ATE154938T1 - Inhibitorvariante der menschlichen protease vom kunitz-typ - Google Patents
Inhibitorvariante der menschlichen protease vom kunitz-typInfo
- Publication number
- ATE154938T1 ATE154938T1 AT93902105T AT93902105T ATE154938T1 AT E154938 T1 ATE154938 T1 AT E154938T1 AT 93902105 T AT93902105 T AT 93902105T AT 93902105 T AT93902105 T AT 93902105T AT E154938 T1 ATE154938 T1 AT E154938T1
- Authority
- AT
- Austria
- Prior art keywords
- amino acid
- xaa
- naturally occurring
- occurring amino
- image
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Prostheses (AREA)
- Production Of Liquid Hydrocarbon Mixture For Refining Petroleum (AREA)
- Amplifiers (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK9200001 | 1992-01-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE154938T1 true ATE154938T1 (de) | 1997-07-15 |
Family
ID=8153770
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT93902105T ATE154938T1 (de) | 1992-01-07 | 1993-01-07 | Inhibitorvariante der menschlichen protease vom kunitz-typ |
Country Status (18)
Country | Link |
---|---|
US (1) | US5576294A (de) |
EP (1) | EP0621871B1 (de) |
JP (1) | JP3350549B2 (de) |
KR (1) | KR100278036B1 (de) |
AT (1) | ATE154938T1 (de) |
AU (1) | AU676145B2 (de) |
CA (1) | CA2127249A1 (de) |
CZ (1) | CZ284911B6 (de) |
DE (1) | DE69311893T2 (de) |
ES (1) | ES2104121T3 (de) |
FI (1) | FI943233A (de) |
HU (1) | HU218104B (de) |
IL (1) | IL104325A (de) |
NO (1) | NO942550L (de) |
NZ (1) | NZ246569A (de) |
PL (1) | PL175422B1 (de) |
WO (1) | WO1993014121A1 (de) |
ZA (1) | ZA9395B (de) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060134087A1 (en) * | 1988-09-02 | 2006-06-22 | Dyax Corp. | ITI-D1 Kunitz domain mutants as hNE inhibitors |
US5455338A (en) * | 1993-11-05 | 1995-10-03 | Zymogenetics, Inc. | DNA encoding novel human kunitz-type inhibitors and methods relating thereto |
ATE529444T1 (de) | 1994-01-11 | 2011-11-15 | Dyax Corp | Inhibitoren des humanplasmins, die sich von den kunitz domänen ableiten |
ATE275583T1 (de) * | 1994-01-11 | 2004-09-15 | Dyax Corp | KALLIKREINHEMMENDE ßKUNITZ-DOMÄNEß-PROTEINE UND DERIVATEN DAVON |
US6057287A (en) | 1994-01-11 | 2000-05-02 | Dyax Corp. | Kallikrein-binding "Kunitz domain" proteins and analogues thereof |
US5795954A (en) * | 1994-03-04 | 1998-08-18 | Genentech, Inc. | Factor VIIa inhibitors from Kunitz domain proteins |
US5589359A (en) | 1994-08-05 | 1996-12-31 | Chiron Corporation | Chimeric proteins |
ATE226249T1 (de) * | 1994-08-05 | 2002-11-15 | Chiron Corp | Herstellung des inhibitors fuer die komplexbildung des gewebefaktors |
US5786328A (en) * | 1995-06-05 | 1998-07-28 | Genentech, Inc. | Use of kunitz type plasma kallikrein inhibitors |
US5780265A (en) * | 1995-06-05 | 1998-07-14 | Genentech, Inc. | Kunitz type plasma kallikrein inhibitors |
US6242414B1 (en) | 1995-06-07 | 2001-06-05 | Chiron Corporation | Regulation of cytokine synthesis and release |
US20030199450A1 (en) * | 2001-04-27 | 2003-10-23 | Chiron Corporation | Regulation of cytokine synthesis and release |
US6346510B1 (en) | 1995-10-23 | 2002-02-12 | The Children's Medical Center Corporation | Therapeutic antiangiogenic endostatin compositions |
BR9708021A (pt) * | 1996-03-11 | 1999-07-27 | Bayer Ag | Proteína substancialmente purificada composição farmacêutica sequência de ácido nucleico isolada vetor de express o de protéina auto-replicante e processos para inibir a atividade de protéinas de serina tratar uma condição e preparar um medicamento de uma proteína |
ES2209542T3 (es) * | 1998-12-22 | 2004-06-16 | Bayer Aktiengesellschaft | Metodo para acelerar la velocidad de eliminacion mucociliar usando un inhibidor de serinproteasa de tipo kunitz. |
US20070140979A1 (en) * | 1998-12-22 | 2007-06-21 | Bayer Aktiengesellschaft | Method for accelerating the rate of mucociliary clearance |
GB9916913D0 (en) * | 1999-07-19 | 1999-09-22 | Natural Enviromental Research | Inhibitor proteins |
US20040054082A1 (en) * | 2001-12-03 | 2004-03-18 | Bank David H | Toughened polymer blends with improved surface properties |
US7153829B2 (en) | 2002-06-07 | 2006-12-26 | Dyax Corp. | Kallikrein-inhibitor therapies |
CA2488558C (en) | 2002-06-07 | 2013-08-20 | Dyax Corp. | Prevention and reduction of blood loss |
DK2386310T3 (en) * | 2002-08-28 | 2019-02-25 | Dyax Corp | Methods of preserving organs and tissues |
DE602004031589D1 (de) * | 2003-01-07 | 2011-04-14 | Dyax Corp | Kunitz-domäne-bibliothek |
US6989369B2 (en) | 2003-02-07 | 2006-01-24 | Dyax Corp. | Kunitz domain peptides |
WO2005021557A2 (en) * | 2003-08-29 | 2005-03-10 | Dyax Corp. | Poly-pegylated protease inhibitors |
US7235530B2 (en) | 2004-09-27 | 2007-06-26 | Dyax Corporation | Kallikrein inhibitors and anti-thrombolytic agents and uses thereof |
US7276480B1 (en) | 2005-12-30 | 2007-10-02 | Dyax Corp. | Prevention and reduction of blood loss |
WO2007106746A2 (en) * | 2006-03-10 | 2007-09-20 | Dyax Corp. | Formulations for ecallantide |
AU2009327338B2 (en) | 2008-12-19 | 2015-07-02 | Takeda Pharmaceutical Company Limited | TFPI inhibitors and methods of use |
WO2010080833A1 (en) | 2009-01-06 | 2010-07-15 | Dyax Corp. | Treatment of mucositis with kallikrein inhibitors |
CN101798346B (zh) * | 2009-02-06 | 2013-05-29 | 复旦大学 | 一种酵母表达的长效重组人组织因子途径抑制物 |
SI2521568T1 (sl) | 2010-01-06 | 2019-01-31 | Dyax Corp. | Proteini, ki vežejo plazemski kalikrein |
NZ603028A (en) | 2010-03-19 | 2014-11-28 | Baxter Healthcare Sa | Tfpi inhibitors and methods of use |
IL269565B2 (en) | 2011-01-06 | 2024-06-01 | Dyax Corp | KALLIKREIN PLASMA BINDING PROTEINS |
KR101391988B1 (ko) | 2011-11-04 | 2014-05-08 | 동아대학교 산학협력단 | 항섬유소용해 기능을 가진 호박벌 독액의 쿠니츠 타입 세린 프로테아제 저해 폴리펩티드 및 이를 코딩하는 염기서열 |
NZ724133A (en) | 2012-03-21 | 2020-07-31 | Baxalta Inc | Tfpi inhibitors and methods of use |
BR112016022318A2 (pt) | 2014-03-27 | 2017-10-31 | Dyax Corp | método, composição farmacêutica para uso no tratamento de doenças de retina e uso de um anticorpo |
JP7003354B2 (ja) | 2015-12-11 | 2022-03-04 | 武田薬品工業株式会社 | 遺伝性血管性浮腫の発作を治療するための血漿カリクレイン阻害薬およびその用途 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5106833A (en) * | 1987-07-23 | 1992-04-21 | Washington University | Coagulation inhibitors |
DK408089D0 (da) * | 1989-08-18 | 1989-08-18 | Novo Nordisk As | Proteiner |
-
1993
- 1993-01-06 IL IL10432593A patent/IL104325A/xx not_active IP Right Cessation
- 1993-01-07 PL PL93304468A patent/PL175422B1/pl unknown
- 1993-01-07 ES ES93902105T patent/ES2104121T3/es not_active Expired - Lifetime
- 1993-01-07 CZ CZ941649A patent/CZ284911B6/cs not_active IP Right Cessation
- 1993-01-07 ZA ZA9395A patent/ZA9395B/xx unknown
- 1993-01-07 AU AU33459/93A patent/AU676145B2/en not_active Ceased
- 1993-01-07 AT AT93902105T patent/ATE154938T1/de not_active IP Right Cessation
- 1993-01-07 EP EP93902105A patent/EP0621871B1/de not_active Expired - Lifetime
- 1993-01-07 KR KR1019940702351A patent/KR100278036B1/ko not_active IP Right Cessation
- 1993-01-07 DE DE69311893T patent/DE69311893T2/de not_active Expired - Fee Related
- 1993-01-07 WO PCT/DK1993/000004 patent/WO1993014121A1/en active IP Right Grant
- 1993-01-07 JP JP51199293A patent/JP3350549B2/ja not_active Expired - Fee Related
- 1993-01-07 CA CA002127249A patent/CA2127249A1/en not_active Abandoned
- 1993-01-07 HU HU9401991A patent/HU218104B/hu not_active IP Right Cessation
- 1993-01-07 NZ NZ246569A patent/NZ246569A/en unknown
-
1994
- 1994-07-06 FI FI943233A patent/FI943233A/fi unknown
- 1994-07-06 NO NO942550A patent/NO942550L/no not_active Application Discontinuation
- 1994-10-12 US US08/321,658 patent/US5576294A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JP3350549B2 (ja) | 2002-11-25 |
CZ284911B6 (cs) | 1999-04-14 |
ES2104121T3 (es) | 1997-10-01 |
HU9401991D0 (en) | 1994-09-28 |
KR940703854A (ko) | 1994-12-12 |
HU218104B (hu) | 2000-06-28 |
NZ246569A (en) | 1996-05-28 |
FI943233A0 (fi) | 1994-07-06 |
HUT70295A (en) | 1995-09-28 |
CZ164994A3 (en) | 1994-12-15 |
EP0621871A1 (de) | 1994-11-02 |
FI943233A (fi) | 1994-07-06 |
KR100278036B1 (ko) | 2001-01-15 |
WO1993014121A1 (en) | 1993-07-22 |
NO942550L (no) | 1994-09-07 |
AU676145B2 (en) | 1997-03-06 |
CA2127249A1 (en) | 1993-07-22 |
DE69311893D1 (de) | 1997-08-07 |
NO942550D0 (no) | 1994-07-06 |
JPH07506335A (ja) | 1995-07-13 |
PL175422B1 (pl) | 1998-12-31 |
IL104325A (en) | 2000-10-31 |
ZA9395B (en) | 1993-08-20 |
EP0621871B1 (de) | 1997-07-02 |
DE69311893T2 (de) | 1998-02-05 |
AU3345993A (en) | 1993-08-03 |
US5576294A (en) | 1996-11-19 |
IL104325A0 (en) | 1993-05-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |