ATE152915T1 - Immuntherapeutische vektorkonstrukte gegen krebs - Google Patents
Immuntherapeutische vektorkonstrukte gegen krebsInfo
- Publication number
- ATE152915T1 ATE152915T1 AT93900751T AT93900751T ATE152915T1 AT E152915 T1 ATE152915 T1 AT E152915T1 AT 93900751 T AT93900751 T AT 93900751T AT 93900751 T AT93900751 T AT 93900751T AT E152915 T1 ATE152915 T1 AT E152915T1
- Authority
- AT
- Austria
- Prior art keywords
- altered
- altered cellular
- expression
- vector constructs
- recombinant virus
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 230000001024 immunotherapeutic effect Effects 0.000 title 1
- 241000700605 Viruses Species 0.000 abstract 3
- 230000001413 cellular effect Effects 0.000 abstract 3
- 210000004881 tumor cell Anatomy 0.000 abstract 2
- 102000044159 Ubiquitin Human genes 0.000 abstract 1
- 108090000848 Ubiquitin Proteins 0.000 abstract 1
- 108700025700 Wilms Tumor Genes Proteins 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
- 231100001221 nontumorigenic Toxicity 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4746—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used p53
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/82—Translation products from oncogenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US80032891A | 1991-11-29 | 1991-11-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE152915T1 true ATE152915T1 (de) | 1997-05-15 |
Family
ID=25178122
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT93900751T ATE152915T1 (de) | 1991-11-29 | 1992-11-30 | Immuntherapeutische vektorkonstrukte gegen krebs |
Country Status (10)
Country | Link |
---|---|
US (1) | US5693522A (de) |
EP (1) | EP0615453B1 (de) |
JP (1) | JPH07501942A (de) |
AT (1) | ATE152915T1 (de) |
AU (1) | AU671971B2 (de) |
CA (1) | CA2117303C (de) |
DE (1) | DE69219787T2 (de) |
FI (1) | FI942503A (de) |
NO (1) | NO941986L (de) |
WO (1) | WO1993010814A1 (de) |
Families Citing this family (59)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5662896A (en) * | 1988-03-21 | 1997-09-02 | Chiron Viagene, Inc. | Compositions and methods for cancer immunotherapy |
US5747469A (en) | 1991-03-06 | 1998-05-05 | Board Of Regents, The University Of Texas System | Methods and compositions comprising DNA damaging agents and p53 |
CA2140624C (en) * | 1992-07-22 | 2001-05-01 | Arnold J. Levine | P53 vaccine |
US20030086935A1 (en) * | 1992-07-22 | 2003-05-08 | Levine Arnold J. | p53 vaccine |
JPH08504095A (ja) * | 1992-09-18 | 1996-05-07 | カンジ,インコーポレイテッド | 腫瘍抑制遺伝子を有するレトロウイルスベクターによる遺伝子療法 |
US6953573B1 (en) * | 1993-03-17 | 2005-10-11 | University Of Washington | Compounds for eliciting or enhancing immune reactivity to HER-2/neu protein for prevention or treatment of malignancies in which the HER-2/neu oncogene is associated |
US5700657A (en) * | 1993-12-13 | 1997-12-23 | Genzyme Corporation | Vectors and vector systems including genes encoding tumor suppressor proteins and producer cells transformed thereby |
US5629192A (en) * | 1994-02-04 | 1997-05-13 | The United States Of America As Represented By The Department Of Health And Human Services | ETS1 gene: a human tumor suppressor gene |
KR970702915A (ko) * | 1994-04-29 | 1997-06-10 | 린다 버겐 | 종양 세포의 치료 감응성 향상 방법(Enhancing The Sensitivity of Tumor Cells to Therapies) |
JP4303315B2 (ja) | 1994-05-09 | 2009-07-29 | オックスフォード バイオメディカ(ユーケー)リミテッド | 非交差性レトロウイルスベクター |
JP4125784B2 (ja) * | 1995-10-20 | 2008-07-30 | ユニバーシティ・オブ・ネブラスカ・ボード・オブ・リージェンツ | 抗原提示細胞により仲介される免疫応答を高めるための組成物および方法 |
WO1997024447A1 (en) * | 1996-01-02 | 1997-07-10 | Chiron Corporation | Immunostimulation mediated by gene-modified dendritic cells |
US6365151B1 (en) * | 1996-01-19 | 2002-04-02 | Philadelphia Health And Educational Corporation | Cellular immunogens comprising cognate proto-oxogenes |
US6942862B2 (en) * | 1996-04-01 | 2005-09-13 | University Of Washington | Methods and compositions to generate immunity in humans against self tumor antigens by immunization with homologous foreign proteins |
EP1997900A3 (de) | 1996-04-05 | 2010-10-06 | Novartis Vaccines and Diagnostics, Inc. | Rekombinante Vektoren auf Alphavirus-Basis mit reduzierter Hemmung der zellulären Makromolekularsynthese |
JP2001500738A (ja) * | 1996-09-17 | 2001-01-23 | カイロン コーポレイション | 細胞内疾患を処置するための組成物および方法 |
US6884435B1 (en) * | 1997-01-30 | 2005-04-26 | Chiron Corporation | Microparticles with adsorbent surfaces, methods of making same, and uses thereof |
US20040202680A1 (en) * | 1997-01-30 | 2004-10-14 | O'hagan Derek | Microparticles with adsorbent surfaces, methods of making same, and uses thereof |
AU747577B2 (en) * | 1997-01-30 | 2002-05-16 | Novartis Vaccines And Diagnostics, Inc. | Use of microparticles with adsorbed antigen to stimulate immune responses |
WO1998051369A1 (en) | 1997-05-13 | 1998-11-19 | Edwards Stuart D | Global medical treatment method and apparatus |
FR2775601B1 (fr) * | 1998-03-03 | 2001-09-21 | Merial Sas | Vaccins vivants recombines et adjuves |
US6620382B1 (en) * | 1998-05-22 | 2003-09-16 | Biopheresis Technologies, Llc. | Method and compositions for treatment of cancers |
US7329410B1 (en) * | 1998-09-30 | 2008-02-12 | Corixa Corporation | Compositions and method for WT1 specific immunotherapy |
US7115272B1 (en) | 1998-09-30 | 2006-10-03 | Corixa Corporation | Compositions and methods for WT1 specific immunotherapy |
US20030235557A1 (en) * | 1998-09-30 | 2003-12-25 | Corixa Corporation | Compositions and methods for WT1 specific immunotherapy |
US20030039635A1 (en) * | 1998-09-30 | 2003-02-27 | Corixa Corporation | Compositions and methods for WT1 specific immunotherapy |
US7901693B2 (en) * | 1998-09-30 | 2011-03-08 | Corixa Corporation | Compositions and methods for WT1 specific immunotherapy |
US7655249B2 (en) * | 1998-09-30 | 2010-02-02 | Corixa Corporation | Compositions and methods for WT1 specific immunotherapy |
US7144581B2 (en) * | 2000-10-09 | 2006-12-05 | Corixa Corporation | Compositions and methods for WT1 specific immunotherapy |
US7063854B1 (en) * | 1998-09-30 | 2006-06-20 | Corixa Corporation | Composition and methods for WTI specific immunotherapy |
US7807377B2 (en) | 1998-10-20 | 2010-10-05 | Salvatore Albani | Method of isolating antigen-specific T cells employing artificial antigen presenting cells |
US6787154B2 (en) * | 1998-10-20 | 2004-09-07 | Salvatore Albani | Artificial antigen presenting cells |
JP2002527467A (ja) | 1998-10-20 | 2002-08-27 | サルバトーレ・アルバーニ | 抗原特異的t細胞の単離、定量、特徴づけおよび調節方法 |
GB9907414D0 (en) | 1999-03-31 | 1999-05-26 | Cancer Res Campaign Tech | Improvements relating to prodrugs |
US8647864B2 (en) | 1999-04-14 | 2014-02-11 | Novartis Ag | Compositions and methods for generating an immune response utilizing alphavirus-based vector systems |
AU5003200A (en) | 1999-05-14 | 2000-12-05 | United States Of America As Represented By The Department Of Veterans Affairs, The | Isolation and characterization of epidermal growth factor related protein |
US7049410B2 (en) * | 1999-05-14 | 2006-05-23 | Majumdar Adhip P N | Antibodies to a novel EGF-receptor related protein (ERRP) |
WO2001016167A2 (en) * | 1999-09-01 | 2001-03-08 | The Johns Hopkins University | Beta-catenin, tcf-4, and apc interact to prevent cancer |
US6432409B1 (en) | 1999-09-14 | 2002-08-13 | Antigen Express, Inc. | Hybrid peptides modulate the immune response |
US9289487B2 (en) * | 1999-09-14 | 2016-03-22 | Antigen Express, Inc. | II-key/antigenic epitope hybrid peptide vaccines |
US20030235594A1 (en) * | 1999-09-14 | 2003-12-25 | Antigen Express, Inc. | Ii-Key/antigenic epitope hybrid peptide vaccines |
US6656718B2 (en) | 2000-07-07 | 2003-12-02 | Cancer Research Technology Limited | Modified carboxypeptidase enzymes and their use |
US7919467B2 (en) | 2000-12-04 | 2011-04-05 | Immunotope, Inc. | Cytotoxic T-lymphocyte-inducing immunogens for prevention, treatment, and diagnosis of cancer |
AU2002226030A1 (en) * | 2000-12-04 | 2002-06-18 | Argonex Pharmaceuticals | Cytotoxic t-lymphocyte-inducing immunogens for prevention, treatment, and diagnosis of cancer |
AU2002303330B2 (en) | 2001-05-31 | 2008-07-24 | Novartis Vaccines And Diagnostics, Inc. | Chimeric alphavirus replicon particles |
US7553494B2 (en) | 2001-08-24 | 2009-06-30 | Corixa Corporation | WT1 fusion proteins |
US7179645B2 (en) * | 2002-09-24 | 2007-02-20 | Antigen Express, Inc. | Ii-Key/antigenic epitope hybrid peptide vaccines |
AU2003294220A1 (en) | 2002-09-17 | 2004-04-23 | Antigen Express, Inc. | Ii-KEY/ANTIGENIC EPITOPE HYBRID PEPTIDE VACCINES |
WO2005087260A1 (en) * | 2004-03-04 | 2005-09-22 | Corixa Corporation | Co-encapsulated wt1 polypeptide and immunostimulant microsphere formulations and methods thereof |
EP1765313A2 (de) | 2004-06-24 | 2007-03-28 | Novartis Vaccines and Diagnostics, Inc. | Verbindungen als immunstimulatoren |
CA2571710A1 (en) | 2004-06-24 | 2006-11-02 | Nicholas Valiante | Small molecule immunopotentiators and assays for their detection |
CN101355960A (zh) | 2005-10-18 | 2009-01-28 | 诺华疫苗和诊断公司 | 使用α病毒复制子颗粒进行粘膜和全身免疫 |
US20100010217A1 (en) * | 2006-03-23 | 2010-01-14 | Valiante Nicholas M | Methods for the preparation of imidazole-containing compounds |
CA2646539A1 (en) * | 2006-03-23 | 2007-09-27 | Novartis Ag | Imidazoquinoxaline compounds as immunomodulators |
WO2007109812A2 (en) * | 2006-03-23 | 2007-09-27 | Novartis Ag | Immunopotentiating compounds |
EP4088772A1 (de) * | 2008-01-28 | 2022-11-16 | Implantica Patent Ltd. | Drainagevorrichtung |
CA2750922A1 (en) * | 2009-01-28 | 2010-08-05 | Antigen Express, Inc. | Li-key hybrid peptides that modulate the immune response to influenza |
KR20130121699A (ko) | 2010-05-28 | 2013-11-06 | 테트리스 온라인, 인코포레이티드 | 상호작용 혼성 비동기 컴퓨터 게임 기반구조 |
RU2718663C2 (ru) | 2016-01-19 | 2020-04-13 | Пфайзер Инк. | Противораковые вакцины |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4405712A (en) * | 1981-07-01 | 1983-09-20 | The United States Of America As Represented By The Department Of Health And Human Services | LTR-Vectors |
US4965196A (en) * | 1983-01-19 | 1990-10-23 | Genentech, Inc. | Polycistronic expression vector construction |
GB8424757D0 (en) * | 1984-10-01 | 1984-11-07 | Pasteur Institut | Retroviral vector |
US4797368A (en) * | 1985-03-15 | 1989-01-10 | The United States Of America As Represented By The Department Of Health And Human Services | Adeno-associated virus as eukaryotic expression vector |
US4871838A (en) * | 1985-07-23 | 1989-10-03 | The Board Of Rijks Universiteit Leiden | Probes and methods for detecting activated ras oncogenes |
US4931275A (en) * | 1985-12-02 | 1990-06-05 | Yeda Research & Development Co., Ltd. | Anti-tumor vaccines and their preparation |
CA1310924C (en) * | 1986-04-24 | 1992-12-01 | Francis P. Mccormick | Infective drug delivery system |
US4861719A (en) * | 1986-04-25 | 1989-08-29 | Fred Hutchinson Cancer Research Center | DNA constructs for retrovirus packaging cell lines |
US4980289A (en) * | 1987-04-27 | 1990-12-25 | Wisconsin Alumni Research Foundation | Promoter deficient retroviral vector |
ATE126534T1 (de) * | 1987-05-29 | 1995-09-15 | Dana Farber Cancer Inst Inc | Cis-wirkung-repressionen-sequenzen, cis-wirkung- antirepressionen-sequenzen, vektoren, verfahren zur vorbereitung und anwendung. |
WO1989001973A2 (en) * | 1987-09-02 | 1989-03-09 | Applied Biotechnology, Inc. | Recombinant pox virus for immunization against tumor-associated antigens |
EP0378576B1 (de) * | 1987-09-11 | 1995-01-18 | Whitehead Institute For Biomedical Research | Transduktionsveränderte fibroblasten und ihre anwendung |
WO1989005349A1 (en) * | 1987-12-09 | 1989-06-15 | The Australian National University | Method of combating viral infections |
US4957859A (en) * | 1988-02-16 | 1990-09-18 | Hoffmann-La Roche Inc. | Antibodies for transforming ras protein |
WO1990002806A1 (en) * | 1988-09-01 | 1990-03-22 | Whitehead Institute For Biomedical Research | Recombinant retroviruses with amphotropic and ecotropic host ranges |
CA2425745C (en) * | 1989-03-21 | 2005-03-29 | Philip L. Felgner | Expression of exogenous polynucleotide sequences in a vertebrate |
EP0474727B1 (de) * | 1989-05-19 | 1997-07-23 | Genentech, Inc. | Her2 extrazellulare domäne |
FR2668064B1 (fr) * | 1990-10-23 | 1994-12-16 | Transgene Sa | Composition pharmaceutique pour le traitement ou la prevention d'une tumeur maligne. |
-
1992
- 1992-11-30 CA CA002117303A patent/CA2117303C/en not_active Expired - Fee Related
- 1992-11-30 AU AU32297/93A patent/AU671971B2/en not_active Ceased
- 1992-11-30 WO PCT/US1992/010309 patent/WO1993010814A1/en active IP Right Grant
- 1992-11-30 DE DE69219787T patent/DE69219787T2/de not_active Expired - Fee Related
- 1992-11-30 EP EP93900751A patent/EP0615453B1/de not_active Expired - Lifetime
- 1992-11-30 AT AT93900751T patent/ATE152915T1/de not_active IP Right Cessation
- 1992-11-30 JP JP5510289A patent/JPH07501942A/ja active Pending
-
1994
- 1994-05-27 NO NO941986A patent/NO941986L/no unknown
- 1994-05-27 FI FI942503A patent/FI942503A/fi unknown
-
1995
- 1995-01-11 US US08/371,922 patent/US5693522A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
NO941986L (no) | 1994-07-27 |
FI942503A0 (fi) | 1994-05-27 |
CA2117303C (en) | 2000-10-17 |
NO941986D0 (no) | 1994-05-27 |
DE69219787T2 (de) | 1997-08-28 |
JPH07501942A (ja) | 1995-03-02 |
AU3229793A (en) | 1993-06-28 |
EP0615453A1 (de) | 1994-09-21 |
EP0615453B1 (de) | 1997-05-14 |
DE69219787D1 (de) | 1997-06-19 |
WO1993010814A1 (en) | 1993-06-10 |
FI942503A (fi) | 1994-05-27 |
US5693522A (en) | 1997-12-02 |
AU671971B2 (en) | 1996-09-19 |
CA2117303A1 (en) | 1993-06-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE152915T1 (de) | Immuntherapeutische vektorkonstrukte gegen krebs | |
WO1991002805A3 (en) | Recombinant retroviruses delivering vector constructs to target cells | |
DE68929122D1 (de) | Rekombinante Retroviren | |
CY1113689T1 (el) | Εξασθενημενοι ιοι αρνητικου κλωνου με αλλοιωμενη δραστικοτητα ανταγωνισμου ιντερφερονης για χρηση ως εμβολια και φαρμακευτικα προϊοντα | |
CY1113421T1 (el) | Πυρηνικα οξεα και πολυπεπτιδια υποδοχεα | |
DE69937294D1 (de) | Von cyclophilin b abstammende tumorantigen-peptide | |
RU95112465A (ru) | Пирановые соединения, фармацевтическая композиция, способ получения и промежуточные соединения | |
DE59410380D1 (de) | Endosomolytisch wirksame partikel | |
DK11789D0 (da) | Rekombinante vaccinia-vira | |
ES2156199T3 (es) | Polipeptido inductor de la produccion de interferon-gamma, anticuerpos monoclonales y composicion para el tratamiento o la prevencion de enfermedades sensibles al interferon-gamma. | |
CY1105010T1 (el) | Πεπτιδια που λαμβανονται απο τη συνδεση (g) πρωτεϊνης του αναπνευστικου συνκυτιακου ιου | |
DK0588578T3 (da) | Immunogener | |
ATE170220T1 (de) | Zusammensetzung verwendbar als therapeutisches mittel gegen chronische virale leberkrankheiten | |
KR860005636A (ko) | 활성성분으로 스페르구알린(Spergualin)을 함유하는 주사제 조성물과 그 제조방법. | |
NO912825D0 (no) | Fremgangsmaate for fremstilling av cokonjugate vaksiner omfattende immunogenisk protein, hiv-beslektede peptider og anioniske grupper. | |
DK1149910T3 (da) | Farmaceutisk præparat til behandling af papillomavirustumorer og -infektion | |
NO922953D0 (no) | Rekombinant fremstilt blodfaktorer og fremgangsmaate for ekspresjon av blodfaktorene, samt vacciniavirusrekombinanter | |
DE69322872T2 (de) | Vakzine gegen immunodefizienz-virus der katze (kiv) | |
ATE310828T1 (de) | Implantat und vektor zur behandlung von erworbenen krankheiten | |
RU94028669A (ru) | Векторная конструкция, рекомбинантные вирусы, рекомбинантный ретровирус, клетки-мишени, композиция, применение композиции | |
AU8976691A (en) | Selected peptides of the group-specific antigen (gag) of human immunodeficiency virus (hiv), the preparation and use thereof | |
DK0382075T3 (da) | Phenylhydrazoner af beta-jononer, fremstilling heraf og heraf fremstillede lægemidler og kosmetika |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
REN | Ceased due to non-payment of the annual fee |