ATE196802T1 - Zielspezifische screens und ihre verwendung zur ermittelung von kleinen organischen molekularen pharmakophoren - Google Patents

Zielspezifische screens und ihre verwendung zur ermittelung von kleinen organischen molekularen pharmakophoren

Info

Publication number
ATE196802T1
ATE196802T1 AT95930144T AT95930144T ATE196802T1 AT E196802 T1 ATE196802 T1 AT E196802T1 AT 95930144 T AT95930144 T AT 95930144T AT 95930144 T AT95930144 T AT 95930144T AT E196802 T1 ATE196802 T1 AT E196802T1
Authority
AT
Austria
Prior art keywords
small organic
antibodies
target
parts
domains
Prior art date
Application number
AT95930144T
Other languages
English (en)
Inventor
Arthur J Blume
Original Assignee
Dgi Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dgi Technologies Inc filed Critical Dgi Technologies Inc
Application granted granted Critical
Publication of ATE196802T1 publication Critical patent/ATE196802T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2869Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854Immunoglobulins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55Fab or Fab'
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Polyesters Or Polycarbonates (AREA)
AT95930144T 1994-08-03 1995-08-02 Zielspezifische screens und ihre verwendung zur ermittelung von kleinen organischen molekularen pharmakophoren ATE196802T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28608494A 1994-08-03 1994-08-03
US08/473,105 US6010861A (en) 1994-08-03 1995-06-07 Target specific screens and their use for discovering small organic molecular pharmacophores
PCT/US1995/010182 WO1996004557A2 (en) 1994-08-03 1995-08-02 Target specific screens and their use for discovering small organic molecular pharmacophores

Publications (1)

Publication Number Publication Date
ATE196802T1 true ATE196802T1 (de) 2000-10-15

Family

ID=26963579

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95930144T ATE196802T1 (de) 1994-08-03 1995-08-02 Zielspezifische screens und ihre verwendung zur ermittelung von kleinen organischen molekularen pharmakophoren

Country Status (8)

Country Link
US (3) US6010861A (de)
EP (2) EP1028315A3 (de)
JP (1) JPH10507517A (de)
AT (1) ATE196802T1 (de)
AU (1) AU3363195A (de)
CA (1) CA2196679A1 (de)
DE (1) DE69519033T2 (de)
WO (1) WO1996004557A2 (de)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6010861A (en) * 1994-08-03 2000-01-04 Dgi Biotechnologies, Llc Target specific screens and their use for discovering small organic molecular pharmacophores
FI962269A (fi) * 1996-05-30 1997-12-01 Univ Helsinki Licensing Järjestelmä taudin aiheuttajia estävien peptidien seulomiseksi ja taudin aiheuttajien neutralisointikohtien kuvaamiseksi
US5928888A (en) * 1996-09-26 1999-07-27 Aurora Biosciences Corporation Methods and compositions for sensitive and rapid, functional identification of genomic polynucleotides and secondary screening capabilities
US6617114B1 (en) 1996-10-31 2003-09-09 Karo Bio Ab Identification of drug complementary combinatorial libraries
WO1998019162A1 (en) * 1996-10-31 1998-05-07 Novalon Pharmaceutical Corporation Identification of drugs using complementary combinatorial libraries
US6434542B1 (en) * 1997-04-17 2002-08-13 Smithkline Beecham Corporation Statistical deconvoluting of mixtures
GB9722131D0 (en) * 1997-10-20 1997-12-17 Medical Res Council Method
CA2312913A1 (en) * 1997-12-12 1999-06-24 Jeffrey C. Way Compounds and methods for the inhibition of protein-protein interactions
US6846625B1 (en) 1998-01-09 2005-01-25 Cubist Pharmaceuticals, Inc. Method for identifying validated target and assay combination for drug development
US6475726B1 (en) 1998-01-09 2002-11-05 Cubist Pharmaceuticals, Inc. Method for identifying validated target and assay combinations for drug development
JP2002530081A (ja) * 1998-11-18 2002-09-17 ジェネンテック・インコーポレーテッド 親抗体より高度な結合親和性を持つ抗体変異体
US6329145B1 (en) * 1999-02-09 2001-12-11 Gilead Science, Inc. Determining non-nucleic acid molecule binding to target by competition with nucleic acid ligand
WO2000053740A1 (fr) * 1999-03-10 2000-09-14 Ajinomoto Co.,Inc. Procede de criblage de regulateur d'activite de biomolecule
US6343257B1 (en) * 1999-04-23 2002-01-29 Peptor Ltd. Identifying pharmacophore containing combinations of scaffold molecules and substituents from a virtual library
CA2402780A1 (en) 2000-03-29 2001-10-04 Dgi Biotechnologies, L.L.C. Insulin and igf-1 receptor agonists and antagonists
US7858559B2 (en) * 2000-11-17 2010-12-28 University Of Rochester In vitro methods of producing and identifying immunoglobulin molecules in eukaryotic cells
US20050196755A1 (en) * 2000-11-17 2005-09-08 Maurice Zauderer In vitro methods of producing and identifying immunoglobulin molecules in eukaryotic cells
US20020150895A1 (en) * 2000-12-22 2002-10-17 Raymond Wheeler Method and apparatus for filtering and extending RNA alignment coverage
US20030104402A1 (en) * 2001-01-23 2003-06-05 University Of Rochester Methods of producing or identifying intrabodies in eukaryotic cells
AU2002240131A1 (en) * 2001-01-26 2002-08-06 Bioinformatics Dna Codes, Llc Modular computational models for predicting the pharmaceutical properties of chemical compounds
US6989236B1 (en) * 2001-02-09 2006-01-24 University Of Kentucky Research Foundation Methods to identify plant metabolites
DE10125258A1 (de) * 2001-05-23 2003-01-09 November Ag Molekulare Medizin Verfahren zur Bestimmung des Bindeverhaltens von an Ziel-Molekülen spezifisch bindenden Liganden
JP4303105B2 (ja) * 2001-06-28 2009-07-29 ドマンティス リミテッド 二重特異性リガンドとその利用
RU2348647C2 (ru) * 2001-08-06 2009-03-10 Кьюбист Фармасьютикалз, Инк Новые депсипептиды и способы их получения
EP1421379A2 (de) * 2001-08-07 2004-05-26 Sunesis Pharmaceuticals, Inc. Cysteinmutanten und verfahren zum nachweis der bindung von liganden an biologische moleküle
CA2480202A1 (en) * 2002-04-10 2003-10-23 Transtech Pharma, Inc. System and method for data analysis, manipulation, and visualization
US6728593B2 (en) 2002-06-06 2004-04-27 The Hong Kong Polytechnic University System for analysis of fabric surface
US20050033470A1 (en) * 2002-06-06 2005-02-10 The Hong Kong Polytechnic University System and method for the three-dimensional analysis and reconstruction of the surface of a thin flexible material
ATE328906T1 (de) * 2002-06-28 2006-06-15 Domantis Ltd Dual-specifische liganden mit erhöhter halbwertszeit
DE60329500D1 (de) * 2002-07-12 2009-11-12 Morehouse School Of Medicine Verfahren zur identifikation von salzempfindlichen personen
US20040235056A1 (en) * 2003-05-07 2004-11-25 Mallouk Thomas E. Method of assembling particle libraries
GB2406094B (en) * 2003-09-17 2007-06-06 Antisoma Plc Modified antibody comprising an amino acid substitution mutation which confers increased stability
EP1522858A1 (de) * 2003-10-10 2005-04-13 Jean-Christophe Roegel Methoden für Selektion von Verbindungen unter Verwendung von Antikörpern mit Aktivität als Agonist, Antagonist oder allosterischen Modulatoren
US7737327B2 (en) * 2004-03-09 2010-06-15 The University Of Kentucky Research Foundation Methods for screening for genes and small molecules that activate mammalian receptor proteins
FR2869416B1 (fr) * 2004-04-27 2007-01-12 Centre Nat Rech Scient Cnrse Procede d'identification d'un ligand capable de moduler selectivement une cascade fonctionnelle impliquant une cible et ses applications pour le criblage a haut-debit de molecules d'interet.
US20060193849A1 (en) * 2005-02-25 2006-08-31 Antisoma Plc Biological materials and uses thereof
WO2007087266A2 (en) * 2006-01-23 2007-08-02 Errico Joseph P Methods and compositions of targeted drug development
WO2008006087A2 (en) * 2006-07-07 2008-01-10 The Regents Of The University Of California Antibodies to conformationally trapped proteins
EP2045326A1 (de) * 2007-10-05 2009-04-08 Bayer CropScience AG Verfahren zum Identifizieren des Interaktionspartners eines Wirkstoffes
EP2758565A4 (de) * 2011-09-23 2015-03-04 Merck Sharp & Dohme Zelloberflächenanzeige von liganden für insulin und/oder des insulin-wachstumsfaktor 1-rezeptors und anwendungen davon
CA3038846A1 (en) 2016-10-12 2018-04-19 Janssen Biotech, Inc. Methods for screening for modulators of gdf15-like biological activity
CN112924437B (zh) * 2019-12-06 2023-02-21 核工业西南物理研究院 一种激光诱导击穿光谱绝对定量分析方法
KR102580358B1 (ko) * 2021-06-17 2023-09-20 한국건설기술연구원 임의 위치 계측 및 다중 공간분해능 계측이 가능한 분포형 센싱 기법을 활용한 구조물 건전성 모니터링 장치 및 방법

Family Cites Families (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4593002A (en) * 1982-01-11 1986-06-03 Salk Institute Biotechnology/Industrial Associates, Inc. Viruses with recombinant surface proteins
US4797363A (en) * 1984-03-19 1989-01-10 Board Of Trustees, University Of Illinois Bacteriophages as recognition and identification agents
US5144010A (en) * 1984-08-27 1992-09-01 The Trustees Of Columbia University In The City Of New York Method of producing monoclonal auto-anti-idiotypic antibodies
EP0590689B2 (de) * 1985-03-30 2006-08-16 KAUFFMAN, Stuart A. Verfahren zum Erhalten von DNS, RNS, Peptiden, Polypeptiden oder Proteinen durch DMS-Rekombinant-Verfahren
US6492107B1 (en) * 1986-11-20 2002-12-10 Stuart Kauffman Process for obtaining DNA, RNA, peptides, polypeptides, or protein, by recombinant DNA technique
US4962777A (en) * 1985-05-21 1990-10-16 Transfresh Corporation Systems for cleaning and cooling produce
US5866363A (en) * 1985-08-28 1999-02-02 Pieczenik; George Method and means for sorting and identifying biological information
US4818684A (en) * 1985-09-10 1989-04-04 The Trustees Of Columbia University In The City Of New York Auto-anti-idiotypic monoclonal antibodies to steroid receptors and uses thereof
GB8607679D0 (en) * 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US5030576A (en) * 1986-04-30 1991-07-09 Genentech, Inc. Receptors for efficient determination of ligands and their antagonists or agonists
US4859609A (en) * 1986-04-30 1989-08-22 Genentech, Inc. Novel receptors for efficient determination of ligands and their antagonists or agonists
US5260203A (en) * 1986-09-02 1993-11-09 Enzon, Inc. Single polypeptide chain binding molecules
US4946778A (en) * 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
DE3883899T3 (de) * 1987-03-18 1999-04-22 Sb2, Inc., Danville, Calif. Geänderte antikörper.
US5217869A (en) * 1987-10-13 1993-06-08 Terrapin Technologies, Inc. Method to produce immunodiagnostic reagents
US5300425A (en) * 1987-10-13 1994-04-05 Terrapin Technologies, Inc. Method to produce immunodiagnostic reagents
US5133866A (en) * 1988-03-24 1992-07-28 Terrapin Technologies, Inc. Method to identify analyte-bending ligands
US4963263A (en) * 1988-03-24 1990-10-16 Terrapin Technologies, Inc. Method of identity analyte-binding peptides
KR890701761A (ko) * 1987-10-13 1989-12-21 제롤드 엘.글릭 면역 진단시약의 제조방법
CA1339198C (en) * 1988-02-12 1997-08-05 Gregory Paul Winter Antibodies to the antigen campath-1
WO1989009233A1 (en) * 1988-03-24 1989-10-05 Terrapin Technologies, Inc. Molecular sticks for controlling protein conformation
JP3105898B2 (ja) * 1988-04-16 2000-11-06 セルテック リミテッド 組換えdnaタンパクの製造方法
US5223409A (en) * 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US5663143A (en) * 1988-09-02 1997-09-02 Dyax Corp. Engineered human-derived kunitz domains that inhibit human neutrophil elastase
EP0768377A1 (de) * 1988-09-02 1997-04-16 Protein Engineering Corporation Herstellung und Auswahl von Rekombinantproteinen mit verschiedenen Bindestellen
US5681726A (en) * 1988-09-19 1997-10-28 Stratagene Method of double stranded DNA synthesis
DE68913658T3 (de) * 1988-11-11 2005-07-21 Stratagene, La Jolla Klonierung von Immunglobulin Sequenzen aus den variablen Domänen
US4962277A (en) * 1988-12-09 1990-10-09 Scripps Clinic And Research Foundation Deletion analogues of magainin peptides
US5096815A (en) * 1989-01-06 1992-03-17 Protein Engineering Corporation Generation and selection of novel dna-binding proteins and polypeptides
US5198346A (en) * 1989-01-06 1993-03-30 Protein Engineering Corp. Generation and selection of novel DNA-binding proteins and polypeptides
US5215963A (en) * 1989-10-24 1993-06-01 Berlex Laboratories, Inc. Solubilization and purification of the active gastrin releasing peptide receptor
WO1991010907A1 (en) * 1990-01-22 1991-07-25 Synbiotics Corporation Pharmacologically active compound screening antibodies and hierarchical cluster analysis
US5427908A (en) * 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
GB9012995D0 (en) * 1990-06-11 1990-08-01 Celltech Ltd Multivalent antigen-binding proteins
US5723286A (en) * 1990-06-20 1998-03-03 Affymax Technologies N.V. Peptide library and screening systems
GB9015198D0 (en) * 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
AU665190B2 (en) * 1990-07-10 1995-12-21 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
GB9016299D0 (en) * 1990-07-25 1990-09-12 Brien Caroline J O Binding substances
US5264563A (en) * 1990-08-24 1993-11-23 Ixsys Inc. Process for synthesizing oligonucleotides with random codons
US5871974A (en) * 1990-09-28 1999-02-16 Ixsys Inc. Surface expression libraries of heteromeric receptors
US5698426A (en) * 1990-09-28 1997-12-16 Ixsys, Incorporated Surface expression libraries of heteromeric receptors
IL99553A0 (en) * 1990-09-28 1992-08-18 Ixsys Inc Compositions containing oligonucleotides linked to expression elements,a kit for the preparation of vectors useful for the expression of a diverse population of random peptides and methods utilizing the same
IL99552A0 (en) * 1990-09-28 1992-08-18 Ixsys Inc Compositions containing procaryotic cells,a kit for the preparation of vectors useful for the coexpression of two or more dna sequences and methods for the use thereof
US5770434A (en) * 1990-09-28 1998-06-23 Ixsys Incorporated Soluble peptides having constrained, secondary conformation in solution and method of making same
AU9166691A (en) * 1990-12-20 1992-07-22 Ixsys, Inc. Optimization of binding proteins
AU648630B2 (en) * 1990-12-21 1994-04-28 Creative Biomolecules, Inc. Biosynthetic PDGF antagonists
US5322699A (en) * 1991-02-04 1994-06-21 The Rockefeller University Leukocyte-derived CR3 modulator, integrin modulating factor-1 (IMF-1)
EP0523949B1 (de) * 1991-07-15 2003-06-25 The Wellcome Foundation Limited Herstellung von Antikörpern
NL9101290A (nl) * 1991-07-23 1993-02-16 Stichting Rega V Z W Recombinant dna-molecuul voor de expressie van een fv-fragment van een antilichaam.
US5230998A (en) * 1991-07-25 1993-07-27 Neurath Alexander R Method for the prescreening of drugs targeted to the V3 hypervariable loop of the HIV-1 envelope glycoprotein gp 120
US5270170A (en) * 1991-10-16 1993-12-14 Affymax Technologies N.V. Peptide library and screening method
ATE463573T1 (de) * 1991-12-02 2010-04-15 Medimmune Ltd Herstellung von autoantikörpern auf phagenoberflächen ausgehend von antikörpersegmentbibliotheken
US5488099A (en) * 1992-03-06 1996-01-30 Persson, Deceased; Hakan B. Multifunctional chimeric neurotrophic factors
US5597920A (en) * 1992-04-30 1997-01-28 Neurogen Corporation Gabaa receptor subtypes and methods for screening drug compounds using imidazoquinoxalines and pyrrolopyrimidines to bind to gabaa receptor subtypes
EP0671951A4 (de) * 1992-12-01 1997-05-21 Protein Design Labs Inc Humanisierte antikörper, die mit 1-selektine reagieren.
AU6132994A (en) * 1993-02-02 1994-08-29 Scripps Research Institute, The Methods for producing antibody libraries using universal or randomized immunoglobulin light chains
ATE529444T1 (de) * 1994-01-11 2011-11-15 Dyax Corp Inhibitoren des humanplasmins, die sich von den kunitz domänen ableiten
ATE275583T1 (de) * 1994-01-11 2004-09-15 Dyax Corp KALLIKREINHEMMENDE ßKUNITZ-DOMÄNEß-PROTEINE UND DERIVATEN DAVON
US6057287A (en) * 1994-01-11 2000-05-02 Dyax Corp. Kallikrein-binding "Kunitz domain" proteins and analogues thereof
US6010861A (en) * 1994-08-03 2000-01-04 Dgi Biotechnologies, Llc Target specific screens and their use for discovering small organic molecular pharmacophores
US5602024A (en) * 1994-12-02 1997-02-11 Synaptic Pharmaceutical Corporation DNA encoding a hypothalamic atypical neuropeptide Y/peptide YY receptor (Y5) and uses thereof
US5576423A (en) * 1994-12-02 1996-11-19 Schering Corporation Antibodies to the slam protein expressed on activated T cells
US5573423A (en) * 1995-01-18 1996-11-12 Lin; Kuang-Ts'an Innovative distribution cable mounting device
US5605911A (en) * 1995-01-31 1997-02-25 Washington University Use of alpha-2 adrenergic drugs to prevent adverse effects of NMDA receptor hypofunction (NRH)
US5780426A (en) * 1995-06-07 1998-07-14 Ixsys, Incorporated Fivemer cyclic peptide inhibitors of diseases involving αv β3
US5767071A (en) * 1995-06-07 1998-06-16 Ixsys Incorporated Sevenmer cyclic peptide inhibitors of diseases involving αv β3
US6084062A (en) * 1996-03-20 2000-07-04 Dyax Corp. Polypeptides that bind to tissue plasminogen activator (tPA)
US5862514A (en) * 1996-12-06 1999-01-19 Ixsys, Inc. Method and means for synthesis-based simulation of chemicals having biological functions
US6387879B1 (en) * 1997-12-15 2002-05-14 Dgi Biotechnologies, Inc. Compounds that bind growth to hormone receptor

Also Published As

Publication number Publication date
DE69519033T2 (de) 2001-05-17
US20040072271A1 (en) 2004-04-15
EP1028315A3 (de) 2004-01-02
EP0774118B1 (de) 2000-10-04
US6010861A (en) 2000-01-04
WO1996004557A2 (en) 1996-02-15
US20030092057A1 (en) 2003-05-15
EP0774118A2 (de) 1997-05-21
WO1996004557A3 (en) 1996-04-25
CA2196679A1 (en) 1996-02-15
AU3363195A (en) 1996-03-04
JPH10507517A (ja) 1998-07-21
DE69519033D1 (de) 2000-11-09
EP1028315A2 (de) 2000-08-16

Similar Documents

Publication Publication Date Title
ATE196802T1 (de) Zielspezifische screens und ihre verwendung zur ermittelung von kleinen organischen molekularen pharmakophoren
ATE522610T1 (de) Menschliche, metabotrope glutamatrezeptor- subtypen (hmr6) und verwandte dns-verbindungen
ATE529509T1 (de) Selektion von proteinen unter verwendung von rna- protein-fusionen
ATE204290T1 (de) Zusammensetzungen und verfahren zur immobilisierung von nukleinsäure auf festträgern
DK1870465T3 (da) Fremgangsmåde til chemokinreceptor 88C
ATE361364T1 (de) Antikörper gegen die ed-b domäne von fibronektin, ihre herstellung und verwendungen
DE122008000039I1 (de) Modularer Zusammenbau von Antikorpergenen, dadurchhergestellte Antikorper und deren Anwendungen.
DE69714654D1 (de) Verwendung von einem Metalloporphyrinkonjugat für den Nachweis biologischer Verbindungen
DK0630405T3 (da) Hidtil ukendt 7-transmembranreceptor benævnt V28
ATE335498T1 (de) Methode mit hoher durchsatzrate zur funktionellen klassifizierung von in einem genomischen versuchsansatz identifizierten proteinen
DE69730235D1 (de) Neuartige Verfahren und Zusammensetzungen zur Entdeckung von neuen multimerischen Molekülen, basierend auf einer kombinatorisichen Bibliothek
DE58909458D1 (de) Antigenkonstrukte von "Major Histocompatibility Complex" Klasse I Antigenen mit spezifischen Trägermolekülen, ihre Herstellung und Verwendung.
DE69435038D1 (de) Aktivin rezeptor-ähnliche kinase (alk), gehörend zur tgf rezeptorfamilie und/oder zur bmp rezeptorfamilie
FR10C0048I2 (fr) Nouvelle proteine et methode de production associee
DE69932712D1 (de) Vorhersage über die rezeptor-modulierende wirkung von verbindungen
DE69612457D1 (de) Screening-Verfahren zur Ligand-Identifizierung von Zielproteinen
DK0845005T3 (da) TRAF-inhibitorer
NO904160L (no) Ligandholdig medium for kromatografisk separering, og fremgangsmaate til fremstilling av mediet.
EP0574414A4 (de) Wachstumsfaktor-ligand, der an den erbb-2-rezeptor bindet und die zellulären reaktionen induziert.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties