ATE112285T1 - Adenosin-derivate, die eine aktivität gegen bluthochdruck haben. - Google Patents
Adenosin-derivate, die eine aktivität gegen bluthochdruck haben.Info
- Publication number
- ATE112285T1 ATE112285T1 AT90810026T AT90810026T ATE112285T1 AT E112285 T1 ATE112285 T1 AT E112285T1 AT 90810026 T AT90810026 T AT 90810026T AT 90810026 T AT90810026 T AT 90810026T AT E112285 T1 ATE112285 T1 AT E112285T1
- Authority
- AT
- Austria
- Prior art keywords
- group
- hydrogen
- alkyl group
- anantipressous
- activity
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1005658A JPH0725785B2 (ja) | 1989-01-11 | 1989-01-11 | アデノシン誘導体及び該化合物を有効成分として含有する医薬組成物 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE112285T1 true ATE112285T1 (de) | 1994-10-15 |
Family
ID=11617214
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT90810026T ATE112285T1 (de) | 1989-01-11 | 1990-01-11 | Adenosin-derivate, die eine aktivität gegen bluthochdruck haben. |
Country Status (7)
Country | Link |
---|---|
US (2) | US4985409A (de) |
EP (1) | EP0378518B1 (de) |
JP (1) | JPH0725785B2 (de) |
AT (1) | ATE112285T1 (de) |
DE (1) | DE69012840T2 (de) |
DK (1) | DK0378518T3 (de) |
ES (1) | ES2064700T3 (de) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5298508A (en) * | 1988-07-19 | 1994-03-29 | The United States Of America As Represented By The Department Of Health And Human Services | Irreversible inhibitors of adenosine receptors |
GB2226027B (en) * | 1988-12-13 | 1992-05-20 | Sandoz Ltd | Adenosine derivatives,their production and use |
JPH0725785B2 (ja) * | 1989-01-11 | 1995-03-22 | 日本臓器製薬株式会社 | アデノシン誘導体及び該化合物を有効成分として含有する医薬組成物 |
US5646265A (en) | 1990-01-11 | 1997-07-08 | Isis Pharmceuticals, Inc. | Process for the preparation of 2'-O-alkyl purine phosphoramidites |
US5914396A (en) * | 1990-01-11 | 1999-06-22 | Isis Pharmaceuticals, Inc. | 2'-O-modified nucleosides and phosphoramidites |
US7101993B1 (en) | 1990-01-11 | 2006-09-05 | Isis Pharmaceuticals, Inc. | Oligonucleotides containing 2′-O-modified purines |
US5792844A (en) * | 1990-07-27 | 1998-08-11 | Isis Pharmaceuticals, Inc. | Oligonucleoside linkages containing adjacent nitrogen atoms |
US5677437A (en) * | 1990-07-27 | 1997-10-14 | Isis Pharmaceuticals, Inc. | Heteroatomic oligonucleoside linkages |
US5378825A (en) * | 1990-07-27 | 1995-01-03 | Isis Pharmaceuticals, Inc. | Backbone modified oligonucleotide analogs |
US5610289A (en) | 1990-07-27 | 1997-03-11 | Isis Pharmaceuticals, Inc. | Backbone modified oligonucleotide analogues |
US5618704A (en) * | 1990-07-27 | 1997-04-08 | Isis Pharmacueticals, Inc. | Backbone-modified oligonucleotide analogs and preparation thereof through radical coupling |
US5623070A (en) | 1990-07-27 | 1997-04-22 | Isis Pharmaceuticals, Inc. | Heteroatomic oligonucleoside linkages |
US5561134A (en) * | 1990-09-25 | 1996-10-01 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties |
DK0550631T3 (da) * | 1990-09-25 | 1997-01-20 | Rhone Poulenc Rorer Int | Forbindelser med blodtrykssænkende virkning og virkning mod iskæmi |
HUT61567A (en) * | 1990-12-07 | 1993-01-28 | Sandoz Ag | Process for producing new pharmaceutical compositions comprising 2'-o-alkyladenosine derivatives and for producing 6-cyclohexyl-2'-o-methyladenosinehydrate |
US5965722A (en) * | 1991-05-21 | 1999-10-12 | Isis Pharmaceuticals, Inc. | Antisense inhibition of ras gene with chimeric and alternating oligonucleotides |
US5206222A (en) * | 1991-05-22 | 1993-04-27 | Vanderbilt University | Methods for the reduction of myocardial reperfusion injury |
AU4772493A (en) * | 1992-07-15 | 1994-02-14 | United States Of America, Represented By The Secretary, Department Of Health And Human Services, The | Sulfo-derivatives of adenosine |
EP0601322A3 (de) * | 1992-10-27 | 1994-10-12 | Nippon Zoki Pharmaceutical Co | Adenosindeaminaseinhibitor. |
GB9301000D0 (en) * | 1993-01-20 | 1993-03-10 | Glaxo Group Ltd | Chemical compounds |
US5596094A (en) * | 1994-05-26 | 1997-01-21 | Sandoz Ltd. | Process for preparing 2' -0- alkyl adenosine derivatives |
US6376472B1 (en) * | 1996-07-08 | 2002-04-23 | Aventis Pharmaceuticals, Inc. | Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties |
TW528755B (en) | 1996-12-24 | 2003-04-21 | Glaxo Group Ltd | 2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives |
YU44900A (sh) | 1998-01-31 | 2003-01-31 | Glaxo Group Limited | Derivati 2-(purin-9-il)tetrahidrofuran-3,4-diola |
US6495528B1 (en) | 1998-06-23 | 2002-12-17 | Smithkline Beecham Corporation | 2-(Purin -9-yl)-tetrahydrofuran-3,4-diol derivatives |
JP3619017B2 (ja) | 1998-06-24 | 2005-02-09 | 日本臓器製薬株式会社 | 新規アラビノシルアデニン誘導体 |
EP1018514B1 (de) | 1998-07-22 | 2004-05-12 | Daiichi Suntory Pharma Co., Ltd. | Nf-kappa b inhibitoren, die indanderivate als aktiven bestandteil enthalten |
AR049384A1 (es) * | 2004-05-24 | 2006-07-26 | Glaxo Group Ltd | Derivados de purina |
WO2006089053A2 (en) | 2005-02-17 | 2006-08-24 | Wyeth | Cycloalkylfused indole, benzothiophene, benzofuran and indene derivatives |
GB0514809D0 (en) | 2005-07-19 | 2005-08-24 | Glaxo Group Ltd | Compounds |
CN100355769C (zh) * | 2005-11-16 | 2007-12-19 | 华东师范大学 | 2'-甲氧基腺苷的制备方法 |
WO2009032057A2 (en) | 2007-08-29 | 2009-03-12 | Adam Lubin | Method for the selective therapy of disease |
WO2017137528A1 (en) | 2016-02-12 | 2017-08-17 | Charité - Universitätsmedizin Berlin | Adenosine a1 receptor agonist for use in treatment of status epilepticus |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL130136C (de) * | 1966-10-20 | |||
NL7203984A (de) * | 1971-04-10 | 1972-10-12 | ||
DE2136624A1 (de) * | 1971-07-22 | 1973-02-08 | Boehringer Mannheim Gmbh | N (6)-substituierte adenosin-derivate und verfahren zur herstellung derselben |
US3922261A (en) * | 1972-06-21 | 1975-11-25 | Merck Patent Gmbh | Adenosine derivative |
DE2628202A1 (de) * | 1976-06-23 | 1977-12-29 | Max Planck Gesellschaft | Verfahren zur herstellung von 2'-substituierten-d-ribofuranosylpurinderivaten |
US4501735A (en) * | 1983-12-05 | 1985-02-26 | Warner-Lambert Company | N6-(1- and 2-benzocycloalkyl) adenosines |
US4657897A (en) * | 1984-06-22 | 1987-04-14 | Warner-Lambert Company | N6 -substituted adenosines for treating pain |
US4657898A (en) * | 1984-06-22 | 1987-04-14 | Warner-Lambert Company | N6 -substituted adenosines and method of use |
US4791103A (en) * | 1985-02-08 | 1988-12-13 | Warner-Lambert Company | 2,N6 -disubstituted adenosines, derivatives and methods of use |
US4663313A (en) * | 1984-10-26 | 1987-05-05 | Warner-Lambert Company | N6 -tricyclic adenosines for treating hypertension |
ZA858154B (en) * | 1984-10-26 | 1986-06-25 | Warner Lambert Co | N6-substituted deoxyribose analogs of adenosines |
AU575438B2 (en) * | 1984-10-26 | 1988-07-28 | Warner-Lambert Company | N6 - substituted deoxyribose analogues of adenosines |
US4626526A (en) * | 1984-10-26 | 1986-12-02 | Warner-Lambert Company | (S)-N6 -2-hydroxypropyladenosines |
CA1255297A (en) * | 1984-10-26 | 1989-06-06 | Bharat Trivedi | N.sup.6-benzopyrano and benzothiopyrano adenosines |
US4593019A (en) * | 1984-10-26 | 1986-06-03 | Warner-Lambert Company | N6 -tricyclic adenosines |
US4683223A (en) * | 1985-09-09 | 1987-07-28 | Warner-Lambert Company | N6 -Benzopyrano-and benzothiopyrano adenosines and methods of use |
US4614732A (en) * | 1984-10-26 | 1986-09-30 | Warner-Lambert Company | N6 -acenaphthyl adenosines and analogs thereof |
ZA857998B (en) * | 1984-10-26 | 1986-05-28 | Warner Lambert Co | N6-substituted adenosines |
JPS61103892A (ja) * | 1984-10-26 | 1986-05-22 | ワーハー‐ランバート・コンパニー | N↑6‐アセナフチルアデノシン類およびそれらの類縁体 |
US4616003A (en) * | 1984-10-26 | 1986-10-07 | Warner-Lambert Company | N6 -dihydroxypropyladenosines |
AU579412B2 (en) * | 1984-10-26 | 1988-11-24 | Warner-Lambert Company | N` - substituted adenosines |
AU8276187A (en) * | 1986-10-31 | 1988-05-25 | Warner-Lambert Company | Selected n6-substituted adenosines having selective a2 binding activity |
AU8274187A (en) * | 1986-10-31 | 1988-05-25 | Warner-Lambert Company | Heteroaromatic derivatives of adenosine |
JPH0723394B2 (ja) * | 1986-11-27 | 1995-03-15 | 日本臓器製薬株式会社 | 新規アデノシン誘導体及び該化合物を有効成分として含有する医薬組成物 |
US4837207A (en) * | 1987-05-13 | 1989-06-06 | Warner-Lambert Company | Diastereoisomers of n6 -endo-bicyclo[2.2.1]heptyladenosine as antihypertensives with selective action |
GB2226027B (en) * | 1988-12-13 | 1992-05-20 | Sandoz Ltd | Adenosine derivatives,their production and use |
JPH0725785B2 (ja) * | 1989-01-11 | 1995-03-22 | 日本臓器製薬株式会社 | アデノシン誘導体及び該化合物を有効成分として含有する医薬組成物 |
-
1989
- 1989-01-11 JP JP1005658A patent/JPH0725785B2/ja not_active Expired - Fee Related
-
1990
- 1990-01-09 US US07/462,246 patent/US4985409A/en not_active Ceased
- 1990-01-11 DK DK90810026.6T patent/DK0378518T3/da active
- 1990-01-11 AT AT90810026T patent/ATE112285T1/de active
- 1990-01-11 EP EP90810026A patent/EP0378518B1/de not_active Expired - Lifetime
- 1990-01-11 DE DE69012840T patent/DE69012840T2/de not_active Expired - Fee Related
- 1990-01-11 ES ES90810026T patent/ES2064700T3/es not_active Expired - Lifetime
-
1992
- 1992-12-28 US US07/997,446 patent/USRE37077E1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DK0378518T3 (da) | 1994-10-24 |
DE69012840D1 (de) | 1994-11-03 |
USRE37077E1 (en) | 2001-02-27 |
EP0378518A3 (en) | 1990-12-27 |
DE69012840T2 (de) | 1995-03-16 |
ES2064700T3 (es) | 1995-02-01 |
JPH0725785B2 (ja) | 1995-03-22 |
JPH02184696A (ja) | 1990-07-19 |
EP0378518A2 (de) | 1990-07-18 |
EP0378518B1 (de) | 1994-09-28 |
US4985409A (en) | 1991-01-15 |
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