ATE186721T1 - Vitamin d3 derivat und verfahren zu dessen herstellung - Google Patents

Vitamin d3 derivat und verfahren zu dessen herstellung

Info

Publication number
ATE186721T1
ATE186721T1 AT95921131T AT95921131T ATE186721T1 AT E186721 T1 ATE186721 T1 AT E186721T1 AT 95921131 T AT95921131 T AT 95921131T AT 95921131 T AT95921131 T AT 95921131T AT E186721 T1 ATE186721 T1 AT E186721T1
Authority
AT
Austria
Prior art keywords
sub
vitamin
derivative
production
group
Prior art date
Application number
AT95921131T
Other languages
English (en)
Inventor
Masayasu Tabe
Atsuo Hazato
Kenji Manabe
Qingzhi Gao
Hiroko Tanaka
Original Assignee
Teijin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teijin Ltd filed Critical Teijin Ltd
Application granted granted Critical
Publication of ATE186721T1 publication Critical patent/ATE186721T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/675—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids of saturated hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/716—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/58—One oxygen atom, e.g. butenolide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D317/34—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
AT95921131T 1994-06-07 1995-06-07 Vitamin d3 derivat und verfahren zu dessen herstellung ATE186721T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP12514494 1994-06-07
JP22018594 1994-09-14
JP22322994 1994-09-19

Publications (1)

Publication Number Publication Date
ATE186721T1 true ATE186721T1 (de) 1999-12-15

Family

ID=27315056

Family Applications (3)

Application Number Title Priority Date Filing Date
AT98101653T ATE201397T1 (de) 1994-06-07 1995-06-07 Vitamin d3 derivate und ein verfahren zu ihrer herstellung
AT95921131T ATE186721T1 (de) 1994-06-07 1995-06-07 Vitamin d3 derivat und verfahren zu dessen herstellung
AT98101654T ATE205190T1 (de) 1994-06-07 1995-06-07 Vitamin d3-derivate und ein verfahren zu ihrer herstellung

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT98101653T ATE201397T1 (de) 1994-06-07 1995-06-07 Vitamin d3 derivate und ein verfahren zu ihrer herstellung

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT98101654T ATE205190T1 (de) 1994-06-07 1995-06-07 Vitamin d3-derivate und ein verfahren zu ihrer herstellung

Country Status (6)

Country Link
US (3) US5719297A (de)
EP (3) EP0712843B1 (de)
AT (3) ATE201397T1 (de)
DE (3) DE69521065T2 (de)
ES (1) ES2138212T3 (de)
WO (1) WO1995033716A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE201397T1 (de) * 1994-06-07 2001-06-15 Teijin Ltd Vitamin d3 derivate und ein verfahren zu ihrer herstellung
DE19619036A1 (de) 1996-04-30 1997-11-13 Schering Ag Neue Vitamin D-Derivate mit carbo- oder heterocyclischen Substituenten an C-25, Verfahren zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln
GB2321244B (en) * 1997-01-20 2000-11-22 Pharmacia & Upjohn Spa Vitamin D3 analogues,process for preparing them,and their use as antiproliferative and antitumour agents
CN1090180C (zh) * 1997-06-25 2002-09-04 帝人株式会社 维生素d3衍生物及其用于炎性呼吸道疾病的治疗剂
EP1123921A4 (de) 1998-10-23 2003-08-20 Teijin Ltd Vitamin d 3 derivate und diese enthaltende heilmittel für entzündliche erkrankungen der atemwege
DE19935771A1 (de) * 1999-07-23 2001-02-01 Schering Ag Neue Vitamin D-Derivate mit cyclischen Substrukturen in den Seitenketten, Verfahren und Zwischenprodukte zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln
US20020137731A1 (en) 2000-05-30 2002-09-26 Gewirtz David A. Combination of radiation and vitamin D3 analogs for the treatment of cancer
CA2420759A1 (en) * 2000-08-30 2003-02-27 Daishiro Miura Parathyroid hormone production inhibitors containing vitamin d3 derivatives
RS52139B (en) 2001-06-13 2012-08-31 Magnachem International Laboratories Inc. LACTON FORMULATIONS AND PROCEDURE FOR THEIR USE
AU2008202109B2 (en) * 2001-06-13 2012-02-02 Magnachem International Laboratories, Inc Lactone formulations and method of use
US20050101575A1 (en) * 2002-02-20 2005-05-12 Karuya Takenouchi Vitamin d3 derivatives and remedies using the same
EP1342796A3 (de) * 2002-02-22 2004-01-02 Teijin Limited Verbindung zur Behandlung der Paget Knochenkrankheit
CN102579427A (zh) 2002-11-05 2012-07-18 马格纳化学国际实验室公司 合成的内酯制剂及其使用方法
US9073885B2 (en) 2003-01-30 2015-07-07 Teijin Pharma Limited Vitamin D3 lactone derivatives
AU2004207720A1 (en) * 2003-01-31 2004-08-12 Teijin Pharma Limited Crystal of (23S)-1alpha-hydroxy-27-nor-25-methylenevitamin D3-26,23-lactone and process for producing the same
WO2005102315A1 (en) 2004-04-23 2005-11-03 Magnachem International Laboratories, Inc. Synthetic lactone formulations for pain control
US8501431B2 (en) 2008-10-24 2013-08-06 Magnachem International Laboratories, Inc. Method for screening for compounds selectively interacting with RAD9
JPWO2010053165A1 (ja) 2008-11-04 2012-04-05 帝人ファーマ株式会社 ビタミンｄ３ラクタム誘導体
KR101666255B1 (ko) * 2013-01-08 2016-10-13 삼성에스디아이 주식회사 이차 전지

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58118516A (ja) * 1981-12-29 1983-07-14 Teijin Ltd １α，２５−ジヒドロキシビタミンＤ↓３−２６，２３−ラクトンを含有するカルシユウム調節剤
JPS58210011A (ja) * 1982-05-31 1983-12-07 Kureha Chem Ind Co Ltd 抗腫瘍剤
JPS60185715A (ja) * 1984-03-05 1985-09-21 Teijin Ltd 骨形成促進剤
ATE154008T1 (de) * 1993-02-05 1997-06-15 Teijin Ltd Lacton-verbindung und verfahren zu ihrer herstellung
ATE201397T1 (de) * 1994-06-07 2001-06-15 Teijin Ltd Vitamin d3 derivate und ein verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
DE69513367T2 (de) 2000-06-08
DE69522589D1 (de) 2001-10-11
EP0854138A2 (de) 1998-07-22
DE69521065T2 (de) 2001-10-25
EP0854139A2 (de) 1998-07-22
EP0712843A1 (de) 1996-05-22
US5719297A (en) 1998-02-17
ATE205190T1 (de) 2001-09-15
DE69513367D1 (de) 1999-12-23
EP0854138B1 (de) 2001-05-23
EP0854139B1 (de) 2001-09-05
US5986112A (en) 1999-11-16
ATE201397T1 (de) 2001-06-15
EP0712843B1 (de) 1999-11-17
EP0712843A4 (de) 1996-11-13
WO1995033716A1 (fr) 1995-12-14
DE69521065D1 (de) 2001-06-28
ES2138212T3 (es) 2000-01-01
US6177586B1 (en) 2001-01-23
EP0854139A3 (de) 1998-09-23
EP0854138A3 (de) 1998-09-23
DE69522589T2 (de) 2002-04-18

Similar Documents

Publication Publication Date Title
DE69513367T2 (de) Vitamin d3 derivat und verfahren zu dessen herstellung
ATE365171T1 (de) Verfahren zur herstellung einer epoxyverbindung
DE69332577D1 (de) Verfahren zur Herstellung von 13-Ether-Derivaten von Milbemycinen und Zwischenprodukte
ATE143007T1 (de) Vitamin-d derivat, verfahren zu dessen herstellung sowie zwischenprodukte dafür
DE69527400D1 (de) Wasserlösliche camptothecin-derivate, verfahren zu deren herstellung und deren verwendung als antitumor-mittel
CA2053820A1 (en) Method of Inhibiting Metabolism of Cholesterol
ATE157973T1 (de) Carbazolon - derivate und verfahren zu ihrer herstellung
NZ322318A (en) Method for preparing camptothecin derivatives
DE69907656D1 (de) Polyethoxylierte retinamid-derivate und verfahren zu ihrer herstellung
ATE189219T1 (de) Verfahren zur herstellung von liponsaeure
ATE166060T1 (de) Neue (estradiol-derivat)-chlorambucil-konjugate, verfahren zu ihrer herstellung und pharmazeutische präparate
ATE189887T1 (de) Vitamin-d-derivat und verfahren zu seiner herstellung
DE69518252D1 (de) Verfahren zur herstellung von 5,6-dihydroxy-2-amino-1,2,3,4-tetrahydronaphthalin-derivaten
DE3884518D1 (de) Naphthothiazepin-derivate und verfahren zu ihrer herstellung.
DE68907857D1 (de) Beta-d-phenylthioxyloside, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
AU8687091A (en) Novel process for producing 6-(3-dimethylaminopropionyl) forskolin
HUP0002895A2 (hu) 3-Azabiciklo[3.1.0]hexánok, eljárás előállításukra és alkalmazásuk
DE69609707D1 (de) Phenoxyethylamin-derivate mit hoher affinität fur den 5-ht1a-rezeptor, verfahren zu ihrer herstellung, ihre verwendung als medikamente und sie enthaltende pharmazeutische zusammensetzungen
YU49004B (sh) LANOSTA-7,9-DIEN-3Гџ, 32-DIOL I POSTUPAK ZA NJEGOVO DOBIJANJE
DE59008713D1 (de) Verfahren zur herstellung von 21-brom-4-pregnen-3,20-dion-derivaten.
AU2148899A (en) 15-methyl-cyclopropanosteroids and method for the production thereof
DE59607507D1 (de) L-aspartyl-l-thienylalaninmethylester, verfahren zu deren herstellung und verwendung als süssstoff
MX9605208A (es) Nuevos derivados de eritromicina, su procedimiento de preparacion y su aplicacion como medicamentos.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification