ATE210729T1 - Verfahren zur herstellung von trans-4-hydroxy-l- prolin - Google Patents

Verfahren zur herstellung von trans-4-hydroxy-l- prolin

Info

Publication number
ATE210729T1
ATE210729T1 AT94113955T AT94113955T ATE210729T1 AT E210729 T1 ATE210729 T1 AT E210729T1 AT 94113955 T AT94113955 T AT 94113955T AT 94113955 T AT94113955 T AT 94113955T AT E210729 T1 ATE210729 T1 AT E210729T1
Authority
AT
Austria
Prior art keywords
proline
hydroxy
trans
useful
aqueous medium
Prior art date
Application number
AT94113955T
Other languages
English (en)
Inventor
Akio Ozaki
Hideo Mori
Takeshi Shibasaki
Katsuhiko Ando
Shigeru Chiba
Original Assignee
Kyowa Hakko Kogyo Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Kk filed Critical Kyowa Hakko Kogyo Kk
Application granted granted Critical
Publication of ATE210729T1 publication Critical patent/ATE210729T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/14—Glutamic acid; Glutamine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/24—Proline; Hydroxyproline; Histidine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/11—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors (1.14.11)
    • C12Y114/11002—Procollagen-proline dioxygenase (1.14.11.2), i.e. proline-hydroxylase

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT94113955T 1993-09-07 1994-09-06 Verfahren zur herstellung von trans-4-hydroxy-l- prolin ATE210729T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP22194093 1993-09-07
JP33256193 1993-12-27

Publications (1)

Publication Number Publication Date
ATE210729T1 true ATE210729T1 (de) 2001-12-15

Family

ID=26524587

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94113955T ATE210729T1 (de) 1993-09-07 1994-09-06 Verfahren zur herstellung von trans-4-hydroxy-l- prolin

Country Status (7)

Country Link
EP (1) EP0641862B1 (de)
KR (1) KR100356926B1 (de)
CN (2) CN1085253C (de)
AT (1) ATE210729T1 (de)
DE (1) DE69429396T2 (de)
ES (1) ES2164675T3 (de)
HK (1) HK1051218A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100460579B1 (ko) * 1995-03-07 2005-01-15 교와 핫꼬 고교 가부시끼가이샤 트랜스-4-히드록시-l-프롤린의 제조방법
JP3739143B2 (ja) * 1996-09-03 2006-01-25 協和醗酵工業株式会社 トランス−４−ヒドロキシ−ｌ−プロリンの製造法
CA2234412C (en) * 1997-06-09 2008-09-02 Kyowa Hakko Kogyo Co., Ltd. Method for producing optically active compound
HUE042605T2 (hu) 2012-05-08 2019-07-29 Codexis Inc Biokatalizátorok és kémiai vegyületek hidroxilálására szolgáló eljárások
WO2013170050A1 (en) 2012-05-11 2013-11-14 Codexis, Inc. Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
HUE053379T2 (hu) 2013-11-13 2021-06-28 Codexis Inc Génmódosított imin-reduktázok és eljárások keton és amin vegyületek reduktív aminálására
HUE053363T2 (hu) 2014-11-25 2021-06-28 Codexis Inc Módosított iminreduktázok és eljárások keton- és aminvegyületek reduktív aminálására
CN105483069B (zh) * 2015-12-09 2019-01-18 浙江绿创生物科技有限公司 一株生产反式-4-羟基-l-脯氨酸的重组菌株及其构建与应用
EP3469088B1 (de) 2016-06-09 2023-09-06 Codexis, Inc. Biokatalysatoren und verfahren zur hydroxylierung von chemischen verbindungen
CA3027189A1 (en) 2016-06-15 2017-12-21 Codexis, Inc. Engineered beta-glucosidases and glucosylation methods
IL264686B2 (en) 2016-08-26 2024-07-01 Codexis Inc Engineered imine reductases and methods for reversible amination of ketone and amine compounds
CN116855551A (zh) * 2023-08-22 2023-10-10 石家庄市冀荣药业有限公司 一种生物法转化生产l-羟脯氨酸的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1986000924A1 (en) * 1984-07-31 1986-02-13 Yoshiki Nagai Process for preparing human proline hydroxylase
US5374542A (en) * 1991-08-26 1994-12-20 Kyowa Hakko Kogyo Co., Ltd. Process for producing 4-hydroxy-L-proline
JPH05236980A (ja) * 1991-12-17 1993-09-17 Sankyo Co Ltd トランス−４−ヒドロキシ−ｌ−プロリンの製造法

Also Published As

Publication number Publication date
KR950008692A (ko) 1995-04-19
CN1392257A (zh) 2003-01-22
CN1171992C (zh) 2004-10-20
DE69429396D1 (de) 2002-01-24
HK1051218A1 (en) 2003-07-25
CN1085253C (zh) 2002-05-22
EP0641862B1 (de) 2001-12-12
EP0641862A2 (de) 1995-03-08
ES2164675T3 (es) 2002-03-01
CN1106457A (zh) 1995-08-09
KR100356926B1 (ko) 2003-01-10
EP0641862A3 (de) 1997-06-04
DE69429396T2 (de) 2002-06-13

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