ATE176905T1 - Pyrimidine-cyanoguanidine als kaliumkanalblocker - Google Patents
Pyrimidine-cyanoguanidine als kaliumkanalblockerInfo
- Publication number
- ATE176905T1 ATE176905T1 AT94904387T AT94904387T ATE176905T1 AT E176905 T1 ATE176905 T1 AT E176905T1 AT 94904387 T AT94904387 T AT 94904387T AT 94904387 T AT94904387 T AT 94904387T AT E176905 T1 ATE176905 T1 AT E176905T1
- Authority
- AT
- Austria
- Prior art keywords
- alkyl
- hydrogen
- pyrimidine
- cyanoguanidine
- potassium channel
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US1993/005458 WO1994004499A1 (en) | 1992-08-13 | 1993-06-11 | Cyanoguanidines as potassium channel blockers |
PCT/US1993/011332 WO1994029280A1 (en) | 1993-06-11 | 1993-11-26 | Pyrimidine cyanoguanidines as k-channel blockers |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE176905T1 true ATE176905T1 (de) | 1999-03-15 |
Family
ID=22236674
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT94904387T ATE176905T1 (de) | 1993-06-11 | 1993-11-26 | Pyrimidine-cyanoguanidine als kaliumkanalblocker |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP0703904B1 (de) |
JP (1) | JPH08511264A (de) |
AT (1) | ATE176905T1 (de) |
AU (1) | AU673785B2 (de) |
CA (1) | CA2161325A1 (de) |
DE (1) | DE69323633T2 (de) |
DK (1) | DK0703904T3 (de) |
ES (1) | ES2127918T3 (de) |
GR (1) | GR3029737T3 (de) |
NZ (1) | NZ259600A (de) |
WO (1) | WO1994029280A1 (de) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007022964A2 (de) | 2005-08-24 | 2007-03-01 | Abbott Gmbh & Co. Kg | Hetaryl substituierte guanidinverbindungen und ihre verwendung als bindungspartner für 5-ht5-rezeptoren |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1489879A (en) * | 1974-12-20 | 1977-10-26 | Leo Pharm Prod Ltd | N'-cyano-n'-3-pyridylguanidines |
NL8000869A (nl) * | 1979-02-16 | 1980-08-19 | Eisai Co Ltd | Cyanoguanidine-derivaten en werkwijze voor de bereiding daarvan. |
NZ229828A (en) * | 1988-08-09 | 1992-03-26 | Squibb & Sons Inc | Aryl cyanoguanidine derivatives and pharmaceutical compositions |
EP0381504A3 (de) * | 1989-02-03 | 1991-09-04 | Eli Lilly And Company | Guanidin-Derivate |
US5006523A (en) * | 1989-10-26 | 1991-04-09 | E. R. Squibb & Sons, Inc. | Antiarrhythmic agents: aryl cyanoguanidine potassium channel blockers |
-
1993
- 1993-11-26 AT AT94904387T patent/ATE176905T1/de not_active IP Right Cessation
- 1993-11-26 WO PCT/US1993/011332 patent/WO1994029280A1/en active IP Right Grant
- 1993-11-26 NZ NZ259600A patent/NZ259600A/xx unknown
- 1993-11-26 CA CA002161325A patent/CA2161325A1/en not_active Abandoned
- 1993-11-26 DK DK94904387T patent/DK0703904T3/da active
- 1993-11-26 EP EP94904387A patent/EP0703904B1/de not_active Expired - Lifetime
- 1993-11-26 ES ES94904387T patent/ES2127918T3/es not_active Expired - Lifetime
- 1993-11-26 AU AU10303/95A patent/AU673785B2/en not_active Ceased
- 1993-11-26 JP JP7501716A patent/JPH08511264A/ja active Pending
- 1993-11-26 DE DE69323633T patent/DE69323633T2/de not_active Expired - Fee Related
-
1999
- 1999-03-19 GR GR990400822T patent/GR3029737T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
EP0703904B1 (de) | 1999-02-24 |
AU673785B2 (en) | 1996-11-21 |
NZ259600A (en) | 1997-08-22 |
EP0703904A1 (de) | 1996-04-03 |
WO1994029280A1 (en) | 1994-12-22 |
DE69323633T2 (de) | 1999-07-08 |
AU1030395A (en) | 1995-01-03 |
DK0703904T3 (da) | 1999-09-27 |
JPH08511264A (ja) | 1996-11-26 |
ES2127918T3 (es) | 1999-05-01 |
DE69323633D1 (de) | 1999-04-01 |
GR3029737T3 (en) | 1999-06-30 |
CA2161325A1 (en) | 1994-12-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
REN | Ceased due to non-payment of the annual fee |