ATA393976A - Verfahren zur herstellung von 1- (2-tetrahydrofuryl)-5-fluoruracil - Google Patents

Verfahren zur herstellung von 1- (2-tetrahydrofuryl)-5-fluoruracil

Info

Publication number: ATA393976A
Authority: AT; Austria
Prior art keywords: fluoruracil; tetrahydrofuryl; preparation
Prior art date: 1976-05-28

Application number

AT393976A

Other languages

English (en)

Other versions

AT344190B (de

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1976-05-28

Filing date

1976-05-28

Publication date

1977-11-15

1976-05-28 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

1976-05-28 Priority to AT685277A priority Critical patent/AT346361B/de

1976-05-28 Priority to AT393976A priority patent/AT344190B/de

1977-05-17 Priority to US05/797,898 priority patent/US4169201A/en

1977-05-20 Priority to ZA00773025A priority patent/ZA773025B/xx

1977-05-20 Priority to NZ184158A priority patent/NZ184158A/xx

1977-05-20 Priority to IL52134A priority patent/IL52134A0/xx

1977-05-23 Priority to IT7723876A priority patent/IT1086270B/it

1977-05-24 Priority to AU25430/77A priority patent/AU2543077A/en

1977-05-24 Priority to DE19772723450 priority patent/DE2723450A1/de

1977-05-25 Priority to NL7705754A priority patent/NL7705754A/xx

1977-05-26 Priority to JP6054277A priority patent/JPS52144678A/ja

1977-05-27 Priority to BE177974A priority patent/BE855121A/xx

1977-05-27 Priority to LU77438A priority patent/LU77438A1/xx

1977-05-27 Priority to FR7716362A priority patent/FR2352814A1/fr

1977-05-27 Priority to DK235477A priority patent/DK235477A/da

1977-05-27 Priority to SE7706269A priority patent/SE7706269L/xx

1977-11-15 Publication of ATA393976A publication Critical patent/ATA393976A/de

1978-07-10 Application granted granted Critical

1978-07-10 Publication of AT344190B publication Critical patent/AT344190B/de

Links

WFWLQNSHRPWKFK-UHFFFAOYSA-N Tegafur Chemical compound O=C1NC(=O)C(F)=CN1C1OCCC1 WFWLQNSHRPWKFK-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Plural Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)

AT393976A 1976-05-28 1976-05-28 Verfahren zur herstellung von 1- (2-tetrahydrofuryl)-5-fluoruracil AT344190B (de)

Priority Applications (16)

Application Number	Priority Date	Filing Date	Title
AT685277A AT346361B (de)	1976-05-28	1976-05-28	Verfahren zur herstellung des neuen 1- (2,3- dihydro-2-furyl)-5-fluoruracils
AT393976A AT344190B (de)	1976-05-28	1976-05-28	Verfahren zur herstellung von 1- (2-tetrahydrofuryl)-5-fluoruracil
US05/797,898 US4169201A (en)	1976-05-28	1977-05-17	Novel ester precursor intermediates and antipodes for the preparation of 1-(2-tetrahydrofuryl)-5-fluorouracil
ZA00773025A ZA773025B (en)	1976-05-28	1977-05-20	Uracil derivatives and process for the preparation thereof
NZ184158A NZ184158A (en)	1976-05-28	1977-05-20	Uracil derivatives: preparation and pharmaceutical preparations
IL52134A IL52134A0 (en)	1976-05-28	1977-05-20	Uracil derivatives process for the preparation thereof and pharmaceutical compositions containing them
IT7723876A IT1086270B (it)	1976-05-28	1977-05-23	Uracil-derivati e procedimento per la loro preparazione
DE19772723450 DE2723450A1 (de)	1976-05-28	1977-05-24	Uracilderivate und verfahren zu ihrer herstellung
AU25430/77A AU2543077A (en)	1976-05-28	1977-05-24	Uracil derivatives
NL7705754A NL7705754A (nl)	1976-05-28	1977-05-25	Werkwijze voor het bereiden van uracilderivaten.
JP6054277A JPS52144678A (en)	1976-05-28	1977-05-26	Production of uracil derivatives
BE177974A BE855121A (fr)	1976-05-28	1977-05-27	Derives d'uracile et procede pour leur preparation
LU77438A LU77438A1 (de)	1976-05-28	1977-05-27
FR7716362A FR2352814A1 (fr)	1976-05-28	1977-05-27	Derives d'uracile, leur preparation et leur application en tant que medicaments
DK235477A DK235477A (da)	1976-05-28	1977-05-27	Fremgangsmade til fremstilling af uracilderivater
SE7706269A SE7706269L (sv)	1976-05-28	1977-05-27	Uracilderivat och forfarande for framstellning derav

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
AT393976A AT344190B (de)	1976-05-28	1976-05-28	Verfahren zur herstellung von 1- (2-tetrahydrofuryl)-5-fluoruracil

Publications (2)

Publication Number	Publication Date
ATA393976A true ATA393976A (de)	1977-11-15
AT344190B AT344190B (de)	1978-07-10

Family

ID=3557472

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT393976A AT344190B (de)	1976-05-28	1976-05-28	Verfahren zur herstellung von 1- (2-tetrahydrofuryl)-5-fluoruracil
AT685277A AT346361B (de)	1976-05-28	1976-05-28	Verfahren zur herstellung des neuen 1- (2,3- dihydro-2-furyl)-5-fluoruracils

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
AT685277A AT346361B (de)	1976-05-28	1976-05-28	Verfahren zur herstellung des neuen 1- (2,3- dihydro-2-furyl)-5-fluoruracils

Country Status (15)

Country	Link
US (1)	US4169201A (de)
JP (1)	JPS52144678A (de)
AT (2)	AT344190B (de)
AU (1)	AU2543077A (de)
BE (1)	BE855121A (de)
DE (1)	DE2723450A1 (de)
DK (1)	DK235477A (de)
FR (1)	FR2352814A1 (de)
IL (1)	IL52134A0 (de)
IT (1)	IT1086270B (de)
LU (1)	LU77438A1 (de)
NL (1)	NL7705754A (de)
NZ (1)	NZ184158A (de)
SE (1)	SE7706269L (de)
ZA (1)	ZA773025B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5639090A (en) *	1979-09-07	1981-04-14	Taiho Yakuhin Kogyo Kk	5-substituted uracil derivative and its preparation
JPS5699478A (en) *	1980-01-11	1981-08-10	Taiho Yakuhin Kogyo Kk	5-fluorouracil derivative and its preparation
SU1235864A1 (ru) *	1983-03-11	1986-06-07	Отделение ордена Ленина института химической физики АН СССР	Нитроксильные производные 5-фторурацила,обладающие противоопухолевой активностью
JPH0196191A (ja) *	1987-10-06	1989-04-14	Taiho Yakuhin Kogyo Kk	２’−デオキシウリジン誘導体
US5502177A (en) *	1993-09-17	1996-03-26	Gilead Sciences, Inc.	Pyrimidine derivatives for labeled binding partners
US6538001B1 (en) *	1998-10-12	2003-03-25	Nikolai Borisovich Leonidov	Crystalline modification of 5-fluoro-1-(tetrahydro-2-furyl) uracil and complex compounds based thereon, producing antineoplastic effect

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2949451A (en) *	1959-04-21	1960-08-16	Hoffmann La Roche	Preparation of thymidine and deoxyfluorouridine, and intermediates therefor
US3635946A (en) *	1969-07-22	1972-01-18	Solomon Aronovich Giller	N1-(2'-furanidyl)-derivatives of 5-substituted uracils
US4039546A (en) *	1975-04-28	1977-08-02	Solomon Aronovich Giller	Method of preparing N1 -(2'-furanidyl)-5-substituted uracils

1976
- 1976-05-28 AT AT393976A patent/AT344190B/de not_active IP Right Cessation
- 1976-05-28 AT AT685277A patent/AT346361B/de not_active IP Right Cessation
1977
- 1977-05-17 US US05/797,898 patent/US4169201A/en not_active Expired - Lifetime
- 1977-05-20 IL IL52134A patent/IL52134A0/xx unknown
- 1977-05-20 NZ NZ184158A patent/NZ184158A/xx unknown
- 1977-05-20 ZA ZA00773025A patent/ZA773025B/xx unknown
- 1977-05-23 IT IT7723876A patent/IT1086270B/it active
- 1977-05-24 AU AU25430/77A patent/AU2543077A/en not_active Expired
- 1977-05-24 DE DE19772723450 patent/DE2723450A1/de active Pending
- 1977-05-25 NL NL7705754A patent/NL7705754A/xx not_active Application Discontinuation
- 1977-05-26 JP JP6054277A patent/JPS52144678A/ja active Pending
- 1977-05-27 DK DK235477A patent/DK235477A/da not_active Application Discontinuation
- 1977-05-27 LU LU77438A patent/LU77438A1/xx unknown
- 1977-05-27 FR FR7716362A patent/FR2352814A1/fr not_active Withdrawn
- 1977-05-27 BE BE177974A patent/BE855121A/xx unknown
- 1977-05-27 SE SE7706269A patent/SE7706269L/xx unknown

Also Published As

Publication number	Publication date
AT346361B (de)	1978-11-10
IT1086270B (it)	1985-05-28
JPS52144678A (en)	1977-12-02
SE7706269L (sv)	1977-11-29
BE855121A (fr)	1977-11-28
AT344190B (de)	1978-07-10
DK235477A (da)	1977-11-29
US4169201A (en)	1979-09-25
AU2543077A (en)	1978-11-30
IL52134A0 (en)	1977-07-31
ATA685277A (de)	1978-03-15
FR2352814A1 (fr)	1977-12-23
DE2723450A1 (de)	1977-12-15
NZ184158A (en)	1979-08-31
NL7705754A (nl)	1977-11-30
ZA773025B (en)	1978-04-26
LU77438A1 (de)	1978-06-26

Legal Events

Date	Code	Title	Description
1980-08-15	ELJ	Ceased due to non-payment of the annual fee
2001-03-15	ELJ	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DD133680A5 (de)	1979-01-17	Verfahren zur herstellung von polyaetherpolyolen
DD128672A5 (de)	1977-11-30	Verfahren zur herstellung von m-aryloxybenzaldehyden
DD132015A5 (de)	1978-08-16	Verfahren zur herstellung von trans-hexahydro-pyrido-indolen
AT348995B (de)	1979-03-12	Verfahren zur herstellung von acylcyaniden
DD129777A5 (de)	1978-02-08	Verfahren zur herstellung von phenoxypropionsaeurederivaten
DD128659A5 (de)	1977-11-30	Verfahren zur herstellung von 4-androsten-3-onen
AT347926B (de)	1979-01-25	Verfahren zur herstellung von acylcyaniden
DD129903A5 (de)	1978-02-15	Verfahren zur herstellung von benzoylcyanid
DD131018A5 (de)	1978-05-24	Verfahren zur herstellung von 2-chlorsulfinylazetidin-4-onen
DD132013A5 (de)	1978-08-16	Verfahren zur herstellung von benzoylcyanid
DD133795A5 (de)	1979-01-24	Verfahren zur herstellung von 4a-aryloctahydro-1h-2-pyrindinen
ATA393976A (de)	1977-11-15	Verfahren zur herstellung von 1- (2-tetrahydrofuryl)-5-fluoruracil
AT348509B (de)	1979-02-26	Verfahren zur herstellung von acylcyaniden
ATA706577A (de)	1979-09-15	Verfahren zur herstellung von substituierten 1-carbamoyl-2-cyanaziridinen
PT67048B (de)	1979-02-16	Verfahren zur herstellung von 1-amino-2-hydroxy-3-heterocyclyloxy-propanen
DD130241A5 (de)	1978-03-15	Verfahren zur herstellung von benzoylcyanid
DD137228A5 (de)	1979-08-22	Verfahren zur herstellung von 4-(1-hydroxy-1-methylaethyl)-3-cyclohexen-1-on-ketalen
DD129915A5 (de)	1978-02-15	Verfahren zur herstellung von 7-alkoxy-3-chlormethyl-3-cephemen
DD129782A5 (de)	1978-02-08	Verfahren zur herstellung von cholecystokinin-pancreozymin-octapeptidamid-sulfatester
DD128953A1 (de)	1977-12-21	Verfahren zur herstellung von alkalizellulose
DD128591A5 (de)	1977-11-30	Verfahren zur herstellung von 2-oxo-1-pyrrolidinen
ATA486078A (de)	1979-09-15	Verfahren zur herstellung von 1-(4-isopropyl- mercaptophenyl)-2-n-octylaminopropanol
DD133797A5 (de)	1979-01-24	Verfahren zur herstellung von trans-5a-aryldecahydrobenzazepinen
DD129980A5 (de)	1978-02-22	Verfahren zur herstellung von trans-dihydroindolen
DD129792A5 (de)	1978-02-08	Verfahren zur herstellung von 1-oxadethiacephalosporinen