CA2131775A1 - Process for producing trans-4-hydroxy-l-proline - Google Patents

Process for producing trans-4-hydroxy-l-proline

Info

Publication number
CA2131775A1
CA2131775A1 CA002131775A CA2131775A CA2131775A1 CA 2131775 A1 CA2131775 A1 CA 2131775A1 CA 002131775 A CA002131775 A CA 002131775A CA 2131775 A CA2131775 A CA 2131775A CA 2131775 A1 CA2131775 A1 CA 2131775A1
Authority
CA
Canada
Prior art keywords
proline
hydroxy
trans
useful
aqueous medium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002131775A
Other languages
French (fr)
Other versions
CA2131775C (en
Inventor
Akio Ozaki
Hideo Mori
Takeshi Shibasaki
Katsuhiko Ando
Shigeru Chiba
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Publication of CA2131775A1 publication Critical patent/CA2131775A1/en
Application granted granted Critical
Publication of CA2131775C publication Critical patent/CA2131775C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Provided is a process for industrially producing trans-4-hydroxy-L-proline, which is useful as a raw material for medicines or as an additive to foods. In the process, L-proline is converted into trans-4-hydroxy-L-proline in the presence of an enzyme source which is derived from a microorganism belonging to the genus Dactylosporangium or Amycolatopsis and which catalyzes the hydroxylation of L-proline into trans-4-hydroxy-L-proline, a divalent iron ion and 2-ketoglutaric acid, in an aqueous medium, and the produced trans-4-hydroxy-L-proline is collected from the aqueous medium. Also provided is a novel enzyme L-proline-4-hydroxylase, which is useful for the process.
CA002131775A 1993-12-27 1994-09-09 Process for producing trans-4-hydroxy-l-proline Expired - Fee Related CA2131775C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP33256193 1993-12-27
JP332561/93 1993-12-27

Publications (2)

Publication Number Publication Date
CA2131775A1 true CA2131775A1 (en) 1995-06-28
CA2131775C CA2131775C (en) 2002-02-26

Family

ID=18256303

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002131775A Expired - Fee Related CA2131775C (en) 1993-12-27 1994-09-09 Process for producing trans-4-hydroxy-l-proline

Country Status (1)

Country Link
CA (1) CA2131775C (en)

Also Published As

Publication number Publication date
CA2131775C (en) 2002-02-26

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Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed