ATE181557T1 - Zusammensetzungen und methoden zur anwendung von reaktiven antiviralen polymeren - Google Patents

Zusammensetzungen und methoden zur anwendung von reaktiven antiviralen polymeren

Info

Publication number
ATE181557T1
ATE181557T1 AT94909760T AT94909760T ATE181557T1 AT E181557 T1 ATE181557 T1 AT E181557T1 AT 94909760 T AT94909760 T AT 94909760T AT 94909760 T AT94909760 T AT 94909760T AT E181557 T1 ATE181557 T1 AT E181557T1
Authority
AT
Austria
Prior art keywords
rna
viruses
virus
compositions
methods
Prior art date
Application number
AT94909760T
Other languages
English (en)
Inventor
Jui H Wang
Insung Kang
Mohammed H Raham
Original Assignee
Jui H Wang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jui H Wang filed Critical Jui H Wang
Application granted granted Critical
Publication of ATE181557T1 publication Critical patent/ATE181557T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
AT94909760T 1993-02-24 1994-02-23 Zusammensetzungen und methoden zur anwendung von reaktiven antiviralen polymeren ATE181557T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2205593A 1993-02-24 1993-02-24

Publications (1)

Publication Number Publication Date
ATE181557T1 true ATE181557T1 (de) 1999-07-15

Family

ID=21807582

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94909760T ATE181557T1 (de) 1993-02-24 1994-02-23 Zusammensetzungen und methoden zur anwendung von reaktiven antiviralen polymeren

Country Status (8)

Country Link
US (1) US5496546A (de)
EP (1) EP0686043B1 (de)
CN (1) CN1078478C (de)
AT (1) ATE181557T1 (de)
AU (1) AU6247594A (de)
CA (1) CA2156394A1 (de)
DE (1) DE69419244T2 (de)
WO (1) WO1994019012A2 (de)

Families Citing this family (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5858988A (en) * 1993-02-24 1999-01-12 Wang; Jui H. Poly-substituted-phenyl-oligoribo nucleotides having enhanced stability and membrane permeability and methods of use
US6291438B1 (en) 1993-02-24 2001-09-18 Jui H. Wang Antiviral anticancer poly-substituted phenyl derivatized oligoribonucleotides and methods for their use
AU3216695A (en) * 1994-08-29 1996-03-22 University Of North Carolina At Chapel Hill, The Lipid analogs for treating viral infections
US7135584B2 (en) * 1995-08-07 2006-11-14 Wake Forest University Lipid analogs for treating viral infections
US6468991B1 (en) 1997-01-16 2002-10-22 Cyclis Pharmaceuticals, Inc. Method of treating rhinoviral infections
US6271358B1 (en) * 1998-07-27 2001-08-07 Isis Pharmaceuticals, Inc. RNA targeted 2′-modified oligonucleotides that are conformationally preorganized
DE60032235T2 (de) 1999-04-30 2007-11-15 Cyclops Genome Sciences Ltd., West Kirby Ribonukleinsäurederivate
US7026469B2 (en) * 2000-10-19 2006-04-11 Wake Forest University School Of Medicine Compositions and methods of double-targeting virus infections and cancer cells
MY164523A (en) 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
CN101099745A (zh) 2000-05-26 2008-01-09 艾登尼科斯（开曼）有限公司 处理黄病毒和瘟病毒的方法和组合物
KR101005299B1 (ko) 2000-10-18 2011-01-04 파마셋 인코포레이티드 바이러스 감염 및 비정상적인 세포 증식의 치료를 위한 변형된 뉴클레오시드
US7309696B2 (en) 2000-10-19 2007-12-18 Wake Forest University Compositions and methods for targeting cancer cells
US20020137076A1 (en) * 2000-11-28 2002-09-26 Shultz John W. RNA polymers and uses thereof
AU2002232660A1 (en) * 2000-12-15 2002-06-24 Pharmasset Ltd. Antiviral agents for treatment of flaviviridae infections
EP1397326A2 (de) * 2001-05-29 2004-03-17 Koninklijke Philips Electronics N.V. Metall-keramik verbund
GB0114286D0 (en) * 2001-06-12 2001-08-01 Hoffmann La Roche Nucleoside Derivatives
CN100469131C (zh) * 2001-08-31 2009-03-11 汤姆森许可公司 实现条件存取***和传输、接收及处理内容的方法和设备
JP2005504087A (ja) * 2001-09-28 2005-02-10 イデニクス（ケイマン）リミテツド ４’が修飾されたヌクレオシドを使用するｃ型肝炎ウイルス治療のための方法および組成物
EP1480982A4 (de) * 2002-02-14 2007-08-01 Pharmasset Inc Modifizierte fluorinierte nukleosidanaloga
TW200500375A (en) 2002-06-28 2005-01-01 Idenix Cayman Ltd Modified 2' and 3'-nucleoside prodrugs for treating flaviviridae
MXPA05001298A (es) * 2002-08-01 2005-11-04 Pharmasset Inc Compuestos con el sistema biciclo[4.2.1] nonano para el tratamiento de infecciones por flaviviridae.
RU2005118421A (ru) 2002-11-15 2006-01-20 Айденикс (Кайман) Лимитед (Ky) 2'-разветвленные нуклеозиды и мутация flaviviridae
WO2004053073A2 (en) * 2002-12-05 2004-06-24 The Research Foundation Of State University Of Newyork HIGH EFFICACY ANTISENSE Riα PKA POLY-DNP OLIGORIBONUCLEOTIDES
US20040248841A1 (en) * 2003-03-13 2004-12-09 Wang Jui H. Poly-DNP-siRNA
CA2734066A1 (en) 2003-05-30 2005-01-13 Pharmasset, Inc. Modified fluorinated nucleoside analogues
EP1658302B1 (de) 2003-07-25 2010-08-25 IDENIX Pharmaceuticals, Inc. Purin nucleoside für die behandlung von durch flavividrae verursachten krankheiten, einschliesslich hepatitis c
GB0500020D0 (en) 2005-01-04 2005-02-09 Novartis Ag Organic compounds
US20050187191A1 (en) * 2004-02-20 2005-08-25 Kucera Louis S. Methods and compositions for the treatment of respiratory syncytial virus
US20050187192A1 (en) * 2004-02-20 2005-08-25 Kucera Pharmaceutical Company Phospholipids for the treatment of infection by togaviruses, herpes viruses and coronaviruses
WO2006000922A2 (en) * 2004-06-23 2006-01-05 Idenix (Cayman) Limited 5-aza-7-deazapurine derivatives for treating infections with flaviviridae
CN101023094B (zh) * 2004-07-21 2011-05-18 法莫赛特股份有限公司 烷基取代的2-脱氧-2-氟代-d-呋喃核糖基嘧啶和嘌呤及其衍生物的制备
AU2005285045B2 (en) * 2004-09-14 2011-10-13 Gilead Pharmasset Llc Preparation of 2'fluoro-2'- alkyl- substituted or other optionally substituted ribofuranosyl pyrimidines and purines and their derivatives
KR101059593B1 (ko) 2006-04-11 2011-08-25 노파르티스 아게 Ｈｃｖ/ｈｉｖ 억제제 및 이들의 용도
BRPI0808089A2 (pt) 2007-02-28 2014-07-15 Conatus Pharmaceuticals Inc Método para tratar uma doença do fígado, para diminuir um nível elevado de uma enzima do fígado, para inibir uma cascata de sinalização de tnf-alfa e uma cascata de sinalização de alfa-faz, para reduzir um dano ao fígado, para suprimir a apoptose excessiva em uma célula de fígado, e para inibir a replicação do vírus da hepatite c.
WO2008106167A1 (en) * 2007-02-28 2008-09-04 Conatus Pharmaceuticals, Inc. Combination therapy comprising matrix metalloproteinase inhibitors and caspase inhibitors for the treatment of liver diseases
US7964580B2 (en) 2007-03-30 2011-06-21 Pharmasset, Inc. Nucleoside phosphoramidate prodrugs
TW200946541A (en) * 2008-03-27 2009-11-16 Idenix Pharmaceuticals Inc Solid forms of an anti-HIV phosphoindole compound
US8173621B2 (en) * 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
ES2458358T3 (es) 2008-07-02 2014-05-05 Idenix Pharmaceuticals, Inc. Compuestos y composiciones farmacéuticas para el tratamiento de infecciones víricas
BRPI0922508A8 (pt) * 2008-12-23 2016-01-19 Pharmasset Inc Análogos de nucleosídeo
KR20110104074A (ko) 2008-12-23 2011-09-21 파마셋 인코포레이티드 퓨린 뉴클레오시드의 합성
SG172359A1 (en) 2008-12-23 2011-07-28 Pharmasset Inc Nucleoside phosphoramidates
JP5690286B2 (ja) 2009-03-04 2015-03-25 イデニク プハルマセウティカルス，インコーポレイテッド ホスホチオフェン及びホスホチアゾールｈｃｖポリメラーゼ阻害剤
US20110182850A1 (en) 2009-04-10 2011-07-28 Trixi Brandl Organic compounds and their uses
US8512690B2 (en) 2009-04-10 2013-08-20 Novartis Ag Derivatised proline containing peptide compounds as protease inhibitors
US8618076B2 (en) 2009-05-20 2013-12-31 Gilead Pharmasset Llc Nucleoside phosphoramidates
TWI598358B (zh) * 2009-05-20 2017-09-11 基利法瑪席特有限責任公司 核苷磷醯胺
TW201117812A (en) 2009-08-05 2011-06-01 Idenix Pharmaceuticals Inc Macrocyclic serine protease inhibitors
WO2011063076A1 (en) 2009-11-19 2011-05-26 Itherx Pharmaceuticals, Inc. Methods of treating hepatitis c virus with oxoacetamide compounds
CA2784748A1 (en) 2009-12-18 2011-06-23 Idenix Pharmaceuticals, Inc. 5,5-fused arylene or heteroarylene hepatitis c virus inhibitors
PL3290428T3 (pl) 2010-03-31 2022-02-07 Gilead Pharmasset Llc Tabletka zawierająca krystaliczny (S)-2-(((S)-(((2R,3R,4R,5R)-5-(2,4-diokso-3,4-dihydropirymidyn-1(2H)-ylo)-4-fluoro-3-hydroksy-4-metylotetrahydrofuran-2-ylo)metoksy)(fenoksy)fosforylo)amino)propanian izopropylu
PT2752422T (pt) 2010-03-31 2017-11-07 Gilead Pharmasset Llc Síntese estereosseletiva de princípios ativos contendo fósforo
EP2552203B1 (de) 2010-04-01 2017-03-22 Idenix Pharmaceuticals LLC. Verbindungen und zusammensetzungen zur behandlung von virusinfektionen
EA201390532A1 (ru) 2010-10-08 2013-09-30 Новартис Аг Композиции сульфамидых ингибиторов ns3, содержащие витамин е
PT3042910T (pt) 2010-11-30 2019-04-16 Gilead Pharmasset Llc 2'-espiro-nucleósidos para utilização na terapia da hepatite c
WO2012080050A1 (en) 2010-12-14 2012-06-21 F. Hoffmann-La Roche Ag Solid forms of a phenoxybenzenesulfonyl compound
WO2012092540A1 (en) * 2010-12-30 2012-07-05 Ibis Biosciences, Inc. Methods for the synthesis of polyadenylic acid
AR085352A1 (es) 2011-02-10 2013-09-25 Idenix Pharmaceuticals Inc Inhibidores macrociclicos de serina proteasa, sus composiciones farmaceuticas y su uso para tratar infecciones por hcv
WO2012107584A1 (en) 2011-02-11 2012-08-16 Universite Pierre Et Marie Curie (Paris 6) Methods for predicting outcome of a hepatitis virus infection
JP2014514295A (ja) 2011-03-31 2014-06-19 アイディニックス ファーマシューティカルズ インコーポレイテッド ウイルス感染の治療のための化合物および薬学的組成物
US20120252721A1 (en) 2011-03-31 2012-10-04 Idenix Pharmaceuticals, Inc. Methods for treating drug-resistant hepatitis c virus infection with a 5,5-fused arylene or heteroarylene hepatitis c virus inhibitor
JP2014521679A (ja) 2011-08-03 2014-08-28 シテリ Ｈｃｖ免疫療法
TW201329096A (zh) 2011-09-12 2013-07-16 Idenix Pharmaceuticals Inc 經取代羰氧基甲基磷酸醯胺化合物及用於治療病毒感染之藥學組成物
EP2755985B1 (de) 2011-09-12 2017-11-01 Idenix Pharmaceuticals LLC Verbindungen und zusammensetzungen zur behandlung von virusinfektionen
AR089650A1 (es) 2011-10-14 2014-09-10 Idenix Pharmaceuticals Inc Fosfatos 3,5-ciclicos sustituidos de compuestos de nucleotido de purina y composiciones farmaceuticas para el tratamiento de infecciones virales
US8889159B2 (en) 2011-11-29 2014-11-18 Gilead Pharmasset Llc Compositions and methods for treating hepatitis C virus
WO2013082476A1 (en) 2011-11-30 2013-06-06 Emory University Antiviral jak inhibitors useful in treating or preventing retroviral and other viral infections
US8809354B2 (en) 2011-12-31 2014-08-19 Sheikh Riazuddin 3-amino-2-(4-nitrophenyl)-4-(3H)-quinazolinone or derivatives thereof for treating or preventing antiviral infections
US20130217644A1 (en) 2012-02-13 2013-08-22 Idenix Pharmaceuticals, Inc. Pharmaceutical Compositions of 2'-C-Methyl-Guanosine, 5'-[2[(3-Hydroxy-2,2-Dimethyl-1-Oxopropyl)Thio]Ethyl N-(Phenylmethyl)Phosphoramidate]
MD20140134A2 (ro) 2012-05-22 2015-04-30 Idenix Pharmaceuticals, Inc. Compuşi ai D-aminoacizilor pentru tratamentul bolilor hepatice
EP2852605B1 (de) 2012-05-22 2018-01-31 Idenix Pharmaceuticals LLC 3',5'-cyclische phosphat-prodrugs für hcv-infektion
WO2013177188A1 (en) 2012-05-22 2013-11-28 Idenix Pharmaceuticals, Inc. 3',5'-cyclic phosphoramidate prodrugs for hcv infection
MX353422B (es) 2012-10-08 2018-01-12 Idenix Pharmaceuticals Llc Análogos de 2'-cloronucleósido para infección por vhc.
EP2909223B1 (de) 2012-10-19 2017-03-22 Idenix Pharmaceuticals LLC Dinukleotidverbindungen für hcv-infektion
EP2909222B1 (de) 2012-10-22 2021-05-26 Idenix Pharmaceuticals LLC 2',4'-verbrückten nukleoside für hcv-infektion
US20140140952A1 (en) 2012-11-14 2014-05-22 Idenix Pharmaceuticals, Inc. D-Alanine Ester of Sp-Nucleoside Analog
EP2920195A1 (de) 2012-11-14 2015-09-23 IDENIX Pharmaceuticals, Inc. D-alaninester eines rp-nukleosidanalogons
US9211300B2 (en) 2012-12-19 2015-12-15 Idenix Pharmaceuticals Llc 4′-fluoro nucleosides for the treatment of HCV
US9309275B2 (en) 2013-03-04 2016-04-12 Idenix Pharmaceuticals Llc 3′-deoxy nucleosides for the treatment of HCV
WO2014137930A1 (en) 2013-03-04 2014-09-12 Idenix Pharmaceuticals, Inc. Thiophosphate nucleosides for the treatment of hcv
EP2981542B1 (de) 2013-04-01 2021-09-15 Idenix Pharmaceuticals LLC 2',4'-fluor-nukleoside zur behandlung von hcv
US10005779B2 (en) 2013-06-05 2018-06-26 Idenix Pharmaceuticals Llc 1′,4′-thio nucleosides for the treatment of HCV
US20150037282A1 (en) 2013-08-01 2015-02-05 Idenix Pharmaceuticals, Inc. D-amino acid phosphoramidate pronucleotides of halogeno pyrimidine compounds for liver disease
PL3038601T3 (pl) 2013-08-27 2020-08-24 Gilead Pharmasset Llc Formulacja złożona dwóch związków przeciwwirusowych
WO2015042375A1 (en) 2013-09-20 2015-03-26 Idenix Pharmaceuticals, Inc. Hepatitis c virus inhibitors
WO2015061683A1 (en) 2013-10-25 2015-04-30 Idenix Pharmaceuticals, Inc. D-amino acid phosphoramidate and d-alanine thiophosphoramidate pronucleotides of nucleoside compounds useful for the treatment of hcv
EP3063165A1 (de) 2013-11-01 2016-09-07 Idenix Pharmaceuticals LLC D-alanin-phosphoramidat-pronukleotide von 2'-methyl-2'-fluor-guanosin-nukleosid-verbindungen zur behandlung von hcv
US20170198005A1 (en) 2013-11-27 2017-07-13 Idenix Pharmaceuticals Llc 2'-dichloro and 2'-fluoro-2'-chloro nucleoside analogues for hcv infection
WO2015095419A1 (en) 2013-12-18 2015-06-25 Idenix Pharmaceuticals, Inc. 4'-or nucleosides for the treatment of hcv
US20170135990A1 (en) 2014-03-05 2017-05-18 Idenix Pharmaceuticals Llc Pharmaceutical compositions comprising a 5,5-fused heteroarylene flaviviridae inhibitor and their use for treating or preventing flaviviridae infection
US20170066779A1 (en) 2014-03-05 2017-03-09 Idenix Pharmaceuticals Llc Solid forms of a flaviviridae virus inhibitor compound and salts thereof
EP3131914B1 (de) 2014-04-16 2023-05-10 Idenix Pharmaceuticals LLC 3'-substituierte methyl- oder alkynylnukleoside zur behandlung von hcv

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4966843A (en) * 1982-11-01 1990-10-30 Cetus Corporation Expression of interferon genes in Chinese hamster ovary cells
US5091374A (en) * 1987-07-17 1992-02-25 Hem Research Inc. Double-stranded RNA correction of abnormalities in circulating immune complexes and monocyte function
JP3310281B2 (ja) * 1989-11-08 2002-08-05 ベイラー カレッジ オブ メディシン ノーワーク及び関連のウィルスを検出し同定するための方法と試薬
WO1991007989A1 (en) * 1989-11-28 1991-06-13 Universite Laval A method of inactivating human immunodeficiency virus
US5132292A (en) * 1990-05-25 1992-07-21 Hem Research, Inc. Treatment of viral hepatitis

Also Published As

Publication number Publication date
EP0686043A4 (de) 1996-04-17
DE69419244D1 (de) 1999-07-29
DE69419244T2 (de) 1999-10-14
WO1994019012A3 (en) 1994-10-27
CA2156394A1 (en) 1994-09-01
EP0686043B1 (de) 1999-06-23
US5496546A (en) 1996-03-05
WO1994019012A2 (en) 1994-09-01
CN1078478C (zh) 2002-01-30
CN1121313A (zh) 1996-04-24
EP0686043A1 (de) 1995-12-13
AU6247594A (en) 1994-09-14

Similar Documents

Publication Publication Date Title
ATE181557T1 (de) Zusammensetzungen und methoden zur anwendung von reaktiven antiviralen polymeren
KR100486765B1 (ko) 핵산의 선택적 변형방법 및 조성물
US6093564A (en) Methods and compositions for the selective modification of nucleic acids
US5156973A (en) Antiviral blood sampling process and apparatus
Quinnan Jr et al. Inactivation of human T‐cell lymphotropic virus, type III by heat, chemicals, and irradiation
WO1998051660A9 (en) Methods and compositions for the selective modification of nucleic acids
JPH03503287A (ja) 生体に適切なウィルス不活性化アルブミン
DE69738535D1 (de) Antivirale mittel aus pflanzenextrakten und deren verwendung zur behandlung viraler infektionen
BR9007758A (pt) Processo para inibir o crescimento ou replicacao dos virus da imuno deficiencia humana,compostos,composto intermediario e formulacao farmaceutica para inibir o crescimento ou replicacao do hiv
Sofer Virus Inactivation in the 1990s—and into the 21st Century
BR9912142A (pt) 6-benzil-4-oxipirimidinas substituìdas, processopara sua preparação e composições contendo-as
ATE189394T1 (de) Methode zur behandlung von viralen infektionen
BRPI0411679A (pt) agente para inibição da reprodução de vìrus na membrana, método para a produção da mesma, composição farmacêutica e método para inibição da infecção viral
CA2394797A1 (en) Process for producing virus-free plasma protein composition by porous membrane treatment, virus-free plasma protein composition and method of removing viruses
WO2002083157A1 (fr) Plasma sanguin humain exempt de groupe sanguin et son procede de preparation
US6352695B1 (en) Methods and compositions for the selective modification of nucleic acids
KR900001697A (ko) 치료용 화합물
JP4629831B2 (ja) ウィルスの不活化方法
US3259546A (en) Treatment of viruses
Allen et al. Target-organ treatment of neurotropic virus disease with interferon inducers
UA42693C2 (uk) Лікарський засіб для лікування інфекції лентивірусом, препарат для лікування людини, яка інфікована лентивірусом
CN104056268A (zh) 一种具有抗人***瘤病毒及子***症的新型制剂
EA200201039A1 (ru) Антивирусный и антибактериальный фармацевтический препарат и его применение для лечения инфекционных заболеваний
JPH03227925A (ja) エイズ原因ウィルスに対する抗ウイルス剤
TH16738A (th) " อนุพันธ์ยูรีโดที่ออกฤทธิ์ทางชีวภาพที่มีประโยชน์ในการบำบัดโรคที่เกิดจากเล็นทิไวรัส "

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties