ATA144880A - Verfahren zum herstellen von neuen piperidinderivaten und deren salzen - Google Patents

Verfahren zum herstellen von neuen piperidinderivaten und deren salzen

Info

Publication number
ATA144880A
ATA144880A AT0144880A AT144880A ATA144880A AT A144880 A ATA144880 A AT A144880A AT 0144880 A AT0144880 A AT 0144880A AT 144880 A AT144880 A AT 144880A AT A144880 A ATA144880 A AT A144880A
Authority
AT
Austria
Prior art keywords
salts
producing new
piperide
derivatives
piperide derivatives
Prior art date
Application number
AT0144880A
Other languages
English (en)
Other versions
AT376208B (de
Original Assignee
Richardson Merrell Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21845568&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATA144880(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Richardson Merrell Inc filed Critical Richardson Merrell Inc
Publication of ATA144880A publication Critical patent/ATA144880A/de
Application granted granted Critical
Publication of AT376208B publication Critical patent/AT376208B/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/08Bronchodilators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT0144880A 1979-04-10 1980-03-17 Verfahren zum herstellen von neuen piperidinderivaten und deren salzen AT376208B (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/028,813 US4254129A (en) 1979-04-10 1979-04-10 Piperidine derivatives

Publications (2)

Publication Number Publication Date
ATA144880A true ATA144880A (de) 1984-03-15
AT376208B AT376208B (de) 1984-10-25

Family

ID=21845568

Family Applications (1)

Application Number Title Priority Date Filing Date
AT0144880A AT376208B (de) 1979-04-10 1980-03-17 Verfahren zum herstellen von neuen piperidinderivaten und deren salzen

Country Status (19)

Country Link
US (1) US4254129A (de)
JP (1) JPS55141469A (de)
AT (1) AT376208B (de)
AU (1) AU531146B2 (de)
BE (1) BE882703A (de)
CA (1) CA1123438A (de)
CH (1) CH643245A5 (de)
DE (1) DE3007498A1 (de)
DK (1) DK153709C (de)
ES (1) ES8103735A1 (de)
FR (1) FR2453854A1 (de)
IL (1) IL59158A (de)
IT (1) IT1143960B (de)
NL (2) NL190580C (de)
NO (2) NO154521C (de)
NZ (1) NZ192653A (de)
PH (1) PH17023A (de)
SE (1) SE448726B (de)
ZA (1) ZA80332B (de)

Families Citing this family (115)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4929605A (en) * 1987-10-07 1990-05-29 Merrell Dow Pharmaceuticals Inc. Pharmaceutical composition for piperidinoalkanol derivatives
AR240018A1 (es) * 1987-10-07 1990-01-31 Merrell Pharma Inc Procedimiento para preparar una composicion que comprende derivados de piperidinoalcanol.
CN1053570C (zh) 1987-10-07 2000-06-21 默尔多药物公司 哌啶子基链烷醇的药用组合物-减充血剂复方的制备方法
US4908372A (en) * 1988-10-13 1990-03-13 Merrell Dow Pharmaceuticals Inc. Antihistaminic piperidinyl benzimidazoles
AR245888A1 (es) * 1989-01-23 1994-03-30 Merrell Pharma Inc Procedimiento para la preparacion de una composicion farmaceutica liquida de derivados de piperidinoalcanol.
DE3917241A1 (de) * 1989-05-26 1990-11-29 Schaper & Bruemmer Gmbh 4-(hydroxydiphenylmethyl)-1-piperidyl-phenylalkan-derivate
US5190029A (en) * 1991-02-14 1993-03-02 Virginia Commonwealth University Formulation for delivery of drugs by metered dose inhalers with reduced or no chlorofluorocarbon content
US5182097A (en) * 1991-02-14 1993-01-26 Virginia Commonwealth University Formulations for delivery of drugs by metered dose inhalers with reduced or no chlorofluorocarbon content
TW198008B (de) * 1991-04-08 1993-01-11 Green Cross Corp
HU211019B (en) * 1991-12-02 1995-09-28 Richter Gedeon Vegyeszet Process for producing new 1,2,3,6-tetrahydropyridine and piperidine derivatives substituted with n-(hydroxylalkyl) group and compositions comprising such compounds
HUT71097A (en) * 1992-02-13 1995-11-28 Merrell Dow Pharma Piperidinyl-heterocyclic derivatives, containing sulphur pharmaceutical compositions comprising them and process for their preparation
CA2117892C (en) * 1992-04-10 2001-12-18 Chi-Hsin R. King 4-diphenylmethyl piperidine derivatives and process for their preparation
US5631375A (en) * 1992-04-10 1997-05-20 Merrell Pharmaceuticals, Inc. Process for piperidine derivatives
CA2134211C (en) * 1992-05-11 1999-06-29 James K. Woodward Use of terfenadine derivatives as antihistaminics in a hepatically impaired patient
EP0701443B2 (de) * 1992-08-03 2000-11-22 Sepracor, Inc. Terfanadin Metaboliten und deren optisch reine Isomere zur Behandlung von allergischen Krankheiten
US5654433A (en) * 1993-01-26 1997-08-05 Merrell Pharmaceuticals Inc. Process for piperidine derivatives
DE69434696T2 (de) * 1993-06-24 2006-11-16 Amr Technology, Inc. Verfahren zur Herstellung von Verbindungen geeignet als Zwischenprodukte
US20020007068A1 (en) 1999-07-16 2002-01-17 D'ambra Thomas E. Piperidine derivatives and process for their production
DE69431954T2 (de) * 1993-06-25 2003-11-06 Merrell Pharmaceuticals Inc., Cincinnati Neue zwischenprodukte für die herstellung von antihistaminschen 4-diphenylmethyl/diphenylmethoxypiperidin-derivaten
US6147216A (en) * 1993-06-25 2000-11-14 Merrell Pharmaceuticals Inc. Intermediates useful for the preparation of antihistaminic piperidine derivatives
WO1995010278A1 (en) * 1993-10-15 1995-04-20 Hoechst Marion Roussel, Inc. Treatment of allergic disorders with terfenadine carboxylate
DE69426306T2 (de) * 1993-10-25 2001-06-07 Merrell Pharmaceuticals Inc., Cincinnati Stabile pharmazeutische zubereitungen, die terfenadine und ibuprofen enthalten
DK0759904T3 (da) * 1994-05-16 2000-10-02 Merrell Pharma Inc Fremgangsmåde og diastereomere salte anvendelige til den optiske spaltning af racemisk 4-[4-[4-(hydroxydiphenylmethyl)-1-pi
US20030045722A1 (en) * 1994-05-18 2003-03-06 Henton Daniel R. Processes for preparing anhydrous and hydrate forms of antihistaminic piperidine derivatives, polymorphs and pseudomorphs thereof
CA2189007C (en) 1994-05-18 2004-03-02 Daniel R. Henton Processes for preparing anhydrous and hydrate forms of antihistaminic piperidine derivatives, polymorphs and pseudormophs thereof
CN101337922A (zh) * 1994-05-18 2009-01-07 阿温蒂斯药物公司 抗组胺哌啶衍生物,其多晶形物和假同晶物的无水和水合物形式的制备方法
CA2198084C (en) 1994-08-25 2000-03-28 Timothy P. Burkholder Novel substituted piperidines useful for the treatment of allergic diseases
ES2181868T3 (es) * 1995-02-28 2003-03-01 Aventis Pharma Inc Composicion farmaceutica para compuestos de piperidinoalcanol.
NZ306319A (en) * 1995-05-08 1999-08-30 Hoechst Marion Roussel Inc 1-alkylphenyl substituted 4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-butanol derivatives and medicaments
US5574045A (en) * 1995-06-06 1996-11-12 Hoechst Marion Roussel, Inc. Oral pharmaceutical composition of piperidinoalkanol compounds in solution form
US5906747A (en) * 1995-11-13 1999-05-25 Biosepra Inc. Separation of molecules from dilute solutions using composite chromatography media having high dynamic sorptive capacity at high flow rates
US6211199B1 (en) 1995-11-17 2001-04-03 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl-amino)piperidines useful for the treatment of allergic diseases
US6194406B1 (en) 1995-12-20 2001-02-27 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic disease
US6423704B2 (en) 1995-12-20 2002-07-23 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic diseases
US6153754A (en) * 1995-12-21 2000-11-28 Albany Molecular Research, Inc. Process for production of piperidine derivatives
US6201124B1 (en) * 1995-12-21 2001-03-13 Albany Molecular Research, Inc. Process for production of piperidine derivatives
US5932571A (en) * 1996-02-21 1999-08-03 Hoechst Marion Roussel, Inc. Substituted N-methyl-N-(4-(4-(1H-benzimidazol-2-yl) {1,4}diazepan-1-yl)-2-(aryl) butyl) benzamides useful for the treatment of allergic diseases
US5998439A (en) * 1996-02-21 1999-12-07 Hoescht Marion Roussel, Inc. Substituted N-methyl-N-(4-(piperidin-1-yl)-2-(aryl)butyl)benzamides useful for the treatment of allergic diseases
US5922737A (en) * 1996-02-21 1999-07-13 Hoechst Marion Roussel, Inc. Substituted N-methyl-N-(4-(4-(1H-Benzimidazol-2-YL-amino) piperidin-1-YL)-2-(arlyl) butyl) benzamides useful for the treatment of allergic diseases
US5925761A (en) * 1997-02-04 1999-07-20 Sepracor Inc. Synthesis of terfenadine and derivatives
DK0864653T3 (da) * 1997-03-11 2004-07-12 Aventis Pharma Inc Fremgangsmåde til fremstilling af 4-(4-(4-(hydroxydiphenyl)-1-piperidinyl)-1-hydroxybutyl)-alfa,alfa-dimethylphenyleddikesyre og phosphorylerede derivater deraf
US6451815B1 (en) 1997-08-14 2002-09-17 Aventis Pharmaceuticals Inc. Method of enhancing bioavailability of fexofenadine and its derivatives
ID22891A (id) * 1997-08-26 1999-12-16 Hoechst Marion Roussel Inc Komposisi farmasi untuk kombinasi piperidinoalkanol-dekongestan
ES2200260T3 (es) * 1997-12-17 2004-03-01 Aventis Pharma Deutschland Gmbh Procedimiento para la alquilacion de derivados de alquil-o bencilciano en presencia de trialquilaminas o trialquifosfinas.
KR100737710B1 (ko) * 1997-12-23 2007-07-11 쉐링 코포레이션 하나 이상의 류코트리엔 길항제와 데스카보에톡실로라티딘를 포함하는 호흡기 질환 및 피부 질환 치료용 조성물
US6194431B1 (en) 1998-04-14 2001-02-27 Paul D. Rubin Methods and compositions using terfenadine metabolites in combination with leukotriene inhibitors
AU2007200674C1 (en) * 1998-07-02 2011-02-24 Aventisub Llc Novel antihistaminic piperidine derivatives and intermediates for the preparation thereof
US6683094B2 (en) 1998-07-02 2004-01-27 Aventis Pharmaceuticals Inc. Antihistaminic piperidine derivatives and intermediates for the preparation thereof
EP1091938B1 (de) * 1998-07-02 2010-10-20 Aventisub II Inc. Antihistaminische piperidinderivate und zwischenprodukte zu ihrer herstellung
US6673933B2 (en) 1998-07-02 2004-01-06 Aventis Pharmaceutical Inc. Antihistaminic piperidine derivatives and intermediates for the preparation thereof
GB9822170D0 (en) * 1998-10-13 1998-12-02 Danbioyst Uk Ltd Novel formulations of fexofenadine
IN191492B (de) * 1999-05-25 2003-12-06 Ranbaxy Lab Ltd
US6613906B1 (en) * 2000-06-06 2003-09-02 Geneva Pharmaceuticals, Inc. Crystal modification
US6613907B2 (en) 2000-11-08 2003-09-02 Amr Technology, Inc. Process for the production of piperidine derivatives with microorganisms
CH695216A5 (de) * 2001-02-23 2006-01-31 Cilag Ag Verfahren zur Herstellung eines nicht hydratisierten Salzes eines Piperidinderivats und eine so erhältliche neue kristalline Form eines solchen Salzes.
AU2002305162A1 (en) * 2001-04-09 2002-10-21 Teva Pharmaceutical Industries Ltd. Polymorphs of fexofenadine hydrochloride
US20030021849A1 (en) * 2001-04-09 2003-01-30 Ben-Zion Dolitzky Polymorphs of fexofenadine hydrochloride
US7700779B2 (en) * 2001-06-18 2010-04-20 Dr. Reddy's Laboratories Limited Crystalline forms of fexofenadine and its hydrochloride
EE200400010A (et) 2001-06-18 2004-02-16 Dr. Reddy's Laboratories Ltd. 4-[4-[4-(hüdroksüdifenüülmetüül)-1-piperidinüül]-1-hüdroksübutüül]-a,a-dimetüülben seenäädikhappe ja selle hüdrokloriidi uued kristalsed vormid
CA2465913A1 (en) * 2001-11-08 2003-05-15 Judith Aronhime Polymorphs of fexofenadine base
US20030158227A1 (en) * 2001-11-08 2003-08-21 Barnaba Krochmal Polymorphs of fexofenadine base
US6723348B2 (en) * 2001-11-16 2004-04-20 Ethypharm Orodispersible tablets containing fexofenadine
AU2003217676B2 (en) 2002-02-22 2009-06-11 Takeda Pharmaceutical Company Limited Active agent delivery systems and methods for protecting and administering active agents
JP2005532356A (ja) * 2002-06-10 2005-10-27 テバ ファーマシューティカル インダストリーズ リミティド 塩酸フェキソフェナジンの多型体xvi
BR0317364A (pt) * 2002-12-16 2005-11-16 Ranbaxy Lab Ltd Processo para a preparação de fexofenadina
CN1756743A (zh) * 2003-01-31 2006-04-05 兰贝克赛实验室有限公司 制备弗克芬得的方法
US20050026890A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an antihistamine for treatment of asthma or chronic obstructive pulmonary disease
US20050065183A1 (en) * 2003-07-31 2005-03-24 Indranil Nandi Fexofenadine composition and process for preparing
GB0319935D0 (en) * 2003-08-26 2003-09-24 Cipla Ltd Polymorphs
TW200517114A (en) 2003-10-15 2005-06-01 Combinatorx Inc Methods and reagents for the treatment of immunoinflammatory disorders
WO2005102999A2 (en) * 2004-04-26 2005-11-03 Teva Pharmaceutical Industries Ltd. Crystalline forms of fexofenadine hydrochloride and processes for their preparation
WO2006008567A1 (en) * 2004-06-18 2006-01-26 Wockhardt Limited Pharmaceutical compositions for piperidinoalkanol compounds
ITMI20041568A1 (it) * 2004-07-30 2004-10-30 Dipharma Spa "polimorfi di fexofenadina base"
US7498345B2 (en) * 2004-09-17 2009-03-03 Albany Molecular Research, Inc. Process for production of piperidine derivatives
US7498443B2 (en) * 2004-09-17 2009-03-03 Albany Molecular Research, Inc. Process for production of carebastine
US20060148851A1 (en) * 2004-09-28 2006-07-06 Shlomit Wizel Fexofenadine crystal form and processes for its preparation thereof
US20070020330A1 (en) * 2004-11-24 2007-01-25 Medpointe Healthcare Inc. Compositions comprising azelastine and methods of use thereof
TR201820559T4 (tr) * 2004-11-24 2019-01-21 Meda Pharmaceuticals Inc Azelastin içeren kompozisyonlar ve bunların kullanım metotları.
US8758816B2 (en) * 2004-11-24 2014-06-24 Meda Pharmaceuticals Inc. Compositions comprising azelastine and methods of use thereof
JP2008120684A (ja) * 2005-03-07 2008-05-29 Kumamoto Univ 抗アレルギー薬
US20080274196A1 (en) * 2005-08-05 2008-11-06 Lipin Limited Oral Pharmaceutical Suspension Compositions Of Fexofenadine
US20070088065A1 (en) * 2005-10-14 2007-04-19 Jie Du Metaxalone products, method of manufacture, and method of use
US20080292584A1 (en) * 2005-10-14 2008-11-27 Mutual Pharmaceutical Company, Inc. Metaxalone products, method of manufacture, and method of use
WO2007049303A2 (en) * 2005-10-28 2007-05-03 Ind-Swift Laboratories Limited An improved process for the preparation of highly pure fexofenadine
ZA200804550B (en) 2005-11-09 2009-08-26 Combinatorx Inc Methods, compositions, and kits for the treatment of medical conditions
DOP2006000274A (es) * 2005-12-14 2007-10-15 Sanofi Aventis Us Llc Formulación de suspensión de fexofenadina
CN100443470C (zh) * 2006-07-21 2008-12-17 杭州保灵有限公司 一种依巴斯汀的制备方法
ITMI20061491A1 (it) * 2006-07-27 2008-01-28 Archimica Srl Processo per la preparazione di fexofenadina.
ITMI20061492A1 (it) * 2006-07-27 2008-01-28 Archimica Srl Processo per la preparazione di fexofenadina.
US20080161324A1 (en) * 2006-09-14 2008-07-03 Johansen Lisa M Compositions and methods for treatment of viral diseases
EP2420236B1 (de) 2007-04-13 2015-01-14 Southern Research Institute Terfenadine als Anti-Angiogenese-Mittel
ITMI20070987A1 (it) * 2007-05-16 2008-11-17 Dipharma Francis Srl Procedimento per la preparazione di composti chetonici
US20090076080A1 (en) * 2007-09-19 2009-03-19 Protia, Llc Deuterium-enriched fexofenadine
US20090306135A1 (en) 2008-03-24 2009-12-10 Mukesh Kumar Sharma Stable amorphous fexofenadine hydrochloride
AU2009251743A1 (en) * 2008-05-30 2009-12-03 Fairfield Clinical Trials, Llc Method and composition for skin inflammation and discoloration
US20100092479A1 (en) * 2008-08-18 2010-04-15 Combinatorx (Singapore) Pte. Ltd. Compositions and methods for treatment of viral diseases
CN101585805B (zh) * 2009-06-06 2011-07-06 浙江大学宁波理工学院 一种抗过敏药物非索非那定盐酸盐的制备方法
EP2289867A3 (de) 2009-08-19 2012-04-25 Jubilant Organosys Limited Verfahren zur Herstellung von 4-(4-Halogen-1-oxybutyl)-alpha,alpha-dimethylbenzolessigsäure oder Alkylestern davon
CN101671292B (zh) * 2009-10-10 2011-09-07 浙江大学宁波理工学院 盐酸非索非那定的合成方法
US20110130711A1 (en) * 2009-11-19 2011-06-02 Follica, Inc. Hair growth treatment
EP2371817A1 (de) * 2010-04-01 2011-10-05 Arevipharma GmbH Verfahren zur Herstellung von 1-[4-(1,1-Dimethylethyl)phenyl]-4-[4-(diphenylmethoxy)-1-piperidinyl]-1-butanon und Säureadditionssalze daraus
WO2011158262A1 (en) 2010-06-15 2011-12-22 Chemelectiva S.R.L. Polymorphic form of fexofenadine hydrochloride, intermediates and process for its preparation
CN103702961A (zh) 2011-05-23 2014-04-02 赛诺菲 含有n-烷基的氘代化合物的制备方法
JP5362151B2 (ja) 2011-09-29 2013-12-11 塩野義製薬株式会社 Pgd2拮抗剤及びヒスタミン拮抗剤からなるアレルギー性鼻炎治療用医薬
EP2578570A1 (de) 2011-10-07 2013-04-10 Almirall, S.A. Neues Verfahren zur Herstellung von 5-(2-{[6-(2,2-Difluor-2-phenylethoxy)hexyl]amino}-1(R)-hydroxyethyl)-8-hydroxychinolin-2(1H)-on mittels neuen Synthesezwischenstoffen
EP2641900A1 (de) 2012-03-20 2013-09-25 Almirall, S.A. Neuartige polymorphe Kristallformen von 5-(2-{[6-(2,2-difluor-2-phenylethoxy)hexyl]amino}-1-hydroxyethyl)-8-hydroxychinolin-2(1H)-on, Heminapadisylat als Agonist des beta2-adrenergen Rezeptors
CN102659667B (zh) * 2012-04-20 2013-08-14 浙江启明药业有限公司 一种非索非那定关键中间体的合成方法
CN103333100B (zh) * 2013-06-06 2016-04-06 池州东升药业有限公司 一种盐酸非索非那定的合成工艺
ITMI20131652A1 (it) 2013-10-07 2015-04-08 Dipharma Francis Srl Procedimento per la purificazione di derivati dell'acido 2-fenil-2-metil-propanoico
CN104557671B (zh) * 2013-10-10 2018-04-13 池州东升药业有限公司 一种非索非那定及中间体的合成方法
EP2949321A1 (de) 2014-05-26 2015-12-02 Sanovel Ilac Sanayi ve Ticaret A.S. Mehrschichtige formulierungen aus fexofenadin und montelukast
ES2738630T3 (es) 2015-01-22 2020-01-24 Sanofi Aventis Deutschland Procedimiento para la producción de 2-[4-(ciclopropanocarbonil)fenil]-2-metil-propanonitrilo
EP3365327B1 (de) 2015-10-22 2019-11-20 Sanofi-Aventis Deutschland GmbH Verfahren zur herstellung von fexofenadin und darin verwendete zwischenprodukte
GB202212656D0 (en) 2022-08-31 2022-10-12 Novumgen Ltd An orodispersible tablet of fecofenadine and it process of preparation
WO2024153354A1 (en) 2023-01-20 2024-07-25 Opella Healthcare Group Sas Paraben-free fexofenadine formulations

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1242169A (en) * 1969-04-09 1971-08-11 Ucb Sa Piperidine derivatives
US3965257A (en) * 1972-01-28 1976-06-22 Richardson-Merrell Inc. Compositions and methods for the treatment of the symptoms of histamine induced allergic reactions
ZA728544B (en) * 1972-01-28 1974-02-27 Richardson Merrell Inc Alpha-aryl-4-substituted piperidinoalkanol derivatives
BE794598A (fr) * 1972-01-28 1973-05-16 Richardson Merrell Inc Nouveaux derives olefiniques de piperidines substituees en 4 et leur procede de preparation
US3878217A (en) * 1972-01-28 1975-04-15 Richardson Merrell Inc Alpha-aryl-4-substituted piperidinoalkanol derivatives
US3806526A (en) * 1972-01-28 1974-04-23 Richardson Merrell Inc 1-aroylalkyl-4-diphenylmethyl piperidines
BE794596A (fr) * 1972-01-28 1973-05-16 Richardson Merrell Inc Piperidinoalcanone-oximes substituees et leur procede de preparation
US3931197A (en) * 1974-02-08 1976-01-06 Richardson-Merrell Inc. Substituted piperidine derivatives
US3941795A (en) * 1974-02-08 1976-03-02 Richardson-Merrell Inc. α-ARYL-4-SUBSTITUTED PIPERIDINOALKANOL DERIVATIVES
US3946022A (en) * 1974-03-04 1976-03-23 Richardson-Merrell Inc. Piperidine derivatives
US3956296A (en) * 1974-12-11 1976-05-11 A. H. Robins Company, Incorporated 1-Substituted-4-benzylpiperidines
US3922276A (en) * 1974-12-11 1975-11-25 Robins Co Inc A H 1-Substituted-4-benzylidenepiperidines

Also Published As

Publication number Publication date
JPS55141469A (en) 1980-11-05
NZ192653A (en) 1982-03-16
DK153709C (da) 1988-12-27
ES489934A0 (es) 1981-03-16
CA1123438A (en) 1982-05-11
NL190580C (nl) 1994-05-02
AU5501680A (en) 1980-10-16
SE8002634L (sv) 1980-10-11
IL59158A0 (en) 1980-05-30
DK132980A (da) 1980-10-11
SE448726B (sv) 1987-03-16
NO1998017I1 (no) 1998-05-29
BE882703A (fr) 1980-07-31
ZA80332B (en) 1981-01-28
DE3007498A1 (de) 1980-10-23
FR2453854B1 (de) 1983-06-24
JPH0132823B2 (de) 1989-07-10
DK153709B (da) 1988-08-22
FR2453854A1 (fr) 1980-11-07
PH17023A (en) 1984-05-11
NL190580B (nl) 1993-12-01
IL59158A (en) 1984-04-30
NL980013I1 (nl) 1998-06-02
NO801014L (no) 1980-10-13
IT8048245A0 (it) 1980-03-24
NO154521C (no) 1986-10-08
AT376208B (de) 1984-10-25
NL8000754A (nl) 1980-10-14
DE3007498C2 (de) 1989-09-07
AU531146B2 (en) 1983-08-11
US4254129A (en) 1981-03-03
IT1143960B (it) 1986-10-29
CH643245A5 (de) 1984-05-30
NO154521B (no) 1986-06-30
NL980013I2 (nl) 1998-10-01
ES8103735A1 (es) 1981-03-16

Similar Documents

Publication Publication Date Title
AT376208B (de) Verfahren zum herstellen von neuen piperidinderivaten und deren salzen
AT376432B (de) Verfahren zum herstellen von neuen carbostyrilderivaten und von deren saeureadditions-salzen
AT376207B (de) Verfahren zum herstellen von neuen piperidinderivaten und deren saeureadditionssalzen
AT371813B (de) Verfahren zum herstellen von neuen substituierten propanolamin- und morpholinderivaten und von deren isomeren und salzen
AT364851B (de) Verfahren zur herstellung von neuen thienothiazinderivaten und von deren salzen
AT371454B (de) Verfahren zur herstellung von neuen prostanderivaten und von deren salzen
AT366043B (de) Verfahren zur herstellung von neuen chinazolinderivaten und deren salzen
AT374458B (de) Verfahren zum herstellen von neuen piperidinderivaten und deren salzen
AT376210B (de) Verfahren zum herstellen von neuen benzimidazolderivaten und von estern und salzen hievon
AT370095B (de) Verfahren zum herstellen von neuen 1-aryl-alkyl-imidazolderivaten und deren salzen
AT371112B (de) Verfahren zur herstellung von neuen 2-imino-imidazolidin-derivaten und von deren salzen
AT363937B (de) Verfahren zur herstellung von neuen bispidinderivaten und deren salzen
ATA909480A (de) Verfahren zum herstellen von neuen carbostyrilderivaten und ihren salzen
AT375358B (de) Verfahren zum herstellen von neuen piperazinmethaniminderivaten und von deren saeureadditionssalzen
AT365183B (de) Verfahren zur herstellung von neuen 4-amino-2-piperidinochinazolinderivaten und deren salzen
AT372951B (de) Verfahren zum herstellen von neuen benzimidazolen bzw. benzimidazolidinen und von deren salzen
ATA507181A (de) Verfahren zum herstellen von neuen 1-arylalkyl-imidazolderivaten und deren salzen
ATA73877A (de) Verfahren zur herstellung von neuen oxadiazolopyrimidinderivaten und von deren salzen
AT376434B (de) Verfahren zum herstellen von neuen carbostyrilderivaten und von deren saeureadditionssalzen
ATA391583A (de) Verfahren zum herstellen von neuen carbostyrilderivaten und von deren saeureadditionssalzen
AT371809B (de) Verfahren zum herstellen von neuen chinazolinen und ihren salzen
AT352727B (de) Verfahren zur herstellung von neuen indol- derivaten und deren salzen
AT369730B (de) Verfahren zum herstellen von neuen basischen p-chloracetophenonoximaethern
ATA419781A (de) Verfahren zum herstellen von neuen substituierten morpholinderivaten und von deren isomeren und salzen
ATA356778A (de) Verfahren zur herstellung von neuen 4-hydroxy- thiazolidin-2-thion-derivaten und von deren salzen

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties
EFA Change in the company name
EZF Grant of a certificate of protection

Free format text: SZ 20/97, 970613, EXPIRES:20070315

SZA Application filed for a certificate of protection

Free format text: SZ 20/97, 970613

ELA Expired due to lapse of time