ATE168414T1 - Aprotininanaloga - Google Patents

Aprotininanaloga

Info

Publication number
ATE168414T1
ATE168414T1 AT91917143T AT91917143T ATE168414T1 AT E168414 T1 ATE168414 T1 AT E168414T1 AT 91917143 T AT91917143 T AT 91917143T AT 91917143 T AT91917143 T AT 91917143T AT E168414 T1 ATE168414 T1 AT E168414T1
Authority
AT
Austria
Prior art keywords
aminoacid
replaced
residue
negatively charged
aminoacid residue
Prior art date
Application number
AT91917143T
Other languages
English (en)
Inventor
Soren Erik Bjorn
Kjeld Norris
Viggo Diness
Leif Birkeve Norskov-Lauritsen
Niels Dyhr Christensen
Claus Bregengaard
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DK236190A external-priority patent/DK236190D0/da
Priority claimed from DK111891A external-priority patent/DK111891D0/da
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Application granted granted Critical
Publication of ATE168414T1 publication Critical patent/ATE168414T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • C07K14/8117—Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT91917143T 1990-10-01 1991-10-01 Aprotininanaloga ATE168414T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK236190A DK236190D0 (da) 1990-10-01 1990-10-01 Polypeptid
DK111891A DK111891D0 (da) 1991-06-12 1991-06-12 Polypeptid

Publications (1)

Publication Number Publication Date
ATE168414T1 true ATE168414T1 (de) 1998-08-15

Family

ID=26065261

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91917143T ATE168414T1 (de) 1990-10-01 1991-10-01 Aprotininanaloga

Country Status (21)

Country Link
EP (1) EP0551329B1 (de)
JP (1) JP3614850B2 (de)
KR (1) KR100250391B1 (de)
AT (1) ATE168414T1 (de)
AU (1) AU659100B2 (de)
CA (1) CA2092920A1 (de)
CZ (1) CZ285225B6 (de)
DE (1) DE69129809T2 (de)
DK (1) DK0551329T3 (de)
ES (1) ES2121787T3 (de)
FI (1) FI105036B (de)
HU (1) HU219302B (de)
IE (1) IE913433A1 (de)
IL (1) IL99585A0 (de)
MX (1) MX9101382A (de)
NO (1) NO309529B1 (de)
NZ (1) NZ240014A (de)
PT (1) PT99124B (de)
SK (1) SK281540B6 (de)
UA (1) UA34422C2 (de)
WO (1) WO1992006111A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6057287A (en) 1994-01-11 2000-05-02 Dyax Corp. Kallikrein-binding "Kunitz domain" proteins and analogues thereof
RU2182598C2 (ru) * 1994-11-21 2002-05-20 Новартис Аг Модифицированные ингибиторы протеиназы
AU738766B2 (en) * 1994-11-21 2001-09-27 University Of Leeds, The Modified proteinase inhibitors
DE19629982A1 (de) * 1996-07-25 1998-01-29 Bayer Ag Aprotinin-Varianten mit verbesserten Eigenschaften
DE19725014A1 (de) * 1997-06-13 1998-12-17 Bayer Ag Aprotininvarianten mit verbesserten Eigenschaften und Bikunine von Aprotininvarianten
WO2001066801A2 (en) * 2000-03-08 2001-09-13 Complexe Hospitalier De La Sagamie Very low density lipoprotein receptor polymorphisms and uses therefor
CA2488558C (en) 2002-06-07 2013-08-20 Dyax Corp. Prevention and reduction of blood loss
US7153829B2 (en) 2002-06-07 2006-12-26 Dyax Corp. Kallikrein-inhibitor therapies
DK2386310T3 (en) 2002-08-28 2019-02-25 Dyax Corp Methods of preserving organs and tissues
US7235530B2 (en) 2004-09-27 2007-06-26 Dyax Corporation Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
WO2008077478A1 (en) * 2006-12-22 2008-07-03 Bayer Schering Pharma Aktiengesellschaft Preparation and use of variants of the kunitz domain 2 of the human placental bikunin gene
DE102007056231A1 (de) 2007-09-08 2009-03-12 Bayer Healthcare Ag Herstellung und Verwendung von Varianten humander Kunitz-Typ Protease-Inhibitoren (hKTPI)
WO2010080833A1 (en) 2009-01-06 2010-07-15 Dyax Corp. Treatment of mucositis with kallikrein inhibitors
SI2521568T1 (sl) 2010-01-06 2019-01-31 Dyax Corp. Proteini, ki vežejo plazemski kalikrein
IL269565B2 (en) 2011-01-06 2024-06-01 Dyax Corp KALLIKREIN PLASMA BINDING PROTEINS
JP7003354B2 (ja) 2015-12-11 2022-03-04 武田薬品工業株式会社 遺伝性血管性浮腫の発作を治療するための血漿カリクレイン阻害薬およびその用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2188322A (en) * 1986-03-26 1987-09-30 Bayer Ag Aprotinin and analogues thereof produced by a recombinant host
DE3724570A1 (de) * 1987-06-27 1989-01-05 Bayer Ag Human-aprotinin, dessen lys-rest in position 15 gegen einen anderen protogenen aminosaeurerest ausgetauscht ist
DK450187D0 (da) * 1987-08-28 1987-08-28 Novo Industri As Fremgangsmaade til fremstilling af proteiner
DK225488D0 (da) * 1988-04-26 1988-04-26 Novo Industri As Polypeptid
DE3930522A1 (de) * 1989-09-13 1991-03-21 Bayer Ag Rekombinante aprotinin-varianten - gentechnisches verfahren zur mikrobiellen herstellung von homogen prozessierten aprotinin-varianten sowie die therapeutische anwendung derselben

Also Published As

Publication number Publication date
JP3614850B2 (ja) 2005-01-26
ES2121787T3 (es) 1998-12-16
HU219302B (en) 2001-03-28
CZ51793A3 (en) 1994-01-19
AU8546091A (en) 1992-04-28
NO931220D0 (no) 1993-03-31
JPH06501158A (ja) 1994-02-10
EP0551329B1 (de) 1998-07-15
SK281540B6 (sk) 2001-04-09
UA34422C2 (uk) 2001-03-15
CZ285225B6 (cs) 1999-06-16
WO1992006111A1 (en) 1992-04-16
NZ240014A (en) 1992-08-26
PT99124A (pt) 1992-08-31
HU9300943D0 (en) 1993-06-28
FI105036B (fi) 2000-05-31
AU659100B2 (en) 1995-05-11
FI931457A (fi) 1993-03-31
NO309529B1 (no) 2001-02-12
DE69129809D1 (de) 1998-08-20
KR100250391B1 (ko) 2000-05-01
DK0551329T3 (da) 1999-04-19
DE69129809T2 (de) 1998-11-19
FI931457A0 (fi) 1993-03-31
IL99585A0 (en) 1992-08-18
NO931220L (no) 1993-04-01
PT99124B (pt) 1999-03-31
MX9101382A (es) 1992-06-05
CA2092920A1 (en) 1992-04-02
HUT69955A (en) 1995-09-28
SK26493A3 (en) 1993-10-06
IE913433A1 (en) 1992-04-08
EP0551329A1 (de) 1993-07-21

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee