ATE187956T1 - Substituierte kondensierte und verbrückte bicyclische verbindungen als therapeutische mittel - Google Patents

Substituierte kondensierte und verbrückte bicyclische verbindungen als therapeutische mittel

Info

Publication number
ATE187956T1
ATE187956T1 AT95913699T AT95913699T ATE187956T1 AT E187956 T1 ATE187956 T1 AT E187956T1 AT 95913699 T AT95913699 T AT 95913699T AT 95913699 T AT95913699 T AT 95913699T AT E187956 T1 ATE187956 T1 AT E187956T1
Authority
AT
Austria
Prior art keywords
therapeutic agents
bridged bicyclic
bicyclic compounds
compounds
substituted condensed
Prior art date
Application number
AT95913699T
Other languages
English (en)
Inventor
Hong Hu
G Erik Jagdmann Jr
Jose Serafin Mendoza
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of ATE187956T1 publication Critical patent/ATE187956T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08Bridged systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/54Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C07C69/94Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of polycyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D451/00Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06Oxygen atoms
    • C07D451/12Oxygen atoms acylated by aromatic or heteroaromatic carboxylic acids, e.g. ***e
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00Systems containing two condensed rings
    • C07C2602/02Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00Systems containing two condensed rings
    • C07C2602/36Systems containing two condensed rings the rings having more than two atoms in common
    • C07C2602/42Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing seven carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00Systems containing at least three condensed rings
    • C07C2603/56Ring systems containing bridged rings
    • C07C2603/58Ring systems containing bridged rings containing three rings
    • C07C2603/60Ring systems containing bridged rings containing three rings containing at least one ring with less than six members
    • C07C2603/66Ring systems containing bridged rings containing three rings containing at least one ring with less than six members containing five-membered rings
    • C07C2603/68Dicyclopentadienes; Hydrogenated dicyclopentadienes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Communicable Diseases (AREA)
  • Neurosurgery (AREA)
  • Oncology (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Virology (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT95913699T 1994-05-04 1995-03-15 Substituierte kondensierte und verbrückte bicyclische verbindungen als therapeutische mittel ATE187956T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23764594A 1994-05-04 1994-05-04
US08/392,710 US5583221A (en) 1994-05-04 1995-02-23 Substituted fused and bridged bicyclic compounds as therapeutic agents
PCT/US1995/003220 WO1995030640A1 (en) 1994-05-04 1995-03-15 Substituted fused and bridged bicyclic compounds as therapeutic agents

Publications (1)

Publication Number Publication Date
ATE187956T1 true ATE187956T1 (de) 2000-01-15

Family

ID=26930886

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95913699T ATE187956T1 (de) 1994-05-04 1995-03-15 Substituierte kondensierte und verbrückte bicyclische verbindungen als therapeutische mittel

Country Status (11)

Country Link
US (1) US5583221A (de)
EP (1) EP0758312B1 (de)
JP (1) JPH10500106A (de)
AT (1) ATE187956T1 (de)
AU (1) AU1998995A (de)
DE (1) DE69514100T2 (de)
DK (1) DK0758312T3 (de)
ES (1) ES2140672T3 (de)
GR (1) GR3032950T3 (de)
PT (1) PT758312E (de)
WO (1) WO1995030640A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1132372A3 (de) * 2000-03-06 2003-11-19 Solvias AG Bicyclische 1,3-Aminoalcoholen, Komplexe mit d8-Metallen und Verfahren zur Hydrierung
TWI243164B (en) 2001-02-13 2005-11-11 Aventis Pharma Gmbh Acylated indanyl amines and their use as pharmaceuticals
US6887864B2 (en) 2002-03-12 2005-05-03 Hoffmann-La Roche Inc. Azepane derivatives
CN1980948B (zh) 2002-11-27 2011-08-10 Dmi生物科学公司 治疗由增强磷酸化介导的疾病和病况
JP4675033B2 (ja) * 2003-08-21 2011-04-20 広島県 血小板凝集抑制剤及びヒスタミン遊離抑制剤
ES2696598T3 (es) 2005-03-21 2019-01-17 Univ Columbia Compuestos de balanol para su uso en el tratamiento de dolor
WO2007068929A1 (en) * 2005-12-16 2007-06-21 Argenta Discovery Ltd. Cyclic amine derivatives and their uses
WO2007095586A2 (en) * 2006-02-14 2007-08-23 The Trustees Of Columbia University In The City Of New York Neuronal pain pathway modulators
US7977362B2 (en) 2009-03-20 2011-07-12 Bristol-Myers Squibb Company Alpha-(N-benzenesulfonamido)cycloalkyl derivatives
CN115703787A (zh) * 2021-08-04 2023-02-17 成都先导药物开发股份有限公司 1,4-二取代2-氧杂二环[2,2,2]辛烷衍生物的制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2115994A1 (en) * 1991-08-22 1993-03-04 Yali F. Hallock Protein kinase c inhibition and novel compound balanol
EP0687249A1 (de) * 1993-03-03 1995-12-20 Eli Lilly And Company Balanoide als proteinkinase c inhibitoren

Also Published As

Publication number Publication date
EP0758312A1 (de) 1997-02-19
EP0758312B1 (de) 1999-12-22
JPH10500106A (ja) 1998-01-06
DE69514100T2 (de) 2000-05-25
US5583221A (en) 1996-12-10
ES2140672T3 (es) 2000-03-01
DE69514100D1 (de) 2000-01-27
GR3032950T3 (en) 2000-07-31
AU1998995A (en) 1995-11-29
WO1995030640A1 (en) 1995-11-16
DK0758312T3 (da) 2000-05-01
EP0758312A4 (de) 1997-09-10
PT758312E (pt) 2000-06-30

Similar Documents

Publication Publication Date Title
YU40701A (sh) Piperidini kao modulatori ccr5
BR0212042A (pt) Composto, composição farmacêutica, método de tratamento ou prevenção de doenças, e, uso de um composto
MX9702865A (es) Agentes estrogenicos.
EA200400432A1 (ru) Производные мочевины
EA200000592A1 (ru) Азаполициклические соединения, конденсированные с арилом
ME00513B (me) Azabicikloalkani kao modulatori ccr5
BG66085B1 (bg) Фенилаланинови производни
DK1000035T3 (da) Substituerede 6-phenylphenanthridiner
EP0896533A4 (de) Pentafluorobenzensulfonamiden und analoge
ATE355288T1 (de) Verbindungen und therapeutische methoden
LV12291A (lv) Savienojums un farmaceitiskas kompozicijas ar triptazes aktivitates izmainam saistitu slimibu arstesanai
ATE242246T1 (de) (1,2,3)-triazolo(4,5-d)pyrimidin-derivate als antithrombotische mittel
DE69924292D1 (de) Pyrazol verbindungen und ihre verwendung
DK0738269T3 (da) Piperidinderivater med PAF-antagonistaktivitet
DE60301339D1 (de) Pyrazolopyrimidin- und pyrazolotriazinderivate und diese enthaltende pharmazeutische zubereitungen
ATE267187T1 (de) Als entzündungshemmende mittel nützliche dihydrobenzofurane und verwandte verbindungen
SE9804212D0 (sv) Compounds
ATE187956T1 (de) Substituierte kondensierte und verbrückte bicyclische verbindungen als therapeutische mittel
EA200000996A1 (ru) Конденсированные с арилом азаполициклические соединения
NO963331L (no) 5-Heteroarylindol-derivater som benzodiazepin-reseptorsete-agonister og antagonister
EA200000242A1 (ru) Применение фанхинона для лечения болезни альцгеймера
ATE253359T1 (de) Antithrombotische mittel
EE200100520A (et) N-(2-fenüül-4-aminobutüül)-1-naftamiidid neurokiniin-1-retseptori antagonistidena
ATE223376T1 (de) Bisarylcyclobutenderivate als cyclooxygenasehemmer
ATE213233T1 (de) Substituierte caprolactame und deren derivate verwendbar zur behandlung der hiv-krankheit

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee