ATE159248T1 - Imidazol-derivate mit antagonistischer aktivität auf den histamin-h3-receptor - Google Patents
Imidazol-derivate mit antagonistischer aktivität auf den histamin-h3-receptorInfo
- Publication number
- ATE159248T1 ATE159248T1 AT92906664T AT92906664T ATE159248T1 AT E159248 T1 ATE159248 T1 AT E159248T1 AT 92906664 T AT92906664 T AT 92906664T AT 92906664 T AT92906664 T AT 92906664T AT E159248 T1 ATE159248 T1 AT E159248T1
- Authority
- AT
- Austria
- Prior art keywords
- derivatives
- histamine
- receptor
- antagonistic activity
- imidazole derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/68—Halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/91—Nitro radicals
- C07D233/92—Nitro radicals attached in position 4 or 5
- C07D233/94—Nitro radicals attached in position 4 or 5 with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to other ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/91—Nitro radicals
- C07D233/92—Nitro radicals attached in position 4 or 5
- C07D233/95—Nitro radicals attached in position 4 or 5 with hydrocarbon radicals, substituted by nitrogen atoms, attached to other ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL9100365A NL9100365A (nl) | 1991-02-27 | 1991-02-27 | Imidazoolderivaten met agonistische of antagonistische activiteit op de histamine h3-receptor. |
| NL9101764A NL9101764A (nl) | 1991-02-27 | 1991-10-22 | Imidazoolderivaten met agonistische of antagonistische activiteit op de histamine h3 receptor. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE159248T1 true ATE159248T1 (de) | 1997-11-15 |
Family
ID=26646823
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92906664T ATE159248T1 (de) | 1991-02-27 | 1992-02-27 | Imidazol-derivate mit antagonistischer aktivität auf den histamin-h3-receptor |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0573542B1 (de) |
| JP (1) | JPH06505265A (de) |
| AT (1) | ATE159248T1 (de) |
| AU (1) | AU662135B2 (de) |
| CA (1) | CA2104946A1 (de) |
| DE (1) | DE69222757T2 (de) |
| DK (1) | DK0573542T3 (de) |
| ES (1) | ES2108107T3 (de) |
| GR (1) | GR3025554T3 (de) |
| WO (1) | WO1992015567A1 (de) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL9100365A (nl) * | 1991-02-27 | 1992-09-16 | Seed Capital Investments | Imidazoolderivaten met agonistische of antagonistische activiteit op de histamine h3-receptor. |
| US5652258A (en) * | 1995-05-30 | 1997-07-29 | Gliatech, Inc. | 2-(4-imidazoyl) cyclopropyl derivatives |
| JPH11506106A (ja) * | 1995-05-30 | 1999-06-02 | グリアテツク・インコーポレイテツド | １ｈ−４（５）−置換イミダゾール誘導体 |
| US6448282B1 (en) | 1995-05-30 | 2002-09-10 | Gliatech, Inc. | 1H-4(5)-substituted imidazole derivatives |
| US6407132B1 (en) | 1997-07-25 | 2002-06-18 | James Black Foundation Limited | Substituted imidazole derivatives and their use as histamine H3 receptor ligands |
| GB9803536D0 (en) * | 1998-02-19 | 1998-04-15 | Black James Foundation | Histamine H,receptor ligands |
| FR2781798B1 (fr) * | 1998-07-28 | 2000-09-08 | Synthelabo | Derives de 4-phenyl- et de 4,5-diphenylimidazoles, leur preparation et leur application en therapeutique |
| AU3033100A (en) | 1999-01-18 | 2000-08-01 | Boehringer Ingelheim International Gmbh | Substituted imidazoles, their preparation and use |
| US6908926B1 (en) | 1999-04-16 | 2005-06-21 | Novo Nordisk A/S | Substituted imidazoles, their preparation and use |
| US6437147B1 (en) | 2000-03-17 | 2002-08-20 | Novo Nordisk | Imidazole compounds |
| US6610721B2 (en) | 2000-03-17 | 2003-08-26 | Novo Nordisk A/S | Imidazo heterocyclic compounds |
| EP1313470A4 (de) | 2000-08-17 | 2005-02-16 | Gliatech Inc | Neue alicyclische imidazole as h 3 wirkstoffe |
| CA2521000A1 (en) * | 2003-04-03 | 2004-10-21 | Kyowa Hakko Kogyo Co., Ltd. | Preventive and/or therapeutic agent for neuropathic pain |
| EP1707203A1 (de) | 2005-04-01 | 2006-10-04 | Bioprojet | Verwendung von Alkylaminen, die kein Imidazole enthalten, als Histamin H3 Rezeptor Liganden, zur Behandlung von Morbus Parkinson, obstruktiver Schlafapnoe, vaskularer Demenz, Demenz mit Lewy Korpen |
| EP1717235A3 (de) | 2005-04-29 | 2007-02-28 | Bioprojet | Phenoxypropylpiperidine und -pyrrolidine und ihre Verwendung als Liganden für den Histamin H3-Rezeptor |
| EP1717233A1 (de) | 2005-04-29 | 2006-11-02 | Bioprojet | Liganden für den Histamin H3-Rezeptor und ihre therapeutische Anwendung |
| WO2013151982A1 (en) | 2012-04-03 | 2013-10-10 | Arena Pharmaceuticals, Inc. | Methods and compounds useful in treating pruritus, and methods for identifying such compounds |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE758145A (fr) * | 1969-10-29 | 1971-04-28 | Smith Kline French Lab | Iso-thio-urees et derives |
| GB1431589A (en) * | 1973-07-13 | 1976-04-07 | Smith Kline French Lab | Ureas, thioureas and guanidines n,n-disubstituted by heterocyclo- alkylene and/or heterocycloalkylenethioalkylene groups |
| IL49528A (en) * | 1975-05-21 | 1980-11-30 | Smith Kline French Lab | Imidazolyl(or thiazolyl)methylthio(or butyl)guanidine or thiourea derivatives,their preparation and pharmaceutical compositions comprising them |
| US4262125A (en) * | 1979-07-23 | 1981-04-14 | American Home Products Corporation | (1H-Imidazol-5-ylmethyl)isothioureas |
| DK221081A (da) * | 1980-05-31 | 1981-12-01 | Smith Kline French Lab | Fremgangsmaade til fremstilling af heterocyklylalkylanidiner mellemprodukter til anvendelse ved denne fremgangsmaade og en fremgangsmaade til fremstilling af disse mellemprodukter |
| US4503139A (en) * | 1983-05-09 | 1985-03-05 | Polaroid Corporation | Photographic products and processes and novel compounds |
| JPS6176465A (ja) * | 1984-09-21 | 1986-04-18 | Kanto Ishi Pharma Co Ltd | ４−メチル−５−チオホルムアミジノメチルイミダゾ−ルジハイドロクロライド |
| EP0199845B1 (de) * | 1985-04-02 | 1990-08-01 | HEUMANN PHARMA GMBH & CO | Imidazolylalkylguanidinderivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
| NL8601585A (nl) * | 1986-06-19 | 1988-01-18 | Vereniging Voor Christelijk Wetenschappelijk Onderwijs | N-(2-gesubstitueerde alkyl)-n-imidazol-4-yl alkyl guanidine. |
| DE3631334A1 (de) * | 1986-09-15 | 1988-03-17 | Heumann Pharma Gmbh & Co | Neue imidazolylguanidinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
-
1992
- 1992-02-27 DE DE69222757T patent/DE69222757T2/de not_active Expired - Fee Related
- 1992-02-27 JP JP4506423A patent/JPH06505265A/ja active Pending
- 1992-02-27 CA CA002104946A patent/CA2104946A1/en not_active Abandoned
- 1992-02-27 AT AT92906664T patent/ATE159248T1/de not_active IP Right Cessation
- 1992-02-27 ES ES92906664T patent/ES2108107T3/es not_active Expired - Lifetime
- 1992-02-27 WO PCT/NL1992/000041 patent/WO1992015567A1/en active IP Right Grant
- 1992-02-27 DK DK92906664.5T patent/DK0573542T3/da active
- 1992-02-27 EP EP92906664A patent/EP0573542B1/de not_active Expired - Lifetime
- 1992-02-27 AU AU15418/92A patent/AU662135B2/en not_active Ceased
-
1997
- 1997-12-02 GR GR970403203T patent/GR3025554T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU1541892A (en) | 1992-10-06 |
| DK0573542T3 (da) | 1998-05-18 |
| DE69222757D1 (de) | 1997-11-20 |
| WO1992015567A1 (en) | 1992-09-17 |
| ES2108107T3 (es) | 1997-12-16 |
| DE69222757T2 (de) | 1998-02-12 |
| GR3025554T3 (en) | 1998-03-31 |
| JPH06505265A (ja) | 1994-06-16 |
| AU662135B2 (en) | 1995-08-24 |
| EP0573542A1 (de) | 1993-12-15 |
| CA2104946A1 (en) | 1992-08-28 |
| EP0573542B1 (de) | 1997-10-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69222757D1 (de) | Imidazol-derivate mit antagonistischer aktivität auf den histamin-h3-receptor | |
| FI981664A (fi) | Menetelmä ihonhoitokoostumusten valmistamiseksi | |
| ATE269290T1 (de) | Benzoylderivate | |
| NO2000007I1 (no) | Itraconazol inklusjonskompleks med hydroksypropyl-ß -cyklodekstriner | |
| DK0725782T3 (da) | A1-adenosin-receptor-agonister og antiagonister | |
| DE69100848D1 (de) | Hautpflegezusammensetzungen. | |
| ES2058093T3 (es) | Agentes herbicidas y fungicidas a base de derivados de pirazolin-5-ona substituidos. | |
| BR9713884A (pt) | Benzamida heterociclicamente substituìda, usos da mesma e de cetobenzamidoaldeìdos desta, e, preparação medicamentosa. | |
| YU109092A (sh) | Fungicidni derivati 2-imidazolin-5-ona i 2-imidazolin-5-tiona | |
| ATE108437T1 (de) | Substituierte diaminophthalimide und analoga. | |
| BR9712507A (pt) | Derivados de aminotiazol, seu processo de preparo e as composições famacêuticas que os comtêm. | |
| DK165982C (da) | Imidazolylguanidinderivater og laegemidler, der indeholder disse forbindelser | |
| DK122191A (da) | Benzimidazolderivat og fysiologisk acceptable salte heraf samt fremgangsmaade til fremstilling af samme | |
| ITMI931685A1 (it) | Derivati di polialchil-4-piperidinoli atti all'impiego come stabilizzanti per materiali organici | |
| FI892222A (fi) | Peptidalkoholer med antikoagulantverkan. | |
| TR27833A (tr) | Antelmintik'lerin uygulanmasina mahsus ''pour-on'' formülasyonu. | |
| SE8700156L (sv) | Kosmetiska kompositioner med hudlugnande och hudgenerande effekt och forfarande for framstellning derav | |
| ES525297A0 (es) | Procedimiento para la obtencion de derivados de terc.-butanol sustituidos | |
| FI902901A0 (fi) | Dibenzol/1,5/dioxocin-5-one-derivat, deras anvaendning i laekemedel och foerfarande foer deras framstaellning. | |
| DK0767782T3 (da) | Aryl- og heteroarylalkoxynaphthalenderivater | |
| NO903281L (no) | S-substituerte beta-tioakrylamider og anvendelse derav sommikrobiocider. | |
| KR930021629A (ko) | 피페라진 유도체 | |
| FI943119A0 (fi) | Heterosyklisellä renkaalla substituoituja bentsyyliamiinijohdannaisia retrovirusvastaisina yhdisteinä | |
| KR910700238A (ko) | 치환된 아졸, 그의 제조방법, 그를 함유하는 제형 및 살진균제로서의 그의 용도 | |
| ES2105633T3 (es) | Derivados de pirimidinona condensada a heterociclos nitrogenados con actividad antagonista de a ii. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |