ATE115402T1 - Verfahren und zusammensetzung zur verzögerten freigabe von biologisch wirksamen wirkstoffen. - Google Patents

Verfahren und zusammensetzung zur verzögerten freigabe von biologisch wirksamen wirkstoffen.

Info

Publication number
ATE115402T1
ATE115402T1 AT91901710T AT91901710T ATE115402T1 AT E115402 T1 ATE115402 T1 AT E115402T1 AT 91901710 T AT91901710 T AT 91901710T AT 91901710 T AT91901710 T AT 91901710T AT E115402 T1 ATE115402 T1 AT E115402T1
Authority
AT
Austria
Prior art keywords
crystalline phase
liquid crystalline
composition
delayed release
biological agents
Prior art date
Application number
AT91901710T
Other languages
English (en)
Inventor
Pia Lading
Yvonne Lundsholm
Tomas Norling
Original Assignee
Dumex Ltd As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dumex Ltd As filed Critical Dumex Ltd As
Application granted granted Critical
Publication of ATE115402T1 publication Critical patent/ATE115402T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1274—Non-vesicle bilayer structures, e.g. liquid crystals, tubules, cubic phases, cochleates; Sponge phases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0063—Periodont
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Dispersion Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cephalosporin Compounds (AREA)
AT91901710T 1990-11-21 1990-11-21 Verfahren und zusammensetzung zur verzögerten freigabe von biologisch wirksamen wirkstoffen. ATE115402T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/DK1990/000299 WO1992009272A1 (en) 1990-11-21 1990-11-21 Method and composition for controlled delivery of biologically active agents
CA002095354A CA2095354C (en) 1990-11-21 1990-11-21 Method and composition for controlled delivery of biologically active agents

Publications (1)

Publication Number Publication Date
ATE115402T1 true ATE115402T1 (de) 1994-12-15

Family

ID=25676134

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91901710T ATE115402T1 (de) 1990-11-21 1990-11-21 Verfahren und zusammensetzung zur verzögerten freigabe von biologisch wirksamen wirkstoffen.

Country Status (15)

Country Link
US (1) US5143934A (de)
EP (1) EP0558475B1 (de)
JP (1) JPH03135925A (de)
KR (1) KR0180750B1 (de)
AT (1) ATE115402T1 (de)
AU (1) AU647768B2 (de)
CA (1) CA2095354C (de)
DE (1) DE69015212T2 (de)
DK (1) DK0558475T3 (de)
ES (1) ES2065670T3 (de)
FI (1) FI109452B (de)
GR (1) GR3015329T3 (de)
HU (1) HU220216B (de)
NO (1) NO305931B1 (de)
WO (1) WO1992009272A1 (de)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8206744D0 (sv) * 1982-11-26 1982-11-26 Fluidcarbon International Ab Preparat for kontrollerad avgivning av substanser
US5371109A (en) * 1986-07-01 1994-12-06 Drilletten Ab Controlled release composition for a biologically active material dissolved or dispersed in an L2-phase
US5262164A (en) * 1989-11-17 1993-11-16 The Procter & Gamble Company Sustained release compositions for treating periodontal disease
US5620700A (en) * 1990-10-30 1997-04-15 Alza Corporation Injectable drug delivery system and method
EP0643620B1 (de) * 1991-10-04 1999-07-21 Gs Development Ab Teilchen, methode zur herstellung der teilchen und deren verwendung
US5447725A (en) * 1993-06-11 1995-09-05 The Procter & Gamble Company Methods for aiding periodontal tissue regeneration
US5538954A (en) * 1994-06-24 1996-07-23 A/S Dumex (Dumex Ltd.) Salts of tetracyclines
JPH09507233A (ja) * 1993-12-29 1997-07-22 マトリクス ファーマスーティカル，インコーポレイティド 細胞増殖性疾患に罹る宿主の治療方法及び治療のための組成物
ES2270426T3 (es) * 1994-03-18 2007-04-01 Supernus Pharmaceuticals, Inc. Sistema de suministros de farmacos emulsionados.
CA2190604A1 (en) * 1994-05-20 1995-11-30 D. Craig Wright Antibacterial oil-in-water emulsions
SE518578C2 (sv) * 1994-06-15 2002-10-29 Gs Dev Ab Lipidbaserad komposition
FR2726762B1 (fr) * 1994-11-10 1997-01-17 Oreal Composition cosmetique ou dermatologique sous forme d'une dispersion d'une phase huileuse dans une phase aqueuse stabilisee a l'aide de particules de gel cubique et son procede d'obtention
US5824638A (en) * 1995-05-22 1998-10-20 Shire Laboratories, Inc. Oral insulin delivery
US5744062A (en) * 1996-08-29 1998-04-28 R.I.T.A. Corporation Balanced emulsifier blends for oil-in-water emulsions
KR100508229B1 (ko) 1997-03-18 2005-08-17 선스타 가부시키가이샤 고체 입자 형성용 조성물
US6638621B2 (en) * 2000-08-16 2003-10-28 Lyotropic Therapeutics, Inc. Coated particles, methods of making and using
DE69816778T2 (de) 1997-09-09 2004-04-15 Lyotropic Therapeutics, Inc. Beschichtete teilchen, methode zu ihrer herstellung und verwendung
US6017516A (en) * 1997-10-31 2000-01-25 Lekar Pharma Limited Pharmaceutical dental formulation for topical application of metronidazole benzoate and chlorhexidine gluconate
GB9827034D0 (en) * 1998-12-10 1999-02-03 Univ Manchester Delivery formulation
GB0001449D0 (en) * 2000-01-21 2000-03-08 Cortendo Ab Compositions
US6423707B1 (en) 2000-08-28 2002-07-23 California Pacific Medical Center Nitroimidazole ester analogues and therapeutic applications
JP2003171301A (ja) * 2001-11-09 2003-06-20 Mahidol Univ 歯周炎治療における補助剤としてのカルメグゲル
WO2004012680A2 (en) * 2002-08-06 2004-02-12 Lyotropic Therapeutics, Inc. Lipid-drug complexes in reversed liquid and liquid crystalline phases
RS20050170A (en) 2002-08-26 2007-11-15 S.L.A. Pharma Ag., A pharmaceutical composition
JPWO2004019957A1 (ja) * 2002-08-29 2005-12-15 東レ株式会社 ビスホスホン酸誘導体又はその塩を有効成分とする歯周ポケット投与用医薬組成物
EP1415646B1 (de) * 2002-11-01 2009-08-26 Mahidol University Gel, einen antimikrobiellen Extrakt enthaltend als Zusatzmittel in der Therapie von Periodontitis
DE10332680A1 (de) * 2003-07-18 2005-02-17 Biomet Deutschland Gmbh Verwendung von antiseptischen Wirkstoffen in PMMA-Knochenzementen
BRPI0414500A (pt) * 2003-09-19 2006-11-07 Drugtech Corp formulação farmacêutica composição para tratar uma infecção vaginal, e, métodos para tratar uma infecção vaginal, para estabilizar uma formulação de clindamicina, para tratar ou prevenir uma recorrência de uma infecção vaginal em uma paciente e para tratar condições vaginais
US20060140990A1 (en) * 2003-09-19 2006-06-29 Drugtech Corporation Composition for topical treatment of mixed vaginal infections
JPWO2006043705A1 (ja) * 2004-10-19 2008-05-22 独立行政法人産業技術総合研究所 Ｉｉ型キュービック液晶組成物
US20060127437A1 (en) * 2004-12-13 2006-06-15 Misty Anderson Kennedy Semisolid system and combination semisolid, multiparticulate system for sealing tissues and/or controlling biological fluids
AR048742A1 (es) * 2004-12-22 2006-05-24 Gador Sa Sistema de aplicacion de medicamentos intra-oral
US7125954B2 (en) * 2005-01-27 2006-10-24 General Electric Company Method for producing polyether polymers
WO2006098602A1 (en) * 2005-03-18 2006-09-21 Lg Household & Health Care Ltd. Tooth whitener
CN101170993A (zh) * 2005-05-09 2008-04-30 药物技术公司 修饰释放的药物组合物
US20080219935A1 (en) * 2005-07-08 2008-09-11 Sang-Hoon Kwak Phase Transitive Breath Care Products
EA200870153A1 (ru) * 2006-01-05 2008-12-30 Драгтек Корпорейшн Композиция и способ ее использования
KR20080083190A (ko) * 2006-01-05 2008-09-16 드러그테크 코포레이션 외음질 표면에 생체접착을 위한 약물 전달 시스템
WO2010047831A1 (en) * 2008-10-23 2010-04-29 Nycomed Us Inc. Stable metronidazole gel formulations
US10149824B2 (en) * 2009-06-25 2018-12-11 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Reverse hexagonal mesophases (HII) and uses thereof
WO2011001425A1 (en) 2009-07-01 2011-01-06 Dexcel Pharma Technologies Ltd. Local therapeutic release device
US8865198B2 (en) 2010-10-25 2014-10-21 Dexcel Pharma Technologies Ltd. Method for treating a periodontal disease
US9737500B2 (en) 2010-10-29 2017-08-22 Infirst Healthcare Limited Compositions and methods for treating severe pain
US11202831B2 (en) 2010-10-29 2021-12-21 Infirst Healthcare Limited Solid solution compositions and use in cardiovascular disease
US10695432B2 (en) 2010-10-29 2020-06-30 Infirst Healthcare Limited Solid solution compositions and use in severe pain
US9308213B2 (en) 2010-10-29 2016-04-12 Infirst Healthcare Limited Solid solution compositions and use in chronic inflammation
US11224659B2 (en) 2010-10-29 2022-01-18 Infirst Healthcare Limited Solid solution compositions and use in severe pain
US11730709B2 (en) 2010-10-29 2023-08-22 Infirst Healthcare Limited Compositions and methods for treating severe pain
US9504664B2 (en) 2010-10-29 2016-11-29 Infirst Healthcare Limited Compositions and methods for treating severe pain
US8895537B2 (en) 2010-10-29 2014-11-25 Infirst Healthcare Ltd. Compositions and methods for treating cardiovascular diseases
US9271950B2 (en) 2010-10-29 2016-03-01 Infirst Healthcare Limited Compositions for treating chronic inflammation and inflammatory diseases
US10695431B2 (en) 2010-10-29 2020-06-30 Infirst Healthcare Limited Solid solution compositions and use in cardiovascular disease
US9744132B2 (en) 2010-10-29 2017-08-29 Infirst Healthcare Limited Solid solution compositions and use in chronic inflammation
RU2508101C1 (ru) * 2012-10-16 2014-02-27 Открытое акционерное общество "Биосинтез" Мягкая лекарственная форма комбинированного действия для локального лечения заболеваний пародонта
SG11201505245XA (en) * 2013-01-14 2015-08-28 Infirst Healthcare Ltd Compositions and methods for treating severe pain
CA2897878A1 (en) * 2013-01-14 2014-07-17 Infirst Healthcare Limited Solid solution compositions and use in cardiovascular disease
MX366317B (es) * 2013-02-04 2019-07-03 Infirst Healthcare Ltd Composiciones y metodos para tratar la inflamacion cronica y las enfermedades inflamatorias.
CA2910114A1 (en) * 2013-04-26 2014-10-30 Bioglan Ab Composition for use in reducing scab formation and promoting healing

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2196322A (en) * 1937-12-04 1940-04-09 Squibb & Sons Inc Pharmaceutical
DK116528A (de) * 1966-09-30
US4568535A (en) * 1982-08-06 1986-02-04 Loesche Walter J Composition for periodontal administration
US4698359A (en) * 1982-08-24 1987-10-06 Cilag, Ag Medicated suppository
SE8206744D0 (sv) * 1982-11-26 1982-11-26 Fluidcarbon International Ab Preparat for kontrollerad avgivning av substanser
US4780320A (en) * 1986-04-29 1988-10-25 Pharmetrix Corp. Controlled release drug delivery system for the periodontal pocket
EP1169958A1 (de) * 2000-06-28 2002-01-09 Tege Patents Aktiengesellschaft Kocheinheit für einen Verkaufsautomaten

Also Published As

Publication number Publication date
DE69015212T2 (de) 1995-05-04
CA2095354A1 (en) 1992-05-22
DE69015212D1 (de) 1995-01-26
FI932278A0 (fi) 1993-05-19
AU647768B2 (en) 1994-03-31
HU220216B (hu) 2001-11-28
WO1992009272A1 (en) 1992-06-11
KR0180750B1 (ko) 1999-03-20
HU9301346D0 (en) 1993-09-28
NO931832D0 (no) 1993-05-19
NO305931B1 (no) 1999-08-23
US5143934A (en) 1992-09-01
DK0558475T3 (da) 1995-04-24
FI109452B (fi) 2002-08-15
FI932278A (fi) 1993-05-19
CA2095354C (en) 2001-10-09
NO931832L (no) 1993-07-19
AU7049991A (en) 1992-06-25
EP0558475B1 (de) 1994-12-14
EP0558475A1 (de) 1993-09-08
HUT75453A (en) 1997-05-28
JPH03135925A (ja) 1991-06-10
ES2065670T3 (es) 1995-02-16
GR3015329T3 (en) 1995-06-30

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EEIH Change in the person of patent owner
REN Ceased due to non-payment of the annual fee