ATE168414T1 - Aprotininanaloga - Google Patents
AprotininanalogaInfo
- Publication number
- ATE168414T1 ATE168414T1 AT91917143T AT91917143T ATE168414T1 AT E168414 T1 ATE168414 T1 AT E168414T1 AT 91917143 T AT91917143 T AT 91917143T AT 91917143 T AT91917143 T AT 91917143T AT E168414 T1 ATE168414 T1 AT E168414T1
- Authority
- AT
- Austria
- Prior art keywords
- aminoacid
- replaced
- residue
- negatively charged
- aminoacid residue
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
- C07K14/8117—Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK236190A DK236190D0 (da) | 1990-10-01 | 1990-10-01 | Polypeptid |
DK111891A DK111891D0 (da) | 1991-06-12 | 1991-06-12 | Polypeptid |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE168414T1 true ATE168414T1 (de) | 1998-08-15 |
Family
ID=26065261
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT91917143T ATE168414T1 (de) | 1990-10-01 | 1991-10-01 | Aprotininanaloga |
Country Status (21)
Country | Link |
---|---|
EP (1) | EP0551329B1 (de) |
JP (1) | JP3614850B2 (de) |
KR (1) | KR100250391B1 (de) |
AT (1) | ATE168414T1 (de) |
AU (1) | AU659100B2 (de) |
CA (1) | CA2092920A1 (de) |
CZ (1) | CZ285225B6 (de) |
DE (1) | DE69129809T2 (de) |
DK (1) | DK0551329T3 (de) |
ES (1) | ES2121787T3 (de) |
FI (1) | FI105036B (de) |
HU (1) | HU219302B (de) |
IE (1) | IE913433A1 (de) |
IL (1) | IL99585A0 (de) |
MX (1) | MX9101382A (de) |
NO (1) | NO309529B1 (de) |
NZ (1) | NZ240014A (de) |
PT (1) | PT99124B (de) |
SK (1) | SK281540B6 (de) |
UA (1) | UA34422C2 (de) |
WO (1) | WO1992006111A1 (de) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6057287A (en) | 1994-01-11 | 2000-05-02 | Dyax Corp. | Kallikrein-binding "Kunitz domain" proteins and analogues thereof |
RU2182598C2 (ru) * | 1994-11-21 | 2002-05-20 | Новартис Аг | Модифицированные ингибиторы протеиназы |
AU738766B2 (en) * | 1994-11-21 | 2001-09-27 | University Of Leeds, The | Modified proteinase inhibitors |
DE19629982A1 (de) * | 1996-07-25 | 1998-01-29 | Bayer Ag | Aprotinin-Varianten mit verbesserten Eigenschaften |
DE19725014A1 (de) * | 1997-06-13 | 1998-12-17 | Bayer Ag | Aprotininvarianten mit verbesserten Eigenschaften und Bikunine von Aprotininvarianten |
WO2001066801A2 (en) * | 2000-03-08 | 2001-09-13 | Complexe Hospitalier De La Sagamie | Very low density lipoprotein receptor polymorphisms and uses therefor |
CA2488558C (en) | 2002-06-07 | 2013-08-20 | Dyax Corp. | Prevention and reduction of blood loss |
US7153829B2 (en) | 2002-06-07 | 2006-12-26 | Dyax Corp. | Kallikrein-inhibitor therapies |
DK2386310T3 (en) | 2002-08-28 | 2019-02-25 | Dyax Corp | Methods of preserving organs and tissues |
US7235530B2 (en) | 2004-09-27 | 2007-06-26 | Dyax Corporation | Kallikrein inhibitors and anti-thrombolytic agents and uses thereof |
WO2008077478A1 (en) * | 2006-12-22 | 2008-07-03 | Bayer Schering Pharma Aktiengesellschaft | Preparation and use of variants of the kunitz domain 2 of the human placental bikunin gene |
DE102007056231A1 (de) | 2007-09-08 | 2009-03-12 | Bayer Healthcare Ag | Herstellung und Verwendung von Varianten humander Kunitz-Typ Protease-Inhibitoren (hKTPI) |
WO2010080833A1 (en) | 2009-01-06 | 2010-07-15 | Dyax Corp. | Treatment of mucositis with kallikrein inhibitors |
SI2521568T1 (sl) | 2010-01-06 | 2019-01-31 | Dyax Corp. | Proteini, ki vežejo plazemski kalikrein |
IL269565B2 (en) | 2011-01-06 | 2024-06-01 | Dyax Corp | KALLIKREIN PLASMA BINDING PROTEINS |
JP7003354B2 (ja) | 2015-12-11 | 2022-03-04 | 武田薬品工業株式会社 | 遺伝性血管性浮腫の発作を治療するための血漿カリクレイン阻害薬およびその用途 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2188322A (en) * | 1986-03-26 | 1987-09-30 | Bayer Ag | Aprotinin and analogues thereof produced by a recombinant host |
DE3724570A1 (de) * | 1987-06-27 | 1989-01-05 | Bayer Ag | Human-aprotinin, dessen lys-rest in position 15 gegen einen anderen protogenen aminosaeurerest ausgetauscht ist |
DK450187D0 (da) * | 1987-08-28 | 1987-08-28 | Novo Industri As | Fremgangsmaade til fremstilling af proteiner |
DK225488D0 (da) * | 1988-04-26 | 1988-04-26 | Novo Industri As | Polypeptid |
DE3930522A1 (de) * | 1989-09-13 | 1991-03-21 | Bayer Ag | Rekombinante aprotinin-varianten - gentechnisches verfahren zur mikrobiellen herstellung von homogen prozessierten aprotinin-varianten sowie die therapeutische anwendung derselben |
-
1991
- 1991-09-27 IL IL99585A patent/IL99585A0/xx unknown
- 1991-09-30 PT PT99124A patent/PT99124B/pt not_active IP Right Cessation
- 1991-09-30 IE IE343391A patent/IE913433A1/en not_active Application Discontinuation
- 1991-09-30 NZ NZ240014A patent/NZ240014A/en unknown
- 1991-10-01 UA UA93002097A patent/UA34422C2/uk unknown
- 1991-10-01 AT AT91917143T patent/ATE168414T1/de not_active IP Right Cessation
- 1991-10-01 WO PCT/DK1991/000299 patent/WO1992006111A1/en active IP Right Grant
- 1991-10-01 JP JP51609991A patent/JP3614850B2/ja not_active Expired - Fee Related
- 1991-10-01 AU AU85460/91A patent/AU659100B2/en not_active Ceased
- 1991-10-01 ES ES91917143T patent/ES2121787T3/es not_active Expired - Lifetime
- 1991-10-01 DE DE69129809T patent/DE69129809T2/de not_active Expired - Fee Related
- 1991-10-01 EP EP91917143A patent/EP0551329B1/de not_active Expired - Lifetime
- 1991-10-01 CZ CZ93517A patent/CZ285225B6/cs not_active IP Right Cessation
- 1991-10-01 DK DK91917143T patent/DK0551329T3/da active
- 1991-10-01 CA CA002092920A patent/CA2092920A1/en not_active Abandoned
- 1991-10-01 MX MX9101382A patent/MX9101382A/es not_active IP Right Cessation
- 1991-10-01 HU HU9300943A patent/HU219302B/hu not_active IP Right Cessation
- 1991-10-01 SK SK264-93A patent/SK281540B6/sk unknown
-
1993
- 1993-03-31 NO NO931220A patent/NO309529B1/no not_active IP Right Cessation
- 1993-03-31 KR KR1019930701001A patent/KR100250391B1/ko not_active IP Right Cessation
- 1993-03-31 FI FI931457A patent/FI105036B/fi active
Also Published As
Publication number | Publication date |
---|---|
JP3614850B2 (ja) | 2005-01-26 |
ES2121787T3 (es) | 1998-12-16 |
HU219302B (en) | 2001-03-28 |
CZ51793A3 (en) | 1994-01-19 |
AU8546091A (en) | 1992-04-28 |
NO931220D0 (no) | 1993-03-31 |
JPH06501158A (ja) | 1994-02-10 |
EP0551329B1 (de) | 1998-07-15 |
SK281540B6 (sk) | 2001-04-09 |
UA34422C2 (uk) | 2001-03-15 |
CZ285225B6 (cs) | 1999-06-16 |
WO1992006111A1 (en) | 1992-04-16 |
NZ240014A (en) | 1992-08-26 |
PT99124A (pt) | 1992-08-31 |
HU9300943D0 (en) | 1993-06-28 |
FI105036B (fi) | 2000-05-31 |
AU659100B2 (en) | 1995-05-11 |
FI931457A (fi) | 1993-03-31 |
NO309529B1 (no) | 2001-02-12 |
DE69129809D1 (de) | 1998-08-20 |
KR100250391B1 (ko) | 2000-05-01 |
DK0551329T3 (da) | 1999-04-19 |
DE69129809T2 (de) | 1998-11-19 |
FI931457A0 (fi) | 1993-03-31 |
IL99585A0 (en) | 1992-08-18 |
NO931220L (no) | 1993-04-01 |
PT99124B (pt) | 1999-03-31 |
MX9101382A (es) | 1992-06-05 |
CA2092920A1 (en) | 1992-04-02 |
HUT69955A (en) | 1995-09-28 |
SK26493A3 (en) | 1993-10-06 |
IE913433A1 (en) | 1992-04-08 |
EP0551329A1 (de) | 1993-07-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
REN | Ceased due to non-payment of the annual fee |