AT386198B - Verfahren zur herstellung von neuen carbostyrilderivaten und von deren pharmazeutisch annehmbaren salzen - Google Patents

Verfahren zur herstellung von neuen carbostyrilderivaten und von deren pharmazeutisch annehmbaren salzen

Info

Publication number
AT386198B
AT386198B AT0059582A AT59582A AT386198B AT 386198 B AT386198 B AT 386198B AT 0059582 A AT0059582 A AT 0059582A AT 59582 A AT59582 A AT 59582A AT 386198 B AT386198 B AT 386198B
Authority
AT
Austria
Prior art keywords
acceptable salts
pharmaceutical acceptable
producing new
carbostyrile
derivatives
Prior art date
Application number
AT0059582A
Other languages
English (en)
Other versions
ATA59582A (de
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP56022437A external-priority patent/JPS57136517A/ja
Priority claimed from JP56057732A external-priority patent/JPS57171974A/ja
Priority claimed from JP12714581A external-priority patent/JPS5829766A/ja
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Publication of ATA59582A publication Critical patent/ATA59582A/de
Application granted granted Critical
Publication of AT386198B publication Critical patent/AT386198B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
AT0059582A 1981-02-17 1982-02-16 Verfahren zur herstellung von neuen carbostyrilderivaten und von deren pharmazeutisch annehmbaren salzen AT386198B (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP56022437A JPS57136517A (en) 1981-02-17 1981-02-17 Cardiotonic
JP56057732A JPS57171974A (en) 1981-04-15 1981-04-15 Carbostyril derivative
JP12714581A JPS5829766A (ja) 1981-08-12 1981-08-12 カルボスチリル誘導体

Publications (2)

Publication Number Publication Date
ATA59582A ATA59582A (de) 1987-12-15
AT386198B true AT386198B (de) 1988-07-11

Family

ID=27283844

Family Applications (1)

Application Number Title Priority Date Filing Date
AT0059582A AT386198B (de) 1981-02-17 1982-02-16 Verfahren zur herstellung von neuen carbostyrilderivaten und von deren pharmazeutisch annehmbaren salzen

Country Status (21)

Country Link
US (3) US4487772A (de)
KR (1) KR860001337B1 (de)
AT (1) AT386198B (de)
AU (1) AU530264B2 (de)
BE (1) BE892148A (de)
CA (1) CA1199915A (de)
CH (1) CH651827A5 (de)
DE (1) DE3204892A1 (de)
DK (1) DK152287C (de)
ES (2) ES8305334A1 (de)
FI (1) FI77852C (de)
FR (1) FR2512818B1 (de)
GB (1) GB2094789B (de)
IT (1) IT1157002B (de)
MX (1) MX156153A (de)
NL (1) NL8200593A (de)
NO (1) NO159446C (de)
PH (1) PH18085A (de)
PT (1) PT74440B (de)
SE (1) SE445348B (de)
SU (1) SU1331426A3 (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH17194A (en) * 1980-03-06 1984-06-19 Otsuka Pharma Co Ltd Novel carbostyril derivatives,and pharmaceutical composition containing the same
FI77852C (fi) * 1981-02-17 1989-05-10 Otsuka Pharma Co Ltd Foerfarande foer framstaellning av nya, saosom hjaertmediciner anvaendbara substituerade amid- och (maettad heterocykel)karbonylkarbostyrilderivat.
AU532361B2 (en) * 1981-09-01 1983-09-29 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives
FI80022C (fi) * 1982-07-05 1990-04-10 Otsuka Pharma Co Ltd Foerfarande foer framstaellning av ett nytt, terapeutiskt anvaendbart karbostyrilderivat.
US4845100A (en) * 1985-04-12 1989-07-04 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives and salts thereof, processes for preparing the same and cardiotonic composition containing the same
US4921862A (en) * 1986-05-29 1990-05-01 Syntex (U.S.A.) Inc. Carbostyril derivatives as combined thromboxane synthetase and cyclic-amp phosphodiesterase inhibitors
US4792561A (en) * 1986-05-29 1988-12-20 Syntex (U.S.A.) Inc. Carbostyril derivatives as combined thromboxane synthetase and cyclic-AMP phosphodiesterase inhibitors
DE3784401T2 (de) * 1986-07-31 1993-08-12 Otsuka Pharma Co Ltd Karbostyril-derivate und ihre salze, verfahren zu ihrer herstellung und diese enthaltende kardiotonische zusammensetzung.
GB8709448D0 (en) * 1987-04-21 1987-05-28 Pfizer Ltd Heterobicyclic quinoline derivatives
US5227381A (en) * 1988-05-02 1993-07-13 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivative
DE3818830A1 (de) * 1988-06-03 1989-12-14 Boehringer Mannheim Gmbh Bicyclische carboxamide, verfahren zu ihrer herstellung, deren vorstufen, und diese verbindungen enthaltende arzneimittel
JP2686887B2 (ja) * 1992-08-11 1997-12-08 キッセイ薬品工業株式会社 ピペリジノ−３，４−ジヒドロカルボスチリル誘導体
JPH06239858A (ja) * 1993-02-16 1994-08-30 Otsuka Pharmaceut Co Ltd 末梢血管拡張剤
WO1994022826A1 (en) * 1993-04-07 1994-10-13 Otsuka Pharmaceutical Co., Ltd. Peripheral vasodilating agent containing n-acylated 4-amino piperidine derivatives as active ingredients
DK0709384T3 (da) * 1994-10-31 1999-08-23 Merck Patent Gmbh Benzylpiperidinderivater med høj affinitet til aminosyrereceptorers bindingssteder
US6340685B1 (en) * 1998-05-22 2002-01-22 Scios, Inc. Compounds and methods to treat cardiac failure and other disorders
US6589954B1 (en) 1998-05-22 2003-07-08 Scios, Inc. Compounds and methods to treat cardiac failure and other disorders
US6867209B1 (en) 1998-05-22 2005-03-15 Scios, Inc. Indole-type derivatives as inhibitors of p38 kinase
US6448257B1 (en) 1998-05-22 2002-09-10 Scios, Inc. Compounds and methods to treat cardiac failure and other disorders
IL146309A (en) 1999-05-21 2008-03-20 Scios Inc Derivatives of the indole type and pharmaceutical preparations containing them as inhibitors of kinase p38
WO2004014389A1 (en) * 2002-08-13 2004-02-19 Warner-Lambert Company Llc 3,4-dihydroquinolin-2-one, 5,6-fused oxazin-3-one, and 5,6-fused thiazin-3-one derivatives as matrix metalloproteinase inhibitors
BRPI0417571A (pt) * 2003-12-10 2007-03-20 Janssen Pharmaceutica Nv 2-quinolinonas e 2-quinoxalinonas substituìdas por 6-ciclohexil-alquila substituìda como inibidores da poli(adp-ribose) polimerase
MY142362A (en) * 2004-01-29 2010-11-30 Otsuka Pharma Co Ltd Pharmaceutical composition for promoting angiogenesis
WO2007124345A2 (en) 2006-04-21 2007-11-01 The Government Of The United States, As Represented By The Secretary Of Health And Human Services Beta-amyloid pet imaging agents
US20100092479A1 (en) * 2008-08-18 2010-04-15 Combinatorx (Singapore) Pte. Ltd. Compositions and methods for treatment of viral diseases
EP3309151A1 (de) 2009-06-25 2018-04-18 Alkermes Pharma Ireland Limited Heterocyclische verbindungen zur behandlung von neurologischen und psychologischen erkrankungen
NZ603268A (en) 2010-05-04 2015-02-27 Alkermes Pharma Ireland Ltd Process for synthesizing oxidized lactam compounds
AU2011270701B2 (en) 2010-06-24 2015-05-14 Alkermes Pharma Ireland Limited Prodrugs of NH-acidic compounds: ester, carbonate, carbamate and phosphonate derivatives
EP3717477B1 (de) * 2017-11-28 2022-07-20 F. Hoffmann-La Roche AG Neue heterocyclische verbindungen
CN111566105A (zh) 2018-01-08 2020-08-21 豪夫迈·罗氏有限公司 作为MAGL抑制剂的八氢吡啶并[1,2-α]吡嗪类化合物
CN109651285B (zh) * 2019-01-30 2020-06-30 苏州大学 多溴代苯并[1,3]噁嗪衍生物的合成方法
JP2023539690A (ja) 2020-09-03 2023-09-15 エフ． ホフマン－ラ ロシュ アーゲー 複素環式化合物

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2437297A1 (de) * 1973-08-06 1975-02-20 Montedison Spa Derivate der chinolin-8-carboxylsaeuren

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2997474A (en) * 1959-10-12 1961-08-22 Paul A J Janssen 1-aryl-omega-(4-arylpiperazine) alkanols
US3555030A (en) * 1964-11-25 1971-01-12 Smith Kline French Lab Muscle relaxant and analgesic compositions
US4115569A (en) * 1971-11-19 1978-09-19 Hoechst Aktiengesellschaft Cyclic diamine derivatives
US4256890A (en) * 1972-09-14 1981-03-17 Otsukapharmaceutical Co., Ltd. 3,4-Dihydrocarbostyril derivatives and process for producing the same
US4026897A (en) * 1974-01-31 1977-05-31 Otsuka Pharmaceutical Company 5-[1-Hydroxy-2-(substituted-amino)]alkyl-8-hydroxycarbostyril derivatives
US4022784A (en) * 1974-01-31 1977-05-10 Otsuka Pharmaceutical Company Limited 5-[1-Hydroxy-2-(substituted-amino)]alkyl-8-substituted-carbostyril and -3,4-dihydrocarbostyril derivatives
US4145542A (en) * 1974-06-13 1979-03-20 Otsuka Pharmaceutical Co., Ltd. 5- 1-Hydroxy-2-(heterocyclic-amino)!alkyl-8-hydroxy-3,4-dihydrocarbostyril derivatives
US4070470A (en) * 1974-06-24 1978-01-24 Otsuka Pharmaceutical Co., Ltd. Platelet aggregation inhibiting carbostyrils, their compositions and method of use
JPS51118771A (en) * 1975-04-09 1976-10-18 Otsuka Pharmaceut Co Ltd Method for preparing carbostyryl derivatives
US3994900A (en) * 1976-01-23 1976-11-30 E. R. Squibb & Sons, Inc. 6-(Or 8)-[[(substituted amino)alkyl]oxy(or thio)]-3,4-dihydro-4-phenyl-2(1H)-quinolinones
US4210753A (en) * 1976-03-17 1980-07-01 Otsuka Pharmaceutical Co., Ltd. Carbostyril compounds
GB1589871A (en) * 1976-07-19 1981-05-20 Conder Group Serv Ltd Tank construction
JPS609713B2 (ja) * 1976-10-08 1985-03-12 大塚製薬株式会社 カルボスチリル誘導体
NZ187452A (en) * 1977-06-10 1980-05-27 Otsuka Pharma Co Ltd N- substituted-aminocarbonylpropoxy-carbostyrils and their preparation
JPS5416478A (en) * 1977-07-08 1979-02-07 Otsuka Pharmaceut Co Ltd 3,4-dihydrocarbostyril herivative
DE2928583A1 (de) * 1979-07-14 1981-01-29 Thomae Gmbh Dr K Verfahren zur herstellung von carbostyrilderivaten
PH17194A (en) * 1980-03-06 1984-06-19 Otsuka Pharma Co Ltd Novel carbostyril derivatives,and pharmaceutical composition containing the same
FI77852C (fi) * 1981-02-17 1989-05-10 Otsuka Pharma Co Ltd Foerfarande foer framstaellning av nya, saosom hjaertmediciner anvaendbara substituerade amid- och (maettad heterocykel)karbonylkarbostyrilderivat.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2437297A1 (de) * 1973-08-06 1975-02-20 Montedison Spa Derivate der chinolin-8-carboxylsaeuren

Also Published As

Publication number Publication date
KR860001337B1 (ko) 1986-09-15
DE3204892C2 (de) 1988-03-24
IT1157002B (it) 1987-02-11
FI77852C (fi) 1989-05-10
GB2094789B (en) 1985-01-23
ES509693A0 (es) 1983-04-01
DK152287B (da) 1988-02-15
IT8267177A0 (it) 1982-02-17
DK152287C (da) 1988-07-11
SU1331426A3 (ru) 1987-08-15
SE8200916L (sv) 1982-08-18
US4454130A (en) 1984-06-12
MX156153A (es) 1988-07-19
CA1199915A (en) 1986-01-28
PT74440B (en) 1983-08-24
US4468402A (en) 1984-08-28
AU8052882A (en) 1982-11-11
NO159446C (no) 1988-12-28
ATA59582A (de) 1987-12-15
ES8305334A1 (es) 1983-04-01
BE892148A (fr) 1982-08-16
FI77852B (fi) 1989-01-31
KR830009036A (ko) 1983-12-17
ES518303A0 (es) 1984-01-01
SE445348B (sv) 1986-06-16
PH18085A (en) 1985-03-20
GB2094789A (en) 1982-09-22
US4487772A (en) 1984-12-11
FI820338L (fi) 1982-08-18
CH651827A5 (de) 1985-10-15
AU530264B2 (en) 1983-07-07
PT74440A (en) 1982-03-01
DE3204892A1 (de) 1982-09-23
NO820479L (no) 1982-08-18
FR2512818B1 (fr) 1985-06-21
NO159446B (no) 1988-09-19
ES8401959A1 (es) 1984-01-01
DK66582A (da) 1982-08-18
NL8200593A (nl) 1982-09-16
FR2512818A1 (fr) 1983-03-18

Similar Documents

Publication Publication Date Title
AT386198B (de) Verfahren zur herstellung von neuen carbostyrilderivaten und von deren pharmazeutisch annehmbaren salzen
AT386825B (de) Verfahren zur herstellung von neuen benzimidazolderivaten und von deren salzen
AT375366B (de) Verfahren zur herstellung von neuen indolderivaten und deren pharmazeutisch annehmbaren saeureadditionssalzen
AT385506B (de) Verfahren zur herstellung von neuen carbostyrilderivaten und deren salzen
AT381705B (de) Verfahren zur herstellung von neuen thiazolidindion-derivaten und deren salzen
ATA908381A (de) Verfahren zur herstellung von neuen carbostyrilverbindungen und deren pharmazeutisch annehmbaren salzen
AT381096B (de) Verfahren zur herstellung von neuen cephemverbindungen und deren pharmazeutisch unbedenklichen salzen
AT374188B (de) Verfahren zur herstellung von neuen a-alkylimidazolderivaten und deren salzen
AT381708B (de) Verfahren zur herstellung von neuen macroliden und deren pharmazeutisch annehmbaren salzen
AT383592B (de) Verfahren zur herstellung von neuen carbostyrilderivaten und deren salzen
AT376983B (de) Verfahren zur herstellung von neuen 7-acylaminocephalosporansaeurederivaten und deren salzen
AT379592B (de) Verfahren zur herstellung von neuen benzothiazolin-verbindungen und von deren salzen
AT378188B (de) Verfahren zur herstellung von neuen thiazolidinderivaten und deren salzen
AT381308B (de) Verfahren zur herstellung von neuen fluorprostacyclinen und von deren salzen
AT379804B (de) Verfahren zur herstellung von neuen phenaethylimidazolderivaten und von deren salzen
AT377767B (de) Verfahren zur herstellung von neuen 4-aza-17subst.-5alpha-androstan-3-onen und deren pharmazeutisch verwendbaren salzen
ATA238481A (de) Verfahren zur herstellung von neuen acylaminophenylpyridinderivaten und deren salzen
AT374450B (de) Verfahren zur herstellung von neuen propanolaminderivaten und deren salzen
ATA238683A (de) Verfahren zur herstellung von neuen eburnan-oxim-aether-derivaten und von deren saeureadditionssalzen
AT375355B (de) Verfahren zur herstellung von neuen phenthiazin-derivaten und von deren salzen
AT376438B (de) Verfahren zur herstellung von neuen indolizinderivaten und von deren pharmazeutisch zulaessigen saeureadditionssalzen
AT375932B (de) Verfahren zur herstellung von neuen indolderivaten und deren pharmazeutisch annehmbaren saeureadditionssalzen
ATA471980A (de) Verfahren zur herstellung von neuen prostacyclinen und deren pharmazeutisch verwertbaren salzen
ATA550680A (de) Verfahren zur herstellung von neuen thienothiazin-derivaten und von deren salzen
ATA550780A (de) Verfahren zur herstellung von neuen thienothiazin-derivaten und von deren salzen

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties
ELJ Ceased due to non-payment of the annual fee