ATE157973T1 - Carbazolon - derivate und verfahren zu ihrer herstellung - Google Patents

Carbazolon - derivate und verfahren zu ihrer herstellung

Info

Publication number: ATE157973T1
Authority: AT; Austria
Prior art keywords: formula; methyl; group; chem; carbazolone
Prior art date: 1992-10-14

Application number

AT93116542T

Other languages

English (en)

Inventor

Peter Dr Bod

Kalman Dr Harsanyi

Ferenc Dr Trischler

Eva Fekecs

Attila Csehi

Bela Dr Hegedus

Nee Donat Eva Mersich

Nee Komlosi Gyoergyi Szabo

Nee Sziki Erika Horvath

Original Assignee

Richter Gedeon Vegyeszet

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-10-14

Filing date

1993-10-13

Publication date

1997-09-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26318102&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE157973(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1992-10-14 Priority claimed from HU9203223A external-priority patent/HU212785B/hu

1992-10-14 Priority claimed from HU9203222A external-priority patent/HU212934B/hu

1993-10-13 Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet

1997-09-15 Application granted granted Critical

1997-09-15 Publication of ATE157973T1 publication Critical patent/ATE157973T1/de

Links

AMLYRCOEFHJSFS-UHFFFAOYSA-N carbazol-1-one Chemical compound C1=CC=C2C3=CC=CC(=O)C3=NC2=C1 AMLYRCOEFHJSFS-UHFFFAOYSA-N 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 3
-1 2-methyl-1H-imidazol-1-yl group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 2
FELGMEQIXOGIFQ-CYBMUJFWSA-N (3r)-9-methyl-3-[(2-methylimidazol-1-yl)methyl]-2,3-dihydro-1h-carbazol-4-one Chemical compound CC1=NC=CN1C[C@@H]1C(=O)C(C=2C(=CC=CC=2)N2C)=C2CC1 FELGMEQIXOGIFQ-CYBMUJFWSA-N 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
229960005343 ondansetron Drugs 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Otolaryngology (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Hospice & Palliative Care (AREA)
Plural Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Photoreceptors In Electrophotography (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

AT93116542T 1992-10-14 1993-10-13 Carbazolon - derivate und verfahren zu ihrer herstellung ATE157973T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
HU9203223A HU212785B (en)	1992-10-14	1992-10-14	Process for producing of a carbazolone derivative
HU9203222A HU212934B (en)	1992-10-14	1992-10-14	Process for producing novel alkoxalylated carbazolone derivatives

Publications (1)

Publication Number	Publication Date
ATE157973T1 true ATE157973T1 (de)	1997-09-15

Family

ID=26318102

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93116542T ATE157973T1 (de)	1992-10-14	1993-10-13	Carbazolon - derivate und verfahren zu ihrer herstellung

Country Status (20)

Country	Link
US (2)	US5416221A (de)
EP (1)	EP0595111B2 (de)
JP (1)	JP3378315B2 (de)
KR (1)	KR100289912B1 (de)
CN (2)	CN1052979C (de)
AT (1)	ATE157973T1 (de)
CA (1)	CA2106642C (de)
CZ (1)	CZ284223B6 (de)
DE (1)	DE69313771T3 (de)
DK (1)	DK0595111T4 (de)
EE (1)	EE03071B1 (de)
ES (1)	ES2106936T5 (de)
GR (1)	GR3025599T3 (de)
HR (1)	HRP931292B1 (de)
PL (2)	PL174173B1 (de)
RO (1)	RO115799B1 (de)
RU (1)	RU2119914C1 (de)
SI (1)	SI9300537B (de)
SK (1)	SK281243B6 (de)
UA (2)	UA26893C2 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU226135B1 (en) *	2000-03-28	2008-05-28	Richter Gedeon Nyrt	Intermediate of ondansetron and process for its production
KR100368895B1 (ko) *	2000-03-30	2003-01-24	하나제약 주식회사	1,2,3,9-테트라하이드로-9-메틸-3-[(2-메틸-1ｈ-이미다졸-1-일)메틸]-4ｈ-카바졸-4-온의 제조방법
KR20030042038A (ko) *	2000-10-30	2003-05-27	테바 파마슈티컬 인더스트리즈 리미티드	온단세트론 히드로클로라이드의 신규한 결정 형태 및용매화물 형태와 이들의 제조 방법
EP1207160A1 (de) *	2000-11-20	2002-05-22	Hanmi Pharm. Co., Ltd.	Verfahren zur Herstellung von 1,2,3,9-tetrahydro-9-methyl-3-((2-methyl-1H-imidazol-1-yl)-methyl)-4H-carbazol-4-one
JP2005529142A (ja) *	2002-04-29	2005-09-29	テバジョジセルジャールレースベニュタールシャシャーグ	１，２，３，９−テトラヒドロ−９−メチル−３−［（２−メチル−１ｈ−イミダゾル−１−イル）メチル］−４ｈ−カルバゾル−４−オンの製造方法
JP2005529908A (ja) *	2002-04-30	2005-10-06	テバジョジセルジャールレースベニュタールシャシャーグ	オンダンセトロンの新規結晶形、その製法、当該新規形を含有する医薬組成物、及び当該組成物を用いる吐気の治療方法
US20050131045A1 (en) *	2002-04-30	2005-06-16	Judith Aronhime	Novel crystal forms of ondansetron, processes for their preparation, pharmaceutical, compositions containing the novel forms and methods for treating nausea using them
FI6164U1 (fi) *	2003-01-09	2004-03-15	Synthon Bv	Ondansetronmuotoja
US7390503B1 (en)	2003-08-22	2008-06-24	Barr Laboratories, Inc.	Ondansetron orally disintegrating tablets
US8030345B2 (en) *	2004-07-12	2011-10-04	Cadila Healthcare Limited	Tricyclic pyrazole derivatives as cannabinoid receptor modulators
US7696356B2 (en) *	2004-08-17	2010-04-13	Taro Pharmaceutical Industries Limited	Process for preparing 1,2,3,9-tetrahydro-9-methyl-3-methylene-4H-carbazol-4-one and ondansetron therefrom
US7547791B2 (en) *	2004-10-26	2009-06-16	Ipca Laboratories Ltd.	One-pot process for the preparation of antiemetic agent, 1,2,3,9-tetrahydro-9-methyl-3[(2-methyl)-1H-imidazole-1-yl)methyl]-4H-carbazol-4-O
CN115677561B (zh) *	2022-11-01	2024-04-05	常州兰陵制药有限公司	一种1,2,3,4-四氢-9-甲基-4h-咔唑酮及其合成方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3579534A (en) *	1969-05-09	1971-05-18	American Cyanamid Co	Tetrahydrocarbazolecarboxylates
CN1011237B (zh) *	1984-01-25	1991-01-16	格拉克索公司	1，2，3，9-四氢-3-[(2-甲基-1h-咪唑-1-基)甲基]-4h-咔唑-4-酮类和其盐以及溶剂化物的制备
PT79890B (en) *	1984-01-25	1987-02-03	Glaxo Group Ltd	Process for preparing tetrahydro-methylimidazolylcarbazolones
GB8518743D0 (en) *	1985-07-24	1985-08-29	Glaxo Group Ltd	Heterocyclic compounds
GB8518742D0 (en) *	1985-07-24	1985-08-29	Glaxo Group Ltd	Process
GB8617994D0 (en) *	1986-07-23	1986-08-28	Glaxo Group Ltd	Heterocyclic compounds
GB8628473D0 (en) *	1986-11-28	1987-01-07	Glaxo Group Ltd	Chemical compounds
US4939144A (en) *	1987-10-22	1990-07-03	Glaxo Group Limited	Tricyclic ketone derivatives as 5-HT antagonists

1993
- 1993-09-21 CA CA002106642A patent/CA2106642C/en not_active Expired - Fee Related
- 1993-10-08 HR HR3223/92A patent/HRP931292B1/xx not_active IP Right Cessation
- 1993-10-11 UA UA93002172A patent/UA26893C2/uk unknown
- 1993-10-13 KR KR1019930021223A patent/KR100289912B1/ko not_active IP Right Cessation
- 1993-10-13 DK DK93116542T patent/DK0595111T4/da active
- 1993-10-13 EP EP93116542A patent/EP0595111B2/de not_active Expired - Lifetime
- 1993-10-13 SI SI9300537A patent/SI9300537B/sl not_active IP Right Cessation
- 1993-10-13 RU RU93049416A patent/RU2119914C1/ru not_active IP Right Cessation
- 1993-10-13 SK SK1110-93A patent/SK281243B6/sk unknown
- 1993-10-13 PL PL93300685A patent/PL174173B1/pl not_active IP Right Cessation
- 1993-10-13 PL PL93324329A patent/PL174526B1/pl not_active IP Right Cessation
- 1993-10-13 ES ES93116542T patent/ES2106936T5/es not_active Expired - Lifetime
- 1993-10-13 CN CN93119192A patent/CN1052979C/zh not_active Expired - Fee Related
- 1993-10-13 RO RO93-01370A patent/RO115799B1/ro unknown
- 1993-10-13 US US08/135,407 patent/US5416221A/en not_active Expired - Lifetime
- 1993-10-13 CZ CZ932156A patent/CZ284223B6/cs not_active IP Right Cessation
- 1993-10-13 JP JP25588093A patent/JP3378315B2/ja not_active Expired - Fee Related
- 1993-10-13 DE DE69313771T patent/DE69313771T3/de not_active Expired - Fee Related
- 1993-10-13 AT AT93116542T patent/ATE157973T1/de not_active IP Right Cessation
1994
- 1994-07-19 EE EE9400092A patent/EE03071B1/xx not_active IP Right Cessation
- 1994-11-25 US US08/344,871 patent/US5478949A/en not_active Expired - Lifetime
1997
- 1997-12-04 GR GR970403244T patent/GR3025599T3/el unknown
1999
- 1999-05-11 CN CN99106445A patent/CN1083430C/zh not_active Expired - Fee Related
- 1999-05-24 UA UA99052847A patent/UA27022C2/uk unknown

Also Published As

Publication number	Publication date
ES2106936T5 (es)	2001-12-16
KR940009152A (ko)	1994-05-20
US5478949A (en)	1995-12-26
PL300685A1 (en)	1994-04-18
DK0595111T3 (da)	1998-04-14
EE03071B1 (et)	1998-02-16
CN1052979C (zh)	2000-05-31
US5416221A (en)	1995-05-16
SI9300537A (en)	1994-06-30
SK111093A3 (en)	1994-11-09
CN1235967A (zh)	1999-11-24
RO115799B1 (ro)	2000-06-30
KR100289912B1 (ko)	2001-09-17
ES2106936T3 (es)	1997-11-16
CN1089941A (zh)	1994-07-27
SK281243B6 (sk)	2001-01-18
EP0595111A1 (de)	1994-05-04
DE69313771D1 (de)	1997-10-16
CN1083430C (zh)	2002-04-24
PL174526B1 (pl)	1998-08-31
PL174173B1 (pl)	1998-06-30
HRP931292B1 (en)	1999-08-31
SI9300537B (sl)	2003-02-28
RU2119914C1 (ru)	1998-10-10
UA26893C2 (uk)	1999-12-29
JPH06293734A (ja)	1994-10-21
EP0595111B1 (de)	1997-09-10
EP0595111B2 (de)	2001-08-16
CA2106642C (en)	2005-08-16
DE69313771T2 (de)	1998-02-12
HRP931292A2 (en)	1994-12-31
DE69313771T3 (de)	2002-04-18
GR3025599T3 (en)	1998-03-31
CZ284223B6 (cs)	1998-09-16
UA27022C2 (uk)	2000-02-28
CA2106642A1 (en)	1994-04-15
JP3378315B2 (ja)	2003-02-17
DK0595111T4 (da)	2001-10-22
CZ215693A3 (en)	1994-05-18

Legal Events

Date	Code	Title
1998-02-15	UEP	Publication of translation of european patent specification
2001-11-15	UEP	Publication of translation of european patent specification
2009-07-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE38661T1 (de)	1988-12-15	Zwischenprodukt und verfahren zu dessen herstellung.
ATE157973T1 (de)	1997-09-15	Carbazolon - derivate und verfahren zu ihrer herstellung
ATE242241T1 (de)	2003-06-15	Imidazopyridinderivate und verfahren zu ihrer herstellung
IL102093A0 (en)	1993-01-14	1-methylcarbapenem derivatives,processes for the preparation thereof,and pharmaceutical compositions containing the same
DE69522589D1 (de)	2001-10-11	Vitamin D3-Derivate und ein Verfahren zu ihrer Herstellung
DE69331652T2 (de)	2002-10-17	Azetidinonverbindung und Verfahren zu ihrer Herstellung
ATE134623T1 (de)	1996-03-15	Salicyl(thio)etherderivate, verfahren und zwischenprodukte zu ihrer herstellung
ATE47856T1 (de)	1989-11-15	11-substituierte 5h,11h-pyrrolo(2,1c>(1,4>benzoxazepine, ein verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
HU9200172D0 (en)	1992-04-28	Substituted 1,2,3,4-tetrahydro-cyclopenta/b/indole-and 1,2,3,3a,4,8a-hexahydro-cyclopenta/b/indole derivatives, their intermediate products, process for their production and medical preparations containing them
RU93049416A (ru)	1996-04-27	Производные карбазолона и способ их получения
DE3781879T2 (de)	1993-04-08	Anthracyclinderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
ATE171942T1 (de)	1998-10-15	1-piperazinyl-2-butene und 2-butyne, zwischenverbindungen, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3777464D1 (de)	1992-04-23	Fluorine enthaltende vitamin-d3-derivate und verfahren zu ihrer herstellung.
ATE168371T1 (de)	1998-08-15	5-amino-5,6,7,8-tetrahydrochinoline und verwandte verbindungen, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
ATE151422T1 (de)	1997-04-15	8-azabicyclo(3.2.1>octylalkylthiazolidinone, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE69204480T2 (de)	1996-05-02	Anilinderivate und Verfahren zu ihrer Herstellung.
DE69719673D1 (de)	2003-04-17	D-pentofuranose-derivate und verfahren zu ihrer herstellung
ATE92074T1 (de)	1993-08-15	Beta-d-phenylthioxyloside, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
ATE52510T1 (de)	1990-05-15	Benzo(c>-1,5-naphthyridine, ein verfahren und zwischenprodukte zu ihrer herstellung und ihre verwendung als arzneimittel.
DE3851579T2 (de)	1995-04-20	Cyclische Aminothioacetalamide, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen.
NZ332245A (en)	2000-03-27	Substituted benzo-oxazolol carboxylic acid derivatives, process for their production and medicaments containing them
ATE95177T1 (de)	1993-10-15	Naphthothiazepin-derivate und verfahren zu ihrer herstellung.
ZA924888B (en)	1993-04-28	Process for the synthesis of enantiomers of 3-aminochroman compounds
DE69229017T2 (de)	1999-10-07	Glyceraldehyd-3-pentanid und Verfahren zu ihrer Herstellung
DE3483011D1 (de)	1990-09-27	Substituierte alkylamino-derivate von 6,11-dihydro-11-oxo-dibenz(b,e)-oxepin, verfahren zu ihrer herstellung, ihre zwischenprodukte und ihre verwendung als arzneimittel.