AT384428B - Verfahren zur herstellung eines gemisches sulfatgruppenhaltiger polysaccaride - Google Patents

Verfahren zur herstellung eines gemisches sulfatgruppenhaltiger polysaccaride

Info

Publication number
AT384428B
AT384428B AT0213681A AT213681A AT384428B AT 384428 B AT384428 B AT 384428B AT 0213681 A AT0213681 A AT 0213681A AT 213681 A AT213681 A AT 213681A AT 384428 B AT384428 B AT 384428B
Authority
AT
Austria
Prior art keywords
polysaccaride
mixed
producing
sulfate groups
containing sulfate
Prior art date
Application number
AT0213681A
Other languages
English (en)
Other versions
ATA213681A (de
Original Assignee
Pharmindustrie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9241965&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AT384428(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pharmindustrie filed Critical Pharmindustrie
Publication of ATA213681A publication Critical patent/ATA213681A/de
Application granted granted Critical
Publication of AT384428B publication Critical patent/AT384428B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Compounds Of Unknown Constitution (AREA)
AT0213681A 1980-05-14 1981-05-13 Verfahren zur herstellung eines gemisches sulfatgruppenhaltiger polysaccaride AT384428B (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8010791A FR2482611B1 (fr) 1980-05-14 1980-05-14 Nouveaux polysaccharides sulfates, procedes pour leur preparation et leur utilisation comme medicaments

Publications (2)

Publication Number Publication Date
ATA213681A ATA213681A (de) 1987-04-15
AT384428B true AT384428B (de) 1987-11-10

Family

ID=9241965

Family Applications (1)

Application Number Title Priority Date Filing Date
AT0213681A AT384428B (de) 1980-05-14 1981-05-13 Verfahren zur herstellung eines gemisches sulfatgruppenhaltiger polysaccaride

Country Status (23)

Country Link
EP (1) EP0040144B1 (de)
JP (1) JPS6051482B2 (de)
KR (1) KR840001753B1 (de)
AR (1) AR229510A1 (de)
AT (1) AT384428B (de)
AU (1) AU535791B2 (de)
CA (1) CA1181744A (de)
DE (1) DE3165361D1 (de)
DK (1) DK168824B1 (de)
DZ (1) DZ294A1 (de)
ES (1) ES8206555A1 (de)
FI (1) FI67865C (de)
FR (1) FR2482611B1 (de)
GR (1) GR82283B (de)
HU (1) HU188667B (de)
IE (1) IE51283B1 (de)
IL (1) IL62866A (de)
IN (1) IN152828B (de)
MA (1) MA19143A1 (de)
NO (1) NO156129C (de)
NZ (1) NZ197081A (de)
PT (1) PT73024B (de)
ZA (1) ZA813176B (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2548672A1 (fr) * 1983-07-04 1985-01-11 Pharmuka Lab Oligosaccharides sulfates et leur utilisation comme medicaments
DE3422407A1 (de) * 1984-06-16 1986-03-06 B. Braun Melsungen Ag, 3508 Melsungen Verwendung von heparinderivaten zur selektiven extrakorporalen praezipitation von low-density-lipoproteinen aus vollserum oder plasma
EP0209924A1 (de) * 1985-07-12 1987-01-28 Akzo N.V. Antithrombotikum auf Basis von Glykosaminoglykan, Verfahren zu dessen Herstellung und pharmazeutische Zusammensetzung
FR2584728B1 (fr) * 1985-07-12 1987-11-20 Choay Sa Procede de sulfatation de glycosaminoglycanes et de leurs fragments
ES2003197A6 (es) * 1987-01-05 1988-10-16 Rovi Lab Farmaceut Sa Procedimiento de despolimerizacion de la heparina para la obtencion de una heparina de bajo peso molecular dotada de actividad antitrombotica
EP0337327A1 (de) * 1988-04-09 1989-10-18 Bioiberica, S.A. Verfahren zur Herstellung von neuen Oligosaccharid-Fragmenten durch kontrollierte chemische Depolymerisation von Heparin
IT1230582B (it) 1988-10-21 1991-10-28 Opocrin S P A Lab Farmabiologi Oliogosaccaridi di dermatan solfato ed eparina aventi attivita' antiaterosclerotica
IT1234826B (it) * 1989-01-30 1992-05-29 Alfa Wassermann Spa Derivati eparinici e procedimento per la loro preparazione
US5340932A (en) * 1989-08-18 1994-08-23 Ajorca S.A. Substances with heparin-like structure and their method of production
DE4121115B9 (de) * 1990-06-26 2005-09-29 Aventis Pharma S.A. Gemische sulfatierter Polysaccharide mit der Grundstruktur der das Heparin bildenden Polysaccharide und mit niedrigem Molekulargewicht, deren Herstellungsverfahren und Verwendung
FR2663639B1 (fr) * 1990-06-26 1994-03-18 Rhone Poulenc Sante Melanges de polysaccharides de bas poids moleculaires procede de preparation et utilisation.
USRE38743E1 (en) 1990-06-26 2005-06-14 Aventis Pharma S.A. Mixtures of particular LMW heparinic polysaccharides for the prophylaxis/treatment of acute thrombotic events
US5707973A (en) * 1991-04-23 1998-01-13 Rhone-Poulenc Rorer S.A. Sulfated polysaccharids for treatment or prevention of thromboses
IT1256236B (it) * 1992-12-23 1995-11-29 Mediolanum Farmaceutici Srl Oligosaccaridi aventi attivita' biologica e procedimento per la loro preparazione di glicosaminoglicani
ES2077533B1 (es) * 1994-02-28 1996-07-01 Bioiberica Procedimiento de obtencion de fracciones de oligosacaridos por despolimerizacion quimica de heparina.
AP1390A (en) * 1996-11-27 2005-04-15 Aventis Pharmaceuticals Products Inc Pharmaceutical composition comprising a compound having anti-Xa activity and a platelet aggregation antagonist compound.
AUPO556297A0 (en) * 1997-03-11 1997-04-10 Australian National University, The Sulfated oligosaccharides having anticoagulant/ antithrombotic activity
JP4897991B2 (ja) * 1999-07-23 2012-03-14 ラボラトリオス ファルマセウティコス ロビ ソシエダッド アノニマ 超低分子量ヘパリン組成物
US6969705B2 (en) 2000-07-21 2005-11-29 Aventis Pharma S.A. Compositions of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them
FR2811992B1 (fr) * 2000-07-21 2003-07-04 Aventis Pharma Sa Melanges de polysaccharides derives d'heparine, leur preparation et les compositions pharmaceutiques les contenant
ATE356150T1 (de) * 2002-06-20 2007-03-15 Chemi Spa Verfahren zur herstellung von heparinestern
FR2845686B1 (fr) * 2002-10-10 2013-08-30 Aventis Pharma Sa Melanges de polysaccharides derives d'heparine, leur preparation et les compositions pharmaceutiques les contenant
US20040171819A1 (en) 2002-10-10 2004-09-02 Aventis Pharma S.A. Mixtures of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them
JP2006096668A (ja) * 2002-11-08 2006-04-13 Ono Pharmaceut Co Ltd エラスターゼ阻害剤と血液凝固系および／または線溶系酵素阻害剤との組み合わせからなる医薬
DE10260958A1 (de) * 2002-12-20 2004-07-08 Sustech Gmbh & Co. Kg Kompositmaterialien aus Calciumverbindungen und Glucuronsäure- und/oder Iduronsäurehaltigen Polysacchariden
US7956046B2 (en) 2003-07-24 2011-06-07 Aventis Pharma S.A. Oligosaccharide mixtures derived from heparin, preparation thereof and pharmaceutical compositions containing them
ITMI20031679A1 (it) * 2003-08-29 2005-02-28 Opocrin Spa Processo per la produzione di eparine a basso peso
EP1582531A1 (de) 2004-03-24 2005-10-05 Aventis Pharma S.A. Verfahren zur Oxydierung nicht-fraktionierten Heparins und die Detektion der Anwesenheit oder Abwesenheit von Glykoserin in Heparin und in von Heparin abgeleiteten Produkten
US20050261241A1 (en) 2004-05-19 2005-11-24 Celsus Biopharmaceuticals, Inc. Use of dermatan sulfates and/or desulfated heparins to treat or prevent heparinoid-induced autoimmune responses
ATE552004T1 (de) 2005-11-30 2012-04-15 Istituto G Ronzoni Oral verabreichbare heparinderivate
ES2340902B1 (es) * 2008-07-01 2011-05-03 Laboratorios Farmaceuticos Rovi, S.A. Composicion farmaceutica con glicosaminoglicanos y su uso en tratamiento de ulceras cronicas.
EP3144325B1 (de) * 2010-09-14 2020-11-04 University Of Miyazaki Hochreines heparin und herstellungsverfahren dafür
WO2019116217A2 (en) 2017-12-11 2019-06-20 Biological E Limited Process for the preparation of low molecular weight heparin
BR112022000255A8 (pt) 2019-07-09 2022-03-22 Optimvia Llc Métodos para sintetizar polissacarídeos anticoagulantes
CN114072430B (zh) 2020-04-27 2023-07-28 罗威制药股份有限公司 低分子量肝素获取程序以及由此获得的低分子量肝素
EP4182452A1 (de) 2020-07-14 2023-05-24 Optimvia, LLC Verfahren zur synthese von nicht-antikoagulierendem heparansulfat

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3835112A (en) * 1970-06-08 1974-09-10 Etude Et D Exploit De Marques Heparin esters
CA1136620A (en) * 1979-01-08 1982-11-30 Ulf P.F. Lindahl Heparin fragments having selective anticoagulation activity

Also Published As

Publication number Publication date
FI811469L (fi) 1981-11-15
MA19143A1 (fr) 1981-12-31
PT73024B (fr) 1982-07-01
EP0040144A1 (de) 1981-11-18
NO156129B (no) 1987-04-21
ZA813176B (en) 1982-05-26
AU7051981A (en) 1981-11-19
JPS6051482B2 (ja) 1985-11-14
ES502199A0 (es) 1982-08-16
KR840001753B1 (ko) 1984-10-19
DE3165361D1 (en) 1984-09-13
FR2482611A1 (fr) 1981-11-20
HUT34769A (en) 1985-04-28
NO156129C (no) 1987-07-29
ES8206555A1 (es) 1982-08-16
KR830006333A (ko) 1983-09-24
GR82283B (de) 1984-12-13
JPS5710601A (en) 1982-01-20
EP0040144B1 (de) 1984-08-08
AR229510A1 (es) 1983-09-15
IL62866A0 (en) 1981-07-31
FI67865C (fi) 1985-06-10
IN152828B (de) 1984-04-14
AU535791B2 (en) 1984-04-05
DK211981A (da) 1981-11-15
DZ294A1 (fr) 2004-09-13
HU188667B (en) 1986-05-28
DK168824B1 (da) 1994-06-20
ATA213681A (de) 1987-04-15
PT73024A (fr) 1981-06-01
IE811074L (en) 1981-11-14
IL62866A (en) 1984-06-29
FI67865B (fi) 1985-02-28
CA1181744A (fr) 1985-01-29
NO811632L (no) 1981-11-16
NZ197081A (en) 1984-07-31
FR2482611B1 (fr) 1986-03-07
IE51283B1 (en) 1986-11-26

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Legal Events

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EIH Change in the person of patent owner
SZA Application filed for a certificate of protection

Free format text: SZ50/94, 941128

EZF Grant of a certificate of protection

Free format text: SZ 50/94, 941128, EXPIRES:20060308

EFA Change in the company name
ELA Expired due to lapse of time