendem kobalt(ii)-oxid
DE69514512D1 (de)	2000-02-17	Verfahren zur herstellung von benzopyranderivaten
ATE215552T1 (de)	2002-04-15	Verfahren zur herstellung von ivermectin
ATE211460T1 (de)	2002-01-15	Verfahren zur herstellung von substituierten anthrachinonen und deren verwendung zur herstellung von rheinen
DE69927247D1 (de)	2005-10-20	Verfahren zur herstellung von fleischprodukten
DE59106495D1 (de)	1995-10-19	Verfahren zur herstellung von isopropylnaphthalin.